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BLOOD DISORDERS
Dhuha F Shamsaldeen
What is blood ?
Blood is a combination of plasma (watery liquid) and cells
that float in it. It is a specialized bodily fluid that supplies
essentials substances and nutrients, such as sugar,
oxygen, and hormones to our cells, and carries waste away
from those cells
Types of blood cells
Red blood cells - also known as RBCs or
erythrocytes. These are the most abundant
cells, and contain hemoglobin (Hb or
Hgb). Hemoglobin is a protein which contains
iron; it transports oxygen from the lungs to
body tissues and cells. 97% of a human's red
blood cell's dry content is protein.
White blood cells (leukocytes) - these are the
cells of our immune system; they defend the
body against infections and foreign materials.
Platelets (thrombocytes) - are involved in the
clotting (coagulation) of blood. When we bleed
the platelets clump together to help form a
clot.
ANEMIA
• Anemia is a condition in which the hemoglobin
concentration is lower than the normal; it reflects the
presence of fewer than the normal number of erythrocytes
within the circulation.
• As a result, the amount of oxygen delivered to the body
tissues is also diminished.
• Anemia is not a specific disease state but a sign of an
underlying disorder. It is by far the most common
hematologic condition.
Classification of
anemia
hypoproliferative
Results from defective
RBC production
bleeding
Results from RBC loss
hemolytic
Results from RBC
destruction
hypoproliferative
Iron deficiency.
Vitamin B12 deficiency (megaloblastic)
Folate deficiency (megaloblastic)
Decreased erythropoitin production
Cancer/ inflammation
Bleeding
Bleeding from GI
tract, epistaxis
(nosebleed),
trauma, bleeding
from genitourinary
tract
(menorrhagia)
Hemolytic
Sickle anemia
Hypersplenism
( hemolysis)
Drug-induced
anemia
Autoimmune
anemia
Mechanical
heart valve-
related anemia
Stressors
Physiological
• Reduced RBC
production.
• Excessive RBC
destruction.
sociocultural • Diet habits.
developmental
• Age group.
• sex
Clinical manifestations:
Special
complications of
the condition
that produced
anemia
The
duration
of anemia
The speed
of anemia
IRON DEFICIENCY ANEMIA
• Iron deficiency anemia typically results when the intake of
dietary iron is inadequate for hemoglobin synthesis.
• Iron deficiency anemia is the most common type of
anemia in all age groups, and it is the most common
anemia in the world.
Causes
• The most common cause of iron deficiency anemia in
men and women is bleeding from ulcers gastrirtis,
inflammatory bowel disease, or GI tumors. The most
common causes of IDA in premenopusal woman are
menorrhagia ( ie, excessive menstrual bleeding) and
pregnancy with inadequate iron supplementation. Other
causes include iron malabsorption, as is seen after
gastroctomy.
Sings and symptoms
Fatigue Weakness Headache
Dyspnea Palpitations Chest pain
Jaundice
Smooth;
sore tongue
Diagnostic tests
Serum iron
( female 8.9-30.4 umol/l)
( male 11.6-30.4 umol/l)
SERUM Hb
( normal
13.2-17.5
g/dk)
CBC
Bone
marrow
aspiration
Treatment
• Correction of the underlying cause, iron supplements
including :
Oral
• Ferrous phosphate, ferrous
glucanate
IV
or IM
• Administer small dose
Patient education ( taking oral iron
supplements ):
• Take iron on an empty stomach ( 1 hr before or 2 hrs after
the meal). Iron absorption is reduced with food, especially
dairy products.
• To prevent GI distress, the following schedule may work
better if more than one tablet a day is prescribed. Start
with only one tab/day for a few days, then increase to 2
tab/day, then 3 tab/day. This method permits the body to
adjust gradually to the iron.
• Increase the intake of vit C , to enhance iron absorption.
• Eat foods high in fiber to minimize problems with
constipation.
• Remember that stool will become dark in color.
SICKLE CELLANEMIA
• Sickle cell anemia is a severe hemolytic anemia results
from inheritance of the sickle hemoglobin gene.
• The sickle hemoglobin (HbS) acquires a crystal-like
formation when exposed to low oxygen tension.
Clinical manifestations:
Always
anemic (Hb=
7-10gm/dl)
Sometimes
enlargement
of the bones
of face and
skull.
Jaundice
Tachycardia
Sings and symptoms:
Pallor
Decrease
urinary output,
Dark urine-
smoky,brownish
Abdominal or
chest pain.
Swelling and
pain in the joint
Weakness
Mental
depression
Difficulty
concentrating
Diagnostic test
• CBC
• Hgb—men 14-18g/dl, women 12-16g/dl
• Platelet count—150,000-350,000/100ml 0f blood.
• Haematocrit – packed cell volume (PCV).
• Bone marrow puncture
Medical management:
long term RBC
transfusion.
hydroxyurea
(chemotherapy)
Bone marrow
transplant
NURSING DIAGNOSIS AND
INTERVENTIONS
For all anemic patients
Diagnosis: Activity intolerance related to
poor tissue oxygenation.
Give
oxygen
Bed rest
Monitor
vital signs
Observe
urine for
signs of
blood
Give
prescribed
fe
medication
Diagnosis: Pain related to joint
inflammation
Assess
level of
pain
Apply
warm
packs
Use
distraction
technique
Give pain
medication

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Blood disorders

  • 2. What is blood ? Blood is a combination of plasma (watery liquid) and cells that float in it. It is a specialized bodily fluid that supplies essentials substances and nutrients, such as sugar, oxygen, and hormones to our cells, and carries waste away from those cells
  • 3. Types of blood cells Red blood cells - also known as RBCs or erythrocytes. These are the most abundant cells, and contain hemoglobin (Hb or Hgb). Hemoglobin is a protein which contains iron; it transports oxygen from the lungs to body tissues and cells. 97% of a human's red blood cell's dry content is protein. White blood cells (leukocytes) - these are the cells of our immune system; they defend the body against infections and foreign materials. Platelets (thrombocytes) - are involved in the clotting (coagulation) of blood. When we bleed the platelets clump together to help form a clot.
  • 5. • Anemia is a condition in which the hemoglobin concentration is lower than the normal; it reflects the presence of fewer than the normal number of erythrocytes within the circulation. • As a result, the amount of oxygen delivered to the body tissues is also diminished. • Anemia is not a specific disease state but a sign of an underlying disorder. It is by far the most common hematologic condition.
  • 6. Classification of anemia hypoproliferative Results from defective RBC production bleeding Results from RBC loss hemolytic Results from RBC destruction
  • 7. hypoproliferative Iron deficiency. Vitamin B12 deficiency (megaloblastic) Folate deficiency (megaloblastic) Decreased erythropoitin production Cancer/ inflammation
  • 8. Bleeding Bleeding from GI tract, epistaxis (nosebleed), trauma, bleeding from genitourinary tract (menorrhagia)
  • 10. Stressors Physiological • Reduced RBC production. • Excessive RBC destruction. sociocultural • Diet habits. developmental • Age group. • sex
  • 11. Clinical manifestations: Special complications of the condition that produced anemia The duration of anemia The speed of anemia
  • 13. • Iron deficiency anemia typically results when the intake of dietary iron is inadequate for hemoglobin synthesis. • Iron deficiency anemia is the most common type of anemia in all age groups, and it is the most common anemia in the world.
  • 14. Causes • The most common cause of iron deficiency anemia in men and women is bleeding from ulcers gastrirtis, inflammatory bowel disease, or GI tumors. The most common causes of IDA in premenopusal woman are menorrhagia ( ie, excessive menstrual bleeding) and pregnancy with inadequate iron supplementation. Other causes include iron malabsorption, as is seen after gastroctomy.
  • 15. Sings and symptoms Fatigue Weakness Headache Dyspnea Palpitations Chest pain Jaundice Smooth; sore tongue
  • 16. Diagnostic tests Serum iron ( female 8.9-30.4 umol/l) ( male 11.6-30.4 umol/l) SERUM Hb ( normal 13.2-17.5 g/dk) CBC Bone marrow aspiration
  • 17. Treatment • Correction of the underlying cause, iron supplements including : Oral • Ferrous phosphate, ferrous glucanate IV or IM • Administer small dose
  • 18. Patient education ( taking oral iron supplements ): • Take iron on an empty stomach ( 1 hr before or 2 hrs after the meal). Iron absorption is reduced with food, especially dairy products. • To prevent GI distress, the following schedule may work better if more than one tablet a day is prescribed. Start with only one tab/day for a few days, then increase to 2 tab/day, then 3 tab/day. This method permits the body to adjust gradually to the iron. • Increase the intake of vit C , to enhance iron absorption. • Eat foods high in fiber to minimize problems with constipation. • Remember that stool will become dark in color.
  • 20.
  • 21. • Sickle cell anemia is a severe hemolytic anemia results from inheritance of the sickle hemoglobin gene. • The sickle hemoglobin (HbS) acquires a crystal-like formation when exposed to low oxygen tension.
  • 22. Clinical manifestations: Always anemic (Hb= 7-10gm/dl) Sometimes enlargement of the bones of face and skull. Jaundice Tachycardia
  • 23. Sings and symptoms: Pallor Decrease urinary output, Dark urine- smoky,brownish Abdominal or chest pain. Swelling and pain in the joint Weakness Mental depression Difficulty concentrating
  • 24. Diagnostic test • CBC • Hgb—men 14-18g/dl, women 12-16g/dl • Platelet count—150,000-350,000/100ml 0f blood. • Haematocrit – packed cell volume (PCV). • Bone marrow puncture
  • 25. Medical management: long term RBC transfusion. hydroxyurea (chemotherapy) Bone marrow transplant
  • 27. Diagnosis: Activity intolerance related to poor tissue oxygenation. Give oxygen Bed rest Monitor vital signs Observe urine for signs of blood Give prescribed fe medication
  • 28. Diagnosis: Pain related to joint inflammation Assess level of pain Apply warm packs Use distraction technique Give pain medication