BioRN Innovation Tour

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The focus of the Biotech Cluster Rhine-Neckar (BioRN) is on the development of innovative drugs, diagnostics and platform technologies in the field of cell-based and molecular medicine. With this brochure we would like to give you an impression of the highly concentrated knowledge and expertise in medical and biotechnical
research – at our cluster in general and at the Heidelberg Campus Neuenheimer Feld in particular.
While composing this information we, once again, became aware of the impressive number of joint projects and the tight relations and affiliations in our biotech cluster. It is this network that makes highly effective medical research possible, not only for the research institutes but also for the BioRN companies involved – a good reason for companies from outside the BioRN Cluster to join our network and to participate in one of the most innovative
regions in Germany.
The Innovation Tour mainly guides you through the Heidelberg University Campus Neuenheimer Feld and gives you an insight into its institutes and facilities. The tour starts in the north of the campus, at Heidelberg Technology Park (see page 4).
Please do not hesitate to contact us (info@BioRN.org) if you have questions on the Biotech Cluster Rhine-Neckar.

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BioRN Innovation Tour

  1. 1. Innovation Tour Life Science Campus Neuenheimer Feld – Part of the Biotech Cluster Rhine-Neckar, Germany´s Hot Spot for Personalized Medicine and Cancer Research
  2. 2. 3 Editorial The focus of the Biotech Cluster Rhine-Neckar (BioRN) is on the development of innovative drugs, diagnostics and platform tech- nologies in the field of cell-based and molecular medicine. With this brochure we would like to give you an impression of the highly concentrated knowledge and expertise in medical and biotechnical research – at our cluster in general and at the Heidelberg Campus Neuenheimer Feld in particular. While composing this information we, once again, became aware of the impressive number of joint projects and the tight relations and affiliations in our biotech cluster. It is this network that ma- kes highly effective medical research possible, not only for the research institutes but also for the BioRN companies involved – a good reason for companies from outside the BioRN Cluster to join our network and to participate in one of the most innovative regions in Germany. The Innovation Tour mainly guides you through the Heidelberg Uni- versity Campus Neuenheimer Feld and gives you an insight into its institutes and facilities. The tour starts in the north of the campus, at Heidelberg Technology Park (see page 4). Please do not hesitate to contact us (info@BioRN.org) if you have questions on the Biotech Cluster Rhine-Neckar. Yours sincerely BioRN Cluster Management Heidelberg TP Faculty of Biosciences Faculty of Medicine Heidelberg OMZ Hospital NCT HIT Children’s Hospital DKFZ HI-STEM ZMBH Pathology Surgery MPImF
  3. 3. 4 Campus Im Neuenheimer Feld (INF) This brochure will guide you through the Heidelberg Technology Park and through interna- tionally renowned education and research facilities. Heidelberg Technology Park Heidelberg University: Faculty of Bioscience Heidelberg University: Faculty of Medicine Otto-Meyerhoff-Center (OMZ) Heidelberg University Hospital National Center forTumor Diseases (NCT) Heidelberg Ion-Beam Therapy Center (HIT) Children’sHospital German Cancer Research Center (DKFZ) / Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM) Heidelberg University Hospital, Heidelberg University Hospital, Max Planck Institute for Medical Research (MPImF) 2 3 4 5 7 8 9 12 13 6 10 1 11 2 3 3 4 5 5 6 8 9 10 12 13 « « « « « « 1 11 7 Center for Molecular Biology of Heidelberg University (ZMBH) Institute of Pathology Institute of Surgery Heidelberg TP Faculty of Biosciences Faculty of Medicine Heidelberg OMZ Hospital NCT HIT Children’s Hospital DKFZ HI-STEM ZMBH Pathology Surgery MPImF
  4. 4. 5 Services of Technologiepark Heidelberg GmbH • Entrée to an international network of science, business and public life • International Partner Port • Lab and office infrastructure with high flexibility • Education programs • Kindergarten • Supply and waste management for chemicals • Secretary and marketing services • Conference rooms / lounge / restaurant • Car sharing station Offers lab and office infrastructure since 1984: Heidelberg Technology Park, located in the north of Campus Neuenheimer Feld Core facilities of the German Cancer Research Center (DKFZ) are located in buildings of the Heidelberg Technology Park. The Heidelberg Technology Park, conceived as a biology park, is a science park that makes up part of the Ruprecht-Karls-University campus. Covering an area of 80,000 m², with more than 80 resident companies and nearing 1,600 employees, it is amongst the most important biotechnology sites in Germany and amongst the leading worldwide. Since its creation in 1984, the Heidelberg Technology Park, with its mix of bio, medical, information, communication and environmental technologies, as well as environmental business, has grown into an important entity, giving fresh impetus to scientific research and business. New laboratory and office facilities are available. Technologiepark Heidelberg GmbH, as the operating company of the technology park, is the central contact for companies and as- sociated members. The International Partnerport within the Heidelberg Technology Park offers an opportunity for companies and institutions to easily set up their presence in Heidelberg. An EU/German home office, virtual offices and specific services are available. Heidelberg Technology Park The Science park is part of the Campus “Neuenheimer Feld“ and offers services and infra- structure for start-up Heidelberg TP Faculty of Biosciences Faculty of Medicine Heidelberg OMZ Hospital NCT HIT Children’s Hospital DKFZ HI-STEM ZMBH Pathology Surgery MPImF
  5. 5. BioQuant: Platform for the development and con- stant refinement of mathematical models of com- plex biological systems 6 The Faculty of Biosciences is one of twelve faculties at the Uni- versity of Heidelberg. It offers Biology, Biotechnology, Pharmacy and Biochemistry programs to 1.500 undergraduate students and is responsible for more than 1.200 PhD students. With more than 100 tenured and non-tenured research groups, the Faculty of Biosciences is a central player in the Heidelberg Life Sci- ence Community. Its researchers address fundamental questions in all aspects of life sciences – from molecules to complex organisms and from structural biology to behavioral studies. For example, the Heidelberg Institute of Pharmacy and Molecular Biotechnology cov- ers all aspects in the study of medicinal agents, from chemical syn- thesis, the investigation of molecular mechanisms and pharmacol- ogy to bioinformatics, functional genomics and clinical application. Collaborative research centers with strong participation of the Fac- ulty of Biosciences focus, e.g., on cellular surveillance and damage response (SFB1036), maintenance and differentiation of stem cells in development and disease (SFB873) or modelling and simulation in the Biosciences (BIOMS). Researchers of the Faculty of Biosciences are members of the following Centers and Institutes: • Institute of Pharmacy and Molecular Biotechnology • Interdisciplinary Center for Neurosciences (IZN) • Centre for Organismal Studies (COS) • BioQuant • Heidelberg University Biochemistry Center (BZH) • Interdisciplinary Center for Scientific Computing (IWR) • Center of Molecular Biology (ZMBH) These organisatorial structures, which unite colleagues from sev- eral faculties (Biosciences, Chemistry, Mathematics and Medicine) or with dual affiliations (e.g., University and DKFZ), contribute to a highly interdisciplinary and collaborative environment. All Centers and Institutes are located in the Neuenheimer Feld, an outstanding scientific and industrial research environment BioQuant – Model Base of Life BioQuant, the Center for “Quantitative Analysis of Molecular and Cellular Biosystems” at Hei- delberg University was established in 2007 as an interdisciplinary University research center that is solely dedicated to research and training in systems biology. BioQuant’s objective is to function as a platform for the development and constant refinement of mathematical models of complex biological systems as well as the swift validation of scientific hypotheses via experi- mental data. Currently, up to 40 University and non-University research groups are affiliated with BioQuant. In addition to advanced computational tools and methods for data analysis, image process- ing, and modeling, BioQuant’s central technol- ogy platform provides cutting edge technolo- gies for systematic functional imaging with an emphasis highthroughput and high-content microscopy, high-resolution microscopy and electron microscopy. Heidelberg University: Faculty of Biosciences From state of the art molecular biology to front-edge research on pharmaceutical drugs Heidelberg TP Faculty of Biosciences Faculty of Medicine Heidelberg OMZ Hospital NCT HIT Children’s Hospital DKFZ HI-STEM ZMBH Pathology Surgery MPImF
  6. 6. 7 Heidelberg University: Faculty of Medicine One of the leading institutions in the field of medical research and training in Germany Recent studies and rankings confirm that the Heidelberg Faculty of Medicine is one of the leading academic institutions in Germany. The acquisition of external research funding to the tune of over 81 million euros annually confirms this evaluation. In addition, the Faculty and the University Hospital, including about 20 academic teaching hospitals, represent one of the largest medical teaching locations in Germany, admitting over 450 medical and 80 dentistry students every year. With close links between • research labs and hospital wards, • swift implementation of newly acquired knowledge from clinical studies, • practically oriented modern teaching methods and • systematic encouragement for young researchers, the Heidelberg Faculty of Medicine is one of the leading institutions for medical research and training in Germany. Origin of renowned Scientists One of the four original Faculties of the University in 1386, the Fac- ulty of Medicine rose to new heights in the 19th and 20th centuries with the presence of internationally renowned physicians like Her- mann von Helmholtz, Vinzenz Czerny and Ludolf von Krehl. In 1910 and 1922 respectively, Albrecht Kossel and Otto Meyerhof were awarded the Nobel Prize for medicine, a distinction also accorded more recently to Bert Sakmann in 1991 and Harald zur Hausen in 2008. Clinics and Institutes Institutes • Department of General Medicine and Health Services Research • Institute of Anatomy and Cell Biology • Institute of Medical Biometry and Informatics • Institute of Medical History and Ethics • Institute of Human Genetics • Institute of Hygiene • Institute of Immunology and Serology • Institute of Pathology • Institute of Pharmacology • Institute of Physiology and Pathophysiology • Institute and Polyclinic of Occupational and Social Medicine • Institute of Forensic and Traffic Medicine Clinics/Hospitals • University Hospital of Anaesthesiology • University Hospital of Ophthalmology • Surgical Hospital • University Hospital of Gynaecology • University Hospital of Otolaryngology • University Hospital of Dermatology • University Paediatric Hospital • University Hospital of Internal Medicine • University Clinic of Dentistry • Neurosurgical Clinic • Neurological Clinic • Orthopaedic Hospital • Center of Psychosocial Medicine • University Hospital of Radiology Part of the Faculty of Medicine: The Institute for Immunolgy, one of the most important institutions of its kind in Germany Heidelberg TP Faculty of Biosciences Faculty of Medicine Heidelberg OMZ Hospital NCT HIT Children’s Hospital DKFZ HI-STEM ZMBH Pathology Surgery MPImF
  7. 7. 8 Otto-Meyerhof-Center (OMZ) Center for Outpatient Care and Clinical Research in Heidelberg The Otto-Meyerhof-Center (OMZ) is home of the Molecular Medi- cine Partnership Unit (MMPU) and other research groups of the Heidelberg University Hospital. The institute is a joint venture be- tween the Heidelberg Faculty of Medicine and the European Mo- lecular Biology Laboratory (EMBL). They have both strongly con- tributed to making Heidelberg one of the premier centers of life sciences research in the world. Now, both institutions have de- cided to accept the challenge and to jointly build and develop an integrated research activity in Molecular Medicine: The Molecular Medicine Partnership Unit (MMPU). Starting with dedicated laboratory space on the Medical Campus and under joint leadership, the MMPU is assembling an internation- al team of molecular research-oriented MDs, PhDs, PhD students and technicians. The cooperation with the EMBL includes participa- tion in all of EMBL‘s research activities, access to its scientific core facilities and affiliation with the EMBL International PhD Program. A feedback from bedside medicine is wanted The research philosophy aims at the molecular understanding of the basis of human diseases, its applications in diagnosis and therapy, and a feedback from ‚bedside medicine‘ into the research laboratory. Research themes place emphasis on the diseases of childhood, particularly blood disorders, childhood cancers, and chronic lung diseases, in particular cystic fibrosis and on diseases of adoles- cence, particularly cholesterol regulation, hemochromatosis and colorectal cancer. Home of the Molecular Medicine Partnership Unit (MMPU): Otto-Meyerhof-Center Heidelberg TP Faculty of Biosciences Faculty of Medicine Heidelberg OMZ Hospital NCT HIT Children’s Hospital DKFZ HI-STEM ZMBH Pathology Surgery MPImF
  8. 8. 9 Heidelberg University Hospital One of the leading medical centers in Europe Heidelberg University Hospital with its more than 40 specialized clini- cal departments is one of the leading medical centers in Europe. The University Hospital and the cooperating facilities in the region offer outpatient and inpatient diagnostics and therapy for all serve dis- eases. Modern premises with state-of-the-art technological equip- ment designed for efficient workflows in modern healthcare from the framework for high-performance medicine for several ill patients. The University Hospital provides all medical treatment options. The immediate proximity of the departments to each other enables interdisciplinary diagnosis and therapy. Common as well as rare and complex disorders can be treated fully and efficiently. Regular medical care is frequently accompanied by clinical trials that are conducted in all departments with the aim of developing new di- agnostic and therapeutic options. Patients at Heidelberg University Hospital consequently have access to treatment options that are otherwise provided by only a very few centers worldwide. Proven competence in oncology Heidelberg University Hospital is recognized the world over as a cen- ter for treating tumor diseases. A good 100 years ago, Vincenz Czerny founded an institute for cancer research in Heidelberg, uniting cancer therapy and research under one roof. In 1964, this became the re- nowned German Cancer Research Center (DKFZ). Today, the Universi- ty Hospital and the German Cancer Research Center cooperate closely in research and patient care at the National Center for Tumor Diseases, a facility that corresponds in character to the model of the American Comprehensive Cancer Center. Here, current scientific knowledge is put into practice as quickly as possible to benefit patients. Passing on medical knowledge There are currently 3,600 future physicians studying in Heidelberg. They participate in the Heidelberger Curriculum Medicinale (HeiC- uMed), which is the top medical programme in Germany. It offers practical training in small groups oriented toward the curriculum at Harvard Medical School in the US. One focus of the hospital is train- ing non-physician medical personnel. Working with regional coop- eration partners at the Heidelberg academy for health professions, the hospital provides the highest standard of training for nurses and technical assistants. More than 800 positions are available for training and further education. Facts • 1,000,000 patient visits p.a. • More than 50 clinics, departments and institutes • 10,850 employees, including 1,500 profes- sors and MDs • 3,600 medical students Research Topics • Infectious diseases • Vascular ischemia and myogenic dysfunc- tion • Neurosciences • Translational and individualized oncology • Transplantation and individualized immuno- therapy Departments • Center for Child and Adolescent Medicine • Center for Psychosocial Medicine • Department of Anesthesiology (including pain center) • Department of Dermatology • Department of Internal Medicine • Department of Neurology • Department of Neurosurgery • Department of Ophthalmology • Department of Oral, Dental and Maxillofa- cial Diseases • Department of Orthopedics • Department of Otorhinolaryngology (Ear, Nose and Throat) • Department of Radiology • Department of Surgery • Genetic Clinic • Heidelberg Ion-Beam Therapy Center (HIT) • National Center for Tumor Diseases (NCT) • Tropical Medicine Clinic • Women’s Hospital Heidelberg TP Faculty of Biosciences Faculty of Medicine Heidelberg OMZ Hospital NCT HIT Children’s Hospital DKFZ HI-STEM ZMBH Pathology Surgery MPImF
  9. 9. 10 National Center for Tumor Diseases (NCT) Heidelberg Trend-setting platform for the application of laboratory research to clinical practice 2005, the National Center for Tumor Diseases (NCT) Heidelberg was founded as an exceptional alliance between the German Can- cer Research Center (DKFZ), Heidelberg University Medical School (HUMS) together with Heidelberg Medical Faculty and German Can- cer Aid (Deutsche Krebshilfe). NCT is a comprehensive cancer cen- ter uniquely positioned to benefit from the wealth of DKFZ cancer research and the Heidelberg biomedical campus. NCT’s mission is two-fold: to provide optimal interdisciplinary oncology with current clinical therapies and to rapidly transfer scientific knowledge into clinical applications through comprehensive translational and pre- ventive oncology. The new 5500 m2 NCT Core Building has been completed in 2010. NCT is the principal portal of entry for all oncology patients into the medical center, and the primary location of all oncology outpatient care. It integrates and supports all clinical and translational research activities of DKFZ and HUMS. DKFZ’s many scientific disciplines and interactions, including strategic partnerships with university medical centers and industry, provide a strong framework for NCT projects. In 2011, approx. 10,000 newly diagnosed cancer patients were seen at NCT and more than 17,000 anti-tumor therapies were ad- ministered. With more than 50,000 out-patient visits p.a., patient numbers are steadily growing. 300 diagnostic, therapeutic and pre- ventive clinical trials, including investigator initiated trials, were de- veloped and conducted. NCT pursues personalized oncology as a center-wide master strate- gy that coordinates all activities towards individualized cancer medi- cine, including patient-oriented genetics, proteomics, radiooncology, immunology and prevention. The recently established Heidelberg Center for Personalized Oncology (DKFZ-HIPO) forms a dedicated genomics, proteomics and bioinformatics platform of DKFZ, en- abling excellent basic and translational research. Its clinical coun- terpart, the NCT Precision Oncology Program (NCT POP) combines molecular diagnostics, innovative therapeutics development, inter- disciplinary patient care and prevention to define molecularly strati- fied patient cohorts and hypothesis-driven treatments. Towards this goal, the center aims to provide comprehensive high-throughput genetic and molecular analysis as a stratification tool for every NCT patient by 2015. NCT Unique Services » NCT Tumor Boards » NCT Patient and Clinical Trial Center » NCT Biobanking » NCT Clinical Cancer Registry Scientific Program Areas » Clinical Research Program » Molecular Diagnostics Program » Immunotherapy Program » Integrative Radiation Oncology Program » Novel Therapeutics Program » Cancer Prevention, Control and Outcomes Program Interdisciplinary tumor outpatient clinic, opened in August 2010 Heidelberg TP Faculty of Biosciences Faculty of Medicine Heidelberg OMZ Hospital NCT HIT Children’s Hospital DKFZ HI-STEM ZMBH Pathology Surgery MPImF
  10. 10. 11 Heidelberg Ion-Beam Therapy Center (HIT) A unique therapy center which will not only help many patients, but also lead to a confirmed scientific basis for new cancer therapies The Heidelberg Ion-Beam Therapy Center (HIT) is the world´s first heavy ion therapy facility with a movable radiation source (gan- try). The beam head can be rotated by 360° around the patient. Numerous angles of irradiation can be selected. HIT is one of the largest research projects ever implemented in Ger- many. The total cost was about 119 million euros, shared equally by the federal government and Heidelberg University Hospital. The HIT covers an area of 5,027 sq. meters – almost the size of a football field. In the long-term the estimated five to ten percent of cancer patients in whom tumour growth cannot be controlled with conventional radiation therapy because it is technically impossible to administer a sufficiently high radiation dose will benefit from radiation at the Heidelberg Ion-Beam Therapy Center (HIT). These patients have tumors • that are located deep inside the body, • that are extremely resistant to conventional radiation, • that are surrounded by highly radiation-sensitive healthy tissue, such as the optic nerve or bowel, which should not be damaged during treatment. Project partners • Medical Faculty of Heidelberg University • Clinic of Radiation Oncology and Radiation Therapy at Heidelberg University Hospital • German Cancer Research Center (DKFZ) • GSI Helmholtzzentrum for Heavy Ion Research • Forschungszentrum Dresden Rossendorf (FZD) Tumors in the “crossfire” A gantry is a rotable radiation source. HIT is the world’s first therapy facility with a gantry for heavy ions. In addition it is equipped with the intensity-modulated rasterscan technique, which offers the world´s greates radiation pre- cision in radiation therapy. The gantry at HIT is a giant technical steel construction: It is three stories high, 25 m long, 13 m in diameter and weighs 670 tons, 600 of which are rotatable. With a gantry, radio-oncologists can guide the ion beam into the patient at the optimal angle as the beam head can be rotated by 360°. The gantry allows for “crossfire“ irradiation of the tumour. This means that the irradiation from various directions overlaps in the tumour and only there add up to the total dose. Healthy tissue surrounding the tumor receives only a fraction of the radiation and is thus spared to a great extent. In addition, especially favorable entrance channels can be selected that com- pletely spare normal tissue that is extremely sensitive to radiation. Interior view of HIT with accelerator facility, gantry and treatment rooms Heidelberg TP Faculty of Biosciences Faculty of Medicine Heidelberg OMZ Hospital NCT HIT Children’s Hospital DKFZ HI-STEM ZMBH Pathology Surgery MPImF
  11. 11. 12 Children’s Hospital Ultra-modern center for pediatric and adolescent medicine The Children‘s Hospital is part of the Heidelberg University Hospital. It maintains strategic partnerships with the departments of the Paediatric Surgery, the Paediatric Radiology, for Child and Ado- lescent Psychiatry and the Cardiac Surgery. The new building was opened in 2008, and today the hospital is one of the biggest University childrens´s hospital in Germany. The examination and treatment areas are located in a colorful, five-level cube with more than 150 beds and numerous special sections for outpatient therapies. The state-of-the-art equipment includes everything required to practice modern, cutting-edge medicine. More than 150 years of Heidelberg Children‘s hospital With six beds in a rented two-rooms apartment in Heidelbergs suburb Bergheim, the Heidelberg physician Dr. Theodor von Dusch (1824 - 1890) founded the Kinder-Heilanstalt zu Heidelberg, the Heidelberg Children‘s Sanatorium in 1860. In 2010 the Heidelberg Childrens Hospital cele- brated its 150th anniversary. With 150 beds and 6,300 inpatient as well as 36,000 outpatient treatments per year, the Centre for Childrens and Youth Medicine today is one of the biggest university children‘s hospitals in Germany. From the Luisen-Sanatorium to the Angelika Lau- tenschläger Hospital building: The first building of the children‘s Hospital in 1914 Heidelberg TP Faculty of Biosciences Faculty of Medicine Heidelberg OMZ Hospital NCT HIT Children’s Hospital DKFZ HI-STEM ZMBH Pathology Surgery MPImF
  12. 12. 13 German Cancer Research Center (DKFZ) Largest biomedical research institute in Germany To fight cancer through research is the mission of the German Can- cer Research Center (Deutsches Krebsforschungszentrum, DKFZ) Germany‘s largest biomedical research institute. More than 2,650 staff members, including 1,200 scientists, are investigating the mechanisms of cancer and are working to identify cancer risk fac- tors. Moreover, they provide the foundations for developing novel approaches in the prevention, diagnosis, and treatment of cancer. Scientific work at the DKFZ is assigned to seven Research Pro- grams: • Cell Biology and Tumor Biology • Structural and Functional Genomics • Cancer Risk Factors and Prevention • Tumor Immunology • Imaging and Radiooncology • Infection and Cancer • Translational Cancer Research Six core facilities provide the best possible support to the in- vestigators: • Genomics and Proteomics • Imaging and Cytometry • Information Technology • Chemical Biology Core Facility • Animal Laboratory Services • Library The DKFZ’s Office of Technology Transfer works at the interface between research and industry. By securing, marketing and licensing patented and non-patented research results obtained at the DKFZ, the Office helps to facilitate the introduction of novel products includ- ing anti-cancer drugs, diagnostic assays, and research tools. Jointly with Heidelberg University Hospital, DKFZ has established the National Center for Tumor Diseases (NCT) Heidelberg, where promising approaches from cancer research are translated into clin- cal practice. The DKFZ is a member of the Helmholtz Association of National Re- search Centers (Helmholtz-Gemeinschaft Deutscher Forschungs- zentren). Nobel Prize for Medicine Awarded to Harald zur Hausen In 2008, Harald zur Hausen was awarded the Nobel Prize in Medicine. The former Scientific Director of the German Cancer Research Cen- ter, was honored for his outstanding discovery that human papilloma viruses play a critical role in the onset of cervical cancer. His research made it possible to develop a prophylactic vac- cine against one of the most frequent cancers in women. Today, zur Hausen‘s research group is situated at the “Applied Tumor Virology-Building”. Here research focuses on the development of a ther- apeutic vaccine which is able to cure existing infections with carcinogenic human papilloma- viruses. The renovated DKFZ main building with its mod- ern equipment and bright and spacious laborato- ries offers highly attractive working conditions for cancer researchers from all over the world. Heidelberg TP Faculty of Biosciences Faculty of Medicine Heidelberg OMZ Hospital NCT HIT Children’s Hospital DKFZ HI-STEM ZMBH Pathology Surgery MPImF
  13. 13. 14 Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM) A non-profit institute for stem cell technology and experimental medicine The Heidelberg Institute for Stem Cell Technology and Experimen- tal Medicine (HI-STEM) is a public private partnership between the German Cancer Research Center (DKFZ) in Heidelberg and the Dietmar Hopp Foundation. Its aim is to promote translational stem cell research in cancer. The institute was founded in 2008 and is headquartered at the high-tech laboratories of the German Cancer Research Center (DKFZ). Researchers at HI-STEM are working in close collabo- ration with hospitals in and around Heidelberg and the National Center for Tumor Diseases in Heidelberg, and biotechnology and pharmaceutical companies to investigate and develop new methods to push forward the development of new drugs and effective treatments for different types of cancer and to promote their clinical application. Discovery of active and dormant blood stem cells Professor Andreas Trumpp and his team of scientists have made many valuable contributions to stem cell research. They discovered, for example, that hematopoetic stem cells (blood stem cells) can be either active or dormant. Dormant hematopoietic stem cells have the highest self-renewal potential of all blood cells, but they very rarely divide in healthy adult humans (only about five times during a lifetime). The loss of blood cells due, for example, to bleeding or chemotherapy activates dormant hematopoietic stem cells by means of a feedback mechanism. Once activated, they ensure the rapid production of new blood cells and, thus, the re- generation of damaged bone marrow. The discovery of dormant stem cells triggered the search for drugs capable of activating cancer stem cells that are capable of dividing indefinitely yet dormant, making them susceptible to che- motherapy. The Location of HI-STEM at the labs of the DKFZ facilitates a close collaboration of research groups Core of a Leading-edge Cluster Project HI-STEM is a major component of the Biotech- nology Cluster Rhine-Neckar (BioRN), which was recognised as a Leading-edge Cluster for Cell Based & Molecular Medicine in the Rhine- Neckar Metropolitan Region, by the Federal Ministry of Education and Research (BMBF). At the core of the BioRN Leading-Edge Cluster are five so-called collaborative projects. One of these projects is the BioRN Stem Cell Network which bundles and strengthens the region’s scientific excellence in the field of stem cell re- search. HI-STEM, which is located at the DKFZ, is the core of this collaborative project. Heidelberg TP Faculty of Biosciences Faculty of Medicine Heidelberg OMZ Hospital NCT HIT Children’s Hospital DKFZ HI-STEM ZMBH Pathology Surgery MPImF
  14. 14. 15 Center for Molecular Biology of Heidelberg University (ZMBH) Research and higher education in basic and biomedical biology The Center for Molecular Biology (ZMBH) is a pioneering institution notable for its successful basic research, high-quality teaching in ba- sic and biomedical biology and outstanding opportunities for young scientists. The ZMBH has more than 250 researchers and staff from over 20 different countries. Of major interest for the researchers at the ZMBH are the following topics: • regulation of the genome • signaling networks • cellular quality control systems • stem cells and aging Grants from German and European agencies represent a very sig- nificant source of the ZMBH‘s research funding. In addition to indi- vidual project grants ZMBH researchers participate in a number of collaborative research centers (“Sonderforschungsbereiche”) and research training groups (“Graduiertenkollegs”). DKFZ-ZMBH Alliance Founded in 2007, the DKFZ-ZMBH Alliance is a strategic alliance between the Research Program “Cell and Tumor Biology” of the German Cancer Research Center (DKFZ) and the Center for Mo- lecular Biology of Heidelberg University (ZMBH). Its aim is to establish an internationally recognized interdisciplinary research center at the interface between molecular biology, cell bi- ology, tumor biology and biomedicine. Basic research and high-quality teaching in basic and biomedical biology at the ZMBH building Scientific Service Facilities • Advanced Light Microscopy • Biocomputing • Cell Sorting • Mass Spectrometry and Proteomics • Scientific Workshops Heidelberg TP Faculty of Biosciences Faculty of Medicine Heidelberg OMZ Hospital NCT HIT Children’s Hospital DKFZ HI-STEM ZMBH Pathology Surgery MPImF
  15. 15. 16 Heidelberg University Hospital, Institute of Pathology Contributor of patient care, teaching, advanced training, quality management and research The Institute of Pathology consists of three divisions: General Pa- thology, Neuropathology and Applied Tumor Biology. The depart- ment maintains close cooperation with the NCT (NCT Biobanking). Characteristics • Diagnostic of 62,000 tissue samples per year • 3,400 sq. meters lab- and office-space • About 100 employees The new Institute of Pathology was opened in 2012. Working Groups Molecular Tumorpathology • Invasion and Metastasis • Apoptosis • Thorax pathology • Breast cancer • Molecular classification and new markers in HCC • Translational tumor research - “Predictive pathology and biomarker validation“ Molecular Hepatopathology • Molecular Hepatopathology • Intestinal tumor genesis • Pancreas Immunopathology • Invasion and Metastasis • Intestinal immunopathology • Haematopathology • Nephrology In close cooperation with the National Center of Tumor Diseases: The Department of Pathology NCT tissue bank The NCT tissue bank is a facility of the National Center of Tumor diseases (NCT) Heidelberg and is under the aegis of the medical faculty of the Heidelberg University Hospital and the German Cancer Research Center (DKFZ). The tissue bank´s purpose is to collect, characterize, re- gister, file and prepare high-quality tissues and tissue extracts (e.g. in tissue micro arrays) in a high quality for scientific tumor research. Heidelberg TP Faculty of Biosciences Faculty of Medicine Heidelberg OMZ Hospital NCT HIT Children’s Hospital DKFZ HI-STEM ZMBH Pathology Surgery MPImF
  16. 16. 17 Heidelberg University Hospital, Institute of Surgery Leading institution in abdominal surgery The Surgical Hospital of Heidelberg University is one of the most important and traditional surgical centers in Germany. Since its foundation in 1818 the medical directors frequently gave pioneering impulses, for example for the founding of a national cancer research center in 1964 (today the German Cancer Research Center, DKFZ). Today managing director of the Surgery University Hospital is the internationally renowned surgeon Professor Dr. Dr. h. c. Markus W. Büchler. The Surgery is sub-devided into seven sections: • General, Visceral and Transplantation Surgery • Heart Surgery • Vascular Surgery • Urology • Accident Surgery • Pediadric Surgery • Anaesthesiology • Radiology Group Molecular OncoSurgery – Successful pancre- atic cancer research The group Molecular OncoSurgery, part of the section general, vis- ceral and transplantation surgery, is a cooperation between the Uni- versity Hospital Heidelberg and the German Cancer Research Cen- ter (DKFZ). The group is active in pancreatic cancer and was looking for a new approach to eleminate cancer stem cells, which are the driving force of tumors. The team recently found a substance in broccoli that supports cancer therapy. The substance (sorafenib) inhibits resistant tumor stem cells and is also especially effective in combination with sulforaphane, an organic compound found in broccoli. The results has been published in 2010 in the prestigious medical journal Cancer Research. Under one roof: eight sections of surgery Total Number of surgical interventions 2011 2012 In total ambulant 83,804 81,387 165,191 stationary 18,968 19,568 38,536 Heidelberg TP Faculty of Biosciences Faculty of Medicine Heidelberg OMZ Hospital NCT HIT Children’s Hospital DKFZ HI-STEM ZMBH Pathology Surgery MPImF
  17. 17. 18 Max Planck Institute for Medical Research (MPImF) The MPImF is a facility of the Max Planck Society for basic medical research The institution was founded in 1948. Its original goal was to apply the methods of physics and chemistry to basic medical research. In the 1960s, new developments in biology were reflected with the establishment of the Department of Molecular Biology. Today the institute‘s focus lies on Physiology, Central Nerve Sys- tem and Neurology. Domain of six Nobel Laureates Since its foundation, six Nobel laureates worked at the Institute: • Otto Fritz Meyerhof (Physiology) • Richard Kuhn (Chemistry) • Walther Bothe (Physics) • André Michel Lwoff (Physiology or Medicine) • Rudolf Mößbauer (Physics) • Bert Sakmann (Physiology or Medicine) The institute has close ties with Heidelberg University and currently has three departments and two independent junior research groups: • Department of Molecular Neurobiology • Department of Biomedical Optics • Department of Biomolecular Mechanisms • Independent junior research group Behavioural Neurophysiology • Independent junior research group Development and Function of Hypothalamic Neuronal Circuits Direct descendent of the Kaiser Wilhelm Institute for Medical Research (KWImF) and member insti- tute of the Max Planck Society: the MPImF Heidelberg TP Faculty of Biosciences Faculty of Medicine Heidelberg OMZ Hospital NCT HIT Children’s Hospital DKFZ HI-STEM ZMBH Pathology Surgery MPImF
  18. 18. 19 Heidelberg Life Science Campus II Science and business in the new urban district “Bahnstadt“ 2,500 flats and 7,000 jobs, mainly in the field of science, are under construction in the new Bahnstadt city district which will be bigger than the Old Town. New Technology Park Campus II will also be established there. It will offer innovative conditions for science-related companies and science facilities first of all in the field of life sciences. SkyLabs • Ultra modern building that will offer lab and office space • Ground area: 7,400 qm • Rentable area: 19,000 qm • Building owner: Max-Jarecki-Foundation • First residental buildings and public facilities (Kinder- garten) in the direct neighborhood Transport connection between both Campuses From Campus II to Campus “Im Neuenheimer Feld“ • by car: 5 minutes • by public transport: 10 minutes • bicycle lanes: 10 minutes Connection to the main station/to the Frankfurt Airport • New catwalk: 2 minutes to the main station • Train ride to the airport: 40 minutes Location of the Life Science Campus Neuenheimer Feld and Life Science Campus II in Heidelbergs newly founded quarter Bahnstadt Heidelberg TP Faculty of Biosciences Faculty of Medicine Heidelberg OMZ Hospital NCT HIT Children’s Hospital DKFZ HI-STEM ZMBH Pathology Surgery MPImF
  19. 19. 20 BioRN Cluster Management The BioRN Cluster Management GmbH is charged with the co- ordination, integration, development and marketing of the Biotech Cluster Rhine-Neckar (BioRN). The company provides access to R&D collaboration partners, contract research, manufacturing partners, lab and office space. Industry Association BioRN Network • Has developed the Rhine-Neckar Biotech Cluster since 1996 • Has built up a regional network of pharma & biotech companies, service providers and other stakeholders • Has implemented the BioRN Cluster Management to further develop the cluster • Represents the region´s interests in the German biotech community Company Heidelberg Technology Park • Offers services for Start-up & Infrastructure (see page 6) Chamber of Industry and Commerce Rhine-Neckar • Offers economy-oriented services • Represents the interests of the industry towards the state and policy makers • Counsels for official decision makers Rhine-Neckar Metropolitan Region • Home of around 2.4 million people • Platform for joint regional development • Engine of the economic, social and cultural development • Its goal: to be one of the most competitive and attractive regions for business and industry in Europe by the year 2025 On a site of 7,400 square meters an ultra-modern combination of laboratory and office spaces is being constructed in a prominent location in the center of the new district “Bahnstadt“ Services for your Business The BioRN Cluster Management and its local partners provide professional services suppor- ting regional innovation and the growth of your business. Heidelberg TP Faculty of Biosciences Faculty of Medicine Heidelberg OMZ Hospital NCT HIT Children’s Hospital DKFZ HI-STEM ZMBH Pathology Surgery MPImF
  20. 20. 21 Education / Further Development The BioRN Cluster offers a lot of opportunities for further development and qualified pro- fessional training. Here are two examples: HBIGS The Hartmut Hoffmann-Berling International Gradu- ate School of Molecular and Cellular Biology In order to take over leadership later on in their profes- sional career young scientists need excellent education and intensive support. In Heidelberg renowned scientists of the Ruprecht-Karls University and research centres like the European Mo- lecular Biology Laboratory, the Max Planck Institute for Medical Research (MPImF) and the German Can- cer Research Center (DKFZ) aligned their efforts. This alignment resulted in the foundation of the “The Hartmut Hoffmann-Berling International Graduate School of Mo- lecular and Cellular Biology“, abbreviated HBIGS. The aim of the graduate school is to better structure and improve the PhD education by providing additional inter- disciplinary services regarding teaching, individual men- toring and professional career development. Graduate Studies at the German Cancer Research Center The Helmholtz International Graduate School for Cancer Research The Helmholtz International Graduate School for Can- cer Research is the PhD program of the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ). Through the Graduate School, approximately 500 students receive world-class PhD training in interdisci- plinary cancer research. Graduate students are recruited bi-annually from around the world through a highly competitive selection proce- dure. Annual Thesis Advisory Committees (TACs) moni- tor the student’s progress, offer feedback and discuss any other relevant issues of the student’s work. The comprehensive training program for the students com- prises scientific and soft-skills courses, lecture series and career seminars and students also attend the PhD retreat in their second year. Throughout their PhD, scien- tific supervision, networking and cooperation between the graduate student and leading scientists is facilitated at an international level. A further branch of graduate education, the German-Is- raeli Helmholtz Research School in Cancer Biology, was established in 2012 in collaboration with the Weizmann Institute of Science in Rehovot, Israel. Graduate students work on joint scientific projects under supervision of se- nior scientists from both the DKFZ and the Weizmann In- stitute. All projects include an extended research stay at the partner institute. Annual meetings, joint workshops and on-going seminar series and courses of the Re- search School ensure a continuous exchange between the partners. Find out more at www.dkfz.de/phd. Heidelberg TP Faculty of Biosciences Faculty of Medicine Heidelberg OMZ Hospital NCT HIT Children’s Hospital DKFZ HI-STEM ZMBH Pathology Surgery MPImF
  21. 21. Published by: BioRN Cluster Management GmbH Persons responsible according to the press law: Dr. Christian Tidona, Im Neuenheimer Feld 582, 69120 Heidelberg, Germany Phone: +49 6221 655780 • Email: info@BioRN.org Internet: www.BioRN.org Commercial Register: Mannheim, HRB 704801 VAT ID: DE 2630 64 014 Impressum Editors: Eva-Maria Gottmann, Dr. Stephanie Konle Design Concept: www.stockhorn.de Image Copyright: p. 6 Technologiepark Heidelberg • p. 7, 11 Stef- fen Fuchs (Fotograf) • p. 8, 9, 12, 13, 17, 18 Heidelberg University Hospital • p. 14, 15 DKFZ • p. 16 Heidelberg University • p. 19 Kay Sommer • p. 21 bhp.com.de
  22. 22. BioRN Cluster Management GmbH Im Neuenheimer Feld 582 69120 Heidelberg, Germany Phone: +49 6221 655 78 0 Fax: +49 6221 655 78 11 Email: info@BioRN.org www.BioRN.org Cluster Management

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