Changing Design Paradigm for Affordability and Access

Changing the Design Paradigm. Affordability and Access through sustainability. Bala Manian, PhD. ReaMetrix Inc. San Carlos, CA

What is the context of my talk? ,[object Object],[object Object],[object Object],[object Object],[object Object]

Why & how do we need to look at this differently? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Diagnostics – A case study ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Example - CD4/CD8 Reagents ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Measurement of Absolute CD4+ and CD8+ T cell counts using Tri T-STAT 1. Identification of CD3+ T-Cells 2. Enumeration of volume metering beads 3. CD4+ & CD8+ T-Cell counts derived from the CD3+ T-Cell population  CD8 + T-Cells  CD4+ T-Cells

Correlation of Tri T STAT with accepted standards

Tri T-STAT Proven Reproducibility Cell Type Level Mean SD CV (%) CD4+CD3+ T cells High 936 18 1.9 Medium 461 19 4.1 Low 168 7 4.3 CD8+CD3+ T cells High 721 14 2.0 Medium 486 14 2.8 Low 243 11 4.5

How do we define resource poor setting? ,[object Object],[object Object],[object Object],[object Object]

Does India represent Resource poor setting?

What is the existing paradigm? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

What is wrong in this picture? ,[object Object],[object Object],[object Object],[object Object],[object Object]

How to frame the big picture? ,[object Object],[object Object],[object Object],[object Object],[object Object]

Anatomy of the Cost of Goods Sold (COGS) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

How the costs are influenced? ,[object Object],[object Object],[object Object],[object Object]

Different priorities in different environments ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

How to change the paradigm? ,[object Object],[object Object],[object Object],[object Object],[object Object]

Dry Reagents ,[object Object],[object Object],[object Object],[object Object],[object Object]

Sample collection & centralized processing ,[object Object],[object Object],[object Object],[object Object],[object Object]

Post fixation stability of blood sample

Unintended benefits derived from dry reagents ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

What lessons are to be learned? ,[object Object],[object Object],[object Object],[object Object],[object Object]

Thinking differently about Healthcare Delivery ( Work being carried out by HAP (http://www.hapindia.org/))

Saantwanam A health screening project Kerala (India) ,[object Object],[object Object],[object Object],[object Object]

The Investment ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Item Cost [Rs]

[object Object],[object Object],[object Object],[object Object],[object Object],10 glucose estimations 250 15 blood pressure 150 10 BMI 50 Average income/day 450 Total per month 1250 Net income anticipated - over Rs 5000 per month Over 150 care givers servicing 200K screens/ year 20% earning over Rs. 10,000 per month. Expense Income

What questions that arise from this observation? ,[object Object],[object Object],[object Object],[object Object]

In summary… ,[object Object],[object Object],[object Object],[object Object],[object Object]

Changing Design Paradigm for Affordability and Access

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Changing Design Paradigm for Affordability and Access