1. SEMINAR ON
JYOTISHMATI TAILA
Dr.Akshata Swamy
III pg scholar
Dept. of RS&BK
Dr.Shankhargowda
Prof .& HOD (UG)
Dept. of RS & BK
Dr.M.S.Doddamani
Prof. & HOD (PG)
Dept. of RS & BK
2. Introduction
Historical review
Modern review
Ayurvedic properties
Method of prepartion
Karma vivechana
Preparation of jyotishmati taila
Standardisation of Jyotishmati taila
Conclusion
Research works
Dissertation work
Market prepartions
3. INTRODUCTION :
• Jyotismati sneha is a Sirovirecana dravya.' Maximum
references have been traced from sushruta samhita and
Astanga Hrdaya than any other samhitas.
• Nighantus were the first, who critically observed the
'Medhya‘ effect of Jyotismati which was not mentioned
previously by any Granthakaras.
• Jyotishmati is commonly called maalakaangni in India. It
is also known by its synonyms like katabhi, kanguni,
paravatpadi etc.
4. VEDIC PERIOD : (1500-6000 B.C.)
In vedic literature there is no description or reference
regarding the Jyotishmati taila.
SAMHITA PERIOD :
Charaka samhita (2-3 B.C ) :
Used jyotishmati as whole drug not taila
5. Sushruta samhita (2nd B.C ) :
• In Udarachikitsa Jyotishmati phala taila is mentioned
(Su.Ci.14/115)
• Jyotishmati sneha as Shirovirechana dravya explained (Su.Ci
31/5)
• The properties of jyotishmati phala taila are tikshna and laghu
in digestion, katu rasa, katu vipaka, ushna virya and mridu
virechaka and it is useful in the treatment of Kapha roga , Krimi,
Kustha, Prameha and diseases of the head.
Sangraha kala
Astanga Hrudaya (7th cent AD) :
• In Arkadi varga ,mentioned as Pita taila (A.H.Su 15/28) used in
the treatment of Kapha ,Kushta and Visaroga .
•
6. • Nighantu period :
In the era of nighantu Jyotishmati critically observed as
Medhya drug.
• Raja Nighantu :
He mentioned in Guduchhyadi varga , named Jyotishmati
taila as Atitikta
• Shaligrama nighantu :
He mentioned Jyotishmati taila with synonyms of Putitaila
and Pita taila .
• Nighantu Ratnakara :
He mentioned Jyotishmati under Taila varga ,explained 18
different preparations .Smritisagara taila ,Laghu visagarbha
taila etc .
7. Rasa granthas :
Rasa ratna samucchaya :
• Jyotishmati taila mentioned in Taila varga.(R.R.S 10/73).
• Jyotishmati mentioned in Jalauka bandha (R.R.S 11 /93 ).
• Rajata shodhana jyotishmati taila is mentioned .
• In Vajra marana ,Jyotishmati taila is mentioned .
• Ashtamasika rasayana
• Sahasra varshayu rasayana
• Sashtyadhika trinshat Varsayushkara Rasayana (R.R.S 26 / 22)
• Jyotismati Taila in 'Svitra cikitsa' which is also effective clinically
Bhaishajya ratnavali :
Indra bramhivati ,malakangani taila as mardana dravya
8. Modern review :
The Indian materia medica : (Dr. K.M. Nadkarni - 1954)
Dr. K.M. Nadkani in his book has given the description of Jyotismati.
He has described the oil as stimulant and nervine tonic. The decoction of seeds
with or without the addition of aromatics is given in rheumatism, gout, paralysis
and leprosy . Oil is used as pomade for relieving rheumatic pains of a malarious
character and in paralysis.
Indian Medicinal Plants : (Kirtikar and Basu 1933)
The morphology of the plant has been given elaborately. The leaves are
mentioned as emmenagogue. The seeds are believed to be hot and dry,
aphrodisiac and stimulant, useful both as an external and internal remedy in
rheumatism, gout, paralysis, leprosy and other disorders which are supposed to
be caused by cold humours. In the Konkan 4 tolas of the leaf juice is given .
9. Jyotishmati taila :
1)Ref.Yogaratnakara.kushta chikitsa ,AFI
Ingredients :
1 ) Mayuraka (Apamarga )kshara jala -5.376 g
2 ) Jyotishmati taila – 768 g
Special method of preparation :
Mayuraka kshara jala of 768 ml .is boiled along with taila till all the moisture
evaporates .The process is done seven times each with 768 ml.or kshara jala.
Usage : Abhyangartha
Indication : Shwitra
2)Jyotishmati kalpa (B.B.R jakaradi kalpas)
In this kalpa author explained fruits are collected in Aashadh masa purva
paksha and taila is extracted by kuttana method and kalpa is prepared.
11. • Dose : 5-10 drops
• Precaution : If seeds are administered in more than prescribed
doses , it can cause diarrhoea and vomitting . milk of cow and
clarified butter made from cow’s milk should be used as remedy.
• Substitutes and adulterants : Clove oil is used as substitute to
celastrus oil
• Toxicology : Malkanguni oil is reported to be toxic to rats ,LD50
i.p . Of the malkanguni oil is 1.75 gm /kg
• Pharmacological action : Antiemetic , Antiprotozoal , Antiviral
,Tranquillizer , Sedative , Antihistamic , central muscle relaxant .
• Chemical constituents : Celastraine , Celastrol ,
Malkanguniol,Pristimerin , Zeylasterol , Acetic ,benzoic ,formic
,linoleic , palmitic and stearic acids
13. ACTION ON DOSA :
All the texts have clearly mentioned its action on kapha and
vata. Jyotismati alliviates kapha due to its tikta, katu rasas, katu
vipaka, usna virya and usna. Tikshna gunas. Because of Usna virya
and usna guna it alleviates provoked vata. On the other hand with
the same pharmacodynamics it increases the pitta
14. ACTION ON DHATUS :
The drug is generally used in Siroroga. Mental disorders, Pandu,
Vrana, Visphota Vatavyadhi etc. It shows that drug has action on Rasa,
Rakta, Majja and Shukradhatu.
15. ACTION ON MALA :
Due to its Tiksna and Sara guna it causes diarrhoea, if taken in
large doses. It has stimulating action on Mutravaha and Svedavaha
srotasa. It increases the quantity of urine and causes perspiration when
administered internally in the oil form.
17. MEDHYA KARMA : (Evam-Prabhavam)
Jyotismati by its usna, Tiksna gunas, Usna Virya and Katu Vipaka
increases pitta. Increased pitta stimulates sadhakagni which in turn generates
Medha.
Likewise due to its usna, Tiksna guna and Katu rasa it breaks the
'Avarana' of Kapha and Tama in abnormal state; due to which again functions
of Buddhi, Medha and Smriti, are normalized
18. MEDHYA KARMA CONTINUED ;
It has action especially on Rasa, Rakta and Sukradhatu. It is
already cited that the best qualities of these are responsible for good Medha
and Buddhi.
Further Jyotismati is used in oil form which due to its Suksma, Tiksna
and Vyavayi properties; helps to reach directly upto micro faculties.
Moreover snigdha guna of the Jyotismati oil performs dual function of
stimulation of Agni and nourishment of Medha.
Thus Jyotismati stimulates the intellect and sharpens the memory
by increasing the grasping capacity and nourishes the Medha. Hence it is
used in the psychiatry disorders, where the functions of sadhakagni and
Rasa. Rakta,Sukra etc. Dhatu are hampered which reflects on the functions
19. Pre frontal cortex- Functions (Sadhakagni)
It is the anterior part of frontal lobe of cerebral cortex, in front of areas 8 and
44. This area has numerous connections with other areas of the cerebral
cortex, thalamus, hypothalamus, limbic system, and cerebellum.
It forms the center for the higher functions like emotion, learning, memory
and social behavior.
Short-term memories are registered here. It is the center for planned actions, it
is the seat of intelligence; so, it is also called the organ of mind. It is
responsible for the personality of the individual, various autonomic changes
during emotional conditions, because of its connections with hypothalamus
and brainstem.
20. Interrelationship of Buddhi, Medha and Smriti
In the process of genesis of knowledge these are the steps involved and one is
incomplete without the rest. They unite with one another to generate the
knowledge so, in this sense they are undifferentiated.
Buddhi- Descrimination
Buddhi is the faculty of Manas. It is the one which enable to differentiate
between good and bad things .
Medha- Intellect
Medha is the faculty of Buddhi which has the power to retain the experiences
and recall that retained knowledge timely according to the requirement .
Human intelligence can be attributed to a circuit that links the frontal lobes,
which are involved in planning, organization and other highly developed
human abilities, with the parietal region farther back in the brain, which
integrates information from the eyes, ears and other senses.
21. This Parieto- frontal integration theory (P-FIT) best accounts for the
evidence that intelligence depends on several brain regions tightly
linked by axon tracks that form superhighways of information .
Smriti- Memory
• Smriti (Memory) is defined as the ability to recall the past experience or
information.
It is also defined as retention of learned materials.
• Memory is stored in brain by the alteration of synaptic transmission
between the neurons involved in the memory. Storage of memory may be
facilitated or habituated depending upon many factors, such as
neurotransmitter (Serotonin), synaptic transmission, functional
status of brain etc.
22. PREPARATION OF JYOTISMATI OIL DETAILS
Two types of oil are obtained from the Jyotismati seeds.
1) Brown or yellow oil (Malkanguni Oil)
2) Black oil (Oleam Nigrum)
1) Brown or Yellow oil : (Malkanguni Oil)
The seeds extracted by compression or on extraction with
petroleum
ether yield a dark brown or yellow oil (52%) known as Celastrus oil or
MALKANGUNI OIL. The oil deposits a quantity of fat after it has been kept
a short time. Its odour is pungent and acrid and treated with sulphuric acid it
turns of a dark bistre colour. It is much admired as an external application
along with a poultice of the crushed seeds.
23. 2. Black Oil (Oleum Nigrum) :
The Jyotismati seeds submitted to destructive distillation yield
the oil known as 'Oleum Nigrum'. This oil is brought forward by late
Dr.Herklots as a soverign remedy in 'Beri-Beri', when administered in
doses of 10-15 drops twice daily. The oil is empyreumatic and black in
colour.
According to Dr. Dymock the seeds are distilled along with
benzoin, cloves, nutmegs and mace. This oil is manufactured in the
northern circars, the best in Vizagapatam and Ellore, where it is sold in
small blue or black bottles. It is a good diuretic, diaphoretic and nervine
stimulant. Its action as a powerful stimulant is generally followed in a
few hours by free diaphoresis not attended by exhaustion. It is specially
efficacious in recent cases and where the nervous and paralytic
symptoms predominate. The first good effect of this. medicine is
generally the increase in the quantity of urine and with this the dropsical
effusion begins to disappear.
24. The compound and empyreumatic oil obtained by
the destructive distillation of the seeds of Celastrus
panniculata which is commonly known as 'Oleum Nigrum" or
'Black Oil' is quite different from the oil of the same seeds
extracted by compression. The former is black and thick with a
strong and peculiar aromatic smell; and the latter, yellow and
of the consistence of oil.
25. STANDARDISATION OF JYOTISMATI TAILA
Organoleptic study :
i) Rupa (Appearance) : Sticky and more viscous
ii) Varna (colour) : dark brown
iii) Gandha (odour) : acrid and pungent.
iv) Rasa (taste) : bitter.
v) Sparsa (Consistancy or feel) : Sticky (Picchila)
26. PHYSICO CHEMICAL ANALYSIS :
1 . Refractive index at 40°C - 1.479% w/w
2 . Specific gravity at 40/40°C - 0.9170% w/w
3 . Acid value - 1.169% w/w
4 . Iodine value - 59.85% w/w
5 . Saponification value - 182.71% w/w
27. CONCLUSION
• Jyotishmati taila is a drug which stimulates Medhya action especially so best
among shirovirechaka drug.
• It can be concluded that in classical Ayurvedic texts jyotishmati has been used
in various diseases and disorders like shiroroga, prameha, kustha, krimiroga,
udararoga, visarpa, pandu, vrana, visphota, sidhma, unmada, apasmara etc.
• It is said to be intellect promoting, appetite stimulant, remover of doshas from
head through nasal route, effective in Bhagandara and skin disorders etc.
• The uses of jyotishmati explored in this can provide the new treatment
measures in many diseases but overdosing should be avoided at the same time
because of its emetic property (when taken orally) and rubefacient action
(when applied externally.
28. Research works
1) The oil obtained from the seeds of the plant produced sedation in rats in
a dose of 1g /1kg i.m. On i.p.administration ,the same dose of oil
produced sedation but the effect was not so marked .The oil showed
anticonvulsant activity in rats .50-100 mg/kg of oil (as
emulsion)produced fall in cardiac output ,bradycardia and marked
increase in pulse pressure on isolated heart lung preparation .(Gaitonde
et.al 1957).
2) An active fraction (Mal IIIA) had a tranquillizing effect in rats ,mice ,
monkeys ,and cats in dose of 200 mg/kg .It potentiated the effect of
Hexabarbitone and produced hypothermia in mice .Diminution of
Carotid occlusion reflex and hypotension was observed in anaesthetized
cats .Fraction Mal III and Mal III/B produced salivation ,vomitting ,
defaecation and tremors in cats and dogs .
29. 3) A polyster prepared from the oil also decreased amphetamine –induced
hyperactivity and group toxicity in albino rats (Joglekar and Belwani 1967).
4) CLASSICAL USES OF JYOTISHMATI (CELASTRUS PANNICULATUS
LINN) WSR TO AYURVEDIC TEXT.
Dr. Prabhat Kumar Srivastava*
Associate Professor, Department of Dravyaguna, Patanjali Bhartiya Ayurvigyan Evam
Anusandhan Sansthan (Patanjali Ayurved College), Haridwar, Uttarakhand, India
30. Role of Jyotishmati Taila Nasya in the Management of Parkinson’s
Disease Kajaria Divya. Case Report
Assistant Professor, Department of Kayachikitsa, C.B.P.A.C.S, New Delhi .
ABSTRACT :
Parkinson's disease is a slowly progressive disease of late adult life and
is one of the most prevalent neurological disorders. In Charaka Samhita
'Vepathu' has been described as one of eighty types of Nanatmaja
disorders of Vata and Kampa has been mentioned as one of the
Vatikavikara. Because of its crippling nature and non-availability of
curative treatment, this disease has remained a great problem in the
aging society This paper is about management of a known case of
Parkinson with non-invasive, non steroidal, cost effective and safe
Ayurvedic treatment Many simple unexplored treatment wonders are
hidden in Ayurvedic texts that have definite success in management but
are not clinically use because of lack of knowledge, lack of scientific
validation or above all lack of faith
31. CONCLUSION :
Nasya was chosen for the management of Parkinson’s disease. Jyotismati
taila is chosen as sadhana nasya and avara (minimum) dose of it’s given
to the patient (4 drops/ nostrils). Jyotismati (Celastrus paniculata ) is
included under medhya dravya ( memory booster/ neuro regenerator).
Scientific studies showed that it stimulate a significant decrease in the
brain levels of malondialdehyde, with simultaneous significant increases
in levels of glutathione and catalase. The findings of research study
indicate that the aqueous extract of Celastrus paniculatus possess
cognitive-enhancing properties and an antioxidant effect . it can be
concluded that neroregeneration is might be possible with certain drugs,
if they are given through proper route and in proper dose. The only need
is to document such studies to make some good future research proposal.
32. 3) PHARMACOGNOSTIC AND PHARMACEUTICAL ANALYSIS OF
JYOTISHMATI TAILA
R Manu1, C R Harisha2, V J Shukla3 and Alankruta R Dave1
Department of Kayachikitsa, IPGT & RA, GAU, Jamnagar, Gujarat, India.
Pharmacognocy Laboratory, IPGT & RA, GAU, Jamnagar, Gujarat, India.
Pharmaceutical Laboratory, IPGT & RA, GAU, Jamnagar, Gujarat, India.
DISSERTATION WORK
A pharmaco-clinical study on Jyotishmati in the management of
Amavata.
By-Dr.Parashuram
33. Medicines in which jyotishmati taila as ingredient
1. Intellect capsules by Millinium herbals
Indication : Lack of concentration ,senile dimentia ,Moderate depression
Action : Jyotishmati reduces anxiety, mild to moderate depression and
stress activates the neurotransmitters which communicate the information by
signaling to the nerve cells
2 ) Alert capsules by Vasu healthcare
Indication : stress ,anxiety ,Agitation ,loss of memory
Jyotishmati taila – 75 mg, – Oil from Celastrus paniculatus as main ingredient