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Developing a shared infrastructure for
personalised health and medicine research:
experience from the Netherlands
Internat...
The Dutch way of collaborating
2 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018
...
30 April 2009 A-STAR biomarker seminar, Singapore
The Dutch way of
collaborating
Collaboration is key to advance in health research
Dutch CC meeting ‘Personalized Health Care”
Ede, 2 October 2013
Alain v...
Collaboration is key to advance in health research
Dutch CC meeting ‘Personalized Health Care”
Ede, 2 October 2013
Alain v...
Money fuels collaboration
Dutch CC meeting ‘Personalized Health Care”
Ede, 2 October 2013
Alain van Gool
Lecture LKCH, UMC...
Highlights discussed today
• Netherlands Genomics Initiative (NGI)
• Public Private Partnerships (TIP, CTMM, BMM)
• Topsec...
Funding large scale Netherlands technological networks
2002-20103
8 Alain van Gool, Int Conf on Perspectives in Precision ...
Funding large public-private partnership programs
(Centre for Translational Molecular Medicine) (Top Institute Pharma)
(Bi...
Funding large public-private partnership programs
(Centre for Translational Molecular Medicine) (Top Institute Pharma)
(Bi...
11 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018
Redefine private interest in P...
Science for Science
Science for Industry
Science for Society
Strategy building
Nico van Meeteren
Email: meeteren@health-ho...
Ambitions
Dutch Delta
Buck Consultatnts international, 2016
Growth
2017 2017
Growth
An ‘aligned’ cluster reaching out
37 applied universities
69 vocational education
institutes
“If ‘I’ is replaced by ‘we’,
...
Redefine private interest in Public-Private Partnerships
{www.rijksoverheid.nl}
{http://www.zonmw.nl/nl/roadmaps-lsh/}
9 T...
DUTCH TECHCENTER FOR LIFE SCIENCES
NL platform enabling cross-disciplinary research
PARTNERSHIP FOR DATA, TECHNOLOGIES & LEARNING
>100 EXPERT GROUPS INVOLVED SO FAR
Nijmegen
Amsterdam
Wageningen
Utrecht
Rotterdam
Eindhoven
Maastricht
Groningen
Leiden
D...
Enabling Technology Hotels
program
www.dtls.nl
www.zonmw.nl
• Explore and use the DTL network
• 4 rounds of funding 30k pr...
FOCUS ON CRITICAL COMPONENT: THE DATA
{Wilkinson et al, Nature Scientific Data, 2016}
 Data capture
 Data stewardship (F...
FAIR EVOLVING RAPIDLY INTO A GLOBAL MOVEMENT
Rapid acceptance and endorsement process
✓ The conference
✓ The Website
✓ Res...
ALSO THE G20 HAS RECENTLY ADOPTED FAIR!
“We support appropriate efforts to promote open science and facilitate
appropriate...
Personal Health Train
26 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018
27 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018
Redefine public needs: Dutch N...
• 12.000 questions from citizens
• Summarized in 140 cluster questions
• Addressed in 16 routes
• Translated into National...
Highlights discussed today
• Netherlands Genomics Initiative (NGI)
• Public Private Partnerships (TIP, CTMM, BMM)
• Topsec...
www.radboudumc.nl
30 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018
Genomics
Bioinformatics
Animal
Research
Facility
Stem
cells
Translational
neuroscience
Image-guided
treatment
Imaging
Micr...
Build biomarker validation pipelines
Standardisation, harmonisation,
knowledge sharing in:
1. Assay development
2. Clinica...
Collaboration towards Good Biomarker Practices
{van Gool et al, Nature Reviews Drug Discovery, Apr 2017}
COST action CA161...
Fund large scale scientific infrastructures
www.nwo.nl
2016:
• Inventory
• Clustering
• Communicating
2017:
• 1st call for...
The Netherlands X-omics Initiative
www.x-omics.nl
2018-2023 ?
35 Alain van Gool, Int Conf on Perspectives in Precision Med...
Further joining forces in Netherlands
To drive personalized medicine & health research
2015
36 Alain van Gool, Int Conf on...
Organize a scattered landscape …
Knowledge institutes
VSNU
Beta
NFU projects
Topinstitutes
CTMM / TraIT
TI Pharma /
Mondri...
Bring together relevant initiatives …
2014
2016
- 2009 200 biobanks
38 Alain van Gool, Int Conf on Perspectives in Precisi...
Nationwide community in personalized healthcare
www.health-ri.org
39 Alain van Gool, Int Conf on Perspectives in Precision...
1-3-2018 40
Towards life-spanning personalized health and medicine
research
Source: Nico van Meeteren, Health~Holland
41 Alain van Goo...
The ‘funhouse mirror’ effect in Precision Medicine
• Multiple sources of
your data
• EPD
• Diagnostics
• Wearables
• Healt...
Acknowledgements
Hans Wessels Jolein Gloerich
Roel Tans Esther Willems
Maurice van Dael Jenneke Keizer
Dirk Lefeber Moniqu...
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2018 03-01 International Conference on Perspectives in Precision Medicine, Copenhagen, Alain van Gool

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This keynote lecture reviews the historical and ongoing investments in public-private partnerships related to precision medicine and the related technological infrastructures. It served as example to the Danish community how translational biomarkers in precision medicine can be organised, as basis for further collaboration between Denmark and Netherlands.

Veröffentlicht in: Gesundheit & Medizin
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2018 03-01 International Conference on Perspectives in Precision Medicine, Copenhagen, Alain van Gool

  1. 1. Developing a shared infrastructure for personalised health and medicine research: experience from the Netherlands International Conference on Perspectives in Precision Medicine Copenhagen, 1 March 2018 Prof Alain van Gool
  2. 2. The Dutch way of collaborating 2 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018 Source: www.waterschappen.nl Source: www.leestekensvanhetlandschap.nl Source: http://www.deltawerken.com
  3. 3. 30 April 2009 A-STAR biomarker seminar, Singapore The Dutch way of collaborating
  4. 4. Collaboration is key to advance in health research Dutch CC meeting ‘Personalized Health Care” Ede, 2 October 2013 Alain van Gool Lecture LKCH, UMC Utrecht 29 October 2013 Alain van Gool Knowledge validation & application Knowledge translation Knowledge exploitation Fundamental knowledge Universities IndustryUniversity medical centers Applied Research Institutes 4 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018
  5. 5. Collaboration is key to advance in health research Dutch CC meeting ‘Personalized Health Care” Ede, 2 October 2013 Alain van Gool Lecture LKCH, UMC Utrecht 29 October 2013 Alain van Gool Knowledge validation & application Knowledge translation Knowledge exploitation Fundamental knowledge Universities IndustryUniversity medical centers Applied Research Institutes 5 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018
  6. 6. Money fuels collaboration Dutch CC meeting ‘Personalized Health Care” Ede, 2 October 2013 Alain van Gool Lecture LKCH, UMC Utrecht 29 October 2013 Alain van Gool 6 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018
  7. 7. Highlights discussed today • Netherlands Genomics Initiative (NGI) • Public Private Partnerships (TIP, CTMM, BMM) • Topsector Life Science Health (Health~Holland) • Dutch Techcenter for Life Sciences (DTL) • Dutch National Research Agenda (NWA) • Radboudumc Technology Centers (RTC) • Large scale technology Infrastructures (X-omics) • Dutch infrastructure for personalized medicine and health research (Health-RI) 7 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018
  8. 8. Funding large scale Netherlands technological networks 2002-20103 8 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018
  9. 9. Funding large public-private partnership programs (Centre for Translational Molecular Medicine) (Top Institute Pharma) (BioMolecular Materials) 2006-2015 9 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018
  10. 10. Funding large public-private partnership programs (Centre for Translational Molecular Medicine) (Top Institute Pharma) (BioMolecular Materials) 2006-2015 Outcome: 1. Results (drugs, diagnostics, devices) 2. Culture change in Netherlands 10 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018
  11. 11. 11 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018 Redefine private interest in Public-Private Partnerships {www.rijksoverheid.nl} {http://www.zonmw.nl/nl/roadmaps-lsh/} Roadmap Molecular Diagnostics: • Build an efficient biomarker development pipeline in Netherlands • Bring all stakeholders together in a functional open innovation network based on public-private-partnerships • Have end-users (patients) direct biomarker discovery in beginning • Improve progress of biomarkers from discovery to clinical implementation 9 TopSectors Multiple Roadmap teams per TopSector 2011-2012
  12. 12. Science for Science Science for Industry Science for Society Strategy building Nico van Meeteren Email: meeteren@health-holland.com
  13. 13. Ambitions
  14. 14. Dutch Delta Buck Consultatnts international, 2016
  15. 15. Growth 2017 2017
  16. 16. Growth
  17. 17. An ‘aligned’ cluster reaching out 37 applied universities 69 vocational education institutes “If ‘I’ is replaced by ‘we’, even illness turns into wellness”
  18. 18. Redefine private interest in Public-Private Partnerships {www.rijksoverheid.nl} {http://www.zonmw.nl/nl/roadmaps-lsh/} 9 TopSectors Multiple Roadmap teams per TopSector 2011-2012 18 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018
  19. 19. DUTCH TECHCENTER FOR LIFE SCIENCES NL platform enabling cross-disciplinary research
  20. 20. PARTNERSHIP FOR DATA, TECHNOLOGIES & LEARNING
  21. 21. >100 EXPERT GROUPS INVOLVED SO FAR Nijmegen Amsterdam Wageningen Utrecht Rotterdam Eindhoven Maastricht Groningen Leiden Delft Enschede Zeist Hanze University University Groningen UMCG Hubrecht Institute UMCU Utrecht University Wageningen UR PRI TU Twente Radboudumc Radboud University Maastricht Univ. MUMC+ CTMM TUe ErasmusMC Generade LUMC Leiden University Naturalis TUDelft AMC AMOLF CWI NLeSC NKI SURFSARA University of Amsterdam VU University Amsterdam VUMC TNO 20 17 44 13 1 15 6 4 5 1 9 Technology & data hotels  Access to high-tech expertise & facilities  Wetlab & data facilities  Collections of biosamples/cohorts  Public and private labs  Training & education High-quality  experimental design  measuring  data stewardship 21 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018
  22. 22. Enabling Technology Hotels program www.dtls.nl www.zonmw.nl • Explore and use the DTL network • 4 rounds of funding 30k projects • Total 4,2M euro • 5 page proposals • 50% success rate 22 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018
  23. 23. FOCUS ON CRITICAL COMPONENT: THE DATA {Wilkinson et al, Nature Scientific Data, 2016}  Data capture  Data stewardship (FAIR) 23 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018
  24. 24. FAIR EVOLVING RAPIDLY INTO A GLOBAL MOVEMENT Rapid acceptance and endorsement process ✓ The conference ✓ The Website ✓ Research Data Alliance endorsement ✓ DTL flagship project ✓ FORCE11 international partner ✓ Articles accepted in NATURE ✓ NIH accepts FAIR compliance in Life Sciences Commons ✓ DTL Data lead Prof. Barend Mons Chair High Level Expert Group EC ✓ The Personal Health Train Initiative started ✓ EC announces European Open Science Cloud with FAIR as leading principle World 2017 24 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018
  25. 25. ALSO THE G20 HAS RECENTLY ADOPTED FAIR! “We support appropriate efforts to promote open science and facilitate appropriate access to publicly funded research results on findable, accessible, interoperable and reusable (FAIR) principles.” (Statement 12) http://europa.eu/rapid/press-release_STATEMENT-16-2967_en.htm 25 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018
  26. 26. Personal Health Train 26 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018
  27. 27. 27 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018 Redefine public needs: Dutch National Research Agenda 2ND intl Pharma-Nutrition Conference Singapore, 17 April 2013 Alain van Gool Lecture LKCH, UMC Utrecht 29 October 2013 Alain van Gool https://wetenschapsagenda.nl/?lang=en 2016
  28. 28. • 12.000 questions from citizens • Summarized in 140 cluster questions • Addressed in 16 routes • Translated into National Research Agenda • Presented to government
  29. 29. Highlights discussed today • Netherlands Genomics Initiative (NGI) • Public Private Partnerships (TIP, CTMM, BMM) • Topsector Life Science Health (Health~Holland) • Dutch Techcenter for Life Sciences (DTL) • Dutch National Research Agenda (NWA) • Radboudumc Technology Centers (RTC) • Large scale technology Infrastructures (X-omics) • Dutch infrastructure for personalized medicine and health research (Health-RI) 29 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018
  30. 30. www.radboudumc.nl 30 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018
  31. 31. Genomics Bioinformatics Animal Research Facility Stem cells Translational neuroscience Image-guided treatment Imaging Microscopy Biobank Health economics Mass Spectrometry Radboudumc Technology Centers Investigational products Clinical studies Health Data Biostatistics Human performance Data stewardship Molecule Flow cytometry 3D lab 100+ technology experts working in 19 Technology Centers, ~1800 users (internal, external), ~150 consortia www.radboudumc.nl/research/technologycenters 31
  32. 32. Build biomarker validation pipelines Standardisation, harmonisation, knowledge sharing in: 1. Assay development 2. Clinical validation www.biomarkerdevelopmentcenter.nl Rainer Bischoff Theo Luider, Alain van Gool and 32 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018
  33. 33. Collaboration towards Good Biomarker Practices {van Gool et al, Nature Reviews Drug Discovery, Apr 2017} COST action CA16113 http://clinimark.eu 33 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018
  34. 34. Fund large scale scientific infrastructures www.nwo.nl 2016: • Inventory • Clustering • Communicating 2017: • 1st call for proposals (100M) 2018: • Funding 2019: • 2nd call for proposals (100M) 34 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018
  35. 35. The Netherlands X-omics Initiative www.x-omics.nl 2018-2023 ? 35 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018
  36. 36. Further joining forces in Netherlands To drive personalized medicine & health research 2015 36 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018
  37. 37. Organize a scattered landscape … Knowledge institutes VSNU Beta NFU projects Topinstitutes CTMM / TraIT TI Pharma / Mondriaan NL Roadmap largescale research infrastructure/ ESFRI EATRIS- NL/EATRIS DTL/ELIXIR- NL/ELIXIR BBMRI-NL / BBMRI - /ECRIN NeCEN/ INSTRUCT PSI/Life Lines Funding other than ESFRI ZonMW Various charities BioImagingNL/Bioi maging IMI RIVM private institutes NKI Sanquin Top-sectors Ministeries OC&W International community Many different parties BMM Sector/cross-sector platforms Health~Holland NGI/NBIC Registratie aan de Bron Platform Clinical Research Horizon 2020 NWO eScience Center NFU UU LU VU UvA 3TU RUG UM VWS DTLBMS.NL Partners in PPP CRO’s Standardisation institutes NEN NICTIZ Pharma MKB / Spin off Patient organisations Various patient organisations Hospitals Diverse andere ziekenhuizen Suppliers EPD’s suppliers IT companies (IBM, Oracle, SAS etc.) Largescale devices (Philips e.a.) SURF/VANCIS TNO EZ Hubrecht Institute UMC Utrecht LUMC VUmc AMC RadboudMC ErasmusMC UMCG MUMC Radboud KNAW (overig) CBS 37 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018
  38. 38. Bring together relevant initiatives … 2014 2016 - 2009 200 biobanks 38 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018
  39. 39. Nationwide community in personalized healthcare www.health-ri.org 39 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018
  40. 40. 1-3-2018 40
  41. 41. Towards life-spanning personalized health and medicine research Source: Nico van Meeteren, Health~Holland 41 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018
  42. 42. The ‘funhouse mirror’ effect in Precision Medicine • Multiple sources of your data • EPD • Diagnostics • Wearables • Health apps • Commercial health tests • Social media • Surrounding • Each give an (incomplete) image of you • Some you want to see, some you don’t • Not technical issue • Ethical, philosophical 42 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018
  43. 43. Acknowledgements Hans Wessels Jolein Gloerich Roel Tans Esther Willems Maurice van Dael Jenneke Keizer Dirk Lefeber Monique van Scherpenzeel Leo Kluijtmans Ron Wevers Marcel Verbeek Karlien Coene Jan Kremer Bas Bloem Lucien Engelen Paul Smits the Radboudumc Technology Centers and many others Jan van der Greef Ben van Ommen Ivana Bobeldijk Hans Princen Lars Verschuren Marjan van Erk Suzan Wopereis Heleen Wortelboer Wessel Kraaij Jildau Bouwman Peter van Dijken and many others Ruben Kok Barend Mons Jaap Heringa Merlijn van Rijswijk and many others Anton Ussi Florence Bietrix Laura Bermejo Andreas Scherer Sulev Koks Marian Hajduch Toni Andreu and many others Collaborators/funders CarTarDis alain.vangool@radboudumc.nl www.linkedIn.com www.slideshare.net/alainvangool 43 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018

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