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Signal Transducer &Activator of Transcription( STAT)-3 &  T  Helper (Th) 17  Cell in Psoriasis Immunopathogenesis ,[object Object],[object Object]
Signal   transducers   and   activators   of   transcription )  Stat) Family ,[object Object],[object Object],[object Object]
 
 
STAT3 Activation ,[object Object],[object Object],[object Object]
Mechanism of Stat3 signaling ,[object Object]
Psoriasis
Psoriasis ,[object Object],[object Object]
Psoriasis Clinical Presentation
Psoriasis as an immune disorder
Prepsoriasis State
Prepsoriasis State
Development of Psoriasis
Immunopathology of Psoriasis
T-Cell in Psoriasis
T  helper  1  versus 2  in psoriasis ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object]
T helper cell precursors being skewed towards Th1, Th2, Th17 and T regulatory cell (Treg) phenotypes on the basis of the cytokine environment . 
PSORIASIS IS A  Th17  DISEASE  :A  Hypothesis ,[object Object],[object Object],[object Object]
PSORIASIS IS A  Th17  DISEASE ,[object Object],[object Object],[object Object],[object Object]
 
Microbial Antigens &  Th 17  Response ,[object Object]
ACTIVATION of T h 17 &STAT3   ,[object Object],[object Object],[object Object]
STAT3  REGULATION  of CYTOKINE-MEDIATED GENERATION of TH  17 ,[object Object],[object Object],[object Object],[object Object]
 
Proinflammatory  Effects  of  IL17
Stat3 links activated keratinocytes and immunocytes required for development of psoriasis   ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
A positive feedback mechanism for Th1/Th17 inflammation . ,[object Object],[object Object],[object Object]
 
[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object],[object Object]
[object Object],[object Object],[object Object]
 
New Informations
 
Do Other Therapies Work Within This Framework? ,[object Object],[object Object]
Studies on Stat 3 in Psoriasis
Stat 3 in Psoriasis
 
 
New Prospectives &Directions
 
Manipulation of Psorasis
 
Therapeutic  Targets  ( Fitch   et al ,  Current Rheumatology Reports  2007,  9: 461–467 )   Fitch et al.
Message Home
Message Home ,[object Object],[object Object]
THANK YOU

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