Curiosity and observation, creativity and improvisation, collaboration and open communication are core competencies for knowledge workers—in the future more than ever. In addition, determination and persistence, agility and adaptability, supported by good leadership and a little bit of luck, bred success. As we look back and ahead, it becomes apparent that the demands of our societies and globalized, digitalized information economies require answers that go beyond the traditional notion of work in organizations, and knowledge work in particular. Knowledge workers need to be enabled differently in order to succeed in this accelerated and complex time we live in. A new approach to leadership that embraces curiosity, creativity and collaboration is required. To survive, organizations need to constantly innovate and look for sustainable ways to execute their mission. Some of the skills, competencies, methods and approaches that are required for individuals, leaders and organizations can be found in the arts, in particular by observing and learning how artists perform their work.