4th edition of Upcycle your business transformation:

4. 1. Vrijdag 16/06/2017: focus Energie
2. Vrijdag 29/09/2017: focus Chemie
3. Vrijdag 01/12/2017: focus Materialen
4. Vrijdag 02/02/2018: focus Healthcare & life Science
5. Vrijdag 20/04/2018 : focus Smart Human Capital
Upcycle your Business Transformation

5. 14%
11%
12%
10%
10%
9%
9%
7%
5%
4%
3%
3%
2% 1%
Assignments per sector 2007 - 2017
Production food
FMCG
Production Non Food
Services
Pharma & Healthcare
Construction
ICT
Transport & Logistics
Bank & Insurances
Energy
Automotive
Chemistry
Government
Aviation & Aerospace

10. We are XPErts by nature
Farmareus Pfizer stopt onderzoek naar
alzheimer- en parkinsonmedicijnen
Na een reorganisatie bij Pfizer stopt het bedrijf de zoektocht naar nieuwe
medicijnen voor de behandeling van alzheimer en parkinson. Dat heeft
Pfizer zelf bekendgemaakt. Het vrijgekomen budget zal volgens het bedrijf
in ander onderzoek geïnvesteerd worden.

11. Help our life-science partners,
improve quality of life by providing the
expertise they require to develop the
drugs, products and support their
customers and patients need.
OUR MISSION

12. XPE Pharma &
Science Belgian
Footprint
300 XPErts
+ 30 nationalities
Clients in Pharma, Biotech, Medical
Devices, Diagnostics, Laboratories,
Food and Beverage, Veterinary,
Healthcare environment
Offices in Wavre & Brussels
Global Competence Center in Cluj
(Romania)
0
50
100
150
200
250
300
2007 2008 2009 2010 2011 2012 2013 2014 2015 2016
Number of consultants
Launch

13. Fields of XPErtise combined with our Services
STAFFING & CONSULTANCY PROJECT MANAGEMENT & DELIVERY
Technical
Clinical
Medical
EXPERT
SOURCING
OUTSOURCING
SERVICES
Sales &
Marketing
PERMANENT
PLACEMENT

14. XPE experts
XPE expertise
Discovery
phase
Preclinical
research
Research
director
Clinical
studies
Study
manager, CRA,
Data manager,
Statistician,
Medical writer,
Project nurses
Scientific
writing,
publications,
eTMF
management
Submission
and
approval
Regulatory
affairs
Manager,
publishers
RA writing
Pricing and
reimburse-
ment
Market
access
manager
Observational
studies
Manu-
facturing
Validation,
engineer, QA
Officer, Lab
technician,
Supply chain
manager
QA system
management
Go to
market
Sales rep,
Marketing
manager,
Medical science
liaison
Salesforce
outsourcing,
After sales/
Healthcare
Nurses, Elderly
care
Patient support
solutions
Experts & expertise for each phase in the
lifecycle of a drug or medical device
TRANSVERSAL: TRAINING, QUALITY MANAGEMENT, IM & IT, TRAINING SOLUTIONS

15. Adherence to treatment
guidelines for ovarian cancer is
correlated with improved survival
rates.
XPE provides psychological and
adherence training at a patient’s
home.
OVARIAN CANCER

16. About 1.7 to 5 billion cases of
diarrhea occur per year. It is the
second most common cause of
death in children younger than 5.
XPE participated developing a
vaccine to prevent Rotavirus:
• developing clinical studies
protocol,
• writing articles for healthcare
professionals,
• creating presentation
materials for congresses.
DIARRHEA

17. The average fatality rate of Ebola
virus is around 50%. Case fatality
rates have varied from 25% to 90%
in past outbreaks.
XPE participated in the
development of a vaccine by
writing protocols for the clinical
study
EBOLA VIRUS

18. Transformation

19. Develop &
renew expertise
Transformation
• From experts to expertise
• From staffing provider to consultancy and
project management leader
• Talent leadership
• From recruiter to digital marketeer

20. Technology
Transformation/Innovation
•E-platforms
•Videos in publication management
•Digital follow up of PSP
•Innovation manager
•Joined projects with Modis IT &
Engineering

21. Data Protection
Transformation
• Cybersecurity
• GDPR
• Compliance
.

24. VISION ON
TECHNOLOGY FOR
A BETTER WORLD
SUSTAINABLE
SOCIETY

25. WE CREATE
VALUE
BY IMPACT
SUSTAINABLE GROWTH IS THE
ONLY POSSIBLE GROWTH
DIRECT IMPACT
INDIRECT IMPACT
SYSTEM/FRAME CHANGE

26. VITO CONVERTS IDEAS
INTO REALITY
VITO MAKES OUR ENVIRONMENT
HEALTHY AND SUSTAINABLE
FROM SCIENCE
TO APPLICATION
VITO SUPPORTS THESE
SUSTAINABLE
DEVELOPMENT GOALS

27. WE DE-RISK INNOVATION
FOR COMPANIES
WE CONNECT RESEARCH AND MARKET,
KNOWLEDGE AND BUSINESS
WE OFFER
SOLUTIONS
WORLDWIDE

28. WE MAKE FLANDERS AND THE
WORLD MORE SUSTAINABLE
HEALTH
MATERIALS
ENERGY
CHEMISTRY
LAND USE

29. FLEXIBLE ENERGY
SYSTEMS
THE ENERGY LAB
OF THE FUTURE

30. ALTERNATIVES
FOR LIMITED RESOURCES AND
POLLUTING PROCESSES
EFFICIENT SUSTAINABLE
CHEMISTRY

31. TRANSITION
TO A
CIRCULAR
ECONOMY
MATERIALS
CIRCULAR

32. MITIGATE HEALTH
SYSTEMS
PREVENTIVE HEALTH
CARE

33. INSIGHT IN
OUR EARTH
BETTER MANAGING RESOURCES
THANKS TO ADVANCED
ENVIRONMENTAL MONITORING
LAND - WATER - AIR

34. WE PROVIDE SOLUTIONS
WORLDWIDE
227 SCIENTIFIC PUBLICATIONS34 NATIONALITIES
MORE THAN 400 PATENTS
24 NEW
PATENTS EVERY
YEAR
> €170 MILLION TURNOVER
784 EMPLOYEES
76 SME’S
91 PHD’S AND POSTDOCS
Experts
Projects
Experts and Projects
SUSTAINABLE ENTREPRENEURAL INSPIRING CREATIVE

35. VITO PILLARS FOR VALORISATION

36. VITO TECH TRANSFER
WHAT CAN WE DO FOR YOU?
©VITO – Not for distribution
6/02/2018

37. The VITO Tech Transfer Office builds cleantech ventures and
transfers technology for a more sustainable, circular economy.
We connect VITO & aspiring entrepreneurs to start & grow
businesses, that address the societal challenges of tomorrow.
Our quest is to identify, nurture, guide & close opportunities
with capacity to profitable growth & worldwide impact.
TECH TRANSFER TEAM – MISSION

38. PARTNERS IN THE TECH TRANSFER PROCESS
6/02/2018 ©VITO – Not for distribution 40

39. PORTFOLIO
6/02/2018 ©VITO – Not for distribution 42

40. VENTURES
(*) pipeline
<2014
2014
2015
2016
20174
1
2
*

41. VITO SPIN-OFFS & STARTUP LICENCES OVERVIEW
CO2-negative
building materials
Sustainable
thermal energy
systems
Privacy-compliant
patient monitoring
3D coating with
hard materials
Drone flight control
platform SW
Battery data
management SW
Atmospheric
plasma devices
Virtual cycling platform
for homebound elderly
3D backflush membranes
Soil pollutant
Monitoring & modelling
In 3D & over time
20172014
VITOFOAMPortal for mapping
air pollutant exposure
Retina (eye)
health monitoring
(pollution & dementia)
Titanium foam for implants
(partner in China)
Drone flight
Platform SW

42. International research & technology centre
Cleantech & sustainable innovation
Connecting partners & stakeholders
Bridging knowlegde, policy & business
Active Technology Transfer Office & Team
VITO – VISION ON TECHNOLOGY
ENERGY
MATERIALS
CHEMISTRY
HEALTH
LAND USE

43. Thank you

45. A new vision on
Oxygen Therapy for
Hospitals
Keynote – Health & Life Science
02/02/2018
www.oxypoint.eu

46. First Oxypoint Commercial Innovation
The Econo-Comfort O2-Flowmeter
“More Comfort with less O2 spilling!”
6/02/2018 Oxypoint – confidential – Patent protected 51

47. Econo-Comfort O2-Flowmeter = Pneumatic
device
Combines 2 modes:
• Comfort mode (unique for hospitals)
• Continuous mode (standard in hospitals)
• USP:
• More comfort for the patient
• Less consumption (up to 75% less O2)
• ROI for the hospital: 3 to 4 years
6/02/2018 52Oxypoint – confidential – Patent protected

48. O2 delivery in comfort mode
6/02/2018 53
Breathing pattern
Inspiration Expiration
Classic
Continuous O2
Comfort O2
Oxypoint – confidential – Patent protected
Comfort O2

49. “More Comfort”
6/02/2018 54Oxypoint – confidential – Patent protected

50. 55
Patented technology
Measuring relative humidity = “Comfort measurement”
6/02/2018 55
Oxypoint – confidential – Patent protected

51. Continu 5
Comfort 5Comfort 4Comfort 3Comfort 2Comfort 1
Continu 4
Continu 3
Continu 2
Continu 1
Blanco
Relative humidity in the nose
with O2
6/02/2018 56Oxypoint – confidential – Patent protected

52. 6/02/2018 57
No more humidifiers => lower infection risk!
Oxypoint – confidential – Patent protected

53. “Less Spilling”
6/02/2018 Oxypoint – confidential – Patent protected 58

54. University Hospital of Antwerp
Cardiac Surgery ‘Low Care’ (26 beds)
6/02/2018 59Oxypoint – confidential – Patent protected

55. University Hospital of Antwerp
Cardiac Surgery ‘Low Care’ (26 beds)
6/02/2018 60
« Reduced oxygen spilling of ± 75% (mixed use) »
« Equal patient oxygenation confirmed (SaO2) »
Oxypoint – confidential – Patent protected

56. University Hospital of Ghent
Respiratory Care (30 beds)
6/02/2018 61Oxypoint – confidential – Patent protected

57. University Hospital of Ghent
Respiratory Care (30 beds)
6/02/2018 62
« Reduced oxygen spilling of ± 40% (mixed use) »
« Equal patient oxygenation confirmed (SaO2) »
Oxypoint – confidential – Patent protected

58. Valve closes automatically
=> No more open flowmeters
6/02/2018 63Oxypoint – confidential – Patent protected

59. Next generation Hospital Oxygen devices
6/02/2018 64Oxypoint – confidential – Patent protected

60. Connected Hospital Oxygen therapy
Oxypoint – confidential – Patent protected6/02/2018 65

61. Connected Hospital Oxygen therapy
Oxypoint – confidential – Patent protected6/02/2018 66

62. Mobile Hospital Oxygen therapy
Oxypoint – confidential – Patent protected6/02/2018 67

63. Mobile Hospital Oxygen therapy
Oxypoint – confidential – Patent protected6/02/2018 68

64. Ready to grow
6/02/2018 69Oxypoint – confidential – Patent protected

65. 2011 2012 2013 2014 2015 2016 2017
Milestone
Company creation
Milestone
Company
People
Product
Commercial
Milestone
Manufacturer selection
Milestone
CE Mark
Milestone
Proof of Concept
Patent Application (awarded)
Milestone
First customer
Milestone
5 customer references
Milestone
10 customer references
Milestone
First export
Milestone
20 customer
references
Milestone
Growth preparation
VC contacts.
Milestones
“Most promising starter” nomination
Trends Gazellen 2014
Milestones
Trends Gazellen 2015
Milestone
Medica
International
interest
COMMERCIAL VALIDATION
EXPANSION
Company Milestones
Oxypoint – confidential – Patent protected6/02/2018 70
Milestones
Team grows:
5FTE
Milestone
Sold 2000
products
Milestones
Team starts:
2 FTE

66. Fast growing and strong track record of 20 hospitals
Oxypoint – confidential – Patent protected6/02/2018 71

67. Innovation prices and awards

68. Conclusion
Health & Life Science
Highly regulated field and hospitals are slow adopters
Innovation
Promising future pipeline and interesting new tech. ecosystem
Governmental help
Very helpful innovation and growth subsidies
Idea: creating incentives for (hospital) clients to buy innovations
Employment
Phase 1 (past, self-sufficient small team) 2 FTE => 5 FTE
Phase 2 (future, post Series A Financing) 5 FTE => 10 FTE => 16 FTE
6/02/2018 73Oxypoint – confidential – Patent protected

70. SMART & HEALTHY CITIES
- THE ENERGY PERSPECTIVE
February 2018
6/02/2018 ©VITO – Not for distribution 75

71. Urbanisation challenge
6/02/2018
©VITO – Not for distribution
76
Cities take 2%of
global surface

72. • Energyville is a top research institute on sustainable energy system for large urban areas.
Energyville’s 300 researchers develop new technology, knowledge and methodologies, resulting in
new products and services, development of human capital, and science-based policy support from
local to global level.

73. 6/02/2018
©VITO – Not for distribution
78
THE URBAN COMPLEXITY REQUIRES
CREATIVITY, INNOVATION,
INTEGRATION

74. 6/02/2018 ©VITO – Not for distribution 79
TO MAKE OUR CITIES A HEALTHY,
CLEAN AND PRODUCTIVE
ENVIRONMENT

75. NOVEL APPROACH TO URBAN PLANNING – HARDWARE OF THE CITY
6/02/2018
©VITO – Not for distribution
80
ENERGY EFFICIENCY
RENEWABLE GENERATION
STORAGE & FLEXIBILITY

76. 6/02/2018
©VITO – Not for distribution
81
Hooyberghs, H., Verbeke, S., Lauwaet, D., Costa, H., Floater, G., & De Ridder, K. (2017). Influence of climate change on summer
cooling costs and heat stress in urban office buildings. Climatic Change, 144(4), 721-735.
ENERGY EFFICIENCY – THERMAL
COMFORT – HEALTH
the challenge in keeping Western-European office buildings
comfortable until the end of the 21st century … large decreases
in cooling costs (up to 30%) caused by the introduction of
(external) shading and increased night-time ventilation in
actively cooled buildings, and the improvements in working
conditions in free-running buildings caused by moving workers
to cooler locations and splitting workdays in morning and
evening shifts.

77. 6/02/2018
©VITO – Not for distribution
82
BUILT ENVIRONMENT – GREEN –
URBAN CLIMATE

78. component building urban scale
SMARTNESS TO SOLVE THIS
OPTIMIZATION PUZZLE

79. Data processing and algorithms
Sensors and devices
Metering, monitoring devices and
sensors
Aerial and satellite data
Buildings and infrastructures, real time
and predictive climate data
Application generated
data
User and usage related content, context and
feedback data
INCREASING POWER OF DATA

80. Leuven Climate Neutral 2030
THE SOFTWARE - CITYZEN
CENTRED APPROACH

81. Ipsos, 2012
Environmentally friendly behaviour
KnowledgeonEnergy
THÉ ENERGY USER DOES NOT EXIST

82. © VITO EBECS home energy check
Your Energy Plan
DEBURDEN THE END USER
FROM DECISION STRESS

83. 6/02/2018 ©VITO – Not for distribution 88
© VITO EBECS home energy check
www.homefit.be
NEW BUSINESS MODELS
CUSTOMIZED SERVICES

84. 6/02/2018
©VITO – Not for distribution
89
MOBILITY AS A SERVICE
Mobility Comfort @ ¼ of annual cost
SHARED, AUTONOMOUS, CLEAN MOBILITY

85. DRUK OP
GEZONDHEIDSSYSTEMEN
VERLICHTEN
SUSTAINABLE HEALTH@VITO
6/02/2018 ©VITO – Not for distribution 90
Rudi Torfs

86. 6/02/2018 ©VITO – Not for distribution 91
Success of Healthcare is unsustainable

87. VITO icons can be found on: Y:_StoresStore02BeeldDataLogo's__VITOIconen
VITO pictures can be found on: Y:_StoresStore02BeeldDataFoto
Future healthcare will tackle disease by moving away from a ‘one size fits all
approach’, by integrating data on the entire dynamic biological makeup of
each individual, as well as the lifestyle and environmental factors that
interact with this makeup to develop a complex and individual phenotype.
This integrated information will be used to identify the most appropriate
healthcare for individual citizens.

88. https://www.peekvision.org/
Understanding how environment, lifestyle and genotype influence health creates potential for
improved preventative approaches
integration
OMICS

89. Non-invasive early diagnosis of disease for cost-efficient therapies
www.iflexis.com
© www.owlstonemedical.com

90. Empowerment & Participation
The connected city offers citizens the opportunity to actively participate in policy and
sustainability in cities by measuring their own living environment
and regaining information that empowers them to ask for or seek solutions to protect their health
6/02/2018 ©VITO – Not for distribution 95

91. Quality and cost of sensors are improving – enabling more and personal measurements
6/02/2018 ©VITO – Not for distribution 9635$ © Plumelabs – source flow.plumelabs.com
© Plumelabs – source flow.plumelabs.com
139$
?

92. CO-PRODUCTION OF KNOWLEDGE
DENCITY ONDERZOEK NAAR EEN
FIJNMAZIG CITY-SENSING
NETWERK
VOOR OMGEVINGSPARAMETERS
PARTNERS: IMEC, VMM, VITO
DOEL: NETWERK VAN SENSOREN
OPZETTEN DAT KWALITEITSVOLLE
DATA GENEREERT
6/02/2018 ©VITO – Not for distribution 97

93. 6/02/2018 ©VITO – Not for distribution 98
The point of care @ Home: big opportunity for better integration of care in the smart & connected
house
THE IOT PROVIDES COMFORT, SECURITY, LEISURE… AND HEALTH?
indoor air quality
sensor box

94. Activ84Health: user centered design & solution to stay physically active
6/02/2018 ©VITO – Not for distribution 99

95. • INTEGRATED CARE REQUIRES COLLABORATION ACROSS SECTORS AND DATA… LOTS OF DATA
6/02/2018 ©VITO – Not for distribution 100

96. inclusiveness
6/02/2018 ©VITO – Not for distribution 101
Time is right and
technologies are there to
set up large population
studies
Systems biology, sensors,
automatisation, mobile internet, cloud
computing, AI/Machine learning, data
analytics
Just Do It
https://www.nehi.net/writable/publication_files/file/paradox_full_report.pdf

97. No solution [to the problem of poverty] is so effective as providing income to the poor. Whether in
the form of food, housing, health services, education or money, income is an excellent antidote for
deprivation.
John Kenneth Galbraith, The age of uncertainty, 1979
6/02/2018 ©VITO – Not for distribution 102

104. What we have now…
• A system challenged by ( at least) 5 disruptive forces
• The Greying patient ( and Provider…)
• The Lifestyle Epidemic
• The Information Revolution
• The Blessing and Curse of Technology
• The New Health Care Consumer ( and Provider…)
A Rosen, Executive Research
Brief, The Advisory Board, 2014

105. The Greying Patient
110

106. The Greying Provider
111

107. The Lifestyle Epidemic
112

108. The Lifestyle Epidemic
113

109. The Information Revolution
114

110. The Information Revolution
115

111. The Blessing and Curse of technology

112. The Blessing and Curse of Technology
US approves first cancer drug to use patient's own cells
– with $475,000 price tag
117

113. The New Healthcare Consumer
118

114. The New Healthcare Provider
119

116. What we can have…

117. ...but in a world with limited budgets...
122

118. ...where many needs have been met...
123
81,1 80,782,282,382,382,482,983,083,083,784,084,284,4
78,2 77,1
75,4
77,278,077,278,278,978,479,078,479,2
77,5
0
10
20
30
40
50
60
70
80
90
FR SWITZ* ITA* AUS CAN* SWE NOR* GER* NETH OECD
Median
NZ UK** US*
Female Male

119. ...and spending yet more money is insane...
124

120. …where 1 out three dollars/euro’s/…spent is pure waste…

121. …where 50 % of the total budget is spent on 5% of the population…

122. …and where less than 5% is spent on prevention…?!

123. What we should have…
• A system that saves and fosters Health
• Collectively
• Personally
• Predictive
• Preventive
• And that supplies , when saving health fails, Care for
the diseased,of the highest possible quality

124. What is “Quality of Care”
‘The degree to which health services for individuals and populations
increase the likelihood of desired health outcomes and are consistent with
current professional knowledge’ (IOM)
= a worldwide challenge

125. What is “Quality of Care” ?
“Quality” contains various elements
• Effective
• Efficient
• Continuous
• Safe
• Patientcentered
• Timely
• Accessible
• Integrated

126. What we should have…
Bodenheimer & Sinsky, Ann Fam Med 2014;12:573-6

128. How to maximize value for patients in the HC system
Volume-based Value-based
Payment FFS Outcome based
Incentive Volume Value
Focus Acute episodes Populations
Role of provider Single episodes Care continuum
Information Retrospective Real-time & predicitve
Leadership style Managerial
divisional/departemental
thinking
Thinking across organisation

130. Belgian hospitalitis...
International comparison shows
– More acute hospital beds
– Many more psychiatric hospital beds
– More hospital admissions
– Longer hospitalisation stays
– More hospitalisation days / inhabitant
– More medical equipment & usage offering
...than the average European country

131. Netwerking : the New Holy Grail..?

134. The Hospital of the Future is a Network
•Published on February 17, 2017185
Jeroen Tas
Chief Innovation & Strategy Officer at Philips
Connecting Care for Continuous Hlth

136. Focus on CARE in
horizontal networks
Focus on specialisation
in clinical networks

139. Hospital networks:
quo vadis?

140. But:
145
Braithwaite et al: Complexity Science in Healthcare. Aspirations, approaches,
applications and accomplishments. A White Paper. Australian Institute of
Health Innovation.

141. Traditional Systems
• Improvement by decomposing
performance and management
into component elements, and
subsequently recomposing it by
integrating the designed
solution for each element
• Characteristics:
• Ability to de- and recompose
the elements of the system;
“designed”
• Linearity, predictability, “dead”
• Can be complicated, but not
“complex”
• Power with authority and
resources to (re)design the
system
• Works well in automotive,
manufacturing, retail,…
CAS
• Can NOT be addressed thru
hierarchical de/recomposition!
• Characteristics:
• Non-linear & dynamic : system
behaviour may appear to be
random/chaotic
• Composed by individual agents
who’s behaviour is based on
physical, psychological, or social
rules rather than on demands of
the system
• Agents are often conflicting and
intelligent : the overall system
behaviour learns and adapts
• Hence may lead to self-
organisation : patterns emerge
rather than being designed
• No single point of control : no one
is in charge

142. 147

143. 148

144. Real challenges…
• Do we accept that “Healthcare” is ( or at least behaves
like) a CAS (Complex Adaptive System ) with it’s own
governing laws ?
• And, therefore, is in need for a longterm purpose
(“Ikigaï”) and framework design, and should allow for the
role of non-linear thinking? E.g., allowing for Serendipity
• If Integrated Care is that purpose, should the obvious
first step not be...(re)integration..?
• (Hence, “networking” is (only) a means, not a goal)
• Do we accept than, that : “collaboration”, “networking”,…
and therefore Healthcare, is foremost dependent on
human interaction (sometimes two are sufficient…)

145. 150
Build serendipity into your strategy process

146. 6/02/2018 Marc Noppen Vlerick Strategy© 151

147. …so we should never,never forget the Purpose, The
Human Factor…

148. Healthcare 2.0
Marc Noppen,MD,PhD
CEO, University Hospital UZ Brussel
marc.noppen@uzbrussel.be