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# Ideal solubility parameter (solubility of drug part 2)

Solubility of drug, Ideal solubility parameter, Hildebrand solubility parameter, Hansen solubility parameter

Solubility of drug, Ideal solubility parameter, Hildebrand solubility parameter, Hansen solubility parameter

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### Ideal solubility parameter (solubility of drug part 2)

1. 1. IIIrd Semesester B. pharmacy Physical Pharmaceutics-I Unit-I Solubility of drugs(Part-2) (Ideal Solubility Parameter)
2. 2. THANK YOU!
3. 3.  IDAEAL SOLUBILITY PARAMETER • Solubility parameters provides numerical methods to predict interaction between material. • It is used for estimation of whether substance will dissolve in another substance or not. • If values of solubility parameter are same then we can say that one substance is soluble in another. • Two types of solubility parameter Hildebrand solubility parameter Hansen solubility parameter
4. 4. HILDEBRAND SOLUBILITY PARAMETER • Theory of solubility parameter  Scatchard in 1931 Joel H. Hildebrand in 1936 • Def: The solubility parameter is a numerical value that indicates relative solvency behaviour of specific solvent. • It is derived from the cohesive energy density of the solvent, which in turn is derived from the heat of vapourisation.
5. 5. • Cohesive energy density(C) is the forces of attraction per unit volume of solvent. c= Δ H−RT 𝑉𝑚 Where:Type equation here. C=Cohesive energy Δ H= Heat of vaporization R= Gas constant T=Temperature Vm= molar vovume
6. 6. • In 1936 Joel H. Hildebrand proposed the square root of the cohesive energy as a numerical value indicate the solvency behavior of a specific solvent • The quantity represented by the symbol δ δ = 𝐶 • The term Hildebrand be adopted for solubility parameter units, in order to recognize the tremendous contribution that Dr. Hildebrand has made to solubility theory. • Values are shown in both the common form which is derived from cohesive energy densities in calories/cc and newer from which, conforming to standard international units (SI units), is derived form cohesive pressure. The SI units for expressing pressure is the pascal.
7. 7.  HANSEN SOLUBILITY PARAMETER • The most widely accepted three component system to date is the three parameter system developed by Charles M. Hansen in 1966. • Hansen parameter divided the total Hildebrand value into three parts. 1. Dispersion force component, 2. A hydrogen bonding component, 3. A polar component.