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slides of pharmacolgy ... introduction of Diclofen drug and its MOH and adverse reaction etc

Veröffentlicht in: Gesundheit & Medizin
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  2. 2. Introduction of Diclofenac  Diclofenac was first synthesized by Alfred Sallmann and Rudolf Pfister and introduced as Voltaren by Ciba- Geigy (now Novartis) in 1973.  It is a (NSAID) taken or applied to reduce inflammation and as an analgesic reducing pain in certain conditions  . 4/21/2018 2M. AQIB JAVED
  3. 3. Mechanism of action  action is thought to be inhibition of prostaglandin synthesis by inhibition of (COX). It also appears to exhibit bacteriostatic activity by inhibiting bacterial DNA synthesis.  Currently, diclofenac and acetylsalicylic acid are the only NSAIDs to show some antibacterial activity against Gram-negative rods. 4/21/2018 3M. AQIB JAVED
  4. 4. Actions of Dicofenac  nflammatory disorders may include musculoskeletal complaints, especially arthritis, rheumatoid arthritis, polymyositis, dermatomyositis, osteoarthritis, dental pain, temporomandibular joint (TMJ) pain, ankylosing, gout attacks and pain management in cases of kidney stones and gallstones, post-traumatic pain, and is effective against menstrual pain. 4/21/2018 4M. AQIB JAVED
  5. 5. Pharmacokinitics  When given orally the absorption ofdiclofenac is rapid and complete in GIT. Diclofenac binds extensively to plasma albumin.  It is proportional to the dose for oral doses between 25 to 150 mg.  But First Fast Effect greatly effect on it. 4/21/2018 5M. AQIB JAVED
  6. 6. Distribution  distribution diclofenac sodium is 1.4 L/kg. Diclofenac is more than 99% bound to human serum proteins, primarily to albumin. Serum protein binding is achieved with recommended doses. 4/21/2018 6M. AQIB JAVED
  7. 7. Metabolism  Metabolism is manily done by liver.  Excretion:  the excretion of dicofenac is mainly by the urine. 4/21/2018 7M. AQIB JAVED
  8. 8. Side effects  Diclofenac consumption has been associated with significantly increased vascular and coronary risk in a study including coxib, diclofenac, ibuprofen and naproxen. Upper gastrointestinal complications were also reported. Major vascular events were increased by about a third by diclofenac, chiefly due to an increase in major coronary events. 4/21/2018 8M. AQIB JAVED
  9. 9. Con….  Compared with placebo, of 1000 patients allocated to diclofenac for a year, three more had major vascular events, one of which was fatal. Vascular death was increased significantly by diclofenac  Liver: damage occurs infrequently, and is usually reversible.  NSAIDs "are associated with adverse renal (kidney) effects caused by the reduction in synthesis of renal prostaglandins and may be lead to ranal failure. 4/21/2018 9M. AQIB JAVED
  10. 10. Way of addmistration  Voltaren (diclofenac) 50 mg enteric coatedtablets   Arthrotec (diclofenac and miosprostol) 50-mg tablets   Dyloject (diclofenac) 2 ml for IV and IM administration 4/21/2018 10M. AQIB JAVED
  11. 11. Thank you By Muhammad Aqib Javed .. Rise Above Hate 4/21/2018 11M. AQIB JAVED