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Diabetic keto acidosis in children ... Dr.Padmesh

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Dr Padmesh Vadakepat
Dr Padmesh Vadakepat

The document discusses diabetic ketoacidosis (DKA), a life-threatening complication that occurs most often in patients with type 1 diabetes. DKA is characterized by hyperglycemia, metabolic acidosis, and ketosis. It results from a lack of insulin and excess counterregulatory hormones that cause fat and protein breakdown. This leads to ketone accumulation and high blood glucose levels. Treatment involves insulin, intravenous fluids, electrolyte replacement, and monitoring for complications like cerebral edema.

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DIABETIC KETOACIDOSIS Dr.Padmesh. V Dept of Pediatrics Dr.SMCSI Medical College, Karakonam, Trivandrum
DKA ,[object Object],[object Object],[object Object]
DKA :definition ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Physiology of carbohydrate metabolism ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
To develop DKA there must be both a relative lack of insulin and a relative overactivity of counter-regulatory hormones ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Physiology
Physiology of DKA ,[object Object],[object Object]
Physiology of carbohydrate metabolism ,[object Object],[object Object],[object Object],[object Object],To develop DKA there must be both a relative lack of insulin and a relative overactivity of counter-regulatory hormones
[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
Pathophysiology of DKA ,[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
Potassium ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Pathophysiology of Potassium loss ,[object Object],[object Object],[object Object],[object Object],[object Object]
Sodium ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
CLINICAL FEATURES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Lab Abnormalities and Diagnosis ,[object Object],[object Object],[object Object],[object Object],[object Object]
Laboratory Abnormalities and Diagnosis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Should be re-checked after rehydration
[object Object],[object Object],[object Object]
To summarize..
In short…
[object Object],[object Object]
Aims of management: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
TREATMENT OF DKA (Milwaukee DKA PROTOCOL) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],* *
[object Object],[object Object],[object Object],[object Object],IV rate = 85ml/kg + maintenance – bolus 23 hr
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cautious rehydration : ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Complications of DKA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cerebral edema ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cerebral Edema – Clinical Features: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cerebral edema –Treatment : ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object]
 

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