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By: Alejandro Mazo Ramírez
Universidad Pontificia Bolivariana
Facultad de Medicina. III semestre
Introduction
• Also known as hepatoma,
its the most common
type of primary liver
cancer. It is often
produced in people who
have long-term diseases
or bad habits, such as
hepatitis virus type B or
type C, being a long time
smoker, heavy drinking or
having cirrhosis.
Hepatocellular Carcinoma
Hyperuricemia
Introduction
• Uric acid is the final
product of the purine
catabolism. When its levels
in blood are high enough,
aside from acidifying it, it
may denote other
metabolic syndromes.
• Previous studies have
proved that the serum uric
acid level can increase the
incidence rate and
mortality of malignant
tumors.
Objective
• Finding the mechanism of PDZK1
in hepatocellular carcinoma
complicated with hyperuricemia
Methods
Flow Cytometry Assay RT-PCR Analysis
In this study, single cells are rapidly
analized as they pass through
multiple lasers in a solution
It can determine characteristics of
certain cells or even identify tumor
markers
It is done to see if a certain genetic
sequence is present when the study
is done.
Here they are evaluating the
expression of a protein (PDZK1)
Methods
Western blot assay In Vivo Tumorigenesis
A sample of HCC was taken, and after
some processing it was transplanted
into mices with hiperuricemia. After
sacrificing them a sample of tumor
tissue was taken.
This technique is used to detect a
specific protein in a sample (blood
or tissue are commonly used)
It is used gel electrophoresis to
separate proteins according to their
molecular weight.
Results
Results
Discussion
Author What they said Agree/Disagree
M. Chen, X. Lu, C. Lu et
al [35]
In our study, the mRNA
expression of PDZK1 was
signifcantly increased after HCC
after diferent concentrations of
soluble uric acid treatment
Agree
I. Andia and E. Rubio-
Azpeitia [36]
On the other hand, the
interaction between urate
crystals and immune cells can
enhance immunosuppression
and promote angiogenesis
Agree
S. Vadakedath and V.
Kandi[38–40]
Regulatory PDZK1 expression
can afect the proliferation,
migration, and apoptosis of
HCC; uric acid may cause tumor
immune response. It suggests
that PDZK1 may be related to
tumor immunity
Agree
• With the use of molecular
biology new interactions
between different diseases
are being found, resulting in
new treatments never
thought to be found before
Conclusions
• The understanding of the
different impacts that proteins
have in the organism allow the
emergence of new approachs to
various diseases

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Mechanism of PDZK1 in Hepatocellular Carcinoma Complicated with Hyperuricemia

  • 1. By: Alejandro Mazo Ramírez Universidad Pontificia Bolivariana Facultad de Medicina. III semestre
  • 2. Introduction • Also known as hepatoma, its the most common type of primary liver cancer. It is often produced in people who have long-term diseases or bad habits, such as hepatitis virus type B or type C, being a long time smoker, heavy drinking or having cirrhosis. Hepatocellular Carcinoma
  • 3. Hyperuricemia Introduction • Uric acid is the final product of the purine catabolism. When its levels in blood are high enough, aside from acidifying it, it may denote other metabolic syndromes. • Previous studies have proved that the serum uric acid level can increase the incidence rate and mortality of malignant tumors.
  • 4. Objective • Finding the mechanism of PDZK1 in hepatocellular carcinoma complicated with hyperuricemia
  • 5. Methods Flow Cytometry Assay RT-PCR Analysis In this study, single cells are rapidly analized as they pass through multiple lasers in a solution It can determine characteristics of certain cells or even identify tumor markers It is done to see if a certain genetic sequence is present when the study is done. Here they are evaluating the expression of a protein (PDZK1)
  • 6. Methods Western blot assay In Vivo Tumorigenesis A sample of HCC was taken, and after some processing it was transplanted into mices with hiperuricemia. After sacrificing them a sample of tumor tissue was taken. This technique is used to detect a specific protein in a sample (blood or tissue are commonly used) It is used gel electrophoresis to separate proteins according to their molecular weight.
  • 9. Discussion Author What they said Agree/Disagree M. Chen, X. Lu, C. Lu et al [35] In our study, the mRNA expression of PDZK1 was signifcantly increased after HCC after diferent concentrations of soluble uric acid treatment Agree I. Andia and E. Rubio- Azpeitia [36] On the other hand, the interaction between urate crystals and immune cells can enhance immunosuppression and promote angiogenesis Agree S. Vadakedath and V. Kandi[38–40] Regulatory PDZK1 expression can afect the proliferation, migration, and apoptosis of HCC; uric acid may cause tumor immune response. It suggests that PDZK1 may be related to tumor immunity Agree
  • 10. • With the use of molecular biology new interactions between different diseases are being found, resulting in new treatments never thought to be found before Conclusions • The understanding of the different impacts that proteins have in the organism allow the emergence of new approachs to various diseases