6. STAT 1 STAT 2 STAT 3 STAT 4 STAT 5 STAT 6 SH2 DNA Helix 750 851 DNA SH2 Helix 770 SH2 DNA Helix 748 SH2 DNA Helix 734 SH2 DNA Helix 848 Helix SH2 KGTGYIKTEL 701 ERRKYLKHRL 690 SAAPYLKTKF 705 GDKGYVPSVF AVDGYVKPQI KDGRGYVPAT 693 694 641 Activators IFN- , , IFN , EGF, PDGF, Insulin, Ang II, VEGF IFN- , Ang II IL-6, LIF, CNTF, ET-1, serotonin, GM-CSF, IL-10, Leptin, EGF, PDGF, Ang II, FGF, VEGF IL-4 and IL- 12 Prolactin, GH, IL-3, Epo, IL- 5, Ang II, Insulin, GM-CSF IL- 4, IL-13, Ang II, PDGF, FGF
7.
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9. Ang II NH 2 NUCLEUS c-fos YIPP COOH STAT 1 / Fyn + SHP-2 + JAK2 SHP-2 JAK2 P STAT 1 / STAT1 / STAT1 / P P STAT1 / STAT1 / P P Fyn P P SHP-2 MKP-1 STAT 1 / P P Fyn P P JAK2-STAT1 activation
10. NK-22 cell-secreted cytokines stimulate epithelial cells to proliferate, release IL-10 and activate STAT1 and STAT3. M Cella et al. Nature 000, 1-4 (2008)
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15. Class IIB(3)(b) latent cytoplasmic factors These families not present in fungi or plants, hinting at an important evolutionary divergence leading to animals.