SlideShare ist ein Scribd-Unternehmen logo
1 von 9
Downloaden Sie, um offline zu lesen
PATHOPHYSIOLOGY AND
CLINICAL FEATURES OF
HEMOLYTIC ANEMIA
PRESENTED BY:-
K.AGASYA RAJ
Hemolytic anemia = reduced
red-cell life span
•The normal red cell life is 110-120 days after
which the senile cells are removed by bone
marrow and spleenic macrophages.
•Reduced red cell survival leads to increased red
cell production due to erythropoietin drive that can
compensate for the reduced red cell life and
maintain a normal Hb level.
•The mean red cell life is affected by molecular
changes in either the red cell membrane or
haemoglobined red cell survival leads to.
How hemolysis occurs?
• Hemolysis occurs through two ways they
are-
1.INTRAVASCULAR HEMOLYSIS
2.EXTRAVASCULAR HEMOLYSIS
INTRAVASCULAR HEMOLYSIS EXTRAVASCULAR HEMOLYSIS
• PNH,TRANSFUSION RXN
• PHYSICAL / MECHANICAL
TRAUMA
• TOXIC MICROENVIRONMENT
• HEMOGLOBINOPATHIES
•ENZYMOPATHIES
•MEMBRANE DEFECTS
•MEGALOBLASTIC ANAEMIA
•AIHA
•DRUG INDUCED
HAEMOLYSIS PATHWAYS ARE OF
TWO TYPES
drpankajyadav05@gmail.com
drpankajyadav05@gmail.com
Pathophysiology and clinical_features_of_hemolytic_anemia[1]
COMPLICATIONS OF HA
THANK YOU

Weitere ähnliche Inhalte

Was ist angesagt?

Pathology of blood
Pathology of bloodPathology of blood
Pathology of bloodshaimaaf12
 
Hematopoiesis and clotting
Hematopoiesis and clottingHematopoiesis and clotting
Hematopoiesis and clottingANJANI WALIA
 
Lab diagnosis of anaemia/ oral surgery courses  
Lab diagnosis of anaemia/ oral surgery courses  Lab diagnosis of anaemia/ oral surgery courses  
Lab diagnosis of anaemia/ oral surgery courses  Indian dental academy
 
Hemolytic anaemias
Hemolytic anaemiasHemolytic anaemias
Hemolytic anaemiasShiz Wachira
 
Introduction to blood components of blood, pcv
Introduction to blood components of blood, pcvIntroduction to blood components of blood, pcv
Introduction to blood components of blood, pcvshama praveen
 
An Overview of Hemolytic anemia
An Overview of Hemolytic anemiaAn Overview of Hemolytic anemia
An Overview of Hemolytic anemiaPrakash Poudel
 
Haemolytic anemias due to cell membrane defects
Haemolytic anemias due to cell membrane defectsHaemolytic anemias due to cell membrane defects
Haemolytic anemias due to cell membrane defectsQassamAlraee1
 
Hemolytic anemia 3
Hemolytic anemia 3Hemolytic anemia 3
Hemolytic anemia 305813
 
Platelets in health & disease - AJ
Platelets in health & disease - AJ Platelets in health & disease - AJ
Platelets in health & disease - AJ Anu Priya
 
Platelet function and dysfunction
Platelet function and dysfunctionPlatelet function and dysfunction
Platelet function and dysfunctionderosaMSKCC
 

Was ist angesagt? (20)

Red blood cell & bleeding disorders
Red blood cell & bleeding disordersRed blood cell & bleeding disorders
Red blood cell & bleeding disorders
 
Pathology of blood
Pathology of bloodPathology of blood
Pathology of blood
 
Haemolytic anaemia
Haemolytic anaemia Haemolytic anaemia
Haemolytic anaemia
 
Hematopoiesis and clotting
Hematopoiesis and clottingHematopoiesis and clotting
Hematopoiesis and clotting
 
Lab diagnosis of anaemia/ oral surgery courses  
Lab diagnosis of anaemia/ oral surgery courses  Lab diagnosis of anaemia/ oral surgery courses  
Lab diagnosis of anaemia/ oral surgery courses  
 
Hemolytic anaemias
Hemolytic anaemiasHemolytic anaemias
Hemolytic anaemias
 
Introduction to blood components of blood, pcv
Introduction to blood components of blood, pcvIntroduction to blood components of blood, pcv
Introduction to blood components of blood, pcv
 
Hemolytic anemia
Hemolytic anemiaHemolytic anemia
Hemolytic anemia
 
Blood disorders ppt
Blood disorders pptBlood disorders ppt
Blood disorders ppt
 
Anemia
Anemia Anemia
Anemia
 
An Overview of Hemolytic anemia
An Overview of Hemolytic anemiaAn Overview of Hemolytic anemia
An Overview of Hemolytic anemia
 
Platelets
PlateletsPlatelets
Platelets
 
Haemolytic anemias due to cell membrane defects
Haemolytic anemias due to cell membrane defectsHaemolytic anemias due to cell membrane defects
Haemolytic anemias due to cell membrane defects
 
Hemolytic anemia 3
Hemolytic anemia 3Hemolytic anemia 3
Hemolytic anemia 3
 
Platelets in health & disease - AJ
Platelets in health & disease - AJ Platelets in health & disease - AJ
Platelets in health & disease - AJ
 
Platelet function and dysfunction
Platelet function and dysfunctionPlatelet function and dysfunction
Platelet function and dysfunction
 
Haemopoietic system
Haemopoietic systemHaemopoietic system
Haemopoietic system
 
Hemolytic anemia
Hemolytic anemiaHemolytic anemia
Hemolytic anemia
 
Blood and blood cells
Blood and blood cellsBlood and blood cells
Blood and blood cells
 
Heamolytic anaemia
Heamolytic anaemiaHeamolytic anaemia
Heamolytic anaemia
 

Andere mochten auch

Portfolio- English Katarina Popov
Portfolio- English Katarina PopovPortfolio- English Katarina Popov
Portfolio- English Katarina PopovKatarina Popov
 
Diabetes MELLITUS
Diabetes MELLITUSDiabetes MELLITUS
Diabetes MELLITUSAgasya raj
 
REU Presentation
REU PresentationREU Presentation
REU PresentationGabriel Col
 
Disabled Girls Only Football (1)
Disabled Girls Only Football (1)Disabled Girls Only Football (1)
Disabled Girls Only Football (1)Natascia Bernardi
 
โครงงานคอมพิวเตอร์1
โครงงานคอมพิวเตอร์1โครงงานคอมพิวเตอร์1
โครงงานคอมพิวเตอร์1Mind Sirivimol
 
ADF Sales Meeting - Vail 2012
ADF Sales Meeting - Vail 2012ADF Sales Meeting - Vail 2012
ADF Sales Meeting - Vail 2012Maite Sardinas
 
โครงงานคอมพิวเตอร์
โครงงานคอมพิวเตอร์โครงงานคอมพิวเตอร์
โครงงานคอมพิวเตอร์PTtp WgWt
 
Top 8 cash supervisor resume samples
Top 8 cash supervisor resume samplesTop 8 cash supervisor resume samples
Top 8 cash supervisor resume samplesowenwhites99
 
Pengantar pemrograman modular
Pengantar pemrograman modularPengantar pemrograman modular
Pengantar pemrograman modularAkmal Fajar
 
Top 8 pool supervisor resume samples
Top 8 pool supervisor resume samplesTop 8 pool supervisor resume samples
Top 8 pool supervisor resume samplesowenwhites99
 
План на февраль 2016
План на февраль 2016План на февраль 2016
План на февраль 2016supportfranco
 
XIX Milocerski razvojni forum - Kreativna informatika
XIX Milocerski razvojni forum - Kreativna informatikaXIX Milocerski razvojni forum - Kreativna informatika
XIX Milocerski razvojni forum - Kreativna informatikaTarik Zaimovi?
 
Top 8 academic supervisor resume samples
Top 8 academic supervisor resume samplesTop 8 academic supervisor resume samples
Top 8 academic supervisor resume samplesowenwhites99
 
Top 8 casino floor supervisor resume samples
Top 8 casino floor supervisor resume samplesTop 8 casino floor supervisor resume samples
Top 8 casino floor supervisor resume samplesowenwhites99
 

Andere mochten auch (19)

Portfolio- English Katarina Popov
Portfolio- English Katarina PopovPortfolio- English Katarina Popov
Portfolio- English Katarina Popov
 
Diabetes MELLITUS
Diabetes MELLITUSDiabetes MELLITUS
Diabetes MELLITUS
 
REU Presentation
REU PresentationREU Presentation
REU Presentation
 
Disabled Girls Only Football (1)
Disabled Girls Only Football (1)Disabled Girls Only Football (1)
Disabled Girls Only Football (1)
 
โครงงานคอมพิวเตอร์1
โครงงานคอมพิวเตอร์1โครงงานคอมพิวเตอร์1
โครงงานคอมพิวเตอร์1
 
ADF Sales Meeting - Vail 2012
ADF Sales Meeting - Vail 2012ADF Sales Meeting - Vail 2012
ADF Sales Meeting - Vail 2012
 
โครงงานคอมพิวเตอร์
โครงงานคอมพิวเตอร์โครงงานคอมพิวเตอร์
โครงงานคอมพิวเตอร์
 
Nosrati E et al
Nosrati E et alNosrati E et al
Nosrati E et al
 
Nguyen's Portfolio
Nguyen's PortfolioNguyen's Portfolio
Nguyen's Portfolio
 
Top 8 cash supervisor resume samples
Top 8 cash supervisor resume samplesTop 8 cash supervisor resume samples
Top 8 cash supervisor resume samples
 
Pengantar pemrograman modular
Pengantar pemrograman modularPengantar pemrograman modular
Pengantar pemrograman modular
 
Top 8 pool supervisor resume samples
Top 8 pool supervisor resume samplesTop 8 pool supervisor resume samples
Top 8 pool supervisor resume samples
 
flinkguard_futurelink
flinkguard_futurelinkflinkguard_futurelink
flinkguard_futurelink
 
План на февраль 2016
План на февраль 2016План на февраль 2016
План на февраль 2016
 
green_parking
green_parking green_parking
green_parking
 
Untitled Presentation
Untitled PresentationUntitled Presentation
Untitled Presentation
 
XIX Milocerski razvojni forum - Kreativna informatika
XIX Milocerski razvojni forum - Kreativna informatikaXIX Milocerski razvojni forum - Kreativna informatika
XIX Milocerski razvojni forum - Kreativna informatika
 
Top 8 academic supervisor resume samples
Top 8 academic supervisor resume samplesTop 8 academic supervisor resume samples
Top 8 academic supervisor resume samples
 
Top 8 casino floor supervisor resume samples
Top 8 casino floor supervisor resume samplesTop 8 casino floor supervisor resume samples
Top 8 casino floor supervisor resume samples
 

Ähnlich wie Pathophysiology and clinical_features_of_hemolytic_anemia[1]

Ähnlich wie Pathophysiology and clinical_features_of_hemolytic_anemia[1] (20)

Hemolytic anemia.pptx
Hemolytic anemia.pptxHemolytic anemia.pptx
Hemolytic anemia.pptx
 
LABORATORY APPROACH TO HEMOLYTIC ANEMIAS.pptx
LABORATORY APPROACH TO HEMOLYTIC ANEMIAS.pptxLABORATORY APPROACH TO HEMOLYTIC ANEMIAS.pptx
LABORATORY APPROACH TO HEMOLYTIC ANEMIAS.pptx
 
Approach to hemolytic anemias
Approach to hemolytic anemiasApproach to hemolytic anemias
Approach to hemolytic anemias
 
HEM_ANEMIA_1.ppt
HEM_ANEMIA_1.pptHEM_ANEMIA_1.ppt
HEM_ANEMIA_1.ppt
 
Hemolytic anemia
Hemolytic anemiaHemolytic anemia
Hemolytic anemia
 
blood diseases.pptx
blood diseases.pptxblood diseases.pptx
blood diseases.pptx
 
Hemolytic-Anemia.pptx
Hemolytic-Anemia.pptxHemolytic-Anemia.pptx
Hemolytic-Anemia.pptx
 
RBC
RBCRBC
RBC
 
Unexplained leukocytosis in an adult
Unexplained leukocytosis in an adultUnexplained leukocytosis in an adult
Unexplained leukocytosis in an adult
 
hemolytic & aplastic anemia
 hemolytic   &  aplastic anemia  hemolytic   &  aplastic anemia
hemolytic & aplastic anemia
 
Anemia new
Anemia newAnemia new
Anemia new
 
7. Hematopoietic & lymph.pptx
7. Hematopoietic & lymph.pptx7. Hematopoietic & lymph.pptx
7. Hematopoietic & lymph.pptx
 
Anemia
AnemiaAnemia
Anemia
 
Hematology
HematologyHematology
Hematology
 
Rbc Patho B
Rbc  Patho BRbc  Patho B
Rbc Patho B
 
Rbc Patho B
Rbc  Patho BRbc  Patho B
Rbc Patho B
 
ANAEMIAS by Dr DELE
ANAEMIAS by Dr DELEANAEMIAS by Dr DELE
ANAEMIAS by Dr DELE
 
Approach to Anaemia in the ED
Approach to Anaemia in the EDApproach to Anaemia in the ED
Approach to Anaemia in the ED
 
anaemia-171208034251.pdf
anaemia-171208034251.pdfanaemia-171208034251.pdf
anaemia-171208034251.pdf
 
Anaemia veterinary
Anaemia veterinaryAnaemia veterinary
Anaemia veterinary
 

Mehr von Agasya raj

Hoarseness of voice
Hoarseness of  voiceHoarseness of  voice
Hoarseness of voiceAgasya raj
 
Gestational diabetes mellitus
Gestational diabetes mellitusGestational diabetes mellitus
Gestational diabetes mellitusAgasya raj
 
Examination of thyroid
Examination of thyroidExamination of thyroid
Examination of thyroidAgasya raj
 
Carcinoma colon
Carcinoma colonCarcinoma colon
Carcinoma colonAgasya raj
 
Megaloblastic anaemia
Megaloblastic anaemiaMegaloblastic anaemia
Megaloblastic anaemiaAgasya raj
 
IRON DEFICIENCY ANAEMIA
IRON DEFICIENCY ANAEMIAIRON DEFICIENCY ANAEMIA
IRON DEFICIENCY ANAEMIAAgasya raj
 
IN BRIEF DISCUSSION ABOUT DIFFERENT CANCERS
IN BRIEF DISCUSSION ABOUT DIFFERENT CANCERSIN BRIEF DISCUSSION ABOUT DIFFERENT CANCERS
IN BRIEF DISCUSSION ABOUT DIFFERENT CANCERSAgasya raj
 
Clinical features and investigation of carcinoma colon
Clinical features and investigation of carcinoma colonClinical features and investigation of carcinoma colon
Clinical features and investigation of carcinoma colonAgasya raj
 
Glucose receptors1
Glucose receptors1Glucose receptors1
Glucose receptors1Agasya raj
 
Management of malaria 2
Management of malaria 2Management of malaria 2
Management of malaria 2Agasya raj
 

Mehr von Agasya raj (13)

Drowning
DrowningDrowning
Drowning
 
Hoarseness of voice
Hoarseness of  voiceHoarseness of  voice
Hoarseness of voice
 
Gestational diabetes mellitus
Gestational diabetes mellitusGestational diabetes mellitus
Gestational diabetes mellitus
 
Examination of thyroid
Examination of thyroidExamination of thyroid
Examination of thyroid
 
Carcinoma colon
Carcinoma colonCarcinoma colon
Carcinoma colon
 
Megaloblastic anaemia
Megaloblastic anaemiaMegaloblastic anaemia
Megaloblastic anaemia
 
IRON DEFICIENCY ANAEMIA
IRON DEFICIENCY ANAEMIAIRON DEFICIENCY ANAEMIA
IRON DEFICIENCY ANAEMIA
 
IN BRIEF DISCUSSION ABOUT DIFFERENT CANCERS
IN BRIEF DISCUSSION ABOUT DIFFERENT CANCERSIN BRIEF DISCUSSION ABOUT DIFFERENT CANCERS
IN BRIEF DISCUSSION ABOUT DIFFERENT CANCERS
 
Clinical features and investigation of carcinoma colon
Clinical features and investigation of carcinoma colonClinical features and investigation of carcinoma colon
Clinical features and investigation of carcinoma colon
 
Glucose receptors1
Glucose receptors1Glucose receptors1
Glucose receptors1
 
TETANUS
TETANUSTETANUS
TETANUS
 
Management of malaria 2
Management of malaria 2Management of malaria 2
Management of malaria 2
 
Accidents
Accidents Accidents
Accidents
 

Kürzlich hochgeladen

FDMA FLAP - The first dorsal metacarpal artery (FDMA) flap is used mainly for...
FDMA FLAP - The first dorsal metacarpal artery (FDMA) flap is used mainly for...FDMA FLAP - The first dorsal metacarpal artery (FDMA) flap is used mainly for...
FDMA FLAP - The first dorsal metacarpal artery (FDMA) flap is used mainly for...Shubhanshu Gaurav
 
Different drug regularity bodies in different countries.
Different drug regularity bodies in different countries.Different drug regularity bodies in different countries.
Different drug regularity bodies in different countries.kishan singh tomar
 
Bulimia nervosa ( Eating Disorders) Mental Health Nursing.
Bulimia nervosa ( Eating Disorders) Mental Health Nursing.Bulimia nervosa ( Eating Disorders) Mental Health Nursing.
Bulimia nervosa ( Eating Disorders) Mental Health Nursing.aarjukhadka22
 
SGK RỐI LOẠN KALI MÁU CỰC KỲ QUAN TRỌNG.pdf
SGK RỐI LOẠN KALI MÁU CỰC KỲ QUAN TRỌNG.pdfSGK RỐI LOẠN KALI MÁU CỰC KỲ QUAN TRỌNG.pdf
SGK RỐI LOẠN KALI MÁU CỰC KỲ QUAN TRỌNG.pdfHongBiThi1
 
pA2 value, Schild plot and pD2 values- applications in pharmacology
pA2 value, Schild plot and pD2 values- applications in pharmacologypA2 value, Schild plot and pD2 values- applications in pharmacology
pA2 value, Schild plot and pD2 values- applications in pharmacologyDeepakDaniel9
 
Male Infertility, Antioxidants and Beyond
Male Infertility, Antioxidants and BeyondMale Infertility, Antioxidants and Beyond
Male Infertility, Antioxidants and BeyondSujoy Dasgupta
 
Basic structure of hair and hair growth cycle.pptx
Basic structure of hair and hair growth cycle.pptxBasic structure of hair and hair growth cycle.pptx
Basic structure of hair and hair growth cycle.pptxkomalt2001
 
Unit I herbs as raw materials, biodynamic agriculture.ppt
Unit I herbs as raw materials, biodynamic agriculture.pptUnit I herbs as raw materials, biodynamic agriculture.ppt
Unit I herbs as raw materials, biodynamic agriculture.pptPradnya Wadekar
 
CPR.nursingoutlook.pdf , Bsc nursing student
CPR.nursingoutlook.pdf , Bsc nursing studentCPR.nursingoutlook.pdf , Bsc nursing student
CPR.nursingoutlook.pdf , Bsc nursing studentsaileshpanda05
 
Mental health Team. Dr Senthil Thirusangu
Mental health Team. Dr Senthil ThirusanguMental health Team. Dr Senthil Thirusangu
Mental health Team. Dr Senthil Thirusangu Medical University
 
ORAL HYPOGLYCAEMIC AGENTS - PART 2.pptx
ORAL HYPOGLYCAEMIC AGENTS  - PART 2.pptxORAL HYPOGLYCAEMIC AGENTS  - PART 2.pptx
ORAL HYPOGLYCAEMIC AGENTS - PART 2.pptxNIKITA BHUTE
 
Breast cancer -ONCO IN MEDICAL AND SURGICAL NURSING.pptx
Breast cancer -ONCO IN MEDICAL AND SURGICAL NURSING.pptxBreast cancer -ONCO IN MEDICAL AND SURGICAL NURSING.pptx
Breast cancer -ONCO IN MEDICAL AND SURGICAL NURSING.pptxNaveenkumar267201
 
How to cure cirrhosis and chronic hepatitis naturally
How to cure cirrhosis and chronic hepatitis naturallyHow to cure cirrhosis and chronic hepatitis naturally
How to cure cirrhosis and chronic hepatitis naturallyZurück zum Ursprung
 
MedMatch: Your Health, Our Mission. Pitch deck.
MedMatch: Your Health, Our Mission. Pitch deck.MedMatch: Your Health, Our Mission. Pitch deck.
MedMatch: Your Health, Our Mission. Pitch deck.whalesdesign
 
Physiology of Smooth Muscles -Mechanics of contraction and relaxation
Physiology of Smooth Muscles -Mechanics of contraction and relaxationPhysiology of Smooth Muscles -Mechanics of contraction and relaxation
Physiology of Smooth Muscles -Mechanics of contraction and relaxationMedicoseAcademics
 
"Radical excision of DIE in subferile women with deep infiltrating endometrio...
"Radical excision of DIE in subferile women with deep infiltrating endometrio..."Radical excision of DIE in subferile women with deep infiltrating endometrio...
"Radical excision of DIE in subferile women with deep infiltrating endometrio...Sujoy Dasgupta
 

Kürzlich hochgeladen (20)

FDMA FLAP - The first dorsal metacarpal artery (FDMA) flap is used mainly for...
FDMA FLAP - The first dorsal metacarpal artery (FDMA) flap is used mainly for...FDMA FLAP - The first dorsal metacarpal artery (FDMA) flap is used mainly for...
FDMA FLAP - The first dorsal metacarpal artery (FDMA) flap is used mainly for...
 
Different drug regularity bodies in different countries.
Different drug regularity bodies in different countries.Different drug regularity bodies in different countries.
Different drug regularity bodies in different countries.
 
GOUT UPDATE AHMED YEHIA 2024, case based approach with application of the lat...
GOUT UPDATE AHMED YEHIA 2024, case based approach with application of the lat...GOUT UPDATE AHMED YEHIA 2024, case based approach with application of the lat...
GOUT UPDATE AHMED YEHIA 2024, case based approach with application of the lat...
 
Bulimia nervosa ( Eating Disorders) Mental Health Nursing.
Bulimia nervosa ( Eating Disorders) Mental Health Nursing.Bulimia nervosa ( Eating Disorders) Mental Health Nursing.
Bulimia nervosa ( Eating Disorders) Mental Health Nursing.
 
SGK RỐI LOẠN KALI MÁU CỰC KỲ QUAN TRỌNG.pdf
SGK RỐI LOẠN KALI MÁU CỰC KỲ QUAN TRỌNG.pdfSGK RỐI LOẠN KALI MÁU CỰC KỲ QUAN TRỌNG.pdf
SGK RỐI LOẠN KALI MÁU CỰC KỲ QUAN TRỌNG.pdf
 
pA2 value, Schild plot and pD2 values- applications in pharmacology
pA2 value, Schild plot and pD2 values- applications in pharmacologypA2 value, Schild plot and pD2 values- applications in pharmacology
pA2 value, Schild plot and pD2 values- applications in pharmacology
 
Male Infertility, Antioxidants and Beyond
Male Infertility, Antioxidants and BeyondMale Infertility, Antioxidants and Beyond
Male Infertility, Antioxidants and Beyond
 
Basic structure of hair and hair growth cycle.pptx
Basic structure of hair and hair growth cycle.pptxBasic structure of hair and hair growth cycle.pptx
Basic structure of hair and hair growth cycle.pptx
 
Immune labs basics part 1 acute phase reactants ESR, CRP Ahmed Yehia Ismaeel,...
Immune labs basics part 1 acute phase reactants ESR, CRP Ahmed Yehia Ismaeel,...Immune labs basics part 1 acute phase reactants ESR, CRP Ahmed Yehia Ismaeel,...
Immune labs basics part 1 acute phase reactants ESR, CRP Ahmed Yehia Ismaeel,...
 
Rheumatoid arthritis Part 1, case based approach with application of the late...
Rheumatoid arthritis Part 1, case based approach with application of the late...Rheumatoid arthritis Part 1, case based approach with application of the late...
Rheumatoid arthritis Part 1, case based approach with application of the late...
 
Unit I herbs as raw materials, biodynamic agriculture.ppt
Unit I herbs as raw materials, biodynamic agriculture.pptUnit I herbs as raw materials, biodynamic agriculture.ppt
Unit I herbs as raw materials, biodynamic agriculture.ppt
 
CPR.nursingoutlook.pdf , Bsc nursing student
CPR.nursingoutlook.pdf , Bsc nursing studentCPR.nursingoutlook.pdf , Bsc nursing student
CPR.nursingoutlook.pdf , Bsc nursing student
 
Mental health Team. Dr Senthil Thirusangu
Mental health Team. Dr Senthil ThirusanguMental health Team. Dr Senthil Thirusangu
Mental health Team. Dr Senthil Thirusangu
 
ORAL HYPOGLYCAEMIC AGENTS - PART 2.pptx
ORAL HYPOGLYCAEMIC AGENTS  - PART 2.pptxORAL HYPOGLYCAEMIC AGENTS  - PART 2.pptx
ORAL HYPOGLYCAEMIC AGENTS - PART 2.pptx
 
Breast cancer -ONCO IN MEDICAL AND SURGICAL NURSING.pptx
Breast cancer -ONCO IN MEDICAL AND SURGICAL NURSING.pptxBreast cancer -ONCO IN MEDICAL AND SURGICAL NURSING.pptx
Breast cancer -ONCO IN MEDICAL AND SURGICAL NURSING.pptx
 
How to cure cirrhosis and chronic hepatitis naturally
How to cure cirrhosis and chronic hepatitis naturallyHow to cure cirrhosis and chronic hepatitis naturally
How to cure cirrhosis and chronic hepatitis naturally
 
MedMatch: Your Health, Our Mission. Pitch deck.
MedMatch: Your Health, Our Mission. Pitch deck.MedMatch: Your Health, Our Mission. Pitch deck.
MedMatch: Your Health, Our Mission. Pitch deck.
 
Physiology of Smooth Muscles -Mechanics of contraction and relaxation
Physiology of Smooth Muscles -Mechanics of contraction and relaxationPhysiology of Smooth Muscles -Mechanics of contraction and relaxation
Physiology of Smooth Muscles -Mechanics of contraction and relaxation
 
"Radical excision of DIE in subferile women with deep infiltrating endometrio...
"Radical excision of DIE in subferile women with deep infiltrating endometrio..."Radical excision of DIE in subferile women with deep infiltrating endometrio...
"Radical excision of DIE in subferile women with deep infiltrating endometrio...
 
Biologic therapy ice breaking in rheumatology, Case based approach with appli...
Biologic therapy ice breaking in rheumatology, Case based approach with appli...Biologic therapy ice breaking in rheumatology, Case based approach with appli...
Biologic therapy ice breaking in rheumatology, Case based approach with appli...
 

Pathophysiology and clinical_features_of_hemolytic_anemia[1]

  • 1. PATHOPHYSIOLOGY AND CLINICAL FEATURES OF HEMOLYTIC ANEMIA PRESENTED BY:- K.AGASYA RAJ
  • 2. Hemolytic anemia = reduced red-cell life span •The normal red cell life is 110-120 days after which the senile cells are removed by bone marrow and spleenic macrophages. •Reduced red cell survival leads to increased red cell production due to erythropoietin drive that can compensate for the reduced red cell life and maintain a normal Hb level. •The mean red cell life is affected by molecular changes in either the red cell membrane or haemoglobined red cell survival leads to.
  • 3. How hemolysis occurs? • Hemolysis occurs through two ways they are- 1.INTRAVASCULAR HEMOLYSIS 2.EXTRAVASCULAR HEMOLYSIS INTRAVASCULAR HEMOLYSIS EXTRAVASCULAR HEMOLYSIS • PNH,TRANSFUSION RXN • PHYSICAL / MECHANICAL TRAUMA • TOXIC MICROENVIRONMENT • HEMOGLOBINOPATHIES •ENZYMOPATHIES •MEMBRANE DEFECTS •MEGALOBLASTIC ANAEMIA •AIHA •DRUG INDUCED
  • 4. HAEMOLYSIS PATHWAYS ARE OF TWO TYPES