Can Your Genes Make You Happier?

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Deepak Chopra MD (official)

Unlock the Astonishing Power of Your DNA for Optimum Health and Well-Being

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Lessons from Software for Synthetic Biology

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A 2-part webinar for scientists interested in novel drug delivery methods for basic research, drug discovery and development. Learn about novel infusion technologies and how challenges in physiological monitoring and drug delivery are being overcome by implantable and programmable devices. Session 2: Synthetic, Structural, and Mechanistic Investigations of Vitamin B12 Conjugates of the Anorectic Peptide PYY3-36 Presenter: Dr. Robert Doyle, Syracuse University & SUNY, Upstate Medical University Dr. Robert Doyle talks about how vitamin B12 conjugation of Peptide YY3-16 decreases food intake compared to native Peptide – YY3-36 in male rats. Learn how challenges to peptide-based therapies, such as rapid clearance, ready degradation by hydrolysis/proteolysis and poor intestinal uptake and/or a need for blood brain barrier transport can be overcome by using vitamin B12 in the subcutaneously administered drug delivery device iPrecio.

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We asked LinkedIn members worldwide about their levels of interest in the latest wave of technology: whether they’re using wearables, and whether they intend to buy self-driving cars and VR headsets as they become available. We asked them too about their attitudes to technology and to the growing role of Artificial Intelligence (AI) in the devices that they use. The answers were fascinating – and in many cases, surprising. This SlideShare explores the full results of this study, including detailed market-by-market breakdowns of intention levels for each technology – and how attitudes change with age, location and seniority level. If you’re marketing a tech brand – or planning to use VR and wearables to reach a professional audience – then these are insights you won’t want to miss.

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The technologies and people we are designing experiences for are constantly changing, in most cases they are changing at a rate that is difficult keep up with. When we think about how our teams are structured and the design processes we use in light of this challenge, a new design problem (or problem space) emerges, one that requires us to focus inward. How do we structure our teams and processes to be resilient? What would happen if we looked at our teams and design process as IA’s, Designers, Researchers? What strategies would we put in place to help them be successful? This talk will look at challenges we face leading, supporting, or simply being a part of design teams creating experiences for user groups with changing technological needs.

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Your brain is capable of incredible healing and constant reshaping. Through a new relationship with your brain you can transform your life. With increased self-awareness and conscious intention, the brain can be taught to reach far beyond its present limitations. This is a visual excerpt from my book "Super Brain," which I co-authored with Rudolph Tanzi, PhD. To read more, go to: http://www.chopra.com/

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Context. Determining the size distribution of asteroids is key to understanding the collisional history and evolution of the inner Solar System. Aims. We aim to improve our knowledge of the size distribution of small asteroids in the main belt by determining the parallaxes of newly detected asteroids in the Hubble Space Telescope (HST) archive and subsequently their absolute magnitudes and sizes. Methods. Asteroids appear as curved trails in HST images because of the parallax induced by the fast orbital motion of the spacecraft. Taking into account the trajectory of this latter, the parallax effect can be computed to obtain the distance to the asteroids by fitting simulated trajectories to the observed trails. Using distance, we can obtain the absolute magnitude of an object and an estimation of its size assuming an albedo value, along with some boundaries for its orbital parameters. Results. In this work, we analyse a set of 632 serendipitously imaged asteroids found in the ESA HST archive. Images were captured with the ACS/WFC and WFC3/UVIS instruments. A machine learning algorithm (trained with the results of a citizen science project) was used to detect objects in these images as part of a previous study. Our raw data consist of 1031 asteroid trails from unknown objects, not matching any entries in the Minor Planet Center (MPC) database using their coordinates and imaging time. We also found 670 trails from known objects (objects featuring matching entries in the MPC). After an accuracy assessment and filtering process, our analysed HST asteroid set consists of 454 unknown objects and 178 known objects. We obtain a sample dominated by potential main belt objects featuring absolute magnitudes (H) mostly between 15 and 22 mag. The absolute magnitude cumulative distribution logN(H > H0) ∝ αlog(H0) confirms the previously reported slope change for 15 < H < 18, from α ≈ 0.56 to α ≈ 0.26, maintained in our case down to absolute magnitudes of around H ≈ 20, and therefore expanding the previous result by approximately two magnitudes. Conclusions. HST archival observations can be used as an asteroid survey because the telescope pointings are statistically randomly oriented in the sky and cover long periods of time. They allow us to expand the current best samples of astronomical objects at no extra cost in regard to telescope time.

Hubble Asteroid Hunter III. Physical properties of newly found asteroids

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anandsmhk

Jupiter’s moon Io hosts extensive volcanism, driven by tidal heating. The isotopic composition of Io's inventory of volatile chemical elements, including sulfur and chlorine, reflects its outgassing and mass loss history, and thus records information about its evolution. We used millimeter observations of Io’s atmosphere to measure sulfur isotopes in gaseous SO2 and SO, and chlorine isotopes in gaseous NaCl and KCl. We find 34S/32S = 0.0595 ± 0.0038 (equivalent to δ34S = +347 ± 86‰), which is highly enriched compared to average Solar System values and indicates that Io has lost 94 to 99% of its available sulfur. Our measurement of 37Cl/35Cl = 0.403 ± 0.028 (δ37Cl = +263 ± 88‰) shows that chlorine is similarly enriched. These results indicate that Io has been volcanically active for most (or all) of its history, with potentially higher outgassing and mass-loss rates at earlier times.

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Sérgio Sacani

HotJupiters are amongthebest-studied exoplanets, but it is still poorly understood how their chemical composition and cloud properties vary with longitude. Theoretical models predict that clouds may condense on the nightside and that molecular abundances can be driven out of equilibrium by zonal winds. Here we report a phase-resolved emission spectrum of the hot Jupiter WASP-43b measured from 5–12µ 5–12µ 5–12µm with JWST’s Mid-Infrared Instrument (MIRI). 1524 ±35 1524 ±35 and 863±23 The spectra reveal a large day–night temperature contrast (with average brightness temperatures of 1524 ± 35 863 ±23 863 ±23Kelvin, respectively) and evidence for water absorption at all orbital phases. Comparisons with three-dimensional atmospheric models show that both the phase curve shape and emission spectra strongly suggest the presence of nightside clouds which become optically thick to thermal emission at pressures greater than ∼100mbar. The dayside is consistent with a cloudless atmosphere above the mid-infrared photosphere. Con3trary to expectations from equilibrium chemistry but consistent with disequilibrium kinetics models, methane is not detected on the nightside (2σ upper limit of 1–6 parts per million, depending on model assumptions).

Nightside clouds and disequilibrium chemistry on the hot Jupiter WASP-43b

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We explore different scenarios to explain the chemical difference found in the remarkable giant-giant binary system HD138202+CD−3012303. For the first time, we suggest how to distinguish these scenarios by taking advantage of the extensive convective envelopes of giant stars. Methods. We carried out a high-precision determination of stellar parameters and abundances by applying a full line-by-line differential analysis on GHOST high-resolution spectra. We used the FUNDPAR program with ATLAS12 model atmospheres and specific opacities calculated for an arbitrary composition through a doubly iterated method. Physical parameters were estimated with the isochrones package and evolutionary tracks were calculated via MIST models. Results. We found a significant chemical difference between the two stars (∆[Fe/H]∼0.08dex), which is largely unexpected considering the insensitivity of giant stars to planetary ingestion and diffusion effects. We tested the possibility of engulfment events by using several different combinations of stellar mass, ingested mass, metallicity of the engulfed object and different convective envelopes. However, the planetary ingestion scenario does not seem to explain the observed differences. For the first time, we distinguished the source of chemical differences using a giant-giant binary system. By ruling out other possible scenarios such as planet formation and evolutionary effects between the two stars, we suggest that primordial inhomogeneities might explain the observed differences. This remarkable result implies that the metallicity differences that were observed in at least some main-sequence binary systems might be related to primordial inhomogeneities rather than engulfment events. We also discuss the important implications of finding primordial inhomogeneities, which affect chemical tagging and other fields such as planet formation. We strongly encourage the use of giantgiant pairs. They are a relevant complement to main-sequence pairs for determining the origin of the observed chemical differences in multiple systems.

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RecoveringancientrecordsofEarth'smagneticfieldisessentialfordeterminingtheroleofthemagnetosphereinprotectingearlyEarthfromcosmicradiationandatmosphericescape.WepresentpaleomagneticfieldtestshintingthatarecordofEarth's3.7‐billion‐year(Ga)oldmagneticfieldmaybepreservedinthenortheasternIsuaSupracrustalBeltasachemicalremanentmagnetizationacquiredduringamphibolite‐grademetamorphisminthebandedironformation.MultiplepetrologicalandgeochronologicallinesofevidenceindicatethatthenorthernmostpartofIsuahasnotexperiencedmetamorphictemperaturesexceeding380°CsincetheEoarchean,suggestingtherockshavenotbeensignificantlyheatedsincemagnetizationwasacquired.Weuse“pseudo”bakedcontacttests(intrusionsemplaced3.26–3.5Gaago)andafoldtest(folding3.6Gaago)todemonstratethatsomesamplespreserveaca.3.7Garecordofthemagneticfield.Werecoverafieldstrengthof>15μT.ThissuggeststhatEarth'smagneticfieldmayhavebeenweakenoughtoenhanceatmosphericescapeduringtheArchean

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Mustard, as a crop, is susceptible to a variety of pests that can affect its growth and yield. Here’s a rundown of some common pests that target mustard plants: Aphids: These small, sap-sucking insects can cause significant damage by feeding on the leaves and stems. Aphids also excrete a sticky substance known as honeydew, which can lead to the growth of sooty mold on the plants. Flea Beetles: These tiny beetles jump like fleas when disturbed and chew small holes in the leaves. They are particularly damaging in the early growth stages of the plant. Cabbage Loopers: The larvae of a type of moth, these caterpillars are known for their distinctive looping movement. They chew large holes in the leaves and can defoliate plants if present in large numbers. Diamondback Moth Larvae: Another caterpillar pest, these larvae chew small holes in the leaves and can cause extensive damage, especially when infestations are heavy. Whiteflies: These are tiny, winged insects that feed on plant sap and can quickly become a problem in greenhouse or close planting conditions. Like aphids, they also secrete honeydew. Cutworms: These are the larvae of certain types of moths and are known for cutting young plants at the stem base at ground level. They are most destructive during the night. Root Maggots: The larvae of root maggot flies, these pests attack the roots of mustard plants, causing wilting and potentially killing young plants. Harlequin Bugs: These are colorful stink bugs that suck the sap from mustard plant stems and leaves, causing the leaves to become stippled, wilt, and eventually die if the infestation is severe. Mustard Sawfly: The larvae of the mustard sawfly can cause considerable defoliation, as they feed voraciously on the leaves. Clubroot: Caused by a fungus-like organism, clubroot affects the roots, causing them to swell and distort. While technically a disease, it is often associated with pest management because controlling it involves similar preventative strategies. Control Measures: Managing pests in mustard involves a combination of cultural, biological, and chemical methods. Crop rotation, resistant varieties, timely sowing, maintaining plant health, and using natural predators like ladybugs and parasitic wasps can help keep pest populations under control. Chemical pesticides should be used as a last resort due to their potential impact on the environment and non-target species.

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Chemistry is the scientific study of matter, its properties, composition, structure, and the changes it undergoes. It's often divided into various sub-disciplines such as organic chemistry, inorganic chemistry, physical chemistry, analytical chemistry, and biochemistry. Chemistry plays a crucial role in understanding the world around us and has applications in various fields such as medicine, materials science, environmental science, and industry.

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The primary distinction between a test cross and a backcross is that a test cross is used to determine the genotype of a phenotypically dominant individual, whereas a backcross is used to recover a dominant genotype from a parent who has an extreme genotype. The hybrids that are backcrossed are known as 'BC' hybrids. For example, a BC1 hybrid is an F1 hybrid that was crossed with one of its parents or a genetically similar species. The BC2 hybrid is defined as a BC1 hybrid that has been crossed with the same parent or genetically similar species. Other instances include backcrossing in animals. A system of breeding in which repeated backcrosses are made to transfer a specific character to a well-adapted variety for which the variety is deficient is referred to as backcross breeding This approach is infrequently utilized in vegetatively propagated crops such as sugarcane and potatoes, and only with slight alterations. A test cross is a genetic technique for determining an unknown genotype in a dominant person. It is a breeding procedure in which a (known genotype) homozygous recessive individual is paired with an individual of the opposite mating type who has an unknown dominant genotype. The phenotypic characteristics of the resulting children are investigated, and the genotype of the examined individual is determined appropriately. If all of the progeny from the test cross are dominant, we may conclude that the genotype of the tested unknown person is homozygous dominant. If 50% of kids exhibit dominant traits and the remaining 50% exhibit recessive traits, we may conclude that the genotype of the tested unknown individual is heterozygous dominant. #genetics #backcross #testcross #mendel #crosses #monohybridtestcross #backcrossandtestcross #typesofcross #dihybridtestcross #limitationsofcross #applicationsofcross #mscbotany #botany

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