Nitric oxide (NO) is an important vasodilator that improves circulation. In 1998, three Americans received the Nobel Prize in Physiology or Medicine for discovering NO's role in the cardiovascular system. NO dilates blood vessels, promotes angiogenesis, decreases swelling, and increases blood flow and nutrient delivery to cells. Diabetic patients have lower NO levels and circulation problems. Better circulation is critical for conditions like diabetes as it can decrease pain and support wound recovery. There is significant research supporting the benefits of NO in areas like falls prevention, wound healing, and pain relief.