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Graph Annotation: A Tale of Two Binary Relations

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Benjamin Keller
Benjamin Keller

Presentation from Seattle Graph Meetup discussing use of Formal Concept Analysis to annotate graphs. Uses examples from bionformatics/systems biology.

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CRKL ANK3 CABP1 GNB1 PCBD1 PPM1A PRKAC A RYR2 SRI CACNA 1C FAS FADD HOOK1 KCNC1 KCNC2 SMAD2 PIK3R1 SCNN1 B Graph Annotation Seattle/Bellevue Graphs – Data, Processing, Algorithms Meetup 5 August 2014 A Tale of Two Binary Relations Benjamin J. Keller linkedin.com/in/bjkeller Attribution-ShareAlike 3.0 Unported
Context: Systems story telling want to help user understand relationships in data so that they can construct stories about biological systems How do we use biological information and data to go from a list of genes to a story about how symptoms of a genetic disease arise? [ ]
Context: Systems Story Telling Classification Reasoning Model-based Reasoning Narrative Reasoning (based on B. Mirel, Supporting cognition in systems biology analysis; findings on users’ processes and design implications. Journal of Biomedical Discovery and Collaboration 2009; 4:1-17) what of all this is the right stuff? how does it fit together? how does it do something? what stories does it tell?
Context: Systems Story Telling Classification Reasoning Model-based Reasoning Narrative Reasoning individual components networks/ graphs of components system fragments “whole” systems roles contextual classes Grouping Patterns Composition
Two kinds of binary relations individual components networks/ graphs of components roles contextual classes
Two kinds of binary relations component component annotation component Incidence relation Graph ,( ) ,( )
Grouping Start with - a network graph of genes, and - contextual annotations for each Want to visualize what goes together [ saw this before in cytoscape.js presentation ]
Grouping (hypergraph visualization) MeSH: Calcium GO BP: Metal Ion Transport GO MF: Gated Channel Activity GO MF: Cation Channel Activity GO MF: Voltage-Gated Ion Channel Activity MeSH: Phosphorylation MeSH: Signal Transduction MeSH: Intercellular Signaling Peptides and Proteins MeSH: Rats MeSH: Nerve Tissue Proteins MeSH Ion Channel Gating CRKL ANK3 CABP1 CACNA 2D4 CACNB 3 GNB1 PCBD1 RIMS1 PPM1A PRKAC A RYR2 SRI CACNA 1C FAS FADD CNTN1 HOOK1 KCNC1 KCNC2 SMAD3 SMAD2 PIK3R1 SPTBN4 SCN1B SCNN1 B SCN2A
Simplified Groupings MeSH: Calcium GO MF: Voltage-Gated Ion Channel Activity MeSH: Phosphorylation MeSH: Intercellular Signaling Peptides and Proteins MeSH: Nerve Tissue Proteins MeSH Ion Channel Gating CRKL ANK3 CABP1 CACNA 2D4 CACNB 3 GNB1 PCBD1 RIMS1 PPM1A PRKAC A RYR2 SRI CACNA 1C FAS FADD CNTN1 HOOK1 KCNC1 KCNC2 SMAD3 SMAD2 PIK3R1 SPTBN4 SCN1B SCNN1 B SCN2A MeSH: Calcium GO MF: Voltage-Gated Ion Channel Activity MeSH: Phosphorylation MeSH: Intercellular Signaling Peptides and Proteins MeSH: Rats MeSH: Nerve Tissue Proteins CRKL ANK3 CABP1 CACNA 2D4 CACNB 3 GNB1 PCBD1 RIMS1 PPM1A PRKAC A RYR2 SRI CACNA 1C FAS FADD CNTN1 HOOK1 KCNC1 KCNC2 SMAD3 SMAD2 PIK3R1 SPTBN4 SCN1B SCNN1 B SCN2A MeSH: Calcium GO MF: Voltage-Gated Ion Channel Activity MeSH: Signal Transduction MeSH: Nerve Tissue Proteins MeSH Ion Channel Gating CRKL ANK3 CABP1 CACNA 2D4 CACNB 3 GNB1 PCBD1 RIMS1 PPM1A PRKAC A RYR2 SRI CACNA 1C FAS FADD CNTN1 HOOK1 KCNC1 KCNC2 SMAD3 SMAD2 PIK3R1 SPTBN4 SCN1B SCNN1 B SCN2A MeSH: Calcium GO MF: Voltage-Gated Ion Channel Activity MeSH: Signal Transduction MeSH: Rats MeSH: Nerve Tissue Proteins CRKL ANK3 CABP1 CACNA 2D4 CACNB 3 GNB1 PCBD1 RIMS1 PPM1A PRKAC A RYR2 SRI CACNA 1C FAS FADD CNTN1 HOOK1 KCNC1 KCNC2 SMAD3 SMAD2 PIK3R1 SPTBN4 SCN1B SCNN1 B SCN2A MeSH: Calcium GO BP: Metal Ion Transport GO MF: Gated Channel Activity GO MF: Cation Channel Activity MeSH: Phosphorylation MeSH: Intercellular Signaling Peptides and Proteins MeSH: Nerve Tissue Proteins MeSH Ion Channel Gating CRKL ANK3 CABP1 CACNA 2D4 CACNB 3 GNB1 PCBD1 RIMS1 PPM1A PRKAC A RYR2 SRI CACNA 1C FAS FADD CNTN1 HOOK1 KCNC1 KCNC2 SMAD3 SMAD2 PIK3R1 SPTBN4 SCN1B SCNN1 B SCN2A MeSH: Calcium GO BP: Metal Ion Transport GO MF: Gated Channel Activity GO MF: Cation Channel Activity MeSH: Phosphorylation MeSH: Intercellular Signaling Peptides and Proteins MeSH: Rats MeSH: Nerve Tissue Proteins CRKL ANK3 CABP1 CACNA 2D4 CACNB 3 GNB1 PCBD1 RIMS1 PPM1A PRKAC A RYR2 SRI CACNA 1C FAS FADD CNTN1 HOOK1 KCNC1 KCNC2 SMAD3 SMAD2 PIK3R1 SPTBN4 SCN1B SCNN1 B SCN2A MeSH: Calcium GO BP: Metal Ion Transport GO MF: Gated Channel Activity GO MF: Cation Channel Activity MeSH: Signal Transduction MeSH: Nerve Tissue Proteins MeSH Ion Channel Gating CRKL ANK3 CABP1 CACNA 2D4 CACNB 3 GNB1 PCBD1 RIMS1 PPM1A PRKAC A RYR2 SRI CACNA 1C FAS FADD CNTN1 HOOK1 KCNC1 KCNC2 SMAD3 SMAD2 PIK3R1 SPTBN4 SCN1B SCNN1 B SCN2A MeSH: Calcium GO BP: Metal Ion Transport GO MF: Gated Channel Activity GO MF: Cation Channel Activity MeSH: Signal Transduction MeSH: Rats MeSH: Nerve Tissue Proteins CRKL ANK3 CABP1 CACNA 2D4 CACNB 3 GNB1 PCBD1 RIMS1 PPM1A PRKAC A RYR2 SRI CACNA 1C FAS FADD CNTN1 HOOK1 KCNC1 KCNC2 SMAD3 SMAD2 PIK3R1 SPTBN4 SCN1B SCNN1 B SCN2A computed with BLOSOM (Zhao L, Zaki MJ, Ramakrishnan N., KDD 2006, 827-832), support=5
Human-edited Groupings MeSH: Calcium GO BP: Metal Ion Transport GO MF: Gated Channel Activity GO MF: Cation Channel Activity OR MeSH Ion Channel Gating MeSH: Phosphorylation MeSH: Intercellular Signaling Peptides and Proteins MeSH: Nerve Tissue Proteins CRKL ANK3 CABP1 CACNA 2D4 CACNB 3 GNB1 PCBD1 RIMS1 PPM1A PRKAC A RYR2 SRI CACNA 1C FAS FADD CNTN1 HOOK1 KCNC1 KCNC2 SMAD3 SMAD2 PIK3R1 SPTBN4 SCN1B SCNN1 B SCN2A MeSH: Calcium GO BP: Metal Ion Transport GO MF: Gated Channel Activity GO MF: Cation Channel Activity OR MeSH Ion Channel Gating MeSH: Signal Transduction MeSH: Nerve Tissue Proteins CRKL ANK3 CABP1 CACNA 2D4 CACNB 3 GNB1 PCBD1 RIMS1 PPM1A PRKAC A RYR2 SRI CACNA 1C FAS FADD CNTN1 HOOK1 KCNC1 KCNC2 SMAD3 SMAD2 PIK3R1 SPTBN4 SCN1B SCNN1 B SCN2A “user” merged/deleted annotations
Formal Concept Analysis GNB1 PRKACA RatsCNTN1 PIK3R1 Animals SMAD2 SMAD3 Calcium Ankyrins SPTBN4 CRKL Cell Line FADD Phosphorylation Ranvier's Nodes Precipitin Tests Signal Transduction Nerve Tissue ProteinsRIMS1 Two-Hybrid System Techniques Intracellular Signaling Peptides and Pr • Algebraic approach to studying data as incidence relation b/w objects and attributes • Construct formal concepts (biclusters) • Relate to form formal concept lattice
Formal Concept CACNA1C Ion transport protein KCNC1 KCNC2 RYR2 SCN2A Beta1 adrenergic receptor signaling pathway CACNB3 GNB1 PRKACA Beta2 adrenergic receptor signaling pathway cation transport CACNA2D4 SCN1B SCNN1B metal ion transport channel activity ion channel activity gated channel activity cation channel activity alkali metal ion binding calcium channel activity voltage-gated channel activity transmembrane transporter activity voltage-gated ion channel activity substrate specific channel activity voltage-gated cation channel activity ion transmembrane transporter activity substrate-specific transporter activity cation transmembrane transporter activity passive transmembrane transporter activity metal ion transmembrane transporter activity substrate-specific transmembrane transporter activity ANK3 RatsCNTN1 PIK3R1 Animals SMAD2 SMAD3 CABP1 Calcium SRI Ankyrins SPTBN4 CRKL Cell Line FADD Myocardium Jurkat CellsFAS PPM1A Smad2 Protein Phosphorylation Ranvier's Nodes Sodium Channels Calcium Channels Precipitin Tests Protein Subunits Ion Channel Gating Signal Transduction Nerve Tissue ProteinsRIMS1 Patch-Clamp Techniques Sodium Channel Blockers Calcium Channels, L-Type Two-Hybrid System Techniques Ryanodine Receptor Calcium Release Channel Intracellular Signaling Peptides and Proteins • Can view incidence relation as bipartite graph • A formal concept is a biclique: a pair of vertices (A,B) such that for each object a in A there is an edge (a,b) for every attribute b in B • Can construct as closure
Ex: Signal Transduction Beta1 adrenergic receptor signaling pathway GNB1 PRKACA Beta2 adrenergic receptor signaling pathway Rats PIK3R1 Animals SMAD2 SMAD3 Calcium CRKL Cell Line FADD Myocardium Jurkat Cells FAS PPM1A Smad2 Protein Phosphorylation Calcium Channels Precipitin Tests Protein Subunits Ion Channel Gating Signal Transduction Two-Hybrid System Techniques Ryanodine Receptor Calcium Release Channel Intracellular Signaling Peptides and Proteins
Ex: Signal Transduction Beta1 adrenergic receptor signaling pathway GNB1 PRKACA Beta2 adrenergic receptor signaling pathway Rats PIK3R1 Animals SMAD2 SMAD3 Calcium CRKL Cell Line FADD Myocardium Jurkat Cells FAS PPM1A Smad2 Protein Phosphorylation Precipitin Tests Signal Transduction Two-Hybrid System Techniques Ryanodine Receptor Calcium Release Channel Intracellular Signaling Peptides and Proteins
Rats PIK3R1 Animals SMAD2 SMAD3 CRKL Cell Line FADD Jurkat Cells FAS PPM1A Smad2 Protein Phosphorylation Precipitin Tests Signal Transduction Two-Hybrid System Techniques Intracellular Signaling Peptides and Proteins
Subconcept Beta1 adrenergic receptor signaling pathway GNB1 PRKACA Beta2 adrenergic receptor signaling pathway Rats PIK3R1 Animals SMAD2 SMAD3 Calcium CRKL Cell Line FADD Myocardium Jurkat Cells FAS PPM1A Smad2 Protein Phosphorylation Calcium Channels Precipitin Tests Protein Subunits Ion Channel Gating Signal Transduction Two-Hybrid System Techniques Ryanodine Receptor Calcium Release Channel Intracellular Signaling Peptides and Proteins Beta1 adrenergic receptor signaling pathway GNB1 PRKACA Beta2 adrenergic receptor signaling pathway Rats PIK3R1 Animals SMAD2 SMAD3 Calcium CRKL Cell Line FADD Myocardium Jurkat Cells FAS PPM1A Smad2 Protein Phosphorylation Calcium Channels Precipitin Tests Protein Subunits Ion Channel Gating Signal Transduction Two-Hybrid System Techniques Ryanodine Receptor Calcium Release Channel Intracellular Signaling Peptides and Proteins
Subconcept relationship Beta1 adrenergic receptor signaling pathway GNB1 PRKACA Beta2 adrenergic receptor signaling pathway Rats PIK3R1 Animals SMAD2 SMAD3 Calcium CRKL Cell Line FADD Myocardium Jurkat Cells FAS PPM1A Smad2 Protein Phosphorylation Calcium Channels Precipitin Tests Protein Subunits Ion Channel Gating Signal Transduction Two-Hybrid System Techniques Ryanodine Receptor Calcium Release Channel Intracellular Signaling Peptides and Proteins Beta1 adrenergic receptor signaling pathway GNB1 PRKACA Beta2 adrenergic receptor signaling pathway Rats PIK3R1 Animals SMAD2 SMAD3 Calcium CRKL Cell Line FADD Myocardium Jurkat Cells FAS PPM1A Smad2 Protein Phosphorylation Calcium Channels Precipitin Tests Protein Subunits Ion Channel Gating Signal Transduction Two-Hybrid System Techniques Ryanodine Receptor Calcium Release Channel Intracellular Signaling Peptides and Proteins more objects/ fewer attributes fewer objects/ more attributes
Subconcept relationship Beta1 adrenergic receptor signaling pathway GNB1 PRKACA Beta2 adrenergic receptor signaling pathway Rats PIK3R1 Animals SMAD2 SMAD3 Calcium CRKL Cell Line FADD Myocardium Jurkat Cells FAS PPM1A Smad2 Protein Phosphorylation Calcium Channels Precipitin Tests Protein Subunits Ion Channel Gating Signal Transduction Two-Hybrid System Techniques Ryanodine Receptor Calcium Release Channel Intracellular Signaling Peptides and Proteins Beta1 adrenergic receptor signaling pathway GNB1 PRKACA Beta2 adrenergic receptor signaling pathway Rats PIK3R1 Animals SMAD2 SMAD3 Calcium CRKL Cell Line FADD Myocardium Jurkat Cells FAS PPM1A Smad2 Protein Phosphorylation Calcium Channels Precipitin Tests Protein Subunits Ion Channel Gating Signal Transduction Two-Hybrid System Techniques Ryanodine Receptor Calcium Release Channel Intracellular Signaling Peptides and Proteins CRKL, FADD, FAS, GNB1, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 744175 FADD, FAS, PIK3R1, SMAD2, SMAD3; 744175, 748642
Concept Lattice ANK3, CABP1, CACNA1C, CACNA2D4, CACNB3, CNTN1, CRKL, FADD, FAS, GNB1, KCNC1, KCNC2, PIK3R1, PPM1A, PRKACA, RIMS1, RYR2, SCN1B, SCN2A, SCNN1B, SMAD2, SMAD3, SPTBN4, SRI; CACNA1C, CACNB3, GNB1, PRKACA, RYR2; 617414, 617437 CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, RYR2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 ANK3, CACNA1C, CNTN1, GNB1, PIK3R1, PRKACA, SCNN1B; 737748 CNTN1, GNB1, PIK3R1, PRKACA, SMAD2, SMAD3; 738083 CABP1, CACNA1C, PRKACA, RYR2, SRI; 738118 ANK3, SCN1B, SPTBN4; 738391 ANK3, SCNN1B, SPTBN4; 742325 CABP1, CACNA1C, CACNB3, PRKACA, RYR2; 742512 CACNA1C, GNB1, PIK3R1, PRKACA, SCN1B, SCN2A, SCNN1B; 742806 ANK3, CACNA1C, CACNB3, GNB1, SCN1B, SCN2A, SCNN1B; 743584 CRKL, FADD, FAS, GNB1, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 744175 CNTN1, RIMS1, SCN1B, SCN2A, SPTBN4; 744929 CABP1, CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B; 745316 CNTN1, SCN2A, SCNN1B; 745760 CABP1, CACNA1C, CACNA2D4, CACNB3; 745845 CACNA1C, CACNA2D4, CACNB3; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 745845 CABP1, CACNA1C, CACNB3; 742512, 745316, 745845 CNTN1, SCNN1B; 737748, 745760 CNTN1, SCN2A; 744929, 745760 SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 745316, 745760 CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 743584, 745316 SCN1B, SPTBN4; 738391, 744929 SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 744929, 745316 CNTN1; 737748, 738083, 744929, 745760 SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 744929, 745316, 745760 GNB1, PIK3R1, PRKACA, SMAD2, SMAD3; 738083, 744175 CRKL, FADD, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 744175 CRKL, FADD, FAS, PIK3R1; 740606, 744175 CRKL, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 742292, 744175 FADD, GNB1, PIK3R1, SMAD2, SMAD3; 744175, 747193 FADD, FAS, PIK3R1, SMAD2, SMAD3; 744175, 748642 FADD, FAS, PIK3R1; 740606, 744175, 748642 FADD, PIK3R1, SMAD2, SMAD3; 738855, 744175, 747193, 748642 GNB1, PIK3R1, SMAD2, SMAD3; 738083, 744175, 747193 CACNA1C, CACNB3, GNB1; 617414, 617437, 743584 ANK3, CACNA1C, GNB1, SCNN1B; 737748, 743584 ANK3, SCN1B, SCN2A, SCNN1B; 742390, 743584 CACNA1C, GNB1, SCN1B, SCN2A, SCNN1B; 742806, 743584 CACNA1C, GNB1, PIK3R1, PRKACA, SCNN1B; 737748, 742806 CACNA1C, GNB1, SCNN1B; 737748, 742806, 743584 CACNA1C, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, PRKACA, RYR2; 617414, 617437, 742512 CABP1, CACNA1C, PRKACA, RYR2; 738118, 742512 CABP1, CACNA1C; 738118, 742512, 745316, 745845 CACNA1C, CACNB3; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742512, 743584, 745316, 745845 ANK3, SCN1B; 738391, 742390, 743584 ANK3, SCNN1B; 737748, 742325, 742390, 743584 SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 745316 ANK3, SPTBN4; 738391, 742325 CRKL, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 742292, 744175 PPM1A, SMAD2, SMAD3; 741302, 742292, 744175 SMAD2, SMAD3; 738083, 738855, 741302, 742292, 742793, 744175, 747193, 748642 CRKL, FADD, PIK3R1; 738855, 740606, 744175 FADD, PIK3R1; 738855, 740606, 744175, 747193, 748642 PIK3R1, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175, 747193, 748642 CRKL, PIK3R1; 738855, 740606, 742292, 744175 PIK3R1, PRKACA, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175 PIK3R1; 737748, 738083, 738855, 740606, 742292, 742793, 742806, 744175, 747193, 748642 SPTBN4; 738391, 742325, 744929 SCN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 738391, 742390, 742806, 743584, 744929, 745316 ANK3; 737748, 738391, 742325, 742390, 743584 ; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738083, 738118, 738391, 738855, 739640, 740606, 741302, 742292, 742325, 742390, 742512, 742793, 742806, 743584, 744175, 744929, 745316, 745760, 745845, 747193, 748541, 748642 CACNA1C, PRKACA, RYR2, SRI; 738118, 739640, 748541 CACNA1C, PRKACA, RYR2; 617414, 617437, 738118, 739640, 742512, 748541 CACNA1C; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738118, 739640, 742512, 742806, 743584, 745316, 745845, 748541 CNTN1, GNB1, PIK3R1, PRKACA; 737748, 738083 GNB1, PIK3R1, PRKACA; 737748, 738083, 742806, 744175 GNB1, PIK3R1; 737748, 738083, 742806, 744175, 747193 PIK3R1, PRKACA; 737748, 738083, 738855, 742292, 742793, 742806, 744175 SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742325, 742390, 742806, 743584, 745316, 745760 CACNA1C, GNB1, PRKACA; 617414, 617437, 737748, 742806 CACNA1C, GNB1; 617414, 617437, 737748, 742806, 743584 CACNA1C, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742806, 743584, 745316 GNB1, PRKACA; 617414, 617437, 737748, 738083, 742806, 744175 GNB1; 617414, 617437, 737748, 738083, 742806, 743584, 744175, 747193 PRKACA; 617414, 617437, 737748, 738083, 738118, 738855, 739640, 742292, 742512, 742793, 742806, 744175, 748541 CACNA1C, KCNC1, KCNC2, RYR2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 KCNC1, KCNC2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNA2D4, CACNB3, RYR2; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNB3, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 743584, 745316 CACNA1C, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, RYR2; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742512 KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, RYR2; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 738118, 739640, 742512, 748541 CACNA1C, PRKACA; 617414, 617437, 737748, 738118, 739640, 742512, 742806, 748541
Top ANK3, CABP1, CACNA1C, CACNA2D4, CACNB3, CNTN1, CRKL, FADD, FAS, GNB1, KCNC1, KCNC2, PIK3R1, PPM1A, PRKACA, RIMS1, RYR2, SCN1B, SCN2A, SCNN1B, SMAD2, SMAD3, SPTBN4, SRI; CACNA1C, CACNB3, GNB1, PRKACA, RYR2; 617414, 617437 CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, RYR2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 ANK3, CACNA1C, CNTN1, GNB1, PIK3R1, PRKACA, SCNN1B; 737748 CNTN1, GNB1, PIK3R1, PRKACA, SMAD2, SMAD3; 738083 CABP1, CACNA1C, PRKACA, RYR2, SRI; 738118 ANK3, SCN1B, SPTBN4; 738391 ANK3, SCNN1B, SPTBN4; 742325 CABP1, CACNA1C, CACNB3, PRKACA, RYR2; 742512 CACNA1C, GNB1, PIK3R1, PRKACA, SCN1B, SCN2A, SCNN1B; 742806 ANK3, CACNA1C, CACNB3, GNB1, SCN1B, SCN2A, SCNN1B; 743584 CRKL, FADD, FAS, GNB1, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 744175 CNTN1, RIMS1, SCN1B, SCN2A, SPTBN4; 744929 CABP1, CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B; 745316 CNTN1, SCN2A, SCNN1B; 745760 CABP1, CACNA1C, CACNA2D4, CACNB3; 745845 CACNA1C, CACNA2D4, CACNB3; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 745845 CABP1, CACNA1C, CACNB3; 742512, 745316, 745845 CNTN1, SCNN1B; 737748, 745760 CNTN1, SCN2A; 744929, 745760 SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 745316, 745760 CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 743584, 745316 SCN1B, SPTBN4; 738391, 744929 SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 744929, 745316 CNTN1; 737748, 738083, 744929, 745760 SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 744929, 745316, 745760 GNB1, PIK3R1, PRKACA, SMAD2, SMAD3; 738083, 744175 CRKL, FADD, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 744175 CRKL, FADD, FAS, PIK3R1; 740606, 744175 CRKL, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 742292, 744175 FADD, GNB1, PIK3R1, SMAD2, SMAD3; 744175, 747193 FADD, FAS, PIK3R1, SMAD2, SMAD3; 744175, 748642 FADD, FAS, PIK3R1; 740606, 744175, 748642 FADD, PIK3R1, SMAD2, SMAD3; 738855, 744175, 747193, 748642 GNB1, PIK3R1, SMAD2, SMAD3; 738083, 744175, 747193 CACNA1C, CACNB3, GNB1; 617414, 617437, 743584 ANK3, CACNA1C, GNB1, SCNN1B; 737748, 743584 ANK3, SCN1B, SCN2A, SCNN1B; 742390, 743584 CACNA1C, GNB1, SCN1B, SCN2A, SCNN1B; 742806, 743584 CACNA1C, GNB1, PIK3R1, PRKACA, SCNN1B; 737748, 742806 CACNA1C, GNB1, SCNN1B; 737748, 742806, 743584 CACNA1C, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, PRKACA, RYR2; 617414, 617437, 742512 CABP1, CACNA1C, PRKACA, RYR2; 738118, 742512 CABP1, CACNA1C; 738118, 742512, 745316, 745845 CACNA1C, CACNB3; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742512, 743584, 745316, 745845 ANK3, SCN1B; 738391, 742390, 743584 ANK3, SCNN1B; 737748, 742325, 742390, 743584 SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 745316 ANK3, SPTBN4; 738391, 742325 CRKL, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 742292, 744175 PPM1A, SMAD2, SMAD3; 741302, 742292, 744175 SMAD2, SMAD3; 738083, 738855, 741302, 742292, 742793, 744175, 747193, 748642 CRKL, FADD, PIK3R1; 738855, 740606, 744175 FADD, PIK3R1; 738855, 740606, 744175, 747193, 748642 PIK3R1, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175, 747193, 748642 CRKL, PIK3R1; 738855, 740606, 742292, 744175 PIK3R1, PRKACA, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175 PIK3R1; 737748, 738083, 738855, 740606, 742292, 742793, 742806, 744175, 747193, 748642 SPTBN4; 738391, 742325, 744929 SCN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 738391, 742390, 742806, 743584, 744929, 745316 ANK3; 737748, 738391, 742325, 742390, 743584 ; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738083, 738118, 738391, 738855, 739640, 740606, 741302, 742292, 742325, 742390, 742512, 742793, 742806, 743584, 744175, 744929, 745316, 745760, 745845, 747193, 748541, 748642 CACNA1C, PRKACA, RYR2, SRI; 738118, 739640, 748541 CACNA1C, PRKACA, RYR2; 617414, 617437, 738118, 739640, 742512, 748541 CACNA1C; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738118, 739640, 742512, 742806, 743584, 745316, 745845, 748541 CNTN1, GNB1, PIK3R1, PRKACA; 737748, 738083 GNB1, PIK3R1, PRKACA; 737748, 738083, 742806, 744175 GNB1, PIK3R1; 737748, 738083, 742806, 744175, 747193 PIK3R1, PRKACA; 737748, 738083, 738855, 742292, 742793, 742806, 744175 SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742325, 742390, 742806, 743584, 745316, 745760 CACNA1C, GNB1, PRKACA; 617414, 617437, 737748, 742806 CACNA1C, GNB1; 617414, 617437, 737748, 742806, 743584 CACNA1C, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742806, 743584, 745316 GNB1, PRKACA; 617414, 617437, 737748, 738083, 742806, 744175 GNB1; 617414, 617437, 737748, 738083, 742806, 743584, 744175, 747193 PRKACA; 617414, 617437, 737748, 738083, 738118, 738855, 739640, 742292, 742512, 742793, 742806, 744175, 748541 CACNA1C, KCNC1, KCNC2, RYR2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 KCNC1, KCNC2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNA2D4, CACNB3, RYR2; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNB3, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 743584, 745316 CACNA1C, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, RYR2; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742512 KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, RYR2; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 738118, 739640, 742512, 748541 CACNA1C, PRKACA; 617414, 617437, 737748, 738118, 739640, 742512, 742806, 748541 formally: concept formed by closure of empty set of attributes alternative: concept with attributes shared by all objects
Bottom formally: concept formed by closure of empty set of objects alternative: concept with objects with all attributes ANK3, CABP1, CACNA1C, CACNA2D4, CACNB3, CNTN1, CRKL, FADD, FAS, GNB1, KCNC1, KCNC2, PIK3R1, PPM1A, PRKACA, RIMS1, RYR2, SCN1B, SCN2A, SCNN1B, SMAD2, SMAD3, SPTBN4, SRI; CACNA1C, CACNB3, GNB1, PRKACA, RYR2; 617414, 617437 CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, RYR2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 ANK3, CACNA1C, CNTN1, GNB1, PIK3R1, PRKACA, SCNN1B; 737748 CNTN1, GNB1, PIK3R1, PRKACA, SMAD2, SMAD3; 738083 CABP1, CACNA1C, PRKACA, RYR2, SRI; 738118 ANK3, SCN1B, SPTBN4; 738391 ANK3, SCNN1B, SPTBN4; 742325 CABP1, CACNA1C, CACNB3, PRKACA, RYR2; 742512 CACNA1C, GNB1, PIK3R1, PRKACA, SCN1B, SCN2A, SCNN1B; 742806 ANK3, CACNA1C, CACNB3, GNB1, SCN1B, SCN2A, SCNN1B; 743584 CRKL, FADD, FAS, GNB1, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 744175 CNTN1, RIMS1, SCN1B, SCN2A, SPTBN4; 744929 CABP1, CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B; 745316 CNTN1, SCN2A, SCNN1B; 745760 CABP1, CACNA1C, CACNA2D4, CACNB3; 745845 CACNA1C, CACNA2D4, CACNB3; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 745845 CABP1, CACNA1C, CACNB3; 742512, 745316, 745845 CNTN1, SCNN1B; 737748, 745760 CNTN1, SCN2A; 744929, 745760 SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 745316, 745760 CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 743584, 745316 SCN1B, SPTBN4; 738391, 744929 SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 744929, 745316 CNTN1; 737748, 738083, 744929, 745760 SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 744929, 745316, 745760 GNB1, PIK3R1, PRKACA, SMAD2, SMAD3; 738083, 744175 CRKL, FADD, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 744175 CRKL, FADD, FAS, PIK3R1; 740606, 744175 CRKL, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 742292, 744175 FADD, GNB1, PIK3R1, SMAD2, SMAD3; 744175, 747193 FADD, FAS, PIK3R1, SMAD2, SMAD3; 744175, 748642 FADD, FAS, PIK3R1; 740606, 744175, 748642 FADD, PIK3R1, SMAD2, SMAD3; 738855, 744175, 747193, 748642 GNB1, PIK3R1, SMAD2, SMAD3; 738083, 744175, 747193 CACNA1C, CACNB3, GNB1; 617414, 617437, 743584 ANK3, CACNA1C, GNB1, SCNN1B; 737748, 743584 ANK3, SCN1B, SCN2A, SCNN1B; 742390, 743584 CACNA1C, GNB1, SCN1B, SCN2A, SCNN1B; 742806, 743584 CACNA1C, GNB1, PIK3R1, PRKACA, SCNN1B; 737748, 742806 CACNA1C, GNB1, SCNN1B; 737748, 742806, 743584 CACNA1C, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, PRKACA, RYR2; 617414, 617437, 742512 CABP1, CACNA1C, PRKACA, RYR2; 738118, 742512 CABP1, CACNA1C; 738118, 742512, 745316, 745845 CACNA1C, CACNB3; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742512, 743584, 745316, 745845 ANK3, SCN1B; 738391, 742390, 743584 ANK3, SCNN1B; 737748, 742325, 742390, 743584 SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 745316 ANK3, SPTBN4; 738391, 742325 CRKL, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 742292, 744175 PPM1A, SMAD2, SMAD3; 741302, 742292, 744175 SMAD2, SMAD3; 738083, 738855, 741302, 742292, 742793, 744175, 747193, 748642 CRKL, FADD, PIK3R1; 738855, 740606, 744175 FADD, PIK3R1; 738855, 740606, 744175, 747193, 748642 PIK3R1, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175, 747193, 748642 CRKL, PIK3R1; 738855, 740606, 742292, 744175 PIK3R1, PRKACA, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175 PIK3R1; 737748, 738083, 738855, 740606, 742292, 742793, 742806, 744175, 747193, 748642 SPTBN4; 738391, 742325, 744929 SCN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 738391, 742390, 742806, 743584, 744929, 745316 ANK3; 737748, 738391, 742325, 742390, 743584 ; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738083, 738118, 738391, 738855, 739640, 740606, 741302, 742292, 742325, 742390, 742512, 742793, 742806, 743584, 744175, 744929, 745316, 745760, 745845, 747193, 748541, 748642 CACNA1C, PRKACA, RYR2, SRI; 738118, 739640, 748541 CACNA1C, PRKACA, RYR2; 617414, 617437, 738118, 739640, 742512, 748541 CACNA1C; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738118, 739640, 742512, 742806, 743584, 745316, 745845, 748541 CNTN1, GNB1, PIK3R1, PRKACA; 737748, 738083 GNB1, PIK3R1, PRKACA; 737748, 738083, 742806, 744175 GNB1, PIK3R1; 737748, 738083, 742806, 744175, 747193 PIK3R1, PRKACA; 737748, 738083, 738855, 742292, 742793, 742806, 744175 SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742325, 742390, 742806, 743584, 745316, 745760 CACNA1C, GNB1, PRKACA; 617414, 617437, 737748, 742806 CACNA1C, GNB1; 617414, 617437, 737748, 742806, 743584 CACNA1C, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742806, 743584, 745316 GNB1, PRKACA; 617414, 617437, 737748, 738083, 742806, 744175 GNB1; 617414, 617437, 737748, 738083, 742806, 743584, 744175, 747193 PRKACA; 617414, 617437, 737748, 738083, 738118, 738855, 739640, 742292, 742512, 742793, 742806, 744175, 748541 CACNA1C, KCNC1, KCNC2, RYR2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 KCNC1, KCNC2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNA2D4, CACNB3, RYR2; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNB3, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 743584, 745316 CACNA1C, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, RYR2; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742512 KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, RYR2; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 738118, 739640, 742512, 748541 CACNA1C, PRKACA; 617414, 617437, 737748, 738118, 739640, 742512, 742806, 748541
Co-atoms ANK3, CABP1, CACNA1C, CACNA2D4, CACNB3, CNTN1, CRKL, FADD, FAS, GNB1, KCNC1, KCNC2, PIK3R1, PPM1A, PRKACA, RIMS1, RYR2, SCN1B, SCN2A, SCNN1B, SMAD2, SMAD3, SPTBN4, SRI; CACNA1C, CACNB3, GNB1, PRKACA, RYR2; 617414, 617437 CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, RYR2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 ANK3, CACNA1C, CNTN1, GNB1, PIK3R1, PRKACA, SCNN1B; 737748 CNTN1, GNB1, PIK3R1, PRKACA, SMAD2, SMAD3; 738083 CABP1, CACNA1C, PRKACA, RYR2, SRI; 738118 ANK3, SCN1B, SPTBN4; 738391 ANK3, SCNN1B, SPTBN4; 742325 CABP1, CACNA1C, CACNB3, PRKACA, RYR2; 742512 CACNA1C, GNB1, PIK3R1, PRKACA, SCN1B, SCN2A, SCNN1B; 742806 ANK3, CACNA1C, CACNB3, GNB1, SCN1B, SCN2A, SCNN1B; 743584 CRKL, FADD, FAS, GNB1, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 744175 CNTN1, RIMS1, SCN1B, SCN2A, SPTBN4; 744929 CABP1, CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B; 745316 CNTN1, SCN2A, SCNN1B; 745760 CABP1, CACNA1C, CACNA2D4, CACNB3; 745845 CACNA1C, CACNA2D4, CACNB3; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 745845 CABP1, CACNA1C, CACNB3; 742512, 745316, 745845 CNTN1, SCNN1B; 737748, 745760 CNTN1, SCN2A; 744929, 745760 SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 745316, 745760 CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 743584, 745316 SCN1B, SPTBN4; 738391, 744929 SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 744929, 745316 CNTN1; 737748, 738083, 744929, 745760 SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 744929, 745316, 745760 GNB1, PIK3R1, PRKACA, SMAD2, SMAD3; 738083, 744175 CRKL, FADD, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 744175 CRKL, FADD, FAS, PIK3R1; 740606, 744175 CRKL, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 742292, 744175 FADD, GNB1, PIK3R1, SMAD2, SMAD3; 744175, 747193 FADD, FAS, PIK3R1, SMAD2, SMAD3; 744175, 748642 FADD, FAS, PIK3R1; 740606, 744175, 748642 FADD, PIK3R1, SMAD2, SMAD3; 738855, 744175, 747193, 748642 GNB1, PIK3R1, SMAD2, SMAD3; 738083, 744175, 747193 CACNA1C, CACNB3, GNB1; 617414, 617437, 743584 ANK3, CACNA1C, GNB1, SCNN1B; 737748, 743584 ANK3, SCN1B, SCN2A, SCNN1B; 742390, 743584 CACNA1C, GNB1, SCN1B, SCN2A, SCNN1B; 742806, 743584 CACNA1C, GNB1, PIK3R1, PRKACA, SCNN1B; 737748, 742806 CACNA1C, GNB1, SCNN1B; 737748, 742806, 743584 CACNA1C, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, PRKACA, RYR2; 617414, 617437, 742512 CABP1, CACNA1C, PRKACA, RYR2; 738118, 742512 CABP1, CACNA1C; 738118, 742512, 745316, 745845 CACNA1C, CACNB3; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742512, 743584, 745316, 745845 ANK3, SCN1B; 738391, 742390, 743584 ANK3, SCNN1B; 737748, 742325, 742390, 743584 SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 745316 ANK3, SPTBN4; 738391, 742325 CRKL, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 742292, 744175 PPM1A, SMAD2, SMAD3; 741302, 742292, 744175 SMAD2, SMAD3; 738083, 738855, 741302, 742292, 742793, 744175, 747193, 748642 CRKL, FADD, PIK3R1; 738855, 740606, 744175 FADD, PIK3R1; 738855, 740606, 744175, 747193, 748642 PIK3R1, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175, 747193, 748642 CRKL, PIK3R1; 738855, 740606, 742292, 744175 PIK3R1, PRKACA, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175 PIK3R1; 737748, 738083, 738855, 740606, 742292, 742793, 742806, 744175, 747193, 748642 SPTBN4; 738391, 742325, 744929 SCN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 738391, 742390, 742806, 743584, 744929, 745316 ANK3; 737748, 738391, 742325, 742390, 743584 ; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738083, 738118, 738391, 738855, 739640, 740606, 741302, 742292, 742325, 742390, 742512, 742793, 742806, 743584, 744175, 744929, 745316, 745760, 745845, 747193, 748541, 748642 CACNA1C, PRKACA, RYR2, SRI; 738118, 739640, 748541 CACNA1C, PRKACA, RYR2; 617414, 617437, 738118, 739640, 742512, 748541 CACNA1C; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738118, 739640, 742512, 742806, 743584, 745316, 745845, 748541 CNTN1, GNB1, PIK3R1, PRKACA; 737748, 738083 GNB1, PIK3R1, PRKACA; 737748, 738083, 742806, 744175 GNB1, PIK3R1; 737748, 738083, 742806, 744175, 747193 PIK3R1, PRKACA; 737748, 738083, 738855, 742292, 742793, 742806, 744175 SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742325, 742390, 742806, 743584, 745316, 745760 CACNA1C, GNB1, PRKACA; 617414, 617437, 737748, 742806 CACNA1C, GNB1; 617414, 617437, 737748, 742806, 743584 CACNA1C, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742806, 743584, 745316 GNB1, PRKACA; 617414, 617437, 737748, 738083, 742806, 744175 GNB1; 617414, 617437, 737748, 738083, 742806, 743584, 744175, 747193 PRKACA; 617414, 617437, 737748, 738083, 738118, 738855, 739640, 742292, 742512, 742793, 742806, 744175, 748541 CACNA1C, KCNC1, KCNC2, RYR2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 KCNC1, KCNC2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNA2D4, CACNB3, RYR2; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNB3, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 743584, 745316 CACNA1C, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, RYR2; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742512 KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, RYR2; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 738118, 739640, 742512, 748541 CACNA1C, PRKACA; 617414, 617437, 737748, 738118, 739640, 742512, 742806, 748541 immediate subconcepts of the top concept
Chain CACNA1C, CACNB3, GNB1, PRKACA, RYR2; 617414, 617437 CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, RYR2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 NB3, 1B; C, CACNA2D4, CACNB3; 733740, 733911, 736632, 736786, 736810, 736839, 737094, 737232, 737234, 737304, 737332, 737360, 737390, 737431, 737548, 745845 SCN2A, SC 736810, 73 737390, 73 CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 743584, 745316 SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 744929, 745316 SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 744929, 745316, 745760 CACNA1C, CACNB3, GNB1; 617414, 617437, 743584 CA SC CACNA1C, GNB1, SCNN1 737748, 742806, 743584 CACNA1C, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 745316 CACNA1C; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738118, 739640, 742512, 742806, 743584, 745316, 745845, 748541 SCNN1B; 733740, 733911, 736632, 736738, 736786, 736 736836, 737232, 737255, 737304, 737332, 737360, 7373 737431, 737548, 737748, 742325, 742390, 742806, 7435 745316, 745760 CACNA1C, GNB1; 617414, 617437, 737748, 742806, 743584 CACNA1C, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742806, 743584, 745316 CACNA1C, KCNC1, KCNC2, RYR2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 KCNC1, KCNC2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNA2D4, CACNB3, RYR2; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNB3, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 743584, 745316 CACNA1C, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 6632, 737255, 737548, KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, PRKACA; 617414, 617437, 737748, 738118, 739640, 742512, 742806, 748541
Anti-chain ANK3, CABP1, CACNA1C, CACNA2D4, CACNB3, CNTN1, CRKL, FADD, FAS, GNB1, KCNC1, KCNC2, PIK3R1, PPM1A, PRKACA, RIMS1, RYR2, SCN1B, SCN2A, SCNN1B, SMAD2, SMAD3, SPTBN4, SRI; CACNA1C, CACNB3, GNB1, PRKACA, RYR2; 617414, 617437 CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, RYR2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 ANK3, CACNA1C, CNTN1, GNB1, PIK3R1, PRKACA, SCNN1B; 737748 CNTN1, GNB1, PIK3R1, PRKACA, SMAD2, SMAD3; 738083 CABP1, CACNA1C, PRKACA, RYR2, SRI; 738118 ANK3, SCN1B, SPTBN4; 738391 ANK3, SCNN1B, SPTBN4; 742325 CABP1, CACNA1C, CACNB3, PRKACA, RYR2; 742512 CACNA1C, GNB1, PIK3R1, PRKACA, SCN1B, SCN2A, SCNN1B; 742806 ANK3, CACNA1C, CACNB3, GNB1, SCN1B, SCN2A, SCNN1B; 743584 CRKL, FADD, FAS, GNB1, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 744175 CNTN1, RIMS1, SCN1B, SCN2A, SPTBN4; 744929 CABP1, CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B; 745316 CNTN1, SCN2A, SCNN1B; 745760 CABP1, CACNA1C, CACNA2D4, CACNB3; 745845 CACNA1C, CACNA2D4, CACNB3; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 745845 CABP1, CACNA1C, CACNB3; 742512, 745316, 745845 CNTN1, SCNN1B; 737748, 745760 CNTN1, SCN2A; 744929, 745760 SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 745316, 745760 CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 743584, 745316 SCN1B, SPTBN4; 738391, 744929 SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 744929, 745316 CNTN1; 737748, 738083, 744929, 745760 SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 744929, 745316, 745760 GNB1, PIK3R1, PRKACA, SMAD2, SMAD3; 738083, 744175 CRKL, FADD, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 744175 CRKL, FADD, FAS, PIK3R1; 740606, 744175 CRKL, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 742292, 744175 FADD, GNB1, PIK3R1, SMAD2, SMAD3; 744175, 747193 FADD, FAS, PIK3R1, SMAD2, SMAD3; 744175, 748642 FADD, FAS, PIK3R1; 740606, 744175, 748642 FADD, PIK3R1, SMAD2, SMAD3; 738855, 744175, 747193, 748642 GNB1, PIK3R1, SMAD2, SMAD3; 738083, 744175, 747193 CACNA1C, CACNB3, GNB1; 617414, 617437, 743584 ANK3, CACNA1C, GNB1, SCNN1B; 737748, 743584 ANK3, SCN1B, SCN2A, SCNN1B; 742390, 743584 CACNA1C, GNB1, SCN1B, SCN2A, SCNN1B; 742806, 743584 CACNA1C, GNB1, PIK3R1, PRKACA, SCNN1B; 737748, 742806 CACNA1C, GNB1, SCNN1B; 737748, 742806, 743584 CACNA1C, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, PRKACA, RYR2; 617414, 617437, 742512 CABP1, CACNA1C, PRKACA, RYR2; 738118, 742512 CABP1, CACNA1C; 738118, 742512, 745316, 745845 CACNA1C, CACNB3; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742512, 743584, 745316, 745845 ANK3, SCN1B; 738391, 742390, 743584 ANK3, SCNN1B; 737748, 742325, 742390, 743584 SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 745316 ANK3, SPTBN4; 738391, 742325 CRKL, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 742292, 744175 PPM1A, SMAD2, SMAD3; 741302, 742292, 744175 SMAD2, SMAD3; 738083, 738855, 741302, 742292, 742793, 744175, 747193, 748642 CRKL, FADD, PIK3R1; 738855, 740606, 744175 FADD, PIK3R1; 738855, 740606, 744175, 747193, 748642 PIK3R1, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175, 747193, 748642 CRKL, PIK3R1; 738855, 740606, 742292, 744175 PIK3R1, PRKACA, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175 PIK3R1; 737748, 738083, 738855, 740606, 742292, 742793, 742806, 744175, 747193, 748642 SPTBN4; 738391, 742325, 744929 SCN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 738391, 742390, 742806, 743584, 744929, 745316 ANK3; 737748, 738391, 742325, 742390, 743584 ; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738083, 738118, 738391, 738855, 739640, 740606, 741302, 742292, 742325, 742390, 742512, 742793, 742806, 743584, 744175, 744929, 745316, 745760, 745845, 747193, 748541, 748642 CACNA1C, PRKACA, RYR2, SRI; 738118, 739640, 748541 CACNA1C, PRKACA, RYR2; 617414, 617437, 738118, 739640, 742512, 748541 CACNA1C; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738118, 739640, 742512, 742806, 743584, 745316, 745845, 748541 CNTN1, GNB1, PIK3R1, PRKACA; 737748, 738083 GNB1, PIK3R1, PRKACA; 737748, 738083, 742806, 744175 GNB1, PIK3R1; 737748, 738083, 742806, 744175, 747193 PIK3R1, PRKACA; 737748, 738083, 738855, 742292, 742793, 742806, 744175 SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742325, 742390, 742806, 743584, 745316, 745760 CACNA1C, GNB1, PRKACA; 617414, 617437, 737748, 742806 CACNA1C, GNB1; 617414, 617437, 737748, 742806, 743584 CACNA1C, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742806, 743584, 745316 GNB1, PRKACA; 617414, 617437, 737748, 738083, 742806, 744175 GNB1; 617414, 617437, 737748, 738083, 742806, 743584, 744175, 747193 PRKACA; 617414, 617437, 737748, 738083, 738118, 738855, 739640, 742292, 742512, 742793, 742806, 744175, 748541 CACNA1C, KCNC1, KCNC2, RYR2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 KCNC1, KCNC2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNA2D4, CACNB3, RYR2; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNB3, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 743584, 745316 CACNA1C, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, RYR2; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742512 KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, RYR2; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 738118, 739640, 742512, 748541 CACNA1C, PRKACA; 617414, 617437, 737748, 738118, 739640, 742512, 742806, 748541
Groupings (again) • A simplified grouping is represented by a minimal anti-chain in the concept lattice that best covers objects (e.g., vertices) • Heuristic: a. generate concepts for individual annotations b.for each, create chain by selecting subconcept with most objects c. select from chains such that vertex set is covered
Ex: Grouping (BLOSOM) ANK3, CABP1, CACNA1C, CACNA2D4, CACNB3, CNTN1, CRKL, FADD, FAS, GNB1, KCNC1, KCNC2, PIK3R1, PPM1A, PRKACA, RIMS1, RYR2, SCN1B, SCN2A, SCNN1B, SMAD2, SMAD3, SPTBN4, SRI; CACNA1C, CACNB3, GNB1, PRKACA, RYR2; 617414, 617437 CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, RYR2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 ANK3, CACNA1C, CNTN1, GNB1, PIK3R1, PRKACA, SCNN1B; 737748 CNTN1, GNB1, PIK3R1, PRKACA, SMAD2, SMAD3; 738083 CABP1, CACNA1C, PRKACA, RYR2, SRI; 738118 ANK3, SCN1B, SPTBN4; 738391 ANK3, SCNN1B, SPTBN4; 742325 CABP1, CACNA1C, CACNB3, PRKACA, RYR2; 742512 CACNA1C, GNB1, PIK3R1, PRKACA, SCN1B, SCN2A, SCNN1B; 742806 ANK3, CACNA1C, CACNB3, GNB1, SCN1B, SCN2A, SCNN1B; 743584 CRKL, FADD, FAS, GNB1, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 744175 CNTN1, RIMS1, SCN1B, SCN2A, SPTBN4; 744929 CABP1, CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B; 745316 CNTN1, SCN2A, SCNN1B; 745760 CABP1, CACNA1C, CACNA2D4, CACNB3; 745845 CACNA1C, CACNA2D4, CACNB3; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 745845 CABP1, CACNA1C, CACNB3; 742512, 745316, 745845 CNTN1, SCNN1B; 737748, 745760 CNTN1, SCN2A; 744929, 745760 SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 745316, 745760 CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 743584, 745316 SCN1B, SPTBN4; 738391, 744929 SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 744929, 745316 CNTN1; 737748, 738083, 744929, 745760 SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 744929, 745316, 745760 GNB1, PIK3R1, PRKACA, SMAD2, SMAD3; 738083, 744175 CRKL, FADD, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 744175 CRKL, FADD, FAS, PIK3R1; 740606, 744175 CRKL, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 742292, 744175 FADD, GNB1, PIK3R1, SMAD2, SMAD3; 744175, 747193 FADD, FAS, PIK3R1, SMAD2, SMAD3; 744175, 748642 FADD, FAS, PIK3R1; 740606, 744175, 748642 FADD, PIK3R1, SMAD2, SMAD3; 738855, 744175, 747193, 748642 GNB1, PIK3R1, SMAD2, SMAD3; 738083, 744175, 747193 CACNA1C, CACNB3, GNB1; 617414, 617437, 743584 ANK3, CACNA1C, GNB1, SCNN1B; 737748, 743584 ANK3, SCN1B, SCN2A, SCNN1B; 742390, 743584 CACNA1C, GNB1, SCN1B, SCN2A, SCNN1B; 742806, 743584 CACNA1C, GNB1, PIK3R1, PRKACA, SCNN1B; 737748, 742806 CACNA1C, GNB1, SCNN1B; 737748, 742806, 743584 CACNA1C, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, PRKACA, RYR2; 617414, 617437, 742512 CABP1, CACNA1C, PRKACA, RYR2; 738118, 742512 CABP1, CACNA1C; 738118, 742512, 745316, 745845 CACNA1C, CACNB3; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742512, 743584, 745316, 745845 ANK3, SCN1B; 738391, 742390, 743584 ANK3, SCNN1B; 737748, 742325, 742390, 743584 SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 745316 ANK3, SPTBN4; 738391, 742325 CRKL, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 742292, 744175 PPM1A, SMAD2, SMAD3; 741302, 742292, 744175 SMAD2, SMAD3; 738083, 738855, 741302, 742292, 742793, 744175, 747193, 748642 CRKL, FADD, PIK3R1; 738855, 740606, 744175 FADD, PIK3R1; 738855, 740606, 744175, 747193, 748642 PIK3R1, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175, 747193, 748642 CRKL, PIK3R1; 738855, 740606, 742292, 744175 PIK3R1, PRKACA, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175 PIK3R1; 737748, 738083, 738855, 740606, 742292, 742793, 742806, 744175, 747193, 748642 SPTBN4; 738391, 742325, 744929 SCN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 738391, 742390, 742806, 743584, 744929, 745316 ANK3; 737748, 738391, 742325, 742390, 743584 ; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738083, 738118, 738391, 738855, 739640, 740606, 741302, 742292, 742325, 742390, 742512, 742793, 742806, 743584, 744175, 744929, 745316, 745760, 745845, 747193, 748541, 748642 CACNA1C, PRKACA, RYR2, SRI; 738118, 739640, 748541 CACNA1C, PRKACA, RYR2; 617414, 617437, 738118, 739640, 742512, 748541 CACNA1C; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738118, 739640, 742512, 742806, 743584, 745316, 745845, 748541 CNTN1, GNB1, PIK3R1, PRKACA; 737748, 738083 GNB1, PIK3R1, PRKACA; 737748, 738083, 742806, 744175 GNB1, PIK3R1; 737748, 738083, 742806, 744175, 747193 PIK3R1, PRKACA; 737748, 738083, 738855, 742292, 742793, 742806, 744175 SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742325, 742390, 742806, 743584, 745316, 745760 CACNA1C, GNB1, PRKACA; 617414, 617437, 737748, 742806 CACNA1C, GNB1; 617414, 617437, 737748, 742806, 743584 CACNA1C, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742806, 743584, 745316 GNB1, PRKACA; 617414, 617437, 737748, 738083, 742806, 744175 GNB1; 617414, 617437, 737748, 738083, 742806, 743584, 744175, 747193 PRKACA; 617414, 617437, 737748, 738083, 738118, 738855, 739640, 742292, 742512, 742793, 742806, 744175, 748541 CACNA1C, KCNC1, KCNC2, RYR2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 KCNC1, KCNC2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNA2D4, CACNB3, RYR2; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNB3, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 743584, 745316 CACNA1C, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, RYR2; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742512 KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, RYR2; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 738118, 739640, 742512, 748541 CACNA1C, PRKACA; 617414, 617437, 737748, 738118, 739640, 742512, 742806, 748541
Ex: Grouping (BLOSOM) ANK3, CABP1, CACNA1C, CACNA2D4, CACNB3, CNTN1, CRKL, FADD, FAS, GNB1, KCNC1, KCNC2, PIK3R1, PPM1A, PRKACA, RIMS1, RYR2, SCN1B, SCN2A, SCNN1B, SMAD2, SMAD3, SPTBN4, SRI; CACNA1C, CACNB3, GNB1, PRKACA, RYR2; 617414, 617437 CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, RYR2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 ANK3, CACNA1C, CNTN1, GNB1, PIK3R1, PRKACA, SCNN1B; 737748 CNTN1, GNB1, PIK3R1, PRKACA, SMAD2, SMAD3; 738083 CABP1, CACNA1C, PRKACA, RYR2, SRI; 738118 ANK3, SCN1B, SPTBN4; 738391 ANK3, SCNN1B, SPTBN4; 742325 CABP1, CACNA1C, CACNB3, PRKACA, RYR2; 742512 CACNA1C, GNB1, PIK3R1, PRKACA, SCN1B, SCN2A, SCNN1B; 742806 ANK3, CACNA1C, CACNB3, GNB1, SCN1B, SCN2A, SCNN1B; 743584 CRKL, FADD, FAS, GNB1, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 744175 CNTN1, RIMS1, SCN1B, SCN2A, SPTBN4; 744929 CABP1, CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B; 745316 CNTN1, SCN2A, SCNN1B; 745760 CABP1, CACNA1C, CACNA2D4, CACNB3; 745845 CACNA1C, CACNA2D4, CACNB3; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 745845 CABP1, CACNA1C, CACNB3; 742512, 745316, 745845 CNTN1, SCNN1B; 737748, 745760 CNTN1, SCN2A; 744929, 745760 SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 745316, 745760 CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 743584, 745316 SCN1B, SPTBN4; 738391, 744929 SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 744929, 745316 CNTN1; 737748, 738083, 744929, 745760 SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 744929, 745316, 745760 GNB1, PIK3R1, PRKACA, SMAD2, SMAD3; 738083, 744175 CRKL, FADD, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 744175 CRKL, FADD, FAS, PIK3R1; 740606, 744175 CRKL, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 742292, 744175 FADD, GNB1, PIK3R1, SMAD2, SMAD3; 744175, 747193 FADD, FAS, PIK3R1, SMAD2, SMAD3; 744175, 748642 FADD, FAS, PIK3R1; 740606, 744175, 748642 FADD, PIK3R1, SMAD2, SMAD3; 738855, 744175, 747193, 748642 GNB1, PIK3R1, SMAD2, SMAD3; 738083, 744175, 747193 CACNA1C, CACNB3, GNB1; 617414, 617437, 743584 ANK3, CACNA1C, GNB1, SCNN1B; 737748, 743584 ANK3, SCN1B, SCN2A, SCNN1B; 742390, 743584 CACNA1C, GNB1, SCN1B, SCN2A, SCNN1B; 742806, 743584 CACNA1C, GNB1, PIK3R1, PRKACA, SCNN1B; 737748, 742806 CACNA1C, GNB1, SCNN1B; 737748, 742806, 743584 CACNA1C, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, PRKACA, RYR2; 617414, 617437, 742512 CABP1, CACNA1C, PRKACA, RYR2; 738118, 742512 CABP1, CACNA1C; 738118, 742512, 745316, 745845 CACNA1C, CACNB3; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742512, 743584, 745316, 745845 ANK3, SCN1B; 738391, 742390, 743584 ANK3, SCNN1B; 737748, 742325, 742390, 743584 SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 745316 ANK3, SPTBN4; 738391, 742325 CRKL, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 742292, 744175 PPM1A, SMAD2, SMAD3; 741302, 742292, 744175 SMAD2, SMAD3; 738083, 738855, 741302, 742292, 742793, 744175, 747193, 748642 CRKL, FADD, PIK3R1; 738855, 740606, 744175 FADD, PIK3R1; 738855, 740606, 744175, 747193, 748642 PIK3R1, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175, 747193, 748642 CRKL, PIK3R1; 738855, 740606, 742292, 744175 PIK3R1, PRKACA, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175 PIK3R1; 737748, 738083, 738855, 740606, 742292, 742793, 742806, 744175, 747193, 748642 SPTBN4; 738391, 742325, 744929 SCN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 738391, 742390, 742806, 743584, 744929, 745316 ANK3; 737748, 738391, 742325, 742390, 743584 ; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738083, 738118, 738391, 738855, 739640, 740606, 741302, 742292, 742325, 742390, 742512, 742793, 742806, 743584, 744175, 744929, 745316, 745760, 745845, 747193, 748541, 748642 CACNA1C, PRKACA, RYR2, SRI; 738118, 739640, 748541 CACNA1C, PRKACA, RYR2; 617414, 617437, 738118, 739640, 742512, 748541 CACNA1C; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738118, 739640, 742512, 742806, 743584, 745316, 745845, 748541 CNTN1, GNB1, PIK3R1, PRKACA; 737748, 738083 GNB1, PIK3R1, PRKACA; 737748, 738083, 742806, 744175 GNB1, PIK3R1; 737748, 738083, 742806, 744175, 747193 PIK3R1, PRKACA; 737748, 738083, 738855, 742292, 742793, 742806, 744175 SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742325, 742390, 742806, 743584, 745316, 745760 CACNA1C, GNB1, PRKACA; 617414, 617437, 737748, 742806 CACNA1C, GNB1; 617414, 617437, 737748, 742806, 743584 CACNA1C, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742806, 743584, 745316 GNB1, PRKACA; 617414, 617437, 737748, 738083, 742806, 744175 GNB1; 617414, 617437, 737748, 738083, 742806, 743584, 744175, 747193 PRKACA; 617414, 617437, 737748, 738083, 738118, 738855, 739640, 742292, 742512, 742793, 742806, 744175, 748541 CACNA1C, KCNC1, KCNC2, RYR2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 KCNC1, KCNC2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNA2D4, CACNB3, RYR2; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNB3, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 743584, 745316 CACNA1C, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, RYR2; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742512 KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, RYR2; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 738118, 739640, 742512, 748541 CACNA1C, PRKACA; 617414, 617437, 737748, 738118, 739640, 742512, 742806, 748541 MeSH: Calcium GO BP: Metal Ion Transport GO MF: Gated Channel Activity GO MF: Cation Channel Activity MeSH: Signal Transduction MeSH: Nerve Tissue Proteins MeSH Ion Channel Gating CRKL ANK3 CABP1 CACNA 2D4 CACNB 3 GNB1 PCBD1 RIMS1 PPM1A PRKAC A RYR2 SRI CACNA 1C FAS FADD CNTN1 HOOK1 KCNC1 KCNC2 SMAD3 SMAD2 PIK3R1 SPTBN4 SCN1B SCNN1 B SCN2A note: BLOSOM finds minimal generator for a concept: smallest set of attributes with concept as closure
Graph edges and grouping RYR2 CACNA 1C In what situations does this interaction occur?
Graph edges RYR2 CACNA 1C CACNA1C Ion transport protein RYR2 Beta1 adrenergic receptor signaling pathway Beta2 adrenergic receptor signaling pathway cation transport metal ion transport channel activity ion channel activity gated channel activity cation channel activity calcium channel activity transmembrane transporter activity substrate specific channel activity ion transmembrane transporter activity substrate-specific transporter activity cation transmembrane transporter activity passive transmembrane transporter activity metal ion transmembrane transporter activity substrate-specific transmembrane transporter activity Myocardium Calcium Channels
Graph edges CACNA1C Ion transport protein RYR2 Beta1 adrenergic receptor signaling pathway Beta2 adrenergic receptor signaling pathway cation transport metal ion transport channel activity ion channel activity gated channel activity cation channel activity calcium channel activity transmembrane transporter activity substrate specific channel activity ion transmembrane transporter activity substrate-specific transporter activity cation transmembrane transporter activity passive transmembrane transporter activity metal ion transmembrane transporter activity substrate-specific transmembrane transporter activity Myocardium Calcium Channels CACNA1C, RYR2; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 738118, 739640, 742512, 748541
Filter CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, RYR2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CABP1, CACNA1C, PRKACA, RYR2, SRI; 738118 CABP1, CACNA1C, CACNB3, PRKACA, RYR2; 742512 CABP1, CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B; 745316 CABP1, CACNA1C, CACNA2D4, CACNB3; 745845 CACNA1C, CACNA2D4, CACNB3; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 745845 CABP1, CACNA1C, CACNB3; 742512, 745316, 745845 CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 743584, 745316 SC 736 737 SCN 7368 7373 CACNA1C, CACNB3, PRKACA, RYR2; 617414, 617437, 742512 CABP1, CACNA1C, PRKACA, RYR2; 738118, 742512 CABP1, CACNA1C; 738118, 742512, 745316, 745845 CACNA1C, CACNB3; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742512, 743584, 745316, 745845 CACNA1C, PRKACA, RYR2, SRI; 738118, 739640, 748541 CACNA1C, PRKACA, RYR2; 617414, 617437, 738118, 739640, 742512, 748541 CACNA1C; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738118, 739640, 742512, 742806, 743584, 745316, 745845, 748541 CACNA1C, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742806, 743584, 745316 CACNA1C, KCNC1, KCNC2, RYR2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 KCNC1, KCNC2, SCN1B, SCN2A, SCNN1B; 73 736632, 736738, 736786, 736810, 736836, 737 737304, 737332, 737360, 737390, 737431 CACNA1C, CACNA2D4, CACNB3, RYR2; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNB3, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 743584, 745316 CACNA1C, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, RYR2; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742512 KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, RYR2; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 738118, 739640, 742512, 748541 CACNA1C, PRKACA; 617414, 617437, 737748, 738118, 739640, 742512, 742806, 748541
Patterns • Previous examples project annotations onto the graph • For patterns, project the graph onto the annotations • Can use lattice to find emergent schema (Banks et al.) • One heuristic: for each edge (a1,a2) find concepts for a1 and a2, and follow pair of chains upward, adding edges for new objects, until cannot add more Banks E, Nabieva E, Chazelle B, Singh M (2008) PLoS Comput Biol 4(10): e1000203
Constructing Schema
Schema: Moving up chains
Schema: moving up chains
Extracting Schema
Final Schema Recurrent pattern in graph – could be used to match other graphs
More… • Could keep going … • Possible to extract association rules, decision trees and more from concept lattice and use these to annotate functional relationships in graphs (which again is something that has been done other ways) • Also possible to work with multi-valued incidence relations (e.g., numeric data)
Inspired and informed by working with 
 Barbara Mirel and 
 NCIBI DBP scientists at U.Michigan
Resources B Ganter, R Wille. Formal Concept Analysis: Mathematical Foundations, Springer-Verlag, 1999. ! F Kriegel, Visualization of Conceptual Data with Methods of Formal Concept Analysis. Thesis, Technische Universität Dresden, 2012. ! http://www.upriss.org.uk/fca/fca.html

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Graph Annotation: A Tale of Two Binary Relations

  • 1. CRKL ANK3 CABP1 GNB1 PCBD1 PPM1A PRKAC A RYR2 SRI CACNA 1C FAS FADD HOOK1 KCNC1 KCNC2 SMAD2 PIK3R1 SCNN1 B Graph Annotation Seattle/Bellevue Graphs – Data, Processing, Algorithms Meetup 5 August 2014 A Tale of Two Binary Relations Benjamin J. Keller linkedin.com/in/bjkeller Attribution-ShareAlike 3.0 Unported
  • 2. Context: Systems story telling want to help user understand relationships in data so that they can construct stories about biological systems How do we use biological information and data to go from a list of genes to a story about how symptoms of a genetic disease arise? [ ]
  • 3. Context: Systems Story Telling Classification Reasoning Model-based Reasoning Narrative Reasoning (based on B. Mirel, Supporting cognition in systems biology analysis; findings on users’ processes and design implications. Journal of Biomedical Discovery and Collaboration 2009; 4:1-17) what of all this is the right stuff? how does it fit together? how does it do something? what stories does it tell?
  • 4. Context: Systems Story Telling Classification Reasoning Model-based Reasoning Narrative Reasoning individual components networks/ graphs of components system fragments “whole” systems roles contextual classes Grouping Patterns Composition
  • 5. Two kinds of binary relations individual components networks/ graphs of components roles contextual classes
  • 6. Two kinds of binary relations component component annotation component Incidence relation Graph ,( ) ,( )
  • 7. Grouping Start with - a network graph of genes, and - contextual annotations for each Want to visualize what goes together [ saw this before in cytoscape.js presentation ]
  • 8. Grouping (hypergraph visualization) MeSH: Calcium GO BP: Metal Ion Transport GO MF: Gated Channel Activity GO MF: Cation Channel Activity GO MF: Voltage-Gated Ion Channel Activity MeSH: Phosphorylation MeSH: Signal Transduction MeSH: Intercellular Signaling Peptides and Proteins MeSH: Rats MeSH: Nerve Tissue Proteins MeSH Ion Channel Gating CRKL ANK3 CABP1 CACNA 2D4 CACNB 3 GNB1 PCBD1 RIMS1 PPM1A PRKAC A RYR2 SRI CACNA 1C FAS FADD CNTN1 HOOK1 KCNC1 KCNC2 SMAD3 SMAD2 PIK3R1 SPTBN4 SCN1B SCNN1 B SCN2A
  • 9. Simplified Groupings MeSH: Calcium GO MF: Voltage-Gated Ion Channel Activity MeSH: Phosphorylation MeSH: Intercellular Signaling Peptides and Proteins MeSH: Nerve Tissue Proteins MeSH Ion Channel Gating CRKL ANK3 CABP1 CACNA 2D4 CACNB 3 GNB1 PCBD1 RIMS1 PPM1A PRKAC A RYR2 SRI CACNA 1C FAS FADD CNTN1 HOOK1 KCNC1 KCNC2 SMAD3 SMAD2 PIK3R1 SPTBN4 SCN1B SCNN1 B SCN2A MeSH: Calcium GO MF: Voltage-Gated Ion Channel Activity MeSH: Phosphorylation MeSH: Intercellular Signaling Peptides and Proteins MeSH: Rats MeSH: Nerve Tissue Proteins CRKL ANK3 CABP1 CACNA 2D4 CACNB 3 GNB1 PCBD1 RIMS1 PPM1A PRKAC A RYR2 SRI CACNA 1C FAS FADD CNTN1 HOOK1 KCNC1 KCNC2 SMAD3 SMAD2 PIK3R1 SPTBN4 SCN1B SCNN1 B SCN2A MeSH: Calcium GO MF: Voltage-Gated Ion Channel Activity MeSH: Signal Transduction MeSH: Nerve Tissue Proteins MeSH Ion Channel Gating CRKL ANK3 CABP1 CACNA 2D4 CACNB 3 GNB1 PCBD1 RIMS1 PPM1A PRKAC A RYR2 SRI CACNA 1C FAS FADD CNTN1 HOOK1 KCNC1 KCNC2 SMAD3 SMAD2 PIK3R1 SPTBN4 SCN1B SCNN1 B SCN2A MeSH: Calcium GO MF: Voltage-Gated Ion Channel Activity MeSH: Signal Transduction MeSH: Rats MeSH: Nerve Tissue Proteins CRKL ANK3 CABP1 CACNA 2D4 CACNB 3 GNB1 PCBD1 RIMS1 PPM1A PRKAC A RYR2 SRI CACNA 1C FAS FADD CNTN1 HOOK1 KCNC1 KCNC2 SMAD3 SMAD2 PIK3R1 SPTBN4 SCN1B SCNN1 B SCN2A MeSH: Calcium GO BP: Metal Ion Transport GO MF: Gated Channel Activity GO MF: Cation Channel Activity MeSH: Phosphorylation MeSH: Intercellular Signaling Peptides and Proteins MeSH: Nerve Tissue Proteins MeSH Ion Channel Gating CRKL ANK3 CABP1 CACNA 2D4 CACNB 3 GNB1 PCBD1 RIMS1 PPM1A PRKAC A RYR2 SRI CACNA 1C FAS FADD CNTN1 HOOK1 KCNC1 KCNC2 SMAD3 SMAD2 PIK3R1 SPTBN4 SCN1B SCNN1 B SCN2A MeSH: Calcium GO BP: Metal Ion Transport GO MF: Gated Channel Activity GO MF: Cation Channel Activity MeSH: Phosphorylation MeSH: Intercellular Signaling Peptides and Proteins MeSH: Rats MeSH: Nerve Tissue Proteins CRKL ANK3 CABP1 CACNA 2D4 CACNB 3 GNB1 PCBD1 RIMS1 PPM1A PRKAC A RYR2 SRI CACNA 1C FAS FADD CNTN1 HOOK1 KCNC1 KCNC2 SMAD3 SMAD2 PIK3R1 SPTBN4 SCN1B SCNN1 B SCN2A MeSH: Calcium GO BP: Metal Ion Transport GO MF: Gated Channel Activity GO MF: Cation Channel Activity MeSH: Signal Transduction MeSH: Nerve Tissue Proteins MeSH Ion Channel Gating CRKL ANK3 CABP1 CACNA 2D4 CACNB 3 GNB1 PCBD1 RIMS1 PPM1A PRKAC A RYR2 SRI CACNA 1C FAS FADD CNTN1 HOOK1 KCNC1 KCNC2 SMAD3 SMAD2 PIK3R1 SPTBN4 SCN1B SCNN1 B SCN2A MeSH: Calcium GO BP: Metal Ion Transport GO MF: Gated Channel Activity GO MF: Cation Channel Activity MeSH: Signal Transduction MeSH: Rats MeSH: Nerve Tissue Proteins CRKL ANK3 CABP1 CACNA 2D4 CACNB 3 GNB1 PCBD1 RIMS1 PPM1A PRKAC A RYR2 SRI CACNA 1C FAS FADD CNTN1 HOOK1 KCNC1 KCNC2 SMAD3 SMAD2 PIK3R1 SPTBN4 SCN1B SCNN1 B SCN2A computed with BLOSOM (Zhao L, Zaki MJ, Ramakrishnan N., KDD 2006, 827-832), support=5
  • 10. Human-edited Groupings MeSH: Calcium GO BP: Metal Ion Transport GO MF: Gated Channel Activity GO MF: Cation Channel Activity OR MeSH Ion Channel Gating MeSH: Phosphorylation MeSH: Intercellular Signaling Peptides and Proteins MeSH: Nerve Tissue Proteins CRKL ANK3 CABP1 CACNA 2D4 CACNB 3 GNB1 PCBD1 RIMS1 PPM1A PRKAC A RYR2 SRI CACNA 1C FAS FADD CNTN1 HOOK1 KCNC1 KCNC2 SMAD3 SMAD2 PIK3R1 SPTBN4 SCN1B SCNN1 B SCN2A MeSH: Calcium GO BP: Metal Ion Transport GO MF: Gated Channel Activity GO MF: Cation Channel Activity OR MeSH Ion Channel Gating MeSH: Signal Transduction MeSH: Nerve Tissue Proteins CRKL ANK3 CABP1 CACNA 2D4 CACNB 3 GNB1 PCBD1 RIMS1 PPM1A PRKAC A RYR2 SRI CACNA 1C FAS FADD CNTN1 HOOK1 KCNC1 KCNC2 SMAD3 SMAD2 PIK3R1 SPTBN4 SCN1B SCNN1 B SCN2A “user” merged/deleted annotations
  • 11. Formal Concept Analysis GNB1 PRKACA RatsCNTN1 PIK3R1 Animals SMAD2 SMAD3 Calcium Ankyrins SPTBN4 CRKL Cell Line FADD Phosphorylation Ranvier's Nodes Precipitin Tests Signal Transduction Nerve Tissue ProteinsRIMS1 Two-Hybrid System Techniques Intracellular Signaling Peptides and Pr • Algebraic approach to studying data as incidence relation b/w objects and attributes • Construct formal concepts (biclusters) • Relate to form formal concept lattice
  • 12. Formal Concept CACNA1C Ion transport protein KCNC1 KCNC2 RYR2 SCN2A Beta1 adrenergic receptor signaling pathway CACNB3 GNB1 PRKACA Beta2 adrenergic receptor signaling pathway cation transport CACNA2D4 SCN1B SCNN1B metal ion transport channel activity ion channel activity gated channel activity cation channel activity alkali metal ion binding calcium channel activity voltage-gated channel activity transmembrane transporter activity voltage-gated ion channel activity substrate specific channel activity voltage-gated cation channel activity ion transmembrane transporter activity substrate-specific transporter activity cation transmembrane transporter activity passive transmembrane transporter activity metal ion transmembrane transporter activity substrate-specific transmembrane transporter activity ANK3 RatsCNTN1 PIK3R1 Animals SMAD2 SMAD3 CABP1 Calcium SRI Ankyrins SPTBN4 CRKL Cell Line FADD Myocardium Jurkat CellsFAS PPM1A Smad2 Protein Phosphorylation Ranvier's Nodes Sodium Channels Calcium Channels Precipitin Tests Protein Subunits Ion Channel Gating Signal Transduction Nerve Tissue ProteinsRIMS1 Patch-Clamp Techniques Sodium Channel Blockers Calcium Channels, L-Type Two-Hybrid System Techniques Ryanodine Receptor Calcium Release Channel Intracellular Signaling Peptides and Proteins • Can view incidence relation as bipartite graph • A formal concept is a biclique: a pair of vertices (A,B) such that for each object a in A there is an edge (a,b) for every attribute b in B • Can construct as closure
  • 13. Ex: Signal Transduction Beta1 adrenergic receptor signaling pathway GNB1 PRKACA Beta2 adrenergic receptor signaling pathway Rats PIK3R1 Animals SMAD2 SMAD3 Calcium CRKL Cell Line FADD Myocardium Jurkat Cells FAS PPM1A Smad2 Protein Phosphorylation Calcium Channels Precipitin Tests Protein Subunits Ion Channel Gating Signal Transduction Two-Hybrid System Techniques Ryanodine Receptor Calcium Release Channel Intracellular Signaling Peptides and Proteins
  • 14. Ex: Signal Transduction Beta1 adrenergic receptor signaling pathway GNB1 PRKACA Beta2 adrenergic receptor signaling pathway Rats PIK3R1 Animals SMAD2 SMAD3 Calcium CRKL Cell Line FADD Myocardium Jurkat Cells FAS PPM1A Smad2 Protein Phosphorylation Precipitin Tests Signal Transduction Two-Hybrid System Techniques Ryanodine Receptor Calcium Release Channel Intracellular Signaling Peptides and Proteins
  • 15. Rats PIK3R1 Animals SMAD2 SMAD3 CRKL Cell Line FADD Jurkat Cells FAS PPM1A Smad2 Protein Phosphorylation Precipitin Tests Signal Transduction Two-Hybrid System Techniques Intracellular Signaling Peptides and Proteins
  • 16. Subconcept Beta1 adrenergic receptor signaling pathway GNB1 PRKACA Beta2 adrenergic receptor signaling pathway Rats PIK3R1 Animals SMAD2 SMAD3 Calcium CRKL Cell Line FADD Myocardium Jurkat Cells FAS PPM1A Smad2 Protein Phosphorylation Calcium Channels Precipitin Tests Protein Subunits Ion Channel Gating Signal Transduction Two-Hybrid System Techniques Ryanodine Receptor Calcium Release Channel Intracellular Signaling Peptides and Proteins Beta1 adrenergic receptor signaling pathway GNB1 PRKACA Beta2 adrenergic receptor signaling pathway Rats PIK3R1 Animals SMAD2 SMAD3 Calcium CRKL Cell Line FADD Myocardium Jurkat Cells FAS PPM1A Smad2 Protein Phosphorylation Calcium Channels Precipitin Tests Protein Subunits Ion Channel Gating Signal Transduction Two-Hybrid System Techniques Ryanodine Receptor Calcium Release Channel Intracellular Signaling Peptides and Proteins
  • 17. Subconcept relationship Beta1 adrenergic receptor signaling pathway GNB1 PRKACA Beta2 adrenergic receptor signaling pathway Rats PIK3R1 Animals SMAD2 SMAD3 Calcium CRKL Cell Line FADD Myocardium Jurkat Cells FAS PPM1A Smad2 Protein Phosphorylation Calcium Channels Precipitin Tests Protein Subunits Ion Channel Gating Signal Transduction Two-Hybrid System Techniques Ryanodine Receptor Calcium Release Channel Intracellular Signaling Peptides and Proteins Beta1 adrenergic receptor signaling pathway GNB1 PRKACA Beta2 adrenergic receptor signaling pathway Rats PIK3R1 Animals SMAD2 SMAD3 Calcium CRKL Cell Line FADD Myocardium Jurkat Cells FAS PPM1A Smad2 Protein Phosphorylation Calcium Channels Precipitin Tests Protein Subunits Ion Channel Gating Signal Transduction Two-Hybrid System Techniques Ryanodine Receptor Calcium Release Channel Intracellular Signaling Peptides and Proteins more objects/ fewer attributes fewer objects/ more attributes
  • 18. Subconcept relationship Beta1 adrenergic receptor signaling pathway GNB1 PRKACA Beta2 adrenergic receptor signaling pathway Rats PIK3R1 Animals SMAD2 SMAD3 Calcium CRKL Cell Line FADD Myocardium Jurkat Cells FAS PPM1A Smad2 Protein Phosphorylation Calcium Channels Precipitin Tests Protein Subunits Ion Channel Gating Signal Transduction Two-Hybrid System Techniques Ryanodine Receptor Calcium Release Channel Intracellular Signaling Peptides and Proteins Beta1 adrenergic receptor signaling pathway GNB1 PRKACA Beta2 adrenergic receptor signaling pathway Rats PIK3R1 Animals SMAD2 SMAD3 Calcium CRKL Cell Line FADD Myocardium Jurkat Cells FAS PPM1A Smad2 Protein Phosphorylation Calcium Channels Precipitin Tests Protein Subunits Ion Channel Gating Signal Transduction Two-Hybrid System Techniques Ryanodine Receptor Calcium Release Channel Intracellular Signaling Peptides and Proteins CRKL, FADD, FAS, GNB1, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 744175 FADD, FAS, PIK3R1, SMAD2, SMAD3; 744175, 748642
  • 19. Concept Lattice ANK3, CABP1, CACNA1C, CACNA2D4, CACNB3, CNTN1, CRKL, FADD, FAS, GNB1, KCNC1, KCNC2, PIK3R1, PPM1A, PRKACA, RIMS1, RYR2, SCN1B, SCN2A, SCNN1B, SMAD2, SMAD3, SPTBN4, SRI; CACNA1C, CACNB3, GNB1, PRKACA, RYR2; 617414, 617437 CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, RYR2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 ANK3, CACNA1C, CNTN1, GNB1, PIK3R1, PRKACA, SCNN1B; 737748 CNTN1, GNB1, PIK3R1, PRKACA, SMAD2, SMAD3; 738083 CABP1, CACNA1C, PRKACA, RYR2, SRI; 738118 ANK3, SCN1B, SPTBN4; 738391 ANK3, SCNN1B, SPTBN4; 742325 CABP1, CACNA1C, CACNB3, PRKACA, RYR2; 742512 CACNA1C, GNB1, PIK3R1, PRKACA, SCN1B, SCN2A, SCNN1B; 742806 ANK3, CACNA1C, CACNB3, GNB1, SCN1B, SCN2A, SCNN1B; 743584 CRKL, FADD, FAS, GNB1, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 744175 CNTN1, RIMS1, SCN1B, SCN2A, SPTBN4; 744929 CABP1, CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B; 745316 CNTN1, SCN2A, SCNN1B; 745760 CABP1, CACNA1C, CACNA2D4, CACNB3; 745845 CACNA1C, CACNA2D4, CACNB3; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 745845 CABP1, CACNA1C, CACNB3; 742512, 745316, 745845 CNTN1, SCNN1B; 737748, 745760 CNTN1, SCN2A; 744929, 745760 SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 745316, 745760 CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 743584, 745316 SCN1B, SPTBN4; 738391, 744929 SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 744929, 745316 CNTN1; 737748, 738083, 744929, 745760 SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 744929, 745316, 745760 GNB1, PIK3R1, PRKACA, SMAD2, SMAD3; 738083, 744175 CRKL, FADD, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 744175 CRKL, FADD, FAS, PIK3R1; 740606, 744175 CRKL, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 742292, 744175 FADD, GNB1, PIK3R1, SMAD2, SMAD3; 744175, 747193 FADD, FAS, PIK3R1, SMAD2, SMAD3; 744175, 748642 FADD, FAS, PIK3R1; 740606, 744175, 748642 FADD, PIK3R1, SMAD2, SMAD3; 738855, 744175, 747193, 748642 GNB1, PIK3R1, SMAD2, SMAD3; 738083, 744175, 747193 CACNA1C, CACNB3, GNB1; 617414, 617437, 743584 ANK3, CACNA1C, GNB1, SCNN1B; 737748, 743584 ANK3, SCN1B, SCN2A, SCNN1B; 742390, 743584 CACNA1C, GNB1, SCN1B, SCN2A, SCNN1B; 742806, 743584 CACNA1C, GNB1, PIK3R1, PRKACA, SCNN1B; 737748, 742806 CACNA1C, GNB1, SCNN1B; 737748, 742806, 743584 CACNA1C, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, PRKACA, RYR2; 617414, 617437, 742512 CABP1, CACNA1C, PRKACA, RYR2; 738118, 742512 CABP1, CACNA1C; 738118, 742512, 745316, 745845 CACNA1C, CACNB3; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742512, 743584, 745316, 745845 ANK3, SCN1B; 738391, 742390, 743584 ANK3, SCNN1B; 737748, 742325, 742390, 743584 SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 745316 ANK3, SPTBN4; 738391, 742325 CRKL, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 742292, 744175 PPM1A, SMAD2, SMAD3; 741302, 742292, 744175 SMAD2, SMAD3; 738083, 738855, 741302, 742292, 742793, 744175, 747193, 748642 CRKL, FADD, PIK3R1; 738855, 740606, 744175 FADD, PIK3R1; 738855, 740606, 744175, 747193, 748642 PIK3R1, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175, 747193, 748642 CRKL, PIK3R1; 738855, 740606, 742292, 744175 PIK3R1, PRKACA, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175 PIK3R1; 737748, 738083, 738855, 740606, 742292, 742793, 742806, 744175, 747193, 748642 SPTBN4; 738391, 742325, 744929 SCN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 738391, 742390, 742806, 743584, 744929, 745316 ANK3; 737748, 738391, 742325, 742390, 743584 ; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738083, 738118, 738391, 738855, 739640, 740606, 741302, 742292, 742325, 742390, 742512, 742793, 742806, 743584, 744175, 744929, 745316, 745760, 745845, 747193, 748541, 748642 CACNA1C, PRKACA, RYR2, SRI; 738118, 739640, 748541 CACNA1C, PRKACA, RYR2; 617414, 617437, 738118, 739640, 742512, 748541 CACNA1C; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738118, 739640, 742512, 742806, 743584, 745316, 745845, 748541 CNTN1, GNB1, PIK3R1, PRKACA; 737748, 738083 GNB1, PIK3R1, PRKACA; 737748, 738083, 742806, 744175 GNB1, PIK3R1; 737748, 738083, 742806, 744175, 747193 PIK3R1, PRKACA; 737748, 738083, 738855, 742292, 742793, 742806, 744175 SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742325, 742390, 742806, 743584, 745316, 745760 CACNA1C, GNB1, PRKACA; 617414, 617437, 737748, 742806 CACNA1C, GNB1; 617414, 617437, 737748, 742806, 743584 CACNA1C, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742806, 743584, 745316 GNB1, PRKACA; 617414, 617437, 737748, 738083, 742806, 744175 GNB1; 617414, 617437, 737748, 738083, 742806, 743584, 744175, 747193 PRKACA; 617414, 617437, 737748, 738083, 738118, 738855, 739640, 742292, 742512, 742793, 742806, 744175, 748541 CACNA1C, KCNC1, KCNC2, RYR2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 KCNC1, KCNC2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNA2D4, CACNB3, RYR2; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNB3, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 743584, 745316 CACNA1C, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, RYR2; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742512 KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, RYR2; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 738118, 739640, 742512, 748541 CACNA1C, PRKACA; 617414, 617437, 737748, 738118, 739640, 742512, 742806, 748541
  • 20. Top ANK3, CABP1, CACNA1C, CACNA2D4, CACNB3, CNTN1, CRKL, FADD, FAS, GNB1, KCNC1, KCNC2, PIK3R1, PPM1A, PRKACA, RIMS1, RYR2, SCN1B, SCN2A, SCNN1B, SMAD2, SMAD3, SPTBN4, SRI; CACNA1C, CACNB3, GNB1, PRKACA, RYR2; 617414, 617437 CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, RYR2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 ANK3, CACNA1C, CNTN1, GNB1, PIK3R1, PRKACA, SCNN1B; 737748 CNTN1, GNB1, PIK3R1, PRKACA, SMAD2, SMAD3; 738083 CABP1, CACNA1C, PRKACA, RYR2, SRI; 738118 ANK3, SCN1B, SPTBN4; 738391 ANK3, SCNN1B, SPTBN4; 742325 CABP1, CACNA1C, CACNB3, PRKACA, RYR2; 742512 CACNA1C, GNB1, PIK3R1, PRKACA, SCN1B, SCN2A, SCNN1B; 742806 ANK3, CACNA1C, CACNB3, GNB1, SCN1B, SCN2A, SCNN1B; 743584 CRKL, FADD, FAS, GNB1, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 744175 CNTN1, RIMS1, SCN1B, SCN2A, SPTBN4; 744929 CABP1, CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B; 745316 CNTN1, SCN2A, SCNN1B; 745760 CABP1, CACNA1C, CACNA2D4, CACNB3; 745845 CACNA1C, CACNA2D4, CACNB3; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 745845 CABP1, CACNA1C, CACNB3; 742512, 745316, 745845 CNTN1, SCNN1B; 737748, 745760 CNTN1, SCN2A; 744929, 745760 SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 745316, 745760 CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 743584, 745316 SCN1B, SPTBN4; 738391, 744929 SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 744929, 745316 CNTN1; 737748, 738083, 744929, 745760 SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 744929, 745316, 745760 GNB1, PIK3R1, PRKACA, SMAD2, SMAD3; 738083, 744175 CRKL, FADD, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 744175 CRKL, FADD, FAS, PIK3R1; 740606, 744175 CRKL, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 742292, 744175 FADD, GNB1, PIK3R1, SMAD2, SMAD3; 744175, 747193 FADD, FAS, PIK3R1, SMAD2, SMAD3; 744175, 748642 FADD, FAS, PIK3R1; 740606, 744175, 748642 FADD, PIK3R1, SMAD2, SMAD3; 738855, 744175, 747193, 748642 GNB1, PIK3R1, SMAD2, SMAD3; 738083, 744175, 747193 CACNA1C, CACNB3, GNB1; 617414, 617437, 743584 ANK3, CACNA1C, GNB1, SCNN1B; 737748, 743584 ANK3, SCN1B, SCN2A, SCNN1B; 742390, 743584 CACNA1C, GNB1, SCN1B, SCN2A, SCNN1B; 742806, 743584 CACNA1C, GNB1, PIK3R1, PRKACA, SCNN1B; 737748, 742806 CACNA1C, GNB1, SCNN1B; 737748, 742806, 743584 CACNA1C, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, PRKACA, RYR2; 617414, 617437, 742512 CABP1, CACNA1C, PRKACA, RYR2; 738118, 742512 CABP1, CACNA1C; 738118, 742512, 745316, 745845 CACNA1C, CACNB3; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742512, 743584, 745316, 745845 ANK3, SCN1B; 738391, 742390, 743584 ANK3, SCNN1B; 737748, 742325, 742390, 743584 SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 745316 ANK3, SPTBN4; 738391, 742325 CRKL, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 742292, 744175 PPM1A, SMAD2, SMAD3; 741302, 742292, 744175 SMAD2, SMAD3; 738083, 738855, 741302, 742292, 742793, 744175, 747193, 748642 CRKL, FADD, PIK3R1; 738855, 740606, 744175 FADD, PIK3R1; 738855, 740606, 744175, 747193, 748642 PIK3R1, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175, 747193, 748642 CRKL, PIK3R1; 738855, 740606, 742292, 744175 PIK3R1, PRKACA, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175 PIK3R1; 737748, 738083, 738855, 740606, 742292, 742793, 742806, 744175, 747193, 748642 SPTBN4; 738391, 742325, 744929 SCN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 738391, 742390, 742806, 743584, 744929, 745316 ANK3; 737748, 738391, 742325, 742390, 743584 ; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738083, 738118, 738391, 738855, 739640, 740606, 741302, 742292, 742325, 742390, 742512, 742793, 742806, 743584, 744175, 744929, 745316, 745760, 745845, 747193, 748541, 748642 CACNA1C, PRKACA, RYR2, SRI; 738118, 739640, 748541 CACNA1C, PRKACA, RYR2; 617414, 617437, 738118, 739640, 742512, 748541 CACNA1C; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738118, 739640, 742512, 742806, 743584, 745316, 745845, 748541 CNTN1, GNB1, PIK3R1, PRKACA; 737748, 738083 GNB1, PIK3R1, PRKACA; 737748, 738083, 742806, 744175 GNB1, PIK3R1; 737748, 738083, 742806, 744175, 747193 PIK3R1, PRKACA; 737748, 738083, 738855, 742292, 742793, 742806, 744175 SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742325, 742390, 742806, 743584, 745316, 745760 CACNA1C, GNB1, PRKACA; 617414, 617437, 737748, 742806 CACNA1C, GNB1; 617414, 617437, 737748, 742806, 743584 CACNA1C, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742806, 743584, 745316 GNB1, PRKACA; 617414, 617437, 737748, 738083, 742806, 744175 GNB1; 617414, 617437, 737748, 738083, 742806, 743584, 744175, 747193 PRKACA; 617414, 617437, 737748, 738083, 738118, 738855, 739640, 742292, 742512, 742793, 742806, 744175, 748541 CACNA1C, KCNC1, KCNC2, RYR2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 KCNC1, KCNC2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNA2D4, CACNB3, RYR2; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNB3, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 743584, 745316 CACNA1C, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, RYR2; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742512 KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, RYR2; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 738118, 739640, 742512, 748541 CACNA1C, PRKACA; 617414, 617437, 737748, 738118, 739640, 742512, 742806, 748541 formally: concept formed by closure of empty set of attributes alternative: concept with attributes shared by all objects
  • 21. Bottom formally: concept formed by closure of empty set of objects alternative: concept with objects with all attributes ANK3, CABP1, CACNA1C, CACNA2D4, CACNB3, CNTN1, CRKL, FADD, FAS, GNB1, KCNC1, KCNC2, PIK3R1, PPM1A, PRKACA, RIMS1, RYR2, SCN1B, SCN2A, SCNN1B, SMAD2, SMAD3, SPTBN4, SRI; CACNA1C, CACNB3, GNB1, PRKACA, RYR2; 617414, 617437 CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, RYR2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 ANK3, CACNA1C, CNTN1, GNB1, PIK3R1, PRKACA, SCNN1B; 737748 CNTN1, GNB1, PIK3R1, PRKACA, SMAD2, SMAD3; 738083 CABP1, CACNA1C, PRKACA, RYR2, SRI; 738118 ANK3, SCN1B, SPTBN4; 738391 ANK3, SCNN1B, SPTBN4; 742325 CABP1, CACNA1C, CACNB3, PRKACA, RYR2; 742512 CACNA1C, GNB1, PIK3R1, PRKACA, SCN1B, SCN2A, SCNN1B; 742806 ANK3, CACNA1C, CACNB3, GNB1, SCN1B, SCN2A, SCNN1B; 743584 CRKL, FADD, FAS, GNB1, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 744175 CNTN1, RIMS1, SCN1B, SCN2A, SPTBN4; 744929 CABP1, CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B; 745316 CNTN1, SCN2A, SCNN1B; 745760 CABP1, CACNA1C, CACNA2D4, CACNB3; 745845 CACNA1C, CACNA2D4, CACNB3; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 745845 CABP1, CACNA1C, CACNB3; 742512, 745316, 745845 CNTN1, SCNN1B; 737748, 745760 CNTN1, SCN2A; 744929, 745760 SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 745316, 745760 CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 743584, 745316 SCN1B, SPTBN4; 738391, 744929 SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 744929, 745316 CNTN1; 737748, 738083, 744929, 745760 SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 744929, 745316, 745760 GNB1, PIK3R1, PRKACA, SMAD2, SMAD3; 738083, 744175 CRKL, FADD, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 744175 CRKL, FADD, FAS, PIK3R1; 740606, 744175 CRKL, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 742292, 744175 FADD, GNB1, PIK3R1, SMAD2, SMAD3; 744175, 747193 FADD, FAS, PIK3R1, SMAD2, SMAD3; 744175, 748642 FADD, FAS, PIK3R1; 740606, 744175, 748642 FADD, PIK3R1, SMAD2, SMAD3; 738855, 744175, 747193, 748642 GNB1, PIK3R1, SMAD2, SMAD3; 738083, 744175, 747193 CACNA1C, CACNB3, GNB1; 617414, 617437, 743584 ANK3, CACNA1C, GNB1, SCNN1B; 737748, 743584 ANK3, SCN1B, SCN2A, SCNN1B; 742390, 743584 CACNA1C, GNB1, SCN1B, SCN2A, SCNN1B; 742806, 743584 CACNA1C, GNB1, PIK3R1, PRKACA, SCNN1B; 737748, 742806 CACNA1C, GNB1, SCNN1B; 737748, 742806, 743584 CACNA1C, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, PRKACA, RYR2; 617414, 617437, 742512 CABP1, CACNA1C, PRKACA, RYR2; 738118, 742512 CABP1, CACNA1C; 738118, 742512, 745316, 745845 CACNA1C, CACNB3; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742512, 743584, 745316, 745845 ANK3, SCN1B; 738391, 742390, 743584 ANK3, SCNN1B; 737748, 742325, 742390, 743584 SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 745316 ANK3, SPTBN4; 738391, 742325 CRKL, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 742292, 744175 PPM1A, SMAD2, SMAD3; 741302, 742292, 744175 SMAD2, SMAD3; 738083, 738855, 741302, 742292, 742793, 744175, 747193, 748642 CRKL, FADD, PIK3R1; 738855, 740606, 744175 FADD, PIK3R1; 738855, 740606, 744175, 747193, 748642 PIK3R1, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175, 747193, 748642 CRKL, PIK3R1; 738855, 740606, 742292, 744175 PIK3R1, PRKACA, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175 PIK3R1; 737748, 738083, 738855, 740606, 742292, 742793, 742806, 744175, 747193, 748642 SPTBN4; 738391, 742325, 744929 SCN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 738391, 742390, 742806, 743584, 744929, 745316 ANK3; 737748, 738391, 742325, 742390, 743584 ; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738083, 738118, 738391, 738855, 739640, 740606, 741302, 742292, 742325, 742390, 742512, 742793, 742806, 743584, 744175, 744929, 745316, 745760, 745845, 747193, 748541, 748642 CACNA1C, PRKACA, RYR2, SRI; 738118, 739640, 748541 CACNA1C, PRKACA, RYR2; 617414, 617437, 738118, 739640, 742512, 748541 CACNA1C; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738118, 739640, 742512, 742806, 743584, 745316, 745845, 748541 CNTN1, GNB1, PIK3R1, PRKACA; 737748, 738083 GNB1, PIK3R1, PRKACA; 737748, 738083, 742806, 744175 GNB1, PIK3R1; 737748, 738083, 742806, 744175, 747193 PIK3R1, PRKACA; 737748, 738083, 738855, 742292, 742793, 742806, 744175 SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742325, 742390, 742806, 743584, 745316, 745760 CACNA1C, GNB1, PRKACA; 617414, 617437, 737748, 742806 CACNA1C, GNB1; 617414, 617437, 737748, 742806, 743584 CACNA1C, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742806, 743584, 745316 GNB1, PRKACA; 617414, 617437, 737748, 738083, 742806, 744175 GNB1; 617414, 617437, 737748, 738083, 742806, 743584, 744175, 747193 PRKACA; 617414, 617437, 737748, 738083, 738118, 738855, 739640, 742292, 742512, 742793, 742806, 744175, 748541 CACNA1C, KCNC1, KCNC2, RYR2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 KCNC1, KCNC2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNA2D4, CACNB3, RYR2; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNB3, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 743584, 745316 CACNA1C, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, RYR2; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742512 KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, RYR2; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 738118, 739640, 742512, 748541 CACNA1C, PRKACA; 617414, 617437, 737748, 738118, 739640, 742512, 742806, 748541
  • 22. Co-atoms ANK3, CABP1, CACNA1C, CACNA2D4, CACNB3, CNTN1, CRKL, FADD, FAS, GNB1, KCNC1, KCNC2, PIK3R1, PPM1A, PRKACA, RIMS1, RYR2, SCN1B, SCN2A, SCNN1B, SMAD2, SMAD3, SPTBN4, SRI; CACNA1C, CACNB3, GNB1, PRKACA, RYR2; 617414, 617437 CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, RYR2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 ANK3, CACNA1C, CNTN1, GNB1, PIK3R1, PRKACA, SCNN1B; 737748 CNTN1, GNB1, PIK3R1, PRKACA, SMAD2, SMAD3; 738083 CABP1, CACNA1C, PRKACA, RYR2, SRI; 738118 ANK3, SCN1B, SPTBN4; 738391 ANK3, SCNN1B, SPTBN4; 742325 CABP1, CACNA1C, CACNB3, PRKACA, RYR2; 742512 CACNA1C, GNB1, PIK3R1, PRKACA, SCN1B, SCN2A, SCNN1B; 742806 ANK3, CACNA1C, CACNB3, GNB1, SCN1B, SCN2A, SCNN1B; 743584 CRKL, FADD, FAS, GNB1, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 744175 CNTN1, RIMS1, SCN1B, SCN2A, SPTBN4; 744929 CABP1, CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B; 745316 CNTN1, SCN2A, SCNN1B; 745760 CABP1, CACNA1C, CACNA2D4, CACNB3; 745845 CACNA1C, CACNA2D4, CACNB3; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 745845 CABP1, CACNA1C, CACNB3; 742512, 745316, 745845 CNTN1, SCNN1B; 737748, 745760 CNTN1, SCN2A; 744929, 745760 SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 745316, 745760 CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 743584, 745316 SCN1B, SPTBN4; 738391, 744929 SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 744929, 745316 CNTN1; 737748, 738083, 744929, 745760 SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 744929, 745316, 745760 GNB1, PIK3R1, PRKACA, SMAD2, SMAD3; 738083, 744175 CRKL, FADD, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 744175 CRKL, FADD, FAS, PIK3R1; 740606, 744175 CRKL, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 742292, 744175 FADD, GNB1, PIK3R1, SMAD2, SMAD3; 744175, 747193 FADD, FAS, PIK3R1, SMAD2, SMAD3; 744175, 748642 FADD, FAS, PIK3R1; 740606, 744175, 748642 FADD, PIK3R1, SMAD2, SMAD3; 738855, 744175, 747193, 748642 GNB1, PIK3R1, SMAD2, SMAD3; 738083, 744175, 747193 CACNA1C, CACNB3, GNB1; 617414, 617437, 743584 ANK3, CACNA1C, GNB1, SCNN1B; 737748, 743584 ANK3, SCN1B, SCN2A, SCNN1B; 742390, 743584 CACNA1C, GNB1, SCN1B, SCN2A, SCNN1B; 742806, 743584 CACNA1C, GNB1, PIK3R1, PRKACA, SCNN1B; 737748, 742806 CACNA1C, GNB1, SCNN1B; 737748, 742806, 743584 CACNA1C, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, PRKACA, RYR2; 617414, 617437, 742512 CABP1, CACNA1C, PRKACA, RYR2; 738118, 742512 CABP1, CACNA1C; 738118, 742512, 745316, 745845 CACNA1C, CACNB3; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742512, 743584, 745316, 745845 ANK3, SCN1B; 738391, 742390, 743584 ANK3, SCNN1B; 737748, 742325, 742390, 743584 SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 745316 ANK3, SPTBN4; 738391, 742325 CRKL, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 742292, 744175 PPM1A, SMAD2, SMAD3; 741302, 742292, 744175 SMAD2, SMAD3; 738083, 738855, 741302, 742292, 742793, 744175, 747193, 748642 CRKL, FADD, PIK3R1; 738855, 740606, 744175 FADD, PIK3R1; 738855, 740606, 744175, 747193, 748642 PIK3R1, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175, 747193, 748642 CRKL, PIK3R1; 738855, 740606, 742292, 744175 PIK3R1, PRKACA, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175 PIK3R1; 737748, 738083, 738855, 740606, 742292, 742793, 742806, 744175, 747193, 748642 SPTBN4; 738391, 742325, 744929 SCN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 738391, 742390, 742806, 743584, 744929, 745316 ANK3; 737748, 738391, 742325, 742390, 743584 ; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738083, 738118, 738391, 738855, 739640, 740606, 741302, 742292, 742325, 742390, 742512, 742793, 742806, 743584, 744175, 744929, 745316, 745760, 745845, 747193, 748541, 748642 CACNA1C, PRKACA, RYR2, SRI; 738118, 739640, 748541 CACNA1C, PRKACA, RYR2; 617414, 617437, 738118, 739640, 742512, 748541 CACNA1C; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738118, 739640, 742512, 742806, 743584, 745316, 745845, 748541 CNTN1, GNB1, PIK3R1, PRKACA; 737748, 738083 GNB1, PIK3R1, PRKACA; 737748, 738083, 742806, 744175 GNB1, PIK3R1; 737748, 738083, 742806, 744175, 747193 PIK3R1, PRKACA; 737748, 738083, 738855, 742292, 742793, 742806, 744175 SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742325, 742390, 742806, 743584, 745316, 745760 CACNA1C, GNB1, PRKACA; 617414, 617437, 737748, 742806 CACNA1C, GNB1; 617414, 617437, 737748, 742806, 743584 CACNA1C, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742806, 743584, 745316 GNB1, PRKACA; 617414, 617437, 737748, 738083, 742806, 744175 GNB1; 617414, 617437, 737748, 738083, 742806, 743584, 744175, 747193 PRKACA; 617414, 617437, 737748, 738083, 738118, 738855, 739640, 742292, 742512, 742793, 742806, 744175, 748541 CACNA1C, KCNC1, KCNC2, RYR2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 KCNC1, KCNC2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNA2D4, CACNB3, RYR2; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNB3, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 743584, 745316 CACNA1C, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, RYR2; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742512 KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, RYR2; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 738118, 739640, 742512, 748541 CACNA1C, PRKACA; 617414, 617437, 737748, 738118, 739640, 742512, 742806, 748541 immediate subconcepts of the top concept
  • 23. Chain CACNA1C, CACNB3, GNB1, PRKACA, RYR2; 617414, 617437 CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, RYR2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 NB3, 1B; C, CACNA2D4, CACNB3; 733740, 733911, 736632, 736786, 736810, 736839, 737094, 737232, 737234, 737304, 737332, 737360, 737390, 737431, 737548, 745845 SCN2A, SC 736810, 73 737390, 73 CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 743584, 745316 SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 744929, 745316 SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 744929, 745316, 745760 CACNA1C, CACNB3, GNB1; 617414, 617437, 743584 CA SC CACNA1C, GNB1, SCNN1 737748, 742806, 743584 CACNA1C, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 745316 CACNA1C; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738118, 739640, 742512, 742806, 743584, 745316, 745845, 748541 SCNN1B; 733740, 733911, 736632, 736738, 736786, 736 736836, 737232, 737255, 737304, 737332, 737360, 7373 737431, 737548, 737748, 742325, 742390, 742806, 7435 745316, 745760 CACNA1C, GNB1; 617414, 617437, 737748, 742806, 743584 CACNA1C, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742806, 743584, 745316 CACNA1C, KCNC1, KCNC2, RYR2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 KCNC1, KCNC2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNA2D4, CACNB3, RYR2; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNB3, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 743584, 745316 CACNA1C, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 6632, 737255, 737548, KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, PRKACA; 617414, 617437, 737748, 738118, 739640, 742512, 742806, 748541
  • 24. Anti-chain ANK3, CABP1, CACNA1C, CACNA2D4, CACNB3, CNTN1, CRKL, FADD, FAS, GNB1, KCNC1, KCNC2, PIK3R1, PPM1A, PRKACA, RIMS1, RYR2, SCN1B, SCN2A, SCNN1B, SMAD2, SMAD3, SPTBN4, SRI; CACNA1C, CACNB3, GNB1, PRKACA, RYR2; 617414, 617437 CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, RYR2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 ANK3, CACNA1C, CNTN1, GNB1, PIK3R1, PRKACA, SCNN1B; 737748 CNTN1, GNB1, PIK3R1, PRKACA, SMAD2, SMAD3; 738083 CABP1, CACNA1C, PRKACA, RYR2, SRI; 738118 ANK3, SCN1B, SPTBN4; 738391 ANK3, SCNN1B, SPTBN4; 742325 CABP1, CACNA1C, CACNB3, PRKACA, RYR2; 742512 CACNA1C, GNB1, PIK3R1, PRKACA, SCN1B, SCN2A, SCNN1B; 742806 ANK3, CACNA1C, CACNB3, GNB1, SCN1B, SCN2A, SCNN1B; 743584 CRKL, FADD, FAS, GNB1, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 744175 CNTN1, RIMS1, SCN1B, SCN2A, SPTBN4; 744929 CABP1, CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B; 745316 CNTN1, SCN2A, SCNN1B; 745760 CABP1, CACNA1C, CACNA2D4, CACNB3; 745845 CACNA1C, CACNA2D4, CACNB3; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 745845 CABP1, CACNA1C, CACNB3; 742512, 745316, 745845 CNTN1, SCNN1B; 737748, 745760 CNTN1, SCN2A; 744929, 745760 SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 745316, 745760 CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 743584, 745316 SCN1B, SPTBN4; 738391, 744929 SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 744929, 745316 CNTN1; 737748, 738083, 744929, 745760 SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 744929, 745316, 745760 GNB1, PIK3R1, PRKACA, SMAD2, SMAD3; 738083, 744175 CRKL, FADD, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 744175 CRKL, FADD, FAS, PIK3R1; 740606, 744175 CRKL, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 742292, 744175 FADD, GNB1, PIK3R1, SMAD2, SMAD3; 744175, 747193 FADD, FAS, PIK3R1, SMAD2, SMAD3; 744175, 748642 FADD, FAS, PIK3R1; 740606, 744175, 748642 FADD, PIK3R1, SMAD2, SMAD3; 738855, 744175, 747193, 748642 GNB1, PIK3R1, SMAD2, SMAD3; 738083, 744175, 747193 CACNA1C, CACNB3, GNB1; 617414, 617437, 743584 ANK3, CACNA1C, GNB1, SCNN1B; 737748, 743584 ANK3, SCN1B, SCN2A, SCNN1B; 742390, 743584 CACNA1C, GNB1, SCN1B, SCN2A, SCNN1B; 742806, 743584 CACNA1C, GNB1, PIK3R1, PRKACA, SCNN1B; 737748, 742806 CACNA1C, GNB1, SCNN1B; 737748, 742806, 743584 CACNA1C, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, PRKACA, RYR2; 617414, 617437, 742512 CABP1, CACNA1C, PRKACA, RYR2; 738118, 742512 CABP1, CACNA1C; 738118, 742512, 745316, 745845 CACNA1C, CACNB3; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742512, 743584, 745316, 745845 ANK3, SCN1B; 738391, 742390, 743584 ANK3, SCNN1B; 737748, 742325, 742390, 743584 SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 745316 ANK3, SPTBN4; 738391, 742325 CRKL, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 742292, 744175 PPM1A, SMAD2, SMAD3; 741302, 742292, 744175 SMAD2, SMAD3; 738083, 738855, 741302, 742292, 742793, 744175, 747193, 748642 CRKL, FADD, PIK3R1; 738855, 740606, 744175 FADD, PIK3R1; 738855, 740606, 744175, 747193, 748642 PIK3R1, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175, 747193, 748642 CRKL, PIK3R1; 738855, 740606, 742292, 744175 PIK3R1, PRKACA, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175 PIK3R1; 737748, 738083, 738855, 740606, 742292, 742793, 742806, 744175, 747193, 748642 SPTBN4; 738391, 742325, 744929 SCN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 738391, 742390, 742806, 743584, 744929, 745316 ANK3; 737748, 738391, 742325, 742390, 743584 ; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738083, 738118, 738391, 738855, 739640, 740606, 741302, 742292, 742325, 742390, 742512, 742793, 742806, 743584, 744175, 744929, 745316, 745760, 745845, 747193, 748541, 748642 CACNA1C, PRKACA, RYR2, SRI; 738118, 739640, 748541 CACNA1C, PRKACA, RYR2; 617414, 617437, 738118, 739640, 742512, 748541 CACNA1C; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738118, 739640, 742512, 742806, 743584, 745316, 745845, 748541 CNTN1, GNB1, PIK3R1, PRKACA; 737748, 738083 GNB1, PIK3R1, PRKACA; 737748, 738083, 742806, 744175 GNB1, PIK3R1; 737748, 738083, 742806, 744175, 747193 PIK3R1, PRKACA; 737748, 738083, 738855, 742292, 742793, 742806, 744175 SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742325, 742390, 742806, 743584, 745316, 745760 CACNA1C, GNB1, PRKACA; 617414, 617437, 737748, 742806 CACNA1C, GNB1; 617414, 617437, 737748, 742806, 743584 CACNA1C, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742806, 743584, 745316 GNB1, PRKACA; 617414, 617437, 737748, 738083, 742806, 744175 GNB1; 617414, 617437, 737748, 738083, 742806, 743584, 744175, 747193 PRKACA; 617414, 617437, 737748, 738083, 738118, 738855, 739640, 742292, 742512, 742793, 742806, 744175, 748541 CACNA1C, KCNC1, KCNC2, RYR2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 KCNC1, KCNC2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNA2D4, CACNB3, RYR2; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNB3, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 743584, 745316 CACNA1C, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, RYR2; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742512 KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, RYR2; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 738118, 739640, 742512, 748541 CACNA1C, PRKACA; 617414, 617437, 737748, 738118, 739640, 742512, 742806, 748541
  • 25. Groupings (again) • A simplified grouping is represented by a minimal anti-chain in the concept lattice that best covers objects (e.g., vertices) • Heuristic: a. generate concepts for individual annotations b.for each, create chain by selecting subconcept with most objects c. select from chains such that vertex set is covered
  • 26. Ex: Grouping (BLOSOM) ANK3, CABP1, CACNA1C, CACNA2D4, CACNB3, CNTN1, CRKL, FADD, FAS, GNB1, KCNC1, KCNC2, PIK3R1, PPM1A, PRKACA, RIMS1, RYR2, SCN1B, SCN2A, SCNN1B, SMAD2, SMAD3, SPTBN4, SRI; CACNA1C, CACNB3, GNB1, PRKACA, RYR2; 617414, 617437 CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, RYR2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 ANK3, CACNA1C, CNTN1, GNB1, PIK3R1, PRKACA, SCNN1B; 737748 CNTN1, GNB1, PIK3R1, PRKACA, SMAD2, SMAD3; 738083 CABP1, CACNA1C, PRKACA, RYR2, SRI; 738118 ANK3, SCN1B, SPTBN4; 738391 ANK3, SCNN1B, SPTBN4; 742325 CABP1, CACNA1C, CACNB3, PRKACA, RYR2; 742512 CACNA1C, GNB1, PIK3R1, PRKACA, SCN1B, SCN2A, SCNN1B; 742806 ANK3, CACNA1C, CACNB3, GNB1, SCN1B, SCN2A, SCNN1B; 743584 CRKL, FADD, FAS, GNB1, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 744175 CNTN1, RIMS1, SCN1B, SCN2A, SPTBN4; 744929 CABP1, CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B; 745316 CNTN1, SCN2A, SCNN1B; 745760 CABP1, CACNA1C, CACNA2D4, CACNB3; 745845 CACNA1C, CACNA2D4, CACNB3; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 745845 CABP1, CACNA1C, CACNB3; 742512, 745316, 745845 CNTN1, SCNN1B; 737748, 745760 CNTN1, SCN2A; 744929, 745760 SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 745316, 745760 CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 743584, 745316 SCN1B, SPTBN4; 738391, 744929 SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 744929, 745316 CNTN1; 737748, 738083, 744929, 745760 SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 744929, 745316, 745760 GNB1, PIK3R1, PRKACA, SMAD2, SMAD3; 738083, 744175 CRKL, FADD, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 744175 CRKL, FADD, FAS, PIK3R1; 740606, 744175 CRKL, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 742292, 744175 FADD, GNB1, PIK3R1, SMAD2, SMAD3; 744175, 747193 FADD, FAS, PIK3R1, SMAD2, SMAD3; 744175, 748642 FADD, FAS, PIK3R1; 740606, 744175, 748642 FADD, PIK3R1, SMAD2, SMAD3; 738855, 744175, 747193, 748642 GNB1, PIK3R1, SMAD2, SMAD3; 738083, 744175, 747193 CACNA1C, CACNB3, GNB1; 617414, 617437, 743584 ANK3, CACNA1C, GNB1, SCNN1B; 737748, 743584 ANK3, SCN1B, SCN2A, SCNN1B; 742390, 743584 CACNA1C, GNB1, SCN1B, SCN2A, SCNN1B; 742806, 743584 CACNA1C, GNB1, PIK3R1, PRKACA, SCNN1B; 737748, 742806 CACNA1C, GNB1, SCNN1B; 737748, 742806, 743584 CACNA1C, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, PRKACA, RYR2; 617414, 617437, 742512 CABP1, CACNA1C, PRKACA, RYR2; 738118, 742512 CABP1, CACNA1C; 738118, 742512, 745316, 745845 CACNA1C, CACNB3; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742512, 743584, 745316, 745845 ANK3, SCN1B; 738391, 742390, 743584 ANK3, SCNN1B; 737748, 742325, 742390, 743584 SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 745316 ANK3, SPTBN4; 738391, 742325 CRKL, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 742292, 744175 PPM1A, SMAD2, SMAD3; 741302, 742292, 744175 SMAD2, SMAD3; 738083, 738855, 741302, 742292, 742793, 744175, 747193, 748642 CRKL, FADD, PIK3R1; 738855, 740606, 744175 FADD, PIK3R1; 738855, 740606, 744175, 747193, 748642 PIK3R1, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175, 747193, 748642 CRKL, PIK3R1; 738855, 740606, 742292, 744175 PIK3R1, PRKACA, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175 PIK3R1; 737748, 738083, 738855, 740606, 742292, 742793, 742806, 744175, 747193, 748642 SPTBN4; 738391, 742325, 744929 SCN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 738391, 742390, 742806, 743584, 744929, 745316 ANK3; 737748, 738391, 742325, 742390, 743584 ; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738083, 738118, 738391, 738855, 739640, 740606, 741302, 742292, 742325, 742390, 742512, 742793, 742806, 743584, 744175, 744929, 745316, 745760, 745845, 747193, 748541, 748642 CACNA1C, PRKACA, RYR2, SRI; 738118, 739640, 748541 CACNA1C, PRKACA, RYR2; 617414, 617437, 738118, 739640, 742512, 748541 CACNA1C; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738118, 739640, 742512, 742806, 743584, 745316, 745845, 748541 CNTN1, GNB1, PIK3R1, PRKACA; 737748, 738083 GNB1, PIK3R1, PRKACA; 737748, 738083, 742806, 744175 GNB1, PIK3R1; 737748, 738083, 742806, 744175, 747193 PIK3R1, PRKACA; 737748, 738083, 738855, 742292, 742793, 742806, 744175 SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742325, 742390, 742806, 743584, 745316, 745760 CACNA1C, GNB1, PRKACA; 617414, 617437, 737748, 742806 CACNA1C, GNB1; 617414, 617437, 737748, 742806, 743584 CACNA1C, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742806, 743584, 745316 GNB1, PRKACA; 617414, 617437, 737748, 738083, 742806, 744175 GNB1; 617414, 617437, 737748, 738083, 742806, 743584, 744175, 747193 PRKACA; 617414, 617437, 737748, 738083, 738118, 738855, 739640, 742292, 742512, 742793, 742806, 744175, 748541 CACNA1C, KCNC1, KCNC2, RYR2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 KCNC1, KCNC2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNA2D4, CACNB3, RYR2; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNB3, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 743584, 745316 CACNA1C, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, RYR2; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742512 KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, RYR2; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 738118, 739640, 742512, 748541 CACNA1C, PRKACA; 617414, 617437, 737748, 738118, 739640, 742512, 742806, 748541
  • 27. Ex: Grouping (BLOSOM) ANK3, CABP1, CACNA1C, CACNA2D4, CACNB3, CNTN1, CRKL, FADD, FAS, GNB1, KCNC1, KCNC2, PIK3R1, PPM1A, PRKACA, RIMS1, RYR2, SCN1B, SCN2A, SCNN1B, SMAD2, SMAD3, SPTBN4, SRI; CACNA1C, CACNB3, GNB1, PRKACA, RYR2; 617414, 617437 CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, RYR2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 ANK3, CACNA1C, CNTN1, GNB1, PIK3R1, PRKACA, SCNN1B; 737748 CNTN1, GNB1, PIK3R1, PRKACA, SMAD2, SMAD3; 738083 CABP1, CACNA1C, PRKACA, RYR2, SRI; 738118 ANK3, SCN1B, SPTBN4; 738391 ANK3, SCNN1B, SPTBN4; 742325 CABP1, CACNA1C, CACNB3, PRKACA, RYR2; 742512 CACNA1C, GNB1, PIK3R1, PRKACA, SCN1B, SCN2A, SCNN1B; 742806 ANK3, CACNA1C, CACNB3, GNB1, SCN1B, SCN2A, SCNN1B; 743584 CRKL, FADD, FAS, GNB1, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 744175 CNTN1, RIMS1, SCN1B, SCN2A, SPTBN4; 744929 CABP1, CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B; 745316 CNTN1, SCN2A, SCNN1B; 745760 CABP1, CACNA1C, CACNA2D4, CACNB3; 745845 CACNA1C, CACNA2D4, CACNB3; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 745845 CABP1, CACNA1C, CACNB3; 742512, 745316, 745845 CNTN1, SCNN1B; 737748, 745760 CNTN1, SCN2A; 744929, 745760 SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 745316, 745760 CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 743584, 745316 SCN1B, SPTBN4; 738391, 744929 SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 744929, 745316 CNTN1; 737748, 738083, 744929, 745760 SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 744929, 745316, 745760 GNB1, PIK3R1, PRKACA, SMAD2, SMAD3; 738083, 744175 CRKL, FADD, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 744175 CRKL, FADD, FAS, PIK3R1; 740606, 744175 CRKL, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 742292, 744175 FADD, GNB1, PIK3R1, SMAD2, SMAD3; 744175, 747193 FADD, FAS, PIK3R1, SMAD2, SMAD3; 744175, 748642 FADD, FAS, PIK3R1; 740606, 744175, 748642 FADD, PIK3R1, SMAD2, SMAD3; 738855, 744175, 747193, 748642 GNB1, PIK3R1, SMAD2, SMAD3; 738083, 744175, 747193 CACNA1C, CACNB3, GNB1; 617414, 617437, 743584 ANK3, CACNA1C, GNB1, SCNN1B; 737748, 743584 ANK3, SCN1B, SCN2A, SCNN1B; 742390, 743584 CACNA1C, GNB1, SCN1B, SCN2A, SCNN1B; 742806, 743584 CACNA1C, GNB1, PIK3R1, PRKACA, SCNN1B; 737748, 742806 CACNA1C, GNB1, SCNN1B; 737748, 742806, 743584 CACNA1C, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, PRKACA, RYR2; 617414, 617437, 742512 CABP1, CACNA1C, PRKACA, RYR2; 738118, 742512 CABP1, CACNA1C; 738118, 742512, 745316, 745845 CACNA1C, CACNB3; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742512, 743584, 745316, 745845 ANK3, SCN1B; 738391, 742390, 743584 ANK3, SCNN1B; 737748, 742325, 742390, 743584 SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 745316 ANK3, SPTBN4; 738391, 742325 CRKL, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 742292, 744175 PPM1A, SMAD2, SMAD3; 741302, 742292, 744175 SMAD2, SMAD3; 738083, 738855, 741302, 742292, 742793, 744175, 747193, 748642 CRKL, FADD, PIK3R1; 738855, 740606, 744175 FADD, PIK3R1; 738855, 740606, 744175, 747193, 748642 PIK3R1, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175, 747193, 748642 CRKL, PIK3R1; 738855, 740606, 742292, 744175 PIK3R1, PRKACA, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175 PIK3R1; 737748, 738083, 738855, 740606, 742292, 742793, 742806, 744175, 747193, 748642 SPTBN4; 738391, 742325, 744929 SCN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 738391, 742390, 742806, 743584, 744929, 745316 ANK3; 737748, 738391, 742325, 742390, 743584 ; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738083, 738118, 738391, 738855, 739640, 740606, 741302, 742292, 742325, 742390, 742512, 742793, 742806, 743584, 744175, 744929, 745316, 745760, 745845, 747193, 748541, 748642 CACNA1C, PRKACA, RYR2, SRI; 738118, 739640, 748541 CACNA1C, PRKACA, RYR2; 617414, 617437, 738118, 739640, 742512, 748541 CACNA1C; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738118, 739640, 742512, 742806, 743584, 745316, 745845, 748541 CNTN1, GNB1, PIK3R1, PRKACA; 737748, 738083 GNB1, PIK3R1, PRKACA; 737748, 738083, 742806, 744175 GNB1, PIK3R1; 737748, 738083, 742806, 744175, 747193 PIK3R1, PRKACA; 737748, 738083, 738855, 742292, 742793, 742806, 744175 SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742325, 742390, 742806, 743584, 745316, 745760 CACNA1C, GNB1, PRKACA; 617414, 617437, 737748, 742806 CACNA1C, GNB1; 617414, 617437, 737748, 742806, 743584 CACNA1C, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742806, 743584, 745316 GNB1, PRKACA; 617414, 617437, 737748, 738083, 742806, 744175 GNB1; 617414, 617437, 737748, 738083, 742806, 743584, 744175, 747193 PRKACA; 617414, 617437, 737748, 738083, 738118, 738855, 739640, 742292, 742512, 742793, 742806, 744175, 748541 CACNA1C, KCNC1, KCNC2, RYR2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 KCNC1, KCNC2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNA2D4, CACNB3, RYR2; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNB3, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 743584, 745316 CACNA1C, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, RYR2; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742512 KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, RYR2; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 738118, 739640, 742512, 748541 CACNA1C, PRKACA; 617414, 617437, 737748, 738118, 739640, 742512, 742806, 748541 MeSH: Calcium GO BP: Metal Ion Transport GO MF: Gated Channel Activity GO MF: Cation Channel Activity MeSH: Signal Transduction MeSH: Nerve Tissue Proteins MeSH Ion Channel Gating CRKL ANK3 CABP1 CACNA 2D4 CACNB 3 GNB1 PCBD1 RIMS1 PPM1A PRKAC A RYR2 SRI CACNA 1C FAS FADD CNTN1 HOOK1 KCNC1 KCNC2 SMAD3 SMAD2 PIK3R1 SPTBN4 SCN1B SCNN1 B SCN2A note: BLOSOM finds minimal generator for a concept: smallest set of attributes with concept as closure
  • 28. Graph edges and grouping RYR2 CACNA 1C In what situations does this interaction occur?
  • 29. Graph edges RYR2 CACNA 1C CACNA1C Ion transport protein RYR2 Beta1 adrenergic receptor signaling pathway Beta2 adrenergic receptor signaling pathway cation transport metal ion transport channel activity ion channel activity gated channel activity cation channel activity calcium channel activity transmembrane transporter activity substrate specific channel activity ion transmembrane transporter activity substrate-specific transporter activity cation transmembrane transporter activity passive transmembrane transporter activity metal ion transmembrane transporter activity substrate-specific transmembrane transporter activity Myocardium Calcium Channels
  • 30. Graph edges CACNA1C Ion transport protein RYR2 Beta1 adrenergic receptor signaling pathway Beta2 adrenergic receptor signaling pathway cation transport metal ion transport channel activity ion channel activity gated channel activity cation channel activity calcium channel activity transmembrane transporter activity substrate specific channel activity ion transmembrane transporter activity substrate-specific transporter activity cation transmembrane transporter activity passive transmembrane transporter activity metal ion transmembrane transporter activity substrate-specific transmembrane transporter activity Myocardium Calcium Channels CACNA1C, RYR2; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 738118, 739640, 742512, 748541
  • 31. Filter CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, RYR2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CABP1, CACNA1C, PRKACA, RYR2, SRI; 738118 CABP1, CACNA1C, CACNB3, PRKACA, RYR2; 742512 CABP1, CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B; 745316 CABP1, CACNA1C, CACNA2D4, CACNB3; 745845 CACNA1C, CACNA2D4, CACNB3; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 745845 CABP1, CACNA1C, CACNB3; 742512, 745316, 745845 CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 743584, 745316 SC 736 737 SCN 7368 7373 CACNA1C, CACNB3, PRKACA, RYR2; 617414, 617437, 742512 CABP1, CACNA1C, PRKACA, RYR2; 738118, 742512 CABP1, CACNA1C; 738118, 742512, 745316, 745845 CACNA1C, CACNB3; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742512, 743584, 745316, 745845 CACNA1C, PRKACA, RYR2, SRI; 738118, 739640, 748541 CACNA1C, PRKACA, RYR2; 617414, 617437, 738118, 739640, 742512, 748541 CACNA1C; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738118, 739640, 742512, 742806, 743584, 745316, 745845, 748541 CACNA1C, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742806, 743584, 745316 CACNA1C, KCNC1, KCNC2, RYR2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 KCNC1, KCNC2, SCN1B, SCN2A, SCNN1B; 73 736632, 736738, 736786, 736810, 736836, 737 737304, 737332, 737360, 737390, 737431 CACNA1C, CACNA2D4, CACNB3, RYR2; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, CACNB3, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 743584, 745316 CACNA1C, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584, 745316 CACNA1C, CACNB3, RYR2; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742512 KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548 CACNA1C, RYR2; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 738118, 739640, 742512, 748541 CACNA1C, PRKACA; 617414, 617437, 737748, 738118, 739640, 742512, 742806, 748541
  • 32. Patterns • Previous examples project annotations onto the graph • For patterns, project the graph onto the annotations • Can use lattice to find emergent schema (Banks et al.) • One heuristic: for each edge (a1,a2) find concepts for a1 and a2, and follow pair of chains upward, adding edges for new objects, until cannot add more Banks E, Nabieva E, Chazelle B, Singh M (2008) PLoS Comput Biol 4(10): e1000203
  • 37. Final Schema Recurrent pattern in graph – could be used to match other graphs
  • 38. More… • Could keep going … • Possible to extract association rules, decision trees and more from concept lattice and use these to annotate functional relationships in graphs (which again is something that has been done other ways) • Also possible to work with multi-valued incidence relations (e.g., numeric data)
  • 39. Inspired and informed by working with 
 Barbara Mirel and 
 NCIBI DBP scientists at U.Michigan
  • 40. Resources B Ganter, R Wille. Formal Concept Analysis: Mathematical Foundations, Springer-Verlag, 1999. ! F Kriegel, Visualization of Conceptual Data with Methods of Formal Concept Analysis. Thesis, Technische Universität Dresden, 2012. ! http://www.upriss.org.uk/fca/fca.html