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An Integrated Approach For
Prevention of PPH
Akmal Samsor
December, 2011.
Outline
• Maternal Mortality
• Causes of Maternal Mortality
• Prevention of PPH at Health Facility
• Prevention PPH at Home Births
• A world FREE from PPH mortality
Prevention of Postpartum Haemorrhage (An Integrated Approach)
Leading Causes of Maternal Death
Cause of death Developed
countries
Africa Asia LAC
Hemorrhage 13% 34% 31% 21%
Hypertensive
disorders
16% 9% 9% 26%
Sepsis/infections 2% 10% 12% 8%
Abortion 8% 4% 8% 12%
Obstructed labor 0% 4% 9% 13%
Anemia 0% 4% 13% 0%
HIV/AIDS 0% 6% 0% 0%
Source: Khan et al, WHO analysis of causes of maternal death: a systematic review,
The Lancet, March 28, 2006 -- % rounded
Causes of Maternal Mortality
Indirect
14%
HIV
3%
Other direct causes
5%
unclassified
6%
Sepsis
11%
Anemia
8%
Hypertensive
Disorder
10%
Hemorrhage
31%
Unsafe Abortion
5%
Obstructed Labor
7%
Source: Adapted from " WHO Analysis of causes of maternal deaths: A systematic review.” The Lancet, vol 367, April 1,
2006.
Skilled Care During Delivery (AMSTL)
7
Preventing PPH in Births Attended Skilled
Providers
Physiologic
management
Active management OR and 95% CI
Bristol Trial 152/849 (17.9%) 50/846 (5.9%) 3.13
(95% CI 2.3 - 4.2)
Hinchingbrooke Trial 126/764 (16.5%) 51/748 (6.8%) 2·42
(95% CI 1·78-3·30)
p<0·0001
Prendiville et al 1988, Rogers et al 1998.
Niger: Reduction in Post-partum
Hemorrhage
8 USAID HEALTH CARE IMPROVEMENT PROJECT
Percentage of deliveries where Active Management of Third Stage of Labor -AMTSL- was
implemented in accordance to standards. Three groups of hospitals (started 2003-2004,
n=55; 2005, n=21; 2007, n=10) . Total 86 hospitals reporting 2003-2009. Ecuador.
0
10
20
30
40
50
60
70
80
90
100
Percentage
% 2003-2004 0. 1514 1621 3237 3739 4142 4048 5159 5755 55 5857 6565 6168 6665 6966 6571 6463 6771 73 7681 8080 8579 7679 8679 8683 9095 9495 9795 93 8990 9495 9796 9692 9793 9391 9594 9697
% 2005 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1538 5559 4367 6277 8481 8474 7878 7984 82 8889 9389 8277 8182 8079 8487 8892 9084 8892 88 8991 8592 9592 9693 8889 9492 8891 9192
% 2007 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 21 4044 5156 8879 9485 7693 90 8985 8987 8596 9795 9497 10 1010 9810
Jl-03AgSpOt NvDcEn FbMr ABMyJn Jl AgSpOcNvDcEnFb MrAbMyJn Jl AgSpOcNvDcEnFb MrAbMyJn Jl AgSpOcNvDcEn FbMr AbMyJn Jl AgSpOcNvDcEnFb MrAbMyJn Jl AgSpOcNvDcEnFb MrAb
2003 2004 2005 2006 2007 2008 2009
USAID HEALTH CARE IMPROVEMENT PROJECT
9
Deliveries Attended by SBAs
“A woman who
is pregnant has
one foot in the
grave”
. . .
Local Proverb, Chad
Parent Death & Child Survival in
Bangladesh
Cumulative probability of survival of child to age 10 years
Father alive: 88.6%
Father dead: 89.3%
Mother alive: 88.9%
Mother dead: 23.8%
Ronsmans LANCET 2010
Prevention of Postpartum Haemorrhage (An Integrated Approach)
“The significant
problems we face
cannot be solved at
the same level of
thinking we were at
when we created
them.”
Albert Einstein
New Thinking : Community Based
Prevention of PPH
Components of Community Based
Prevention of PPH
BCC component :
• Counseling pregnant
women on BP & CR
• Danger sings of
pregnancy
• Importance of presence
of SBA during delivery
• Misoprostol ( use & side
effects)
Enabling environment
component :
• Distribution of
Misoprostol at 8th month
of pregnancy
• Improving the quality of
AMSTL (SBM-R)
• Community mobilization
to strengthen emergency
transportation services
Implementation
Implementation
Evidence from community based
PPH prevention
Indonesia
 Safety: No women took medication
at wrong time
 Acceptability: women who used
medication said they would
recommend it and purchase the
drug for future births
 Feasibility: Community volunteers
successfully offered information
about PPH and safely distributed
the medication
 Effectiveness: the combination of
skilled providers using oxytocin and
community distribution of
misoprostol allowed 94% coverage
with PPH prevention method
In partnership with Depkes, POGI, IBI &
supported by USAID through the MNH program
Evidence from community based
PPH prevention
Afghanistan
 Safety: 100% took correctly after
birth including 22 sets of twins
 Acceptability: 92% said they would
recommend it and purchase the
drug for future births
 Feasibility: Community volunteers
successfully offered information
about PPH and safely distributed the
medication
 Effectiveness: the combination of
skilled providers using oxytocin and
community distribution of
misoprostol allowed 93% coverage
with PPH prevention method
Sanghvi, et al. 2009.
Evidence from community based
PPH prevention
“Our wives will not die
anymore because of bleeding,
if they take this drug after
birth of the baby and before
expulsion of Baar ( placenta).
We must support and
encourage you. Thank you for
distributing the drug
to our district.”
(A community leader, Afghanistan)
Evidence from community based
PPH prevention
• 18,761 pregnant women were dispensed misoprostol by
FCHVs with no significant adverse events or misuse or
incorrect use
• Proportion of deliveries protected by a uterotonic rose from
10.4% to 72.5%; largest gains were among the poor, illiterate
and those living in remote areas
• Institutional deliveries increased from 9.9% to 16.0%
• MMR among 13,969 misoprostol users was 72/100,000;
significantly lower than among non-users (304/100,000), as
well as the national level of 281/100,000
Rajbhandari, Hodgins, Sanghvi, IJGO march 2010
Evidence from community based
PPH prevention
• 1620 women, placebo-controlled trial
• Misoprostol: oral, stable, positive safety profile—can be
used in the absence of a skilled birth attendant
• Misoprostol associated with
– Reduction in PPH (12% to 6.4%; p<0.0001)
– Reduction in acute severe PPH (1.2% to 0.2%; p<0.0001)
– Decrease in mean PP blood loss (262.3 to 214.3ml; p<0.0001)
– Transitory chills and fever
Source: Derman, et al, Oral misoprostol in preventing postpartum hemorrhage in resource-poor communities:
A randomized controlled trial, The Lancet, Oct. 7, 2006.
Global Policy Change
“ After consideration of the evidence for efficacy
and safety , the Committee decided to add
misoprostol to the List, for the prevention of
PPH in settings where parenteral uterotonics
are not available or feasible”.
World Health Organization, 18th expert committee on the selection and use
of essential medicines (21 to 25 March 2011 Accra, Ghana).
Vision for the future
“ A world FREE
from PPH
mortality”.
World Map in Proportion to Maternal Mortality
Integration: AMTSL & CB prevention of
PPH
Integration will enable the facility based and
community based health care providers to
deliver quality health services;
• Team formation :
• SBAs and CHWs
• Provide CHWs better leadership (SBA Vs CHS)
• SBAs better linked with the communities
• Fallow up of the MCH services clients (ANC, PNC, FP)
• Better tracking of the commodities (misoprostol, FP
pills)
Integration: AMTSL & CB prevention of
PPH (cont …)
• Improved Quality of counseling:
• SBAs no longer doing the routine BP & CR counseling
• CHWs totally responsible for BP & CR counseling
• SBA asking each women visiting the health facility
targeted questions about BP & CR
– Danger sings of pregnancy ?
– Diet during pregnancy ?
– TT vaccination and why?
• Provide feedback to the visiting women
• Quality of counseling (inquiring Vs providing)
• Quality of counseling (listening Vs talking)
Currently how counseling is done ?
• IEC is the duty of every health worker
• CHW is counseling (??) a client
• SBA is counseling(??) a client
• The only time that a woman get a better
counseling is, during the supervisory visits (?)
(filling the checklist)
• Client just listens and providers talks (75% Vs 25%)
• No mechanism to check the quality of counseling
within system only checklists (fear)
Collaboration: AMTSL & CB prevention
of PPH
• Collaboration will enable different partners to
deliver health services at a larger scale
• Effectiveness = Quality * Coverage
• Remaining focused by delivering quality
services to achieve our goals ( Facility based Vs
Community based services/ Facility based and
Community based services)
Collaboration: AMTSL & CB prevention
of PPH
Making this world FREE from PPH mortality ?
Can I do it ?
“NO !”
But Why ?
Change your question.
OK
Can We?
Yes, We can.
This in not a Mission Impossible
Thank you
Comments/Questions ?

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Prevention of Postpartum Haemorrhage (An Integrated Approach)

  • 1. An Integrated Approach For Prevention of PPH Akmal Samsor December, 2011.
  • 2. Outline • Maternal Mortality • Causes of Maternal Mortality • Prevention of PPH at Health Facility • Prevention PPH at Home Births • A world FREE from PPH mortality
  • 4. Leading Causes of Maternal Death Cause of death Developed countries Africa Asia LAC Hemorrhage 13% 34% 31% 21% Hypertensive disorders 16% 9% 9% 26% Sepsis/infections 2% 10% 12% 8% Abortion 8% 4% 8% 12% Obstructed labor 0% 4% 9% 13% Anemia 0% 4% 13% 0% HIV/AIDS 0% 6% 0% 0% Source: Khan et al, WHO analysis of causes of maternal death: a systematic review, The Lancet, March 28, 2006 -- % rounded
  • 5. Causes of Maternal Mortality Indirect 14% HIV 3% Other direct causes 5% unclassified 6% Sepsis 11% Anemia 8% Hypertensive Disorder 10% Hemorrhage 31% Unsafe Abortion 5% Obstructed Labor 7% Source: Adapted from " WHO Analysis of causes of maternal deaths: A systematic review.” The Lancet, vol 367, April 1, 2006.
  • 6. Skilled Care During Delivery (AMSTL)
  • 7. 7 Preventing PPH in Births Attended Skilled Providers Physiologic management Active management OR and 95% CI Bristol Trial 152/849 (17.9%) 50/846 (5.9%) 3.13 (95% CI 2.3 - 4.2) Hinchingbrooke Trial 126/764 (16.5%) 51/748 (6.8%) 2·42 (95% CI 1·78-3·30) p<0·0001 Prendiville et al 1988, Rogers et al 1998.
  • 8. Niger: Reduction in Post-partum Hemorrhage 8 USAID HEALTH CARE IMPROVEMENT PROJECT
  • 9. Percentage of deliveries where Active Management of Third Stage of Labor -AMTSL- was implemented in accordance to standards. Three groups of hospitals (started 2003-2004, n=55; 2005, n=21; 2007, n=10) . Total 86 hospitals reporting 2003-2009. Ecuador. 0 10 20 30 40 50 60 70 80 90 100 Percentage % 2003-2004 0. 1514 1621 3237 3739 4142 4048 5159 5755 55 5857 6565 6168 6665 6966 6571 6463 6771 73 7681 8080 8579 7679 8679 8683 9095 9495 9795 93 8990 9495 9796 9692 9793 9391 9594 9697 % 2005 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1538 5559 4367 6277 8481 8474 7878 7984 82 8889 9389 8277 8182 8079 8487 8892 9084 8892 88 8991 8592 9592 9693 8889 9492 8891 9192 % 2007 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 21 4044 5156 8879 9485 7693 90 8985 8987 8596 9795 9497 10 1010 9810 Jl-03AgSpOt NvDcEn FbMr ABMyJn Jl AgSpOcNvDcEnFb MrAbMyJn Jl AgSpOcNvDcEnFb MrAbMyJn Jl AgSpOcNvDcEn FbMr AbMyJn Jl AgSpOcNvDcEnFb MrAbMyJn Jl AgSpOcNvDcEnFb MrAb 2003 2004 2005 2006 2007 2008 2009 USAID HEALTH CARE IMPROVEMENT PROJECT 9
  • 11. “A woman who is pregnant has one foot in the grave” . . . Local Proverb, Chad
  • 12. Parent Death & Child Survival in Bangladesh Cumulative probability of survival of child to age 10 years Father alive: 88.6% Father dead: 89.3% Mother alive: 88.9% Mother dead: 23.8% Ronsmans LANCET 2010
  • 14. “The significant problems we face cannot be solved at the same level of thinking we were at when we created them.” Albert Einstein
  • 15. New Thinking : Community Based Prevention of PPH
  • 16. Components of Community Based Prevention of PPH BCC component : • Counseling pregnant women on BP & CR • Danger sings of pregnancy • Importance of presence of SBA during delivery • Misoprostol ( use & side effects) Enabling environment component : • Distribution of Misoprostol at 8th month of pregnancy • Improving the quality of AMSTL (SBM-R) • Community mobilization to strengthen emergency transportation services
  • 19. Evidence from community based PPH prevention Indonesia  Safety: No women took medication at wrong time  Acceptability: women who used medication said they would recommend it and purchase the drug for future births  Feasibility: Community volunteers successfully offered information about PPH and safely distributed the medication  Effectiveness: the combination of skilled providers using oxytocin and community distribution of misoprostol allowed 94% coverage with PPH prevention method In partnership with Depkes, POGI, IBI & supported by USAID through the MNH program
  • 20. Evidence from community based PPH prevention Afghanistan  Safety: 100% took correctly after birth including 22 sets of twins  Acceptability: 92% said they would recommend it and purchase the drug for future births  Feasibility: Community volunteers successfully offered information about PPH and safely distributed the medication  Effectiveness: the combination of skilled providers using oxytocin and community distribution of misoprostol allowed 93% coverage with PPH prevention method Sanghvi, et al. 2009.
  • 21. Evidence from community based PPH prevention “Our wives will not die anymore because of bleeding, if they take this drug after birth of the baby and before expulsion of Baar ( placenta). We must support and encourage you. Thank you for distributing the drug to our district.” (A community leader, Afghanistan)
  • 22. Evidence from community based PPH prevention • 18,761 pregnant women were dispensed misoprostol by FCHVs with no significant adverse events or misuse or incorrect use • Proportion of deliveries protected by a uterotonic rose from 10.4% to 72.5%; largest gains were among the poor, illiterate and those living in remote areas • Institutional deliveries increased from 9.9% to 16.0% • MMR among 13,969 misoprostol users was 72/100,000; significantly lower than among non-users (304/100,000), as well as the national level of 281/100,000 Rajbhandari, Hodgins, Sanghvi, IJGO march 2010
  • 23. Evidence from community based PPH prevention • 1620 women, placebo-controlled trial • Misoprostol: oral, stable, positive safety profile—can be used in the absence of a skilled birth attendant • Misoprostol associated with – Reduction in PPH (12% to 6.4%; p<0.0001) – Reduction in acute severe PPH (1.2% to 0.2%; p<0.0001) – Decrease in mean PP blood loss (262.3 to 214.3ml; p<0.0001) – Transitory chills and fever Source: Derman, et al, Oral misoprostol in preventing postpartum hemorrhage in resource-poor communities: A randomized controlled trial, The Lancet, Oct. 7, 2006.
  • 24. Global Policy Change “ After consideration of the evidence for efficacy and safety , the Committee decided to add misoprostol to the List, for the prevention of PPH in settings where parenteral uterotonics are not available or feasible”. World Health Organization, 18th expert committee on the selection and use of essential medicines (21 to 25 March 2011 Accra, Ghana).
  • 25. Vision for the future “ A world FREE from PPH mortality”. World Map in Proportion to Maternal Mortality
  • 26. Integration: AMTSL & CB prevention of PPH Integration will enable the facility based and community based health care providers to deliver quality health services; • Team formation : • SBAs and CHWs • Provide CHWs better leadership (SBA Vs CHS) • SBAs better linked with the communities • Fallow up of the MCH services clients (ANC, PNC, FP) • Better tracking of the commodities (misoprostol, FP pills)
  • 27. Integration: AMTSL & CB prevention of PPH (cont …) • Improved Quality of counseling: • SBAs no longer doing the routine BP & CR counseling • CHWs totally responsible for BP & CR counseling • SBA asking each women visiting the health facility targeted questions about BP & CR – Danger sings of pregnancy ? – Diet during pregnancy ? – TT vaccination and why? • Provide feedback to the visiting women • Quality of counseling (inquiring Vs providing) • Quality of counseling (listening Vs talking)
  • 28. Currently how counseling is done ? • IEC is the duty of every health worker • CHW is counseling (??) a client • SBA is counseling(??) a client • The only time that a woman get a better counseling is, during the supervisory visits (?) (filling the checklist) • Client just listens and providers talks (75% Vs 25%) • No mechanism to check the quality of counseling within system only checklists (fear)
  • 29. Collaboration: AMTSL & CB prevention of PPH • Collaboration will enable different partners to deliver health services at a larger scale • Effectiveness = Quality * Coverage • Remaining focused by delivering quality services to achieve our goals ( Facility based Vs Community based services/ Facility based and Community based services)
  • 30. Collaboration: AMTSL & CB prevention of PPH Making this world FREE from PPH mortality ? Can I do it ? “NO !” But Why ? Change your question. OK Can We? Yes, We can.
  • 31. This in not a Mission Impossible