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Snapshot of investigational anti-Ebola therapies (24 October 2014)
- 1. Snapshot of investigational anti- Ebola therapies ZEENA NACKERDIEN
- 2. Potential anti-Ebola drugs Pre-clinical antivirals References oral T-705 (Favipiravir) Smither et al, 2014 griffithsin (antiviral lectin) Barton et al, 2014 benzodiazepine derivative (compound 7) Basu et al, 2014 S-adenosyl-L-homocysteine hydrolase inhibitor Bray et al, 2000; Huggins et al, 1999 3-deazaneplanocin A Bray et al, 2002 Small molecule inhibitors of ER alpha-glucosidases Chang et al, 2013 FGI-103, FGI-104, FGI-106, dUY11, and LJ-001 de Clerq et al, 2013 novel broad-spectrum small molecule that could block cathepsin L-mediated cleavage Elshabrawy et al, 2014 ribavirin Huggins et al, 1989 a set of selective estrogen receptor modulators (SERMs), including clomiphene and toremifene, which act as potent inhibitors of EBOV infection Johansen et al, 2013 Retinazone Kesel et al, 2014 C795-0925, D011-2120, F694-1532 and G202-0362 Mudhasani et al, 2014 BCX4430 Warren et al, 2014 lamivudine (anecdotal) A Liberian doctor is using HIV drugs to treat Ebola victims. The NIH is intrigued.
- 4. Latest updates on Ebola vaccine trials (clinicaltrials.gov) 2007 2009 2010 2012 2013 2014 2014 2014 2014 2014 2014 NCT02271347 ,CMX001 NCT02231866 ,VRC-EBOADC069-00-VP NCT00646152 , Poly-ICLC NCT02267109 ,Ebola Chimpanzee Adenovirus Vector Vaccine (cAd3-EBO Z) NCT02240875 , cAd3-EBO Z at 1 x 10^10 vp|cAd3-EBO Z at 2.5 x 10^10 vp| cAd3-EBO Z at 5 x NCT00997607 ,Ebola vaccine| Marburg vaccine|Placebo injection NCT01353027 ,Placebo|AVI-6002 NCT00605514 ,VRC-EBODNA023-00-VP|VRC-MARDNA025-00-VP NCT00374309 ,VRC-EBOADV018-00-VP NCT00072605 , VRC-EBODNA012-00-VP 10^10 vp NCT02269423 ,BPSC-1001| Placebo
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- 1. Smither SJ, Eastaugh LS, Steward JA, Nelson M, Lenk RP, Lever MS. Post-exposure efficacy of oral T-705 (Favipiravir) against inhalational Ebola virus infection in a mouse model. Antiviral Res. 2014;104:153-155. 2. Barton C, Kouokam JC, Lasnik AB, et al. Activity of and effect of subcutaneous treatment with the broad-spectrum antiviral lectin griffithsin in two laboratory rodent models. Antimicrob Agents Chemother. 2014;58(1):120-127. 3. Basu A, Li B, Mills DM, et al. Identification of a small-molecule entry inhibitor for filoviruses. J Virol. 2011;85(7):3106-3119. 4. Bray M, Driscoll J, Huggins JW. Treatment of lethal Ebola virus infection in mice with a single dose of an S-adenosyl-L-homocysteine hydrolase inhibitor. Antiviral Res. 2000;45(2):135-147. 5. Bray M, Raymond JL, Geisbert T, Baker RO. 3-deazaneplanocin A induces massively increased interferon-alpha production in Ebola virus-infected mice. Antiviral Res. 2002;55(1):151-159. 6. Chang J, Warren TK, Zhao X, et al. Small molecule inhibitors of ER alpha-glucosidases are active against multiple hemorrhagic fever viruses. Antiviral Res. 2013;98(3):432-440. 7. De Clercq E. A Cutting-Edge View on the Current State of Antiviral Drug Development. Med Res Rev. 2013. 8. Elshabrawy HA, Fan J, Haddad CS, et al. Identification of a broad-spectrum antiviral small molecule against severe acute respiratory syndrome coronavirus and Ebola, Hendra, and Nipah viruses by using a novel high-throughput screening assay. J Virol. 2014;88(8):4353-4365. 9. Huggins J, Zhang ZX, Bray M. Antiviral drug therapy of filovirus infections: S-adenosylhomocysteine hydrolase inhibitors inhibit Ebola virus in vitro and in a lethal mouse model. J Infect Dis. 1999;179 Suppl 1:S240-247. 10. Huggins JW. Prospects for treatment of viral hemorrhagic fevers with ribavirin, a broad-spectrum antiviral drug. Rev Infect Dis. 1989;11 Suppl 4:S750-761. 11. Johansen LM, Brannan JM, Delos SE, et al. FDA-approved selective estrogen receptor modulators inhibit Ebola virus infection. Sci Transl Med. 2013;5(190):190ra179. 12. Kesel AJ, Huang Z, Murray MG, et al. Retinazone inhibits certain blood-borne human viruses including Ebola virus Zaire. Antivir Chem Chemother. 2014;23(5):197-215. 13. Mudhasani R, Kota KP, Retterer C, Tran JP, Whitehouse CA, Bavari S. High content image-based screening of a protease inhibitor library reveals compounds broadly active against Rift Valley fever virus and other highly pathogenic RNA viruses. PLoS Negl Trop Dis. 2014;8(8):e3095. 14. Warren TK, Wells J, Panchal RG, et al. Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430. Nature. 2014;508(7496):402-405.