5. Serous Cell
• Stain darkly with
haematoxylin and eosin
• Rounded nuclei towards the
base
6. Nucleus encodes a message
Aminoacid with specific sequence is synthesized
These pre proteins contain NH2 terminal called signal
sequence
7. Signal sequence is attached to rough endoplasmic
reticulum
RER recognizes the signal sequence and crosses
with the growing polypeptide chain
Newly synthesized protein reaches the cisternal
space of RER
Protein reaches the golgiapparatus
8. • Budding vesicles of RER enter from the cis
face.
vesicles fuses with the golgi saccules
proteins are packed in to vacuoles
(immature granules)
They under go glycosylation and forms
mature granule
9. Mucous Cell
• Mucous cells stain very
lightly
• Completely filled by
mucoid material (stains
poorly)
• This material pushes the
nuclei towards the
basement membrane
• Nuclei are flattened
18. DEVELOPMENT OF SALIVARY
GLAND
• They originate from oral
epithelial buds invading the
underlying ectomesenchyme
• The origin of epithelial buds
Ectodermal in parotid
and minor salivary gland
Endodermal in
submandibular and
sublingual glands
• The connective tissue stroma
and blood vessels origin from
the mesenchyme
19. Gland Location IU life
Parotid gland Corner of stomodium 6th week
Sub mandibular gland Floor of mouth End of 6th week
Sub lingual gland Lateral to sub
mandibular primordium
8th week
Minor salivary glands Buccal epithelium 12th week
20. STAGES OF DEVELOPMENT
• STAGE I:
Bud formation :Induction
of oral epithelium by
underlying mesenchyme
33. Parotid duct
• Thick walled
• About 5 cm long
• Emerges from middle of anterior border
• Relations are :
• superiorly
1. Accessory parotid gland
2. Upper buccal branch of facial nerve
3. Transverse facial vessels
• Inferiorly : The lower buccal branch of the facial nerve
45. Organic components of saliva
Other substances
• Blood group substances, sugars, steroid hormones, amino
acids, ammonia, urea
46.
47. SALIVA SECRETION
• The formation of saliva occurs in two stages.
1. In the first stage - primary saliva.
2. In the second stage, the primary saliva is modified.
50. • Ductal modification of
primary saliva:
• Occurs principally through
reabsorption & secretion of
electrolytes
• The luminal & basolateral
membrane have abundant
transporters that function to
produce a net reabsorption of
Na⁺ & Cl⁻ resulting in
formation of hypotonic final
saliva
• The final electrolyte
composition of saliva varies
depending on the salivary flow
rate
51.
52. Control of secretion
• It is through the activity of the ANS.
Sympathetic and Para sympathetic
postganglionic fibres
secretory, myoepithelial cells, intercalated
ducts, straited ducts
53. • 2 types of innervation are seen
intra epithelial{hypolemmal}
sub epithelial{epilemmal}
• Stimulus secretion coupling ?
54. • Stimulation of alpha , beta and cholinergic
receptors causes ?
• Substance P and vasoactive intestinal
polypeptides
56. • Secretory cells are stimulated. protein
secretion occurs in two pathways
1. primary pathway (main pathway)
2. secondary pathway.
Transcytosis – from basolateral to apical cell
57. Saliva & Age:
• With age, a generalized decrease in saliva
Decreased parenchymal tissue occurs/
medication
• Resting salivary secretion is in the normal range,the volume of
saliva produced during stimulated secretion is less than
normal.
59. • Other functions are
taste perception
speech
tissue repair
digestion
excretory
mastication and deglutition
60.
61. Saliva production
– Differential saliva production by glands
• Unstimulated salivation (Salivary gland at rest)
– 1.5 Liters produced per day (basal rate)
– Major salivary glands: 90% of saliva produced
– Submandibular and sublingual glands: 70% of saliva
• Stimulated salivation
– Saliva production increases 5 fold
– Parotid gland produces majority of saliva
