3. Alternatively fax your registration to +44 (0)870 9090 712 or call +44 (0)870 9090 711
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08.30 Registration & Coffee
09.00 Chairmanās Opening Remarks
Lutz Jermutus,
Senior Director and Product Development Team Leader,
MedImmune
HALF-LIFE EXTENSION OF PEPTIDES
OPENING ADDRESS:
09.10 Recent Progress in the Development of Once-Weekly GLP-1
Receptor Agonists
ā¢Strategies for half-life extension
ā¢Established products in the GLP-1 ļ¬eld
ā¢Emerging technologies, including own data
Dieter Kadereit, Lab Head, Peptides & Insulins, IDD, R&D, Sanoļ¬
09.50 Extending Drug Half-Life to Achieve Monthly Dosing? The Potential
of VeltisĀ® Engineered Albumins for Optimised Dosing
ā¢Short circulatory half-life represents a major obstacle for many
peptide-based therapeutics
ā¢This can be signiļ¬cantly improved by conjugation or fusion to
albumin, due to increased size and recycling via the neonatal
Fc receptor (FcRn)
ā¢The increased FcRn afļ¬nity of the VeltisĀ® engineered albumins
translates to more than doubling of the already long half-life of
native sequence albumin
ā¢We will describe rationally engineered albumins and their
application to improve delivery of peptides
Joanna Hay, Science Manager, Albumedix
10.30 Morning Coffee & Networking Break
11.00 From challenging peptide to drug candidate
ā the dasiglucagon story
ā¢Learnings from native glucagon
ā¢ Optimisation of soluble and chemically stable glucagon analogs
ā¢Clinical summary
Marie Skovgaard, Director Medicinal Chemistry, Zealand Pharma
IMPROVING FUTURE PEPTIDE DEVELOPMENT
11.40 Peptides in the biopharmaceutical industry today and tomorrow
ā¢Small versus big molecules ā beneļ¬ts and differences in
development & manufacturing of peptides
ā¢Industrial pipelines and disease areas addressed by biotherapies
ā¢NBEs versus NCEs
ā¢Future trends in manufacturing
Frank Thielmann, PMO & Operational Excellence Lead, Novartis
12.20 Networking Lunch
13.30 Conquering a peptide optimisation challenge using protein
engineering techniques and deliberate potency reduction
ā¢Challenge: Optimising gp41-binding peptide to be a
component of a tri-functional therapeutic
ā¢Generated libraries of variant peptides fused to a globular
protein, expressed and puriļ¬ed in E. coli
ā¢Reduced the potency of the parental peptide via truncation,
to allow favourable mutations to be recognised
ā¢Final peptide became part of a tri-speciļ¬c biologic therapeutic
with picomolar potency and broad spectrum against HIV
Jonathan Davis, Principal Scientist, Bristol-Myers Squibb
14.10 Optimisation of peptide stability
ā¢Physical and chemical stability
ā¢Methods for determination of physical and chemical stability
ā¢Optimisation of peptide stability
Martin Will, Section Head MedChem, Sanoļ¬
14.50 ReadyFlow - a ļ¬rst in class coagulant for controlling surgical
bleeding
ā¢Unmet needs in the control of surgical bleeding and key factors
to determine success
ā¢HX-P12 peptide: a ļ¬rst in class peptide coagulant
ā¢Design of a particulate hydrogel formulation
ā¢Current ReadyFlow formulation; challenges and progress
Renata Zbozien, Vice President R&D, Haemostatix
15.30 Afternoon Tea & Networking Break
MASS SPECTROMETRY APPLICATIONS AND
CHROMATOGRAPHY STRATEGIES
16.00 The use of high resolution mass spectrometry applications for both
development and commercial peptides
ā¢Mass Spectrometry of peptides that involve ligation
technologies
ā¢Mass Spectrometry for conļ¬rming the removal of solid phase
coupling reagents
ā¢Mass Spectrometry for impurity identiļ¬cation in life cycle
management activities
Marion King, Analytical Development Manager, Ipsen
16.40 Puriļ¬cation, Characterisation and Physicochemical Properties
of Peptides within Discovery Chemistry
ā¢Chromatographic puriļ¬cation strategies for cyclic and linear
peptides including SFC, LC and Flash methodologies
ā¢Stoichiometry of ļ¬nal salt forms using Ion Chromatography
ā¢Extraction strategy to remove TFA from ļ¬nal products
ā¢Physicochemical Trend Analysis on ļ¬nal products
John Reilly, Senior Research Investigator,
Novartis Institutes for BioMedical Research
17.20 Chairmanās Closing Remarks and Close of Day Two
Peptides
www.peptidesevent.com Day Two | Friday 7th July 2017
4. Oral Delivery of Peptides and Proteins
Overview of the workshop:
Topics covered will include:
ā¢ Overview of routes across the intestinal cell wall
ā¢ Encapsulation technologies for peptides and proteins
ā¢ Research and development of absorption enhancement
technologies
ā¢ Application to peptide hormones and vaccine antigens ā
case studies
Why should you attend this workshop:
An increasing number of therapeutic agents are being
developed which are based on peptides, usually made by
recombinant means. A drawback to their widespread use
is their sensitivity to breakdown in the gut, and the barrier to
crossing the intestinal cell wall, imposed by the size of these
molecules. Oral delivery is consequently a problem. Anybody
interested in developing new peptide-based therapeutics
should attend this workshop to ļ¬nd out the latest technologies
being developed, which, after a thirty-year gestation period,
are now beginning to yield successful outcomes.
Programme
08.30 Registration & Coffee
09.00 Opening Remarks
09.10 Session 1 ā Overview of routes across the
intestinal cell wall
Transport via lymphatics or portal vein
09.50 Session 2 ā Encapsulation technologies for
peptides and proteins
Liposomes, polymeric nanoparticles, SLNPs,
oil emulsions
10.30 Morning Coffee
11.00 Session 3 ā Basic research on absorption
enhancement technologies
Comparison of different absorption enhancers
11.40 Session 4 ā Case Studies with peptide hormones
and vaccine antigens
Preclinical and clinical trial results from around
the world
12.20 Closing Remarks
12.30 Close of Workshop
About the workshop leader:
Roger New studied chemistry at Oxford and obtained
a PhD in immunology at St Maryās Hospital, London,
before going to work in Liverpool for 14 years, ļ¬rst at
the Department of Biochemistry, then at the School
of Tropical Medicine and Hygiene. His research activities have
centred on the creation of new technologies to improve the
therapy of disease, during which time he has devised patented
approaches to oral peptide delivery, vaccine carrier systems,
and a technology for discovery of new therapeutics. He has
acted as expert advisor in numerous institutions at home and
overseas, has written a textbook on liposomes, and is honorary
lecturer in Pharmaceutics at Kings College London. Dr Newās
laboratory was the ļ¬rst to demonstrate the in vivo efļ¬cacy of
liposomal amphotericin in leishmaniasis, a product which has
now been commercialised for over ten years. He went into
industry twenty years ago, ļ¬rst in Biocompatibles Ltd, then
Cortecs, and is currently Co-founder and Executive Director
of the biotech R&D company Proxima Concepts Ltd, with
laboratories based in London. Development of the peptide
delivery technology invented by Dr New has resulted in a
product for oral administration of insulin, now in Phase II clinical
trials, and licensed to large pharma in an emerging market.
About the organisation:
Proxima Concepts was founded in 2000, and
has devised four new technologies which it is
exploiting in the biopharmaceutics area:
1. Axcess ā a vehicle for oral delivery of peptides and proteins,
including oral insulin in Phase II
2. Vaxcineāanoil-baseddeliveryvehiclefororaladministration
of vaccine antigens, with particular application to intestinal
and respiratory diseases.
3. Mozaic ā a discovery technology for identifying building
blocks which, in combination, can form therapeutically
active structures.
4. Lexicon ā A cyclic peptide scaffold designed to maximise
interactions with peptide cell receptors.
Workshop Leaders:
Roger New, Co-founder & CSO, Proxima Concepts Ltd
and Driton Vllasaliu, Senior Lecturer, University of Lincoln
HALF-DAY PRE-CONFERENCE WORKSHOP
Wednesday 5th July 2017
08.30 ā 12.30
Holiday Inn Kensington Forum, London, UK
6. PEPTIDES
Conference: Thursday 6th & Friday 7th July 2017, Holiday Inn Kensington Forum, London, UK Workshop: Wednesday 5th July 2017, London, UK
4 WAYS TO REGISTER
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