1.
PULMONARYPULMONARY

2.
INTRODUCTIONINTRODUCTION
Pulmonary Tuberculosis (TB) is an infectiousPulmonary Tuberculosis (TB) is an infectious
disease that mainly affect the lungs parenchyma.disease that mainly affect the lungs parenchyma.
TB is a contagious bacterial (M. tuberculosis)TB is a contagious bacterial (M. tuberculosis)
infection that mainly affects the lungsinfection that mainly affects the lungs
parenchyma, but may spread to other organs.parenchyma, but may spread to other organs.
TB is an ancient disease. Signs of skeletal TBTB is an ancient disease. Signs of skeletal TB
(pott disease) were evident in Europe from(pott disease) were evident in Europe from
Neolithic times, ancient egypt, and in the pre-Neolithic times, ancient egypt, and in the pre-
Columbian New World.Columbian New World.
Physicians in ancient Greece called this illness asPhysicians in ancient Greece called this illness as
“phthisis” reflecting its wasting character.“phthisis” reflecting its wasting character.

3.
TB has remained an enemy of human societyTB has remained an enemy of human society
for all age.for all age.
TB is not only a problem for the personTB is not only a problem for the person
suffering from it or their families but a publicsuffering from it or their families but a public
health problem of the entire world.health problem of the entire world.

4.
DISEASE CLASSIFICATIONDISEASE CLASSIFICATION
INFLAMMATORY
DISEASE
•It is a Chronic specific
Inflammatory infectious
Disease caused by
Mycobacterium Tuberculosis
In human.
•Usually attacks the lungs but
It can also effect any part of
The body.

5.
ETIOLOGYETIOLOGY
TB is caused by the bacteria M. tuberculosisTB is caused by the bacteria M. tuberculosis
(most common cause).(most common cause).
Other than tuberculosis – includes;Other than tuberculosis – includes;
M. avium intracellulareM. avium intracellulare
M. kansasiM. kansasi
M. scrofulaceuruM. scrofulaceuru
M. ulceransM. ulcerans
M. marinum and etc.M. marinum and etc.

6.
It also caused by breathing inIt also caused by breathing in
air droplets from a cough orair droplets from a cough or
sneeze of an infected personsneeze of an infected person
this is called Primary TB.this is called Primary TB.
Risk factors of tuberculosis is;Risk factors of tuberculosis is;
ElderlyElderly
InfantsInfants
Low socioeconomic statusLow socioeconomic status
Crowded living conditionsCrowded living conditions
Disease that weakensDisease that weakens
immune system like HIVimmune system like HIV
AlcoholismAlcoholism
Recent Tubercular infectionRecent Tubercular infection
(within last 2 years) and ect.(within last 2 years) and ect.

7.
TB spread from person to person by airborneTB spread from person to person by airborne
transmission. Infected person release droplettransmission. Infected person release droplet
nuclei (1-5 micro meter in diameter) through,nuclei (1-5 micro meter in diameter) through,
TalkingTalking
CoughingCoughing
SneezingSneezing
LaughingLaughing
SingingSinging
• If not treated properly, TB can be fatal.If not treated properly, TB can be fatal.

8.
PATHOGENESISPATHOGENESIS
Susceptible
Or
Mycobacterium
Tuberculosis
Latent
Infection
Recovery
Reactivation
Active
tuberculosis
Miliary
tuberculosis
Extrapulmonary
Tuberculosis
PULMONARY
TUBERCULOSIS

9.
MANIFESTATIONS-symptomsMANIFESTATIONS-symptoms
The primary stage of TB usually doesn’t causeThe primary stage of TB usually doesn’t cause
symptoms. When symptoms of TB occur, theysymptoms. When symptoms of TB occur, they
may includes;may includes;
FatigueFatigue
FeverFever
Unintentional weight lossUnintentional weight loss

10.
Other symptoms that may occur withOther symptoms that may occur with
this disease;this disease;
Breathing difficultyBreathing difficulty
Chest painChest pain
Wheezing.Wheezing.

11.
MANIFESTATIONS- signsMANIFESTATIONS- signs
 Cough up of mucus and bloodCough up of mucus and blood
 Excessive sweating at night.Excessive sweating at night.

12.
SIGNIFICANT LAB TESTSIGNIFICANT LAB TEST
 Tuberculin skin test (PPD test);Tuberculin skin test (PPD test);
 Injecting a small amount of protein fromInjecting a small amount of protein from
tuberculosis bacteria between thetuberculosis bacteria between the
derived layer of the skin (usuallyderived layer of the skin (usually
forearm).forearm).
 Sputum examination and Cultures;Sputum examination and Cultures;
 Is examined under a microscope to lookIs examined under a microscope to look
for tuberculosis bacteria and used tofor tuberculosis bacteria and used to
grow the bacteria in a culture.grow the bacteria in a culture.

13.
 Interferon-gamma Blood testInterferon-gamma Blood test;;
A simple blood is mixed with syntheticA simple blood is mixed with synthetic
proteins similar to those produced by theproteins similar to those produced by the
tuberculosis bacteria.tuberculosis bacteria.
If people are infected with tuberculosisIf people are infected with tuberculosis
bacteria, their white blood cells producebacteria, their white blood cells produce
certain substances (interferons) in responsecertain substances (interferons) in response
to the synthetic proteins.to the synthetic proteins.

14.
IMAGING CONSIDERATIONIMAGING CONSIDERATION
 Chest CT ScanChest CT Scan
 Chest X-rayChest X-ray

15.
RADIOLOGICAL APPERNCERADIOLOGICAL APPERNCE
• Young male patientYoung male patient
with fever andwith fever and
cough has focalcough has focal
opacity in the leftopacity in the left
lower lobe thatlower lobe that
looks like alooks like a
pneumonia. This is apneumonia. This is a
case of primarycase of primary
tuberculosis in antuberculosis in an
adult.adult.

16.
ReferencesReferences
• www.medicinet.comwww.medicinet.com
• www.nlm.nih.govwww.nlm.nih.gov
• http://www.e-radiography.nethttp://www.e-radiography.net
• www.learningradiology.comwww.learningradiology.com