2. Hemolytic anemia = reduced
red-cell life span
•The normal red cell life is 110-120 days after
which the senile cells are removed by bone
marrow and spleenic macrophages.
•Reduced red cell survival leads to increased red
cell production due to erythropoietin drive that can
compensate for the reduced red cell life and
maintain a normal Hb level.
•The mean red cell life is affected by molecular
changes in either the red cell membrane or
haemoglobined red cell survival leads to.