Expo Day: Bridge Builders Collaborative, American Academy of Clinical Neuropsychology, and Canadian Centre for Aging and Brain Health Innovation

Expo Day: Bridge Builders Collaborative, The American
Academy of Clinical Neuropsychology & The Canadian
Centre for Aging and Brain Health Innovation
SCALEENTREPRENEURSSCIENCE

Sponsors
Expo Day!
8.15am. Charlie Hartwell at The Bridge Builders Collaborative
9am. Dr. Bob Bilder at UCLA
9.30-am. Ron Riesenbach at the Canadian Centre for Aging and Brain
Health Innovation (CC-ABHI)
--10am. Break--
10.30am. Dr. Daniel Perez-Marcos at MindMaze
11am. Alvaro Fernandez at SharpBrains
11.30am. Mark Watson at the Watson Centre for Brain Health
--Noon. Lunch break--
1pm. Franck Tarpin-Bernard at Scientific Brain Training (SBT)
1.30pm. Jessica Poulin at the Arrowsmith Program
Expo Day Agenda

Copyright: 2016 Charlie Hartwell, ShiftIt Institute
The Developing
Mind-Training Industry
Charlie Hartwell, Operating Partner
Bridge Builders Collaborative

Mind-Training is the cognitive capacity to
become aware of how your thoughts impact your
reality, and training your own mind to help create
the conditions for your well-being.
What is Mind Training?

The Evolution of the Movement to Well-Being
30 years ago:
Physical Fitness
SCALEENTREPRENEURSSCIENCE
Today:
Mind–Fitness
(Mind–Training)
Tomorrow:
Fitness
(Well-Being)

Factors Creating Interest in Mind-Training
Technology
Science
Stress
Health Care costs
Brain Fitness Initiative
Mental Health Parity Act
Big Data
Accountable Care Act

Mindfulness is Rigorously Researched, Now Mainstream
8 2 6 7 13 16 18 26 32
53 41
65
115
158
243
272
380
490
542
762
902
0
200
400
600
800
NumberofPublications
Year
Source: Articles in Web of Science TM
Over 4,000 peer-reviewed
articles have appeared in
scientific publications
(half in the past 3 years)

Organizations are engaging in mind-training for various reasons:
Culture
Health Care Costs
Resilience
Innovation
Productivity
Customer
Service
Creativity
Stress Reduction
SafetyTeamwork
Leadership
Recruitment/Retention
Employee Well-Being

It is being adopted in different distributions systems, for different reasons
Medical: Improve health, Better patience experience, Cost
Corporations: Cost, Productivity, Stress
Insurance companies: Customer demand, Cost
Military: Cogitative dominance, Resilience
Education: SEL, Focus, Environment
Government: Early stage
B2C/Retail: Early stage, Mainly trackers, Apps
Sports: Performance, Competitive edge

Mind-training is increasingly being proven to help medical conditions.
Irritable Bowel
Syndrome
Pain Management
Anxiety
Depression
Cardiovascular
disease
Diabetes
ADD/ADHD
Arthritis
PTSD
Cancer
Addictions

How organizations are accessing
Conferences
Apps – Games
In person training
Onsite meditation rooms
Hardware
Virtual RealityRetreats
Live online classes
Other Contemplative Practices

Sports is using Mind-Training as next frontier – some examples
Kevin Love, Eddie George lead Gaiam Yoga
videos
Halo Sports “Neuropriming”
Seattle Seahawks meditating
George Mumford teaching leading teams/athletes to mediate, just launched
Lucid (with Soren G-Wisdom 2.0)
Pro Golfer Andrew Parr uses Muse
(rumor British Open champ does too)
Nike, Reebok, RedBull, Under Armour showing strong interest
US Women’s Beach Volleyball – 3x gold champ meditates
Golden State Warriors values: wisdom, compassion, competitiveness

Successful mind-training companies will either build engaging platforms
or will specifically target high value conditions.
Community
Coaching
Feedback
UX
Content
Examples: Akili, Cansurround, SuperBetter
Prescription
Research
UX
Content
Research
Platforms High Value Conditions
Examples: eMindful, Happify, Headspace, Lumosity

PHYSICAL FITNESS MIND-TRAINING SEGMENTS
Gyms – Fitness Centers
Emotional & Well-Being
B2C
B2B
Training Equipment Brain Training Games
Clothing & Shoes RX Brain Training Games
Wearables Wearables
Videos/Books
Retail
Experiences
Conferences
Market Segments of the Mind-Training Space

State of the Segment
Crowded, 800+ apps, growing, not always a lot of differentiation, lots of media hype
• Estimated 18-45 M Americans meditating.
• Competition based on price, UX,
instructors.
• Cost of acquisition, churn major factors.
• Still relatively small revenue bases – but
some with large valuations
• Headspace est. $220 M valuation
• Has been conversion to stronger
operating teams & outside financing.
• Brands desire to build community
• Leading apps based all over the world –
no central location.
• New entrants trying to capture either
more niche markets or get better
teachers. Recent new apps are for
millenials, sports teams, education
market, etc.
• Some do B2B2C deals – with airlines,
hotels, media, etc.
• Several are working on how to
incorporate with wearables or virtual
reality
Emotional & Mental Well-Being – B2C segment
Headspace Gaiam Meditation Studio
Insight TimerStop, Breathe,
Think
OMG I can
meditate
10% Happier
OmvanaMindfulness App
BuddhifyCalm

Emotional Well-Being – B2B segment
• Google “cool” factor- lots of PR
• Relationship w/ WHIL for digital
• Non-Profit
• Has been in person- for senior execs
• World Economic Forum speakers
• Non-profit – Janice Marturano
• Mainly in-person trainings
• Great global corporate partnerships
• Globally organized
• Non-profit
• 2 RTCs (best science)
• Insurer relationships
• Online live classes
• Behavioral Health Platform
• Converting to B2B
• Raised $9 M 2015
• Focuses on resiliance– early mover
• Customer retention spotty
• In person & digital platform
• CBT w/ coaching
• CBT w/ Coaching

Brain Training Games/Platforms:
• Most developed segment,
several companies at later
stages.
• Larger customer acquisition
budgets.
• Propositions sold on fear
• (in some cases) of cognitive
decline or on benefits of
keeping brain active. Some
focus on performance.
• Significant financing and
acquisitions in this category.
• Lumosity may be first IPO in
mind-training space.
• Controversy around science
of some solutions – Lumosity
fined $2 M. Some companies
appear to have very strong
science.

Emotional & Well Being – B2B segment (continued)
• B2B market is showing growing interest, beginning to
make buying decisions.
• Long sales cycles.
• Currently, some are describing the market as
a “land-grab.”
• Several of the players in the space are
non-profits.
• Competition is based on science, relationships,
engagement, and customer service.
• Pricing is normally PEPM, although some pricing is
shifting to actual engagement.
• Buyers are in Employee Wellness, HR, and Leadership
Development departments.
• Up to this point, there’s not been as much head to head
competition - this is changing.
• Some companies are offering changes in DNA through
hair samples or blood as proof of before/after effects.
• Most companies push the front end of science and
don’t have great back end science.
• Services include such things as in-person, online,
online live…with more people adding community
features and coaching services.
• Terminology is crucial for the sell – it’s important to
fit a solution into the culture of buyers.
• Buyers have many different reasons for engaging in
these solutions.
• The for-profits have attracted quite a bit of early
stage financing.
• There are many small players in this segment doing
coaching, live training.
• Companies are developing their own programs in
some cases – particularly insurers.

RX Brain Training Games
• Some positioned as drug
replacement or enhancement
solutions, seeking FDA
approval
• Companies pursuing FDA are
being looked at/ valued akin to
biotech.
• Science is key underpinning,
w/ randomized control trials
needed and studied for
conditions
• Rich amounts of investment in
RX at large pre-revenue
valuations
• Some companies pursuing
consumer route.

• Various segments and form
factors.
• Crowded field - can be hard to
find points of difference.
• Capital intensive,
manufacturing risk, distribution
& selling risk, need software
solutions.
• Integration happening with
other apps.
• Sometimes software
developed open source by
others.
• Retail has been focused on
fitness wearables, this is new
segment – lots of training.
• Data may turn out to be very
valuable to corporations.
• Research being done using for
treating medical conditions.
Wearables Segment
SENSELabs
VR EEG Sensors in Strips HRV Bracelets Rings Holdables

• Retail segment beginning to grow, and major retailers beginning to put
mind training on the shelves.
• Several groups have looked at building national meditation studios or
brain fitness retail outlets (none is yet past one location/city).
• Conferences are continuing to grow audiences, more conferences
forming.
Other
Retail Experiences Conferences
The Path

The Mind-training industry is organizing itself geographically
San Francisco
Tel Aviv
New York
London
Austin, TX
Sydney
Helsinki
Singapore
Seattle
Other CentersMajor Centers
Boston
Boulder
Toronto

A reflection as mind-training grows:
According to IHRSA, the physical fitness industry
grew from $20.3 B in 2010 to $24.2 B in 2014…
...And the state of health in America
has never been worse
“Mindfulness is quickly following yoga in
becoming a billion-dollar industry.”
- Emma Seppälä – HBR, Dec 14, 2015
... How do we not repeat pattern
of physical fitness?

One View of How it all Fits Together for Cognitive Fitness
Source: TheSharpBrains Guide to Brain Fitness: How to Optimize Brain Health and Performance at Any Age

“Problems cannot be solved at the same level of
awareness that created them.”
Albert Einstein

Mindfulness
Self-Awareness
Understanding
Human Conditioning
Behavior Change
Changing
Stories
Impacting
Greater GoodCurrent
Industry
To improve well-being, society needs to build further bridges in mind-training.

The road to awareness & well-being isn’t a straight path.
Gateway Drugs
Current
Industry
Source: Mindfulness to meaning theory: Garland, Farb, Goldin, Fredrickson

Caring for the
body
Tending the
mind &
emotions
Having
meaningful
relationships/co
mmunity
Knowing your
purpose
Impacting the
greater good
A framework for well-being

To invest in scalable enterprises that help people
connect more deeply to themselves, so they can
lead happier, healthier lives.
We consider mind-fitness and brain-fitness to be
part of an overall umbrella which we classify as
mind-training.
Bridge Builder’s Collaborative Mission

Jeff Walker
Finance
Scott Beck
Retail / Internet
Austin Hearst
Media
Scott Kriens
Technology
Charlie Hartwell
Marketing
/Innovation
Bridge Builders Collaborative Partners
Eric Brooks
Trading/Decision Making

Bridge Builders Value Add – Serving the Entire Mind-Training Industry
Industry
Knowledge
Investments
Connections
Business
Experience
Capital
Engagement
Platform
(gloo)
Physical
Location –
1440
Multiversity
BB Partners
BB Mission

Platform Investment & Partner
How We Evaluate Opportunities
Scalable for-profits
Minimum $1 M revenue
Strong point of difference
Integrated, Seasoned management
Clear need & path in distribution channel
Collaborative leaders
Willing to receive our value add
Path to cash-flow that we can believe in

Technological breakthroughs are creating enormous potential for the future of
neuropsychology and triggering opportunities to create novel strategies for both
assessment and intervention. Cognitive fitness is growing into a multi-billion dollar
industry. Targets have shifted from diagnosis and treatment of established diseases to
early intervention, prevention, and cognitive enhancement. Ubiquitous mobile devices
enable both active and passive sensing of our cognitive and emotional states, and “the
Internet of things” promises to offer both assessment and intervention strategies
previously unimaginable (“...my car/clock/refrigerator does that...”). In keeping with this
trend, the AACN seeks to stimulate innovations capable of changing the landscape of
clinical neuropsychology in fundamental ways.

The pitch ideas need to focus on neuropsychological assessment
and/or intervention, prevention, or improvement of cognitive functions,
and be accessible to broad populations across the United States or the
World. Applications are being accepted in two categories:
• Shoot for the Stars: Unleash your wildest ideas. Change the world.
Transform the practice of clinical neuropsychology. Timeframe: 5 to 10
years.
• Push Current Boundaries: Given current practices for assessment
and treatment or prevention, what is the next logical step to transform
neuropsychology? How can you bring new technologies to enhance the
existing state-of-the-art? Timeframe: 1 to 2 years.

•
•
•
•
•
•
•
•

• WWW.THEAACN.ORG
RBILDER@MEDNET.UCLA.EDU
•
•

45CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION
PRESENTED TO
Sharp Brains Virtual Summit
December 8, 2016 Ron Riesenbach
VP Innovation & CTO
CC-ABHI:
A Solution Accelerator for
Aging and Brain Health

BAYCREST
472 bed long term care home
300 bed complex continuing care hospital
192 suite assisted living facility
120 suite independent living facility
400+ ambulatory clinic visits / day

GLOBAL LEADERSHIP IN
• Geriatric care
• Seniors’ residential living
• Education of future
healthcare professionals
• Research and innovation

Memory & Aging
Executive Function
Cognitive Rehab
Audition and Language
Imaging and Informatics
BAYCREST RESEARCH FOCUS

RESEARCH AT BAYCREST
• The Rotman Research Institute (RRI) is a
premier centre for the study of human
brain function
• 250 researchers with approximately 25 PIs
who hold academic appointments at the
University of Toronto and other partner
universities
• RRI is a world recognized centre for
memory and executive function of the brain

Research Impact
• Top 8% in citation counts (normalized for size)
• Top 7% in most highly-cited papers in the field
• Top 2% in papers in top-tier journals
• Top 6% in publications cited in patents
BAYCREST RESEARCH WORLD RANKING
source: SCIMAGO Institutional Rankings - World-wide ranking in 2014 among 5000 institutes

FUNDING = $124 M
5 Years of Support:
• $42M Government of Canada
• $23.5M Government of Ontario
• $33.1M Industry & Public Sector
• $25M Donors

VISION
A world in which people can age
in the setting of their choice,
maintaining their cognitive,
emotional and physical well-
being, and independence as long
as possible.

MISSION
Accelerate the development of solutions
to meet the urgent needs of an aging
population
Evaluate innovative interventions in
real-world settings
Drive adoption of proven products,
services and processes to patients,
caregivers, researchers, policy-makers
and industry

DEVELOP
Innovative
Solutions
DISSEMINATE
Knowledge and
Best Practices
TEST
Products in
Real-World
Settings
CC-
ABHI
MISSION AREAS

58CANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATIONCANADIAN CENTRE FOR AGING & BRAIN HEALTH INNOVATION
Early Idea
Early
Product or Service
Developed
Product or Service
Proven
Product or Service
Scalable Product
or Service
Proof of Concept
or Prototype
User validated
Product or Service
Developed
Product or Service
Market Ready Innovations
for Knowledge Mobilization
Broad Adoption
Seed Fund Development Validation Mobilization
INNOVATION PIPELINE
58

Challenge Challenge Short Description
Reduce
Emergency
Depart. Visits
Solutions that avoid or reduce unnecessary
emergency department visits for older adults living
with dementia.
Falls Prevention
Solutions that prevent falls or mitigate injury due to
falls in older adults with dementia.
Aging at Home
Solutions for better management of complex
chronic conditions for older adults with dementia at
home.
Cognitive Fitness
Solutions that improve brain health / cognitive
fitness in older adults.
2016/17 Challenge sets
59

GAP #1: INNOVATION AT
THE POINT OF CARE
• Front-line seniors’ care staff include
RNs, personal support workers,
occupational therapists, social workers,
case mgrs., etc.
• They have little opportunity to innovate;
they are told to follow “Best Practices”
• CC-ABHI SPARK program provides up
to $50K to enable front-line health workers to experiment and invent
new ways to deliver care, provide better access or save money

EXAMPLE: SENSORY OBSERVATION
SYSTEM
• SOS is a mobile app designed to replace
and enhance pocket cards used by
personal support workers to monitor for
acute exacerbations in client conditions
• Designed by a Registered Nurse at
Baycrest, a software development
company was employed to rapidly
prototype the app so that real-world
assessment could be undertaken
• The SOS app is now going through it’s third design iteration prior to
being widely deployed

GAP #2: LACK OF SCIENTIFIC EVIDENCE
• Numerous commercial innovations are
entering the marketplace which target
aging and brain health consumers and
professionals
• However, few have objective scientific
evidence showing that they significantly
impact outcomes or address the real
problems in the sector
• CC-ABHI’s Industry Innovation Partnership Program (I2P2)
supports trial-sites with up to $600K to evaluate products and
services providing companies with objective feedback as to the
real efficacy of their innovation

EXAMPLE: Cogniciti.com
• One of the few scientifically
validated on-line brain health
assessments available today
• Offered to the public as a free,
private, and clinically validated
test, backed by Baycrest
• CC-ABHI supported several scientific assessments of
validity against gold-standard face-to-face tests

EXAMPLE: CC-ABHI <> ISRAEL COLLABORATION
• CC-ABHI has partnered with the Israel
Innovation Authority (IIA) to support
Israeli innovators to bring their
products/services to N.A. for
evaluation and refinement
• Funding support from IIA and
CC-ABHI can be $500K or higher
• First competition nearly complete – work to begin in the spring
of 2017

• Researchers around the world are
developing promising new innovations
in their labs
• However, it often takes years for
promising solutions to reach seniors-care
clinicians at the bedside who could use
these innovations
• CC-ABHI’s Clinician and Scientist Partnership Program (CSPP)
supports direct partnership between academic researchers and
practicing clinicians with up to $600K to accelerate promising solutions to
the bedside
GAP #3: SLOW DIFFUSION OF PROMISING
SCIENCE TO CLINICAL TEAMS

• Years of research and clinical practice
have generate a large body of
knowledge detailing the best methods
of care
• However, people change slowly. It is
difficult for end-users to adopt and
use proven practices
• CC-ABHI’s Knowledge Mobilization (KM) program uses advanced
educational approaches to engage learners and support them in their
work practice to ensure the effective adoption of knowledge and its
translation to practice
GAP #4: MOBILIZING KNOWLEDGE AND
DRIVING ADOPTION

EXAMPLE: INTERNATIONAL TELEHEALTH
EDUCATION
• International partnerships with 28
countries worldwide
• Collaborative programming model
invites knowledge transfer with an
international perspective, creating a
greater wealth of experience
• Videoconference and webinar series:
 Behavioural Neurology Rounds  Rotman Research Institute Scientific Rounds
 International Behavioural Neurology Rounds  Geriatric Mental Health Rounds
 Behavioural Support Rounds  Greater Toronto Area Leaders Group Series
 NIRVE (Neurology Residents Rounds)  Aphasia Interest Group Series
 Geriatric Medicine Rounds  Visiting Professor Series

SPARK
Supporting proof of concept
activities for small-scale,
grass-roots innovation by
point-of-care workers.
• Up to $50,000 per project.
• Program Launch: September 2016.
i2p2
Supporting innovation validation
projects led by commercial partners.
• Up to $600,000 per project
• •Program Launch: October 2016
Knowledge Mobilization
Supporting knowledge-transfer
projects by eligible educators
for dissemination of scientifically
validated technology innovations
and best practices.
• Program Launch: January 2017.
CSPP
Supporting cross-disciplinary,
multi-organizational collaboration
projects for innovations at an
advanced stage of development.
• Program Launch: January 2017.
CC-ABHI
FUNDING PROGRAMS
*Terms subject to change
CC-ABHI PROGRAMS
68

SUMMARY
• Our demographic challenge presents us
with a significant opportunity to innovate
• CC-ABHI is working to close the
innovation gaps and accelerate solutions
in aging and brain health
• Come work with us! Go to CC-ABHI.com
and sign yourself up for new program
alerts

70
Thank you
Ron Riesenbach
rriesenbach@Baycrest.org

Q&A

Thank you to all Participants!

Sponsors
Thank you to all Speakers & Sponsors!

To learn more, visit sharpbrains.com

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