Formulation and evaluation_of_microspheres[1]

FORMULATION AND EVALUATION OF MICROSPHERES PRESENTED BY DADHICHI K THAKKAR M.PHARM SEMISTER -I Guided by :-Dr UPENDRA PATEL DEPARTMENT OF PHARMACUETICAL TECHNOLOGY ARIHANT COLLEGE OF PHARMACY GUJARAT TECHNICAL UNIVERSITY. .

CONTENTS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

INTRODUCTION ,[object Object],[object Object],[object Object]

Definition of microspheres ,[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Potential use of microspheres in the pharmaceutical industry ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Polymers used in the Microsphere preparation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Prerequisites for Ideal Microparticulate Carriers ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Types of Microspheres ,[object Object],[object Object],Microcapsule Micromatrix Types of Microspheres

MICROSPHERE MANUFACTURE ,[object Object],[object Object],[object Object],[object Object],[object Object]

GENERAL METHODS OF PREPARATION ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

SINGLE EMULSION BASED METHOD Aq.Solution/suspension of polymer Dispersion in organic phase (Oil/Chloroform) Microspheres in organic phase Microspheres in organic phase MICROSPHERES Stirring, Sonication CROSS LINKING Chemical cross linking (Glutaraldehyde/Formaldehyde/Butanol Heat denaturation Centrifugation, Washing, Separation

Aq.Solution of protein/polymer First emulsion (W/O) MICROSPHERES Dispersion in oil/organic phase Homogenization Separation, Washing, Drying Addition of aq. Solution of PVA Addition to large aq. Phase Denaturation/hardening Multiple emulsion Microspheres in solution DOUBLE EMULSION BASED METHOD

Interfacial Polymerization technique ,[object Object],[object Object],[object Object]

PHASE SEPARATION METHOD Aqueous/Organic.Solution of polymer Drug dispersed or dissolved in polymer solution MICROSPHERES Drug Separation, Washing, Drying Hardening Polymer rich globules Microspheres in aq./organic phase

Salting-out process ,[object Object],[object Object],[object Object]

Emulsification-Solvent evaporation method

Spray drying and spray congealing method ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],The BRACE-Process

The BRACE-Process ,[object Object],[object Object],[object Object],[object Object]

DRUG LOADING ,[object Object],[object Object],[object Object]

ROUTE OF ADMINISTRATION ,[object Object],[object Object]

CHARACTERIZATION ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

PARTICLE SIZE AND SHAPE ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

RELEASE STUDIES ,[object Object],[object Object],[object Object],[object Object]

APPLICATIONS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

OTHER APPLICATIONS ,[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object]

Cancer research ,[object Object]

CONCLUSION ,[object Object],[object Object]

REFERENCES ,[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Formulation and evaluation_of_microspheres[1]

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Formulation and evaluation_of_microspheres[1]