Huateng Pharma provides intermediates for several classes of antidiabetic drugs including SGLT2 inhibitors, DPP-4 inhibitors, and GLP-1 agonists. They offer a one-stop process from development to commercialization of drug intermediates. The document lists several specific intermediates for canagliflozin, dapagliflozin, empagliflozin, sitagliptin, and semaglutide along with their CAS registry numbers. Huateng Pharma will exhibit at CPhI conferences in North America and China in 2023.

1. Huateng Pharma https://us.huatengsci.com
Antidiabetic Drugs Intermediates Production
Huateng Pharma provides a one stop process development service from
concept to commercialization.
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SGLT2 Inhibitors
SGLT2 inhibitors are a class of prescription medicines that are FDA-approved
for use with diet and exercise to lower blood sugar in adults with type 2
diabetes.
Canagliflozin Intermediates
(5-Bromo-2-methylphenyl)[5-(4-fluorophenyl)-2-thienyl]methanone
CAS NO.1132832-75-7
2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene
CAS NO.898566-17-1
2-[(5-bromo-2-methylphenyl)methyl]-5-(4-fluorophenyl)thiophene
CAS NO.1030825-20-7
2-(4-Fluorophenyl)thiophene
CAS NO.58861-48-6
Dapagliflozin Intermediates
4-Iodo-1-chloro-2-(4-ethoxybenzyl)benzene
CAS NO.1103738-29-9
Benzene, 4-bromo-1-chloro-2-[(4-ethoxyphenyl)methyl]-

2. Huateng Pharma https://us.huatengsci.com
CAS NO.461432-23-5
Empagliflozin Intermediates
(3S)-3-[4-[(5-bromo-2-chlorophenyl)methyl]phenoxy]oxolane
CAS NO.915095-89-5
(S)-4-iodo-1-chloro-2-(4-tetrahydrofuran-3-yloxy-benzyl)-benzene
CAS NO.915095-94-2
DPP-4 Inhibitors
DPP-4 inhibitors, known as gliptins, are a class of oral diabetic medications
approved by the Food and Drug Administration (FDA) to treat type 2 diabetes
mellitus in adults.
Sitagliptin Intermediates
3-Trifluoromethyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine
hydrochloride
CAS NO.762240-92-6
(R)-N-Boc-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid
CAS NO.486460-00-8
GLP-1 Agonists
GLP-1 agonists are used to lower blood sugar levels to treat diabetes type 2 by
releasing more insulin into the bloodstream.
Semaglutide Intermediates
Fmoc-L-Lys[Oct-(otBu)-Glu-(otBu)-AEEA-AEEA]-OH
CAS NO.1662688-20-1
tBuO-Ste-Gljavascript:void(0)-OtBu
CAS NO.1118767-16-0
AEEA-AEEA
CAS NO.1143516-05-5

3. Huateng Pharma https://us.huatengsci.com
CH2COOH-PEG2-NH2.HCl
CAS NO.:134979-01-4
Boc-NH-PEG2-CH2COOH
CAS NO.:108466-89-3
Fmoc-NH-PEG2-CH2COOH
CAS NO.:166108-71-0
NH2-PEG2-CH2COOH
CAS NO.:134978-97-5
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CPhI North America 2023
25-27 April, 2023
Pennsylvania Convention Center, Philadelphia
Booth #322
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CPhI China 2023
19-21 June, 2023
Shanghai New International Expo Center
Booth #W1D08
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