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Biotechnology & 
Nanotechnology: Sector 
Profile 
1
Table of Contents 
1. Biotechnology 
1.1 Biotechnology: Indian Scenario 
1.2 Biotechnology: Gujarat Scenario 
2. Nanotechnology 
2.1 Nanotechnology: Global Scenario 
2.2 Nanotechnology: India Scenario 
2.3 Nanotechnology: Gujarat Scenario
1. Biotechnology 
3
1.1 Biotechnology: India Scenario 
4
Biotechnology: India Scenario 
“BT Jogindernagar 
Shimla 
Chandigarh 
Pantnagar 
+ BT = BT” 
“Bharat Today + Bio Technology = Bharat Tomorrow” – Shri NarendraModi, Hon’ble 
Prime Minister 
India is already ranked among the top 12 biotech destinations worldwide and third 
largest in the Asia ‐ Pacific region 
 Increasing government expenditure is likely to augment growth 
Alwar Sohna 
Jodhpur Jaipur 
Gandhinagar 
Anand 
Baroda 
Jamnagar 
Midnapore 
g g p y g g 
 By FY17, India’s biotech industry is estimated to increase to USD 
11.6 billion from USD 4.3 billion in FY12 
 Rising pharmaceuticals market is estimated to aid growth of the 
biotech industry 
Aurangabad 
Pune 
Karwar 
Bhubaneshwar 
Konark 
Hyderabad 
Visakhapatnam 
Bengaluru 
20 
10 
Biotech market (USD billion) 
CAGR: 21.9% 
Kochi 
Madurai 
Chennai 
Puducherry 
0 
4.3 11.6 
FY12 FY17 
Biotech market (USD billion) 
Pharma Biotechnology Parks 
World’s largest producer of Vaccines 
40 
30 
20 
10 
market in India (USD billion) 
15.6 
35.9 
CAGR: 
18.1% 
World’s largest cultivator of Bt Cotton 
1st in terms of growth in transgenic crops 
3rd with 5 
0 
2P0h1a1rma market in Indi2a0 (U16SDF billion) 
Source: Ministry of Health, Government of India, Planning Commission, GSBTM 
highest biotech companies in Asia Pacific
Biotechnology: India Scenario 
Market Share & Future plan 
The Indian biotechnology sector is one of the fastest growing knowledge‐based sectors in India and is expected to 
play a key role in shaping India's rapidly developing economy 
• The 12th Five‐Year Plan aims to accelerate the pace of research, innovation and development to improve 
biotechnology in India 
• Industry growth is concentrated in a relatively small number of companies 
• The Indian Biopharmaceutical segment holds the largest market share in the Biotech Industry in India and 
continues to grab the highest share of the entire Biotechnology sector 
• The government plans to strengthen regulatory science and infrastructure, which involves setting up of 
Biotechnology Regulatory Authority of India (BRAI) and a central agency for regulatory testing and certification 
laboratories 
Market Share of Biotechnology 
S 
12th Five‐Year Plan Fund allocation 
(USD billi ) 
14% 
3% 
1% 
Segments 
Bio - 
pharmaceuticals 
Bio - Services 
billion) Medical Biotech 
21% 26% 
Agri Biotech 
18% Bio - Agriculture 
64% 
Bio - Industrial 
22% 
14% 
Basic bio & emerging 
areas 
Biodiversity, 
bioresources & 
Environment 
6 
17% Capacity building Bio - Informatics 
Source: Planning Commission, FICCI
Biotechnology: India Scenario 
Parks and M&A 
Biotechnology infrastructure is witnessing a shift from traditional clusters to specialized industrial 
infrastructure such as biotech or science parks 
• Set up of biotech parks, incubators as well as pilot Pl E dit billi ) 
projects by the Central and State governments to 
promote and encourage entrepreneurial ventures 
in biotech 
4 
3 
Plan Expenditure (USD billion) 
3.7 
CAGR: 
336.3% 
• The 12th Five Year Plan aims to set up 3‐5 bio‐clusters 
with technology incubators, technology 
parks, innovation centers and entrepreneurship 
development units 
2 
1 
0 
1.1 
11th five year plan 12th five year plan 
Pl Plan E dit Expenditure (USD billi ) 
billion) 
Major Merger and Acquisitions 
• Sun Pharma acquired Ranbaxy Laboratories aboratories to create world s world’s 5 5th largest generic drug makers by sales 
• Matrix Lab acquired by US‐based Mylan Inc 
• Shantha Biotech took over by France‐based Sanofi Aventis 
• Piramal Healthcare acquired by US‐based Abbot Laboratories 
• Dabur Pharma acquired by Fresenius, Singapore 
7 
• Orchid Chemicals acquired by Hospira, US
Biotechnology: India Scenario 
Major Milestones 
1978‐90 1990‐99 Post 2000 
• 1978: India’s first biotech firm, 
Biocon, was setup 
• 1981: Centre for Cellular and 
• 1991: National Centre for 
Biological Sciences pursues R&D 
in molecular biology 
• 2001: The drug authority 
implements Good Clinical 
Practice (GCP) guidelines for 
Molecular Biology was setup in 
Hyderabad 
• 1984: Institute for Microbial 
Technology, Chandigarh was 
setup 
• 1994: Syngene, India’s first 
Contract Research 
Organisation(CRO), starts its 
R&D services 
• 1997: Centre for Biological 
clinical trials 
• 2007: National Biotechnology 
Development Strategy launched 
• 2009: Launch of Biotechnology 
Industry Partnership • 1986: Department of 
Biotechnology (DBT) was 
formed 
• 1987: National Institute of 
I l t b DBT 
Technology (CBT) was 
established to focus on 
bioinformatics and genomics 
• 1998: Monsanto Research 
t bli h d R&D t f 
Programme 
• 2009: National Biotechnology 
Regulatory Authority Bill 2008 to 
be introduced in parliament 
• 2011: Government approved 
Immunology was setup by tti f Bi t h l 
• 1989: Bangalore Genei 
commenced operations 
established an centre for 
plant genomics 
• 1998: DBT approves Mahyco‐ 
Monsanto to grow Bt cotton 
setting up of Biotechnology 
Industry Research Assistance 
Council (BIRAC) 
Source: Exim Bank of India Research, IBEF 8
Biotechnology: India Scenario 
Key segments & Major products of Indian industry 
Biotechnology 
Bio‐informatics 
Bio‐pharma Bio‐services Bio‐agri Bio‐industrial 
Database 
services 
Vaccines CRO Hybrid seeds 
Industrial 
enzymes 
Integrated 
Biotech 
Diagnostic 
Custom 
Manufacturing 
Bio‐fertilizers 
research app 
software 
software 
services 
Therapeutic Bio‐pesticides 
Source: FICCI, IBEF 9
1.2 Biotechnology: Gujarat Scenario 
10
Biotechnology: Gujarat Scenario 
With its strategic initiatives over the last ten years, Gujarat has emerged as a preferable destination for 
investments across the globe 
• Gujarat was ranked as Best Bio‐State in 
b d h i i i i k b 
Gandhinagar 
Biotechnology in Gujarat – Location Analysis 
2007‐08 based on the initiatives taken by 
State Government for the development of 
Biotechnology in the state 
Th l i 
Patan 
Mehsana 
Sabarkantha 
• The present annual turnover in 
biotechnology in Gujarat has been around 
USD 150 – 175 million 
S f h i d i bi h 
Rajkot 
Surendranagar 
• Some of the prominent domestic biotech 
companies include Zydus Cadila, Concord 
biotech, Cadila Pharmaceuticals, Maps 
India and Intas 
Junagadh 
Amreli 
Bharuch 
Surat 
Bhavnagar 
Anand 
• 5 international companies have set up in 
the state – Nanobiosym, Stemcyte 
Technology, Alexendria Real Estate Equities 
I A i P ifi Bi i f ti N t k 
Ahmedabad Biotech Cluster Valsad 
Academic institution Vadodara Biotech Cluster 
M f i i i 
Inc., Asia Pacific Bioinformatics Network 
and Progeniq Pvt. Ltd 
Manufacturing organisation 
R & D organisation 
Source: Gujarat State Biotechnology Mission (GSBTM) 11
Biotechnology: The Next Big Frontier 
Others 8% 
Stakeholders Sector Break-up 
Environment 6% 
Academic 
institutions 
20% 
Industrial 6% 
Agriculture 20% Healthcare Corporates 67% 
R & D institutions 
NGOs 
2% 
11% 
g 60% 
value Gujarat biotech proposition 
Rich 
bioresource 
Rich reservoir of medicinal and 
marine resources 
Strong base of pharma 
and 
healthcare sector 
Emerging Education and 
Research base 
5% 
biodiversity 
of the 
country 
926 species 
of medicinal 
plants 
462 species 
of marine 
flora 
783 species 
of marine 
fauna 
pharma sector 
meeting 45% of 
nation’s needs 
4 agriculture 
universities 
and 29 
biotech 
colleges 
Marine, 
Bioinformatics, 
Agriculture and 
other 
Source: Gujarat State Biotechnology Mission (GSBTM) 12
Biotechnology: Gujarat Scenario 
Investment Snapshot 
12 
10 
8 
Biotech cities of Gujarat 
Commissione 
Major alliances with foreign partners 
Zydus 
Altana and 
Biogen 
Reliance 
6 d Projects 
4 
2 
0 
Under 
Implementati 
on Projects 
Life sciences 
GenMedix 
Intas 
Biopharma 
Virionics 
Corporation 
Synchron 
Parexel and 
Innovance 
Alembic UCB 
Year 2009 saw the largest number of successful MoUs which New Projects 
16 
14 
12 
10 
g brought USD 143.44 million for the state 
The central zone of Gujarat comprising of Ahmedabad, 
Gandhinagar, Mehsana, and Sabarkantha, is the highest 
investment region of Gujarat followed by South zone, 
comprising of Bharuch Surat Navsari and Valsad 
8 
6 
4 
2 
0 
State wide 
investments 
Bharuch, Surat, The different summits of Vibrant Gujarat has seen MoU of 88 
large, medium and small biotech companies, with 52 home 
grown companies and 12 outside state companies, initiating 
their functions in Gujarat 
13 
2007 2009 2011 
The biotech sector has seen the expansion of 18 companies 
and diversification of 6 companies 
Source: Gujarat State Biotechnology Mission (GSBTM)
Gujarat: Industrial Strengths and Opportunities 
Agriculture Biotechnology 
 Gujarat has sizeable agrarian economy with major percentage 
of land under cultivation in central Gujarat 
 Stakeholders in Agri‐biotech segment represent industry, 
Major players 
 Bayer Cropscience Ltd. 
 Excel Cropcare Ltd. 
 Gujarat life sciences 
Opportunities 
 Tissue culture 
 Biofertiliser and Biopesticides 
 Biofuel 
NGOs, Government PSUs and laboratories and Centres of 
Excellence 
Pharmaceutical and  Gujarat State Fertiliser 
Corporation 
 Transgenic crops and GM crops 
 Organic food 
Major players 
healthcare biotechnology 
Opportunities 
 Gujarat’s pharmaceutical sector accounts for around 45% of 
the total pharmaceutical output in the 
country 
 Zydus Cadila 
 Torrent Pharmaceuticals 
 Sun Pharma 
 Concord 
 Biopharmaceuticals 
 Vaccines 
 Diagnostics 
 Monoclonal antibodies 
 The State has around 3267 registered units with total 
investments of US$1.6 billion 
 Cadila Pharma 
 Intas 
 Stem cell 
 Animal healthcare 
Industrial biotechnology Major players 
gy 
 Gujarat being home to the chemical industry, has developed 
strengths in the industrial enzymes 
segment and has been able to leverage its manufacturing 
 Maps (India) Ltd. 
 Anil Biochem Ltd. 
 Americos Industries Inc. 
 Zytex Biotech 
Opportunities 
 Industrial enzymes 
 Yeast‐based products 
 Specialty chemicals 
 Organic amino acid 
strength in industrial biotechnology Source: Gujarat State Biotechnology Mission, An Analytical Report on the Biotechnology Sector in Gujarat 14
Gujarat: Industrial Strengths and Opportunities 
Environmental lb h l 
biotechnology 
 Gujarat has varied climate with diverse ecosystem 
 Various organisations playing key role in the areas of environment 
conser ation incl de centre for En ironment Ed cation The 
Opportunities 
 Biofuel 
 Bioremediation services 
 Effluent treatment / solid waste management 
conservation include Environment Education, Science Ashram, Gujarat Science Foundation, SRISTI, VIKSAT 
Bioinformatics 
 Biofertiliser 
 There are eight universities in Gujarat offering graduate and post 
graduate courses in Bioinformatics 
 Some of the government and industrial organisations involved in 
research include IIAR, GCRI, B.V.Patel PERD centre, Zydus Research 
Opportunities 
 Drug discovery and development 
 Bioinformatics software development 
 Proteomics and Molecular modeling 
esea c c ude , GC , ate ce t e, ydus esea c 
Centre, Dhirubhai Ambani‐IICT among others 
 Structural and functional genomics 
 Analysis of online biological databases 
Marine biotechnology 
 Gujarat has 1600 km long coastline, rich in marine resources Opportunities 
 Marine biotechnology has found its application in an array of 
industries like pharmaceuticals / healthcare, consumer products, 
industrial products and processes, agricultural, environmental 
 Bioprospecting 
 ISO or GMP certified Hatcheries 
 Cultivation of Seaweeds for Biomolecules and Biofuel 
 Diagnostics for Aquaculture 
15 
remediation and pollution control 
Source: Gujarat State Biotechnology Mission, Bioinformatics Compendium, An Analytical Report on the Biotechnology Sector in Gujarat
Gujarat: Value Chain Analysis 
Basic 
research 
Drug 
discovery 
Integration and 
product 
development 
Manufacturing Transportation 
logistics 
Marketing 
and 
sales 
Services 
Business Areas 
R 
& D 
ufacturing 
rketing 
ervices 
 Agriculture 
biotechnology 
 Microbiology 
 Biochemistry 
 Clinical research 
 Industrial testing 
 water, Manu 
Ma 
Se 
Presence across value chain 
Research 
Education Areas 
 Genetic engineering 
 Plant tissue culture 
 Plant and animal 
sciences 
 Pharma technology 
Sea marine 
algae 
 Environmental 
 Agriculture 
 Medicinal and 
aromatic plants 
 Blood riculture 
dustrial 
Marine 
nformatics 
maceutical 
 Industrial 
biotechnology 
collection and 
testing 
 Healthcare 
Seeds 
Agr 
Ind 
M 
Bioin 
Pharm 
Sector areas 
Crop 
protection 
Growth 
Preventive 
medicines 
Diagnostics 
Nutraceuticals 
Biopharma 
therapeutics 
Vaccines 
16 
stimulator Phyto pharmaceuticals 
Source: A Compendium of Biotechnology Organizations in Gujarat, E&Y analysis
Gujarat Biotechnology: Enabling Environment 
Biotechnology 
policy 
• Vadodara – Industrial Park 
• Jamnagar/Bhavnagar – 
Marine Biotechnology Park 
• Gandhinagar/Mehsana – 
A iBi h l P k 
Infrastructure 
 BT parks 
 BT zones 
 SEZs 
Business 
facilitation 
And 
networking 
Agri Biotechnology Park 
• Ahmedabad – 
Surendranagar: Biopharma 
Zone 
• Jamnagar – Dwarka – 
Porbandar: Gujarat 
Biotechnology 
Education 
Marine 
Biotechnology Zone 
• Vapi – Surat – Bharuch – 
Ankleshwar: Biochemical 
Engineering for Industrial 
Biotehnology 
 PG courses 
 Specialised courses 
 Value added 
courses 
Entrepreneurial 
support 
• Under Graduate Programs 
• Post Graduate Programs 
Biotechnology 
research 
• Post Master’s Programs 
17
Biotechnology: Gujarat Scenario 
Investment Opportunities 
R & D / Manufacturing 
Marine Agriculture Pharmaceuticals/ Industrial 
• Aquaculture 
• Enzymes from marine 
resources 
• Marine resources for 
• Ethanol manufacturing unit 
• Manufacturing of biofertilisers 
• Manufacturing of biopesticides 
f i f l di i 
Healthcare 
• Manufacturing of human 
diagnostic kits 
• Manufacturing unit for 
monoclonal antibodies 
• Biopolymer 
manufacturing 
• Manufacturing of 
industrial biocatalysts 
new molecules 
• Manufacturing of plant diagnostic 
kits 
• Biodiesel plant‐based on Jatropha 
• GM crops with seeds 
• Tissue culture 
• Veterinary vaccines 
manufacturing unit 
• Stem cell 
• Bionutraceuticals 
Infrastructure Bioservices 
• Marine biotechnology park 
• Agricultural biotechnology Park 
• Biotechnology training centres 
• Contract research (pre‐clinical and 
Clinical) 
• Bioremediation 
/ 
18 
• Quality certification validation 
facilities
Biotechnology: Gujarat Scenario 
Prominent Players and Start ups and Planned Infrastructure 
Ahmedabad 
Vadodara 
Location Biotech parks (Proposed) 
Vadodara Industrial Park 
Anand Food Biotechnology Park 
Rajkot 
gy 
Jamnagar/Bhavnagar Marine Biotechnology Park 
Gandhinagar/Mehsana Agri Biotechnology Park 
Ankleshwar 
Surat 
Location Biotech zones (Proposed) 
Ahmedabad-Surendranagar Biopharma Zone 
Jamnagar-Dwarka-Porbandar Marine Biotechnology Zone 
F d d f d i 
Vadodara-Anand-Nadiad 
Food and food processing 
for Animal Biotechnology 
Vapi-Surat-Bharuch- 
Ankleshwar 
Biochemical engineering for 
Industrial Biotechnology 
Junagadh-Bhavnagar 
Banaskantha-Mehsana 
Agri Biotechnology 
Source: Gujarat State Biotechnology Mission (GSBTM) 19
Biotechnology: Gujarat Scenario 
Business Infrastructure 
Biotech Park, Savli, Vadodara 
• Developed by Gujarat State Biotechnology Mission (GSBTM) and 
GIDC 
• The park provides well developed infrastructure and basic 
amenities 
• Phase I of 100 acres consists of 38 acres of SEZ area, 62 acres of 
Non SEZ area 
Agro‐Biotech Park and Marine Biotech Park 
• Feasibility studies have been completed for examining the possibilities of developing these industrial 
20 
clusters in Gujarat 
Source: Gujarat State Biotechnology Mission (GSBTM)
Biotechnology: Gujarat Scenario 
Education Infrastructure (1/2) 
• 30 different subjects heads in 25 different universities spread over about 30 towns all over the state 
of Gujarat 
• Subjects like Microbiology, Biochemistry, Biotechnology, Environmental Sciences, Genetics, 
Bioinformatics, Aquatic Biology, Marine Biology, Agriculture Biotechnology, Medical Laboratory 
Technology, Biomedical Engineering etc. are offered 
Education Clusters 
Ahmedabad – Nadiad 
Region 
Rajkot – Amreli Region 
Vadodara – 
Vallabh 
Vidyanagar – 
Surat Region Anand Region 
Source: Gujarat State Biotechnology Mission (GSBTM) 21
Biotechnology: Gujarat Scenario 
Education Infrastructure (2/2) 
GSBTM initiatives in building world‐class 
Biotech Work‐force 
• Initiated various human resource 
development activities right from its 
inception with some general popular 
lectures, supporting seminars/workshops 
etc. and then taking rigorous capacity 
building programmes for students, 
teachers, clinicians/medico fraternity 
researchers, entrepreneurs, etc. 
• Formation of a Network of all Biotech 
teaching Colleges/Departments – Gujarat 
Integrated Bio Network [GIBioN] and a 
Network of Capacity Building Cells 
involving various Colleges/Departments 
of different Universities 
Source: Gujarat State Biotechnology Mission (GSBTM) 22
Biotechnology: Gujarat Scenario 
Research 
■ Gujarat has definite strengths in pharmaceuticals & healthcare, agriculture, animal 
husbandry, medicinal plants, biodiversity sectors while environment and marine are 
potential sectors needing biotechnology applications 
■ Academic organizations largely involved in basic research 
■ Industries mainly engaged in application based research, product development and contract 
research 
■ Major research areas are conservation biology, genetic diagnostics, molecular biology, 
cancer biology genomics proteomics etc 
Research Areas 
USD 2.46 million 
of State support 
biology, genomics, proteomics, Research in Academics 
USD 4.92 million 
of National 
support 
90 DSIR Centers in 
Industries 
• Nearly 11 universities, 70 colleges and 18 
institutes are engaged in research in different 
areas of Biotechnology 
• As per the data of last three years, around 175 
3000 Publications 
300 Research 
Grants 
faculties are active in biotechnology research with 
outcome of around 3000 publications and 30 
patents 
23 
30 Patents 
Source: Gujarat State Biotechnology Mission (GSBTM)
Biotechnology: Gujarat Scenario 
Research Institutions 
Agro Biotech 
 Anand Agriculture University, Anand 
 CP college of Agriculture, Sardar Krushinagar 
 Junagadh Agricultural University, Junagadh 
 Navsari Agricultural University, Navsari 
 National Research Centre in Medicinal and Aromatic plants 
 Genome Research Centre, Baroda 
 National Research Centre Groundnut 
Banaskantha 
for Pharma Biotech 
 L.M. college of pharmacy 
 B.V. Patel PERD (Pharmaceutical Education and Research Development) Centre 
 Nirma Institute of Pharmacy 
Marine Biotech  Centre for Salt and Marine Chemical Research Institute (CSMCRI) 
 Department of Marine Sciences, Bhavnagar University 
Rajkot 
Gandhinagar 
Ahmedabad 
Anand 
Vadodara 
Environment 
Biotech 
 Department of Bioscience, S.P. University 
 The National Institute of Occupational Health 
 Department of Microbiology, MS University of Baroda 
 Department of Microbiology, Gujarat University 
 Department of Life science, Bhavnagar University 
 Gujarat Ecological Education and Research Foundation 
Junagadh Bhavnagar 
Navsari 
Medical Biotech  Cancer Research Institute, Ahmedabad 
 Genetics centre Ahmedabad 
Biotech 
Engineering 
 Department of Microbiology and Biotechnology, MS University of Baroda 
 Department of Biotechnology, Hemchandracharya, North Gujarat University 
 Department of Biochemistry, MS University of Baroda 
 Department of Food and Nutrition, MS University of Baroda 
Bioinformatics 
 MSc in Bioinformatics, Gujarat University 
 Sardar Patel University, Vallabh Vidhyanagar 
 MS University of Baroda 
 Bhavnagar University, Bhavnagar 
 Saurashtra University, Rajkot 
 Indian Institute of Advanced Research, Gandhinagar 
 Sikkim Manipal University, Ahmedabad Study centre 
 Bioinformatics Institute of India, Ahmedabad Study centre 
Source: Gujarat State Biotechnology Mission (GSBTM) 24
Biotechnology: Gujarat Scenario 
Research Infrastructure (1/2) 
Gujarat Genomics 
Initiative (GGI) 
• A collaborative initiative between 
state agencies for undertaking 
Biodiversity Gene Bank 
(BioGene) 
• A collaborative initiative with state 
forest department for using 
Marine Bio‐Resource 
Center (MBRC) 
• Collaborative initiative with forest 
department and state Ayurveda 
g g 
genomic research in Gujarat 
• Activities include undertaking 
research in molecular biology, DNA 
based species identification, 
developing molecular markets for 
p g 
biotechnology application for 
biodiversity conservation and 
management 
• Activities include DNA banking, in– 
vitro banking cryo banking seed 
p y 
university 
• Focuses biotechnology application 
in conservation of Marine flora, 
fauna and microbial bio diversity 
• Activities include DNA based 
key floral and faunal species, 
problem solving, providing services 
to industries, academia, skill 
development in molecular biology 
banking, cryo‐banking, banking, bio‐prospecting research 
and application‐based research 
• Website: www.biogene.in 
species identification for important 
marine microbes, phyto‐plankton 
and other important flora group 
• Website: www.mbrc.res.in 
• Website: www.gujaratgenomics.in 
Source: Gujarat State Biotechnology Mission (GSBTM) 25
Biotechnology: Gujarat Scenario 
Research Infrastructure (2/2) 
The Virtual Institute of 
Bioinformatics [BITVirtual] 
• A collaborative and multi‐institutional project for 
developing research and skills in field of bio‐ 
Shivrath Centre for Excellence in 
Clinical Research 
• Developed under Public‐Private Partnership for 
generating skilled human resources for contract 
p g 
informatics in Gujarat 
• Activities include providing state of art centralized 
bio‐informatics facilities, for research and imparting 
degree programs in Bioinformatics 
• Website: www bitvirtual org 
g g 
research organization 
• Activities include specific skill development and 
educational programs 
• Website: www.shivrath.com 
www.bitvirtual.Genetic Diagnostic Centre 
• A collaborative initiative with Gujarat University and its zoology department for extending molecular and genetic 
diagnostic services to society 
26 
• Activities include research, awareness and services in areas of genetic disorders 
Source: Gujarat State Biotechnology Mission (GSBTM)
Biotechnology: Gujarat Scenario 
Promoting BT Entrepreneurship 
Technology 
Facilitation Cell 
[TFC] 
• Reports & Compilation: Bio‐Business Guides for Businesses of Bio‐fertilizer, Tissue Culture, 
Jatropha, Industrial Enzymes, status of Genetic Disorders in Gujarat, Drug Report etc. 
• Databases: Marine Patent Database, Genome Resource database of Gujarat, Company 
Database, Technology gy Database, technologies available for commercialization, transfers, 
partnerships, Bio‐Suppliers Database, etc 
Biotechnopreneur 
• Include short‐term awareness programmes for viz. creating awareness 
regarding Biotech Business Opportunities and Support Systems in 
Camps 
g g pp pp y 
different sectors of biotechnology 
• Website: www.biotechnopreneur.in 
Biotechnopreneur • Ten‐month long weekend based Structured Capacity Building Programme for Professionals to 
Programme help them spin‐off Biotech Enterprises 
Gujarat Biotech 
Venture Fund 
• Venture fund for biotechnology initiated and supported by State 
• Operational since 2004 and has supported many projects, technologies and companies while 
[GBVF] other projects are in pipeline 
Entrepreneur 
Support Cell [BT‐ESC] 
• GSBTM has formed a cell which provides holding to biotech units/companies in Gujarat and 
facilitation for availing various subsidies, incentives, benefits etc., from various government 
d / i 
ESC] departments/agencies 
Source: Gujarat State Biotechnology Mission (GSBTM) 27
Biotechnology: Gujarat Scenario 
Building Public Consensus & Awareness 
Biotech Awareness Corners [Bio‐A‐Corn] 
• Aesthetically designed Bio‐A‐Corn developed in district Community Science Centres to impart general information 
about biotechnology to stakeholders, general public and students 
Bio‐safety Online Training Programme 
• Online Training Programme with a bid to develop awareness & technical understanding 
regarding the Laws, Technologies and Practices in different countries about ethical adoption of 
Genetic Modification of Biological Resources in Health, Agriculture and Food Sectors 
• Website: www.biosafety.org.in 
Information Dissemination 
• To update the stakeholders with biotechnology development in Gujarat, GSBTM publishes BT‐Chronicle: a quarterly 
Biotech magazine, in electronic and print format 
Seminars, Workshops & Conferences 
• With an objective to encourage interaction and bring national and global expertise at the doorsteps of the Biotech 
stakeholders GSBTM conducts and supports seminars conferences and workshops 
28 
stakeholders, seminars, Source: Gujarat State Biotechnology Mission (GSBTM)
Biotechnology: Gujarat Scenario 
Gujarat State Biotechnology Mission [GSBTM] 
GSBTM: Established in April 2004 as an Autonomous Nodal Agency under the aegis 
of Department of Science and Technology, Gujarat 
Govt. Policy 
Planning 
To promote, support and facilitate 
the overall development of 
biotechnology in Gujarat 
To facilitate the development of 
biotechnology business, 
entrepreneurship and research 
infrastructure 
GSBTM 
Supporting 
Biotechnology 
Infrastructure 
Awareness 
Generation & 
Networking 
GSBTM 
Supporting 
Biotechnology 
Research & 
Technology 
Development 
Encouraging 
Biotechnology 
Entrepreneur‐ship 
Mandate 
To create scientific awareness and To facilitate networking among 
p 
Creation of 
Quality 
Human 
Resources 
stakeholders at regional, national 
and international level 
build public consensus regarding 
the potentials and socio‐economic 
impact of the ethical 
applications of biotechnology 
Source: Gujarat State Biotechnology Mission (GSBTM) 29
Biotechnology: Gujarat Scenario 
Achievements 
Asset & infrastructure creation 
• Scientific assets created worth USD 2.29 million – 
around 50 major instruments and 200 minor 
i 
• Around 75 PG students, 38 faculty of different 
universities engaged in research 
• Around 20 international and 40 national research 
bl 
Advanced study & research 
instruments 
• Platform of establishing 3‐4 science based 
institutes/centres 
publication 
• Creating facilities, initiating research resulting in 
output in high end life science field like Genomics, 
Bioinformatics 
Biotech business & industries 
Entrepreneurship • Establishment of around 75‐80 new biotech industries 
• Around 700‐800 beneficiaries covered by 
entrepreneurship programs 
• Venture support to many start up companies and 
in Gujarat 
• Completed investment of around USD 262.29 million 
• Submitted first whole genome sequence work to an 
International organization 
• 40 M.Phils in bio‐informatics 
• Around 2000 genetic database submission to International 
pp y p p 
technologies 
• 15‐20 new biotech entrepreneurs 
g 
HR and skill building databases 
• DNA barcodes developed for around 100 plant species, 
DNA banking of around 700 species 
• First Whole Mitochondrial genome sequencing done for 
Asiatic lion in India by GSBTM 
G j t th fi t t t t t bli h GSBTM t t l l 
• Around 3000 UG/PG students from 100 organizations 
benefitted by various skill development 
programs/activities 
• Around 150 UG/PG faculty supported by skill 
development increased number 30 
• Gujarat the first state to establish as state level 
nodal agency for biotechnology 
development, of students selection 
in national competitive examination 
Source: Gujarat State Biotechnology Mission (GSBTM)
2. Nanotechnology 
31
2.1 Nanotechnology: Global Scenario 
32
Nanotechnology: Global Scenario 
Nanotechnology — the science of objects 100 nanometers or smaller —has created enormous opportunities 
Potential uses 
• Novel approach to curing human illness 
• Enhanced computational power 
• New materials 
• Improved chemicals and catalysts 
• Bottom‐up manufacturing processes 
Potential support of other • New energy production 
• Next‐generation key technologies 
genomics 
• Power for artificial intelligence 
Promising demonstrations 
• 4nm robot constructed from pieces of DNA 
• Paperclip‐sized nanogenerator producing as much power as an AA battery 
• Solar cells printed onto paper, creating flexible PV at a fraction of current cost 
Nanotechnology market share 2015 
6% 
2% 
4%3% 
New Materials 
31% 
9% 
17% 
Electroics 
Pharmaceuticals 
Chemicals 
Aerospace 
Sustainability 
Healthcare 
33 
28% 
Tools
Nanotechnology: Global Scenario 
Russia 
More than 60 countries have established national nanotechnology programs since 2000 
Japan United States 
Rusnano, one of the world’s most 
ambitious nano‐technology projects, 
represents a determined effort by 
Russian leaders to make their 
country a l b l global l d leader in h 
the nano 
field 
In 2001, the U.S. government created 
the National Nano‐technology 
Initiative, helping to jump‐start U.S. 
nano‐technology work by 
d coordinating nano‐l d related h 
research 
across all federal agencies 
Support for nano‐technology 
research dates back to 2001, and 
nano is now regarded as one of the 
country’s four priority research fields 
France China Brazil 
Minatec was launched in 2006 as a 
collaboration between LETI (the 
Electronics and Information 
Nanotech manufacturing plants 
throughout China are developing 
nano products, including exhaust‐ 
The Brazilian Nano‐technology 
National Laboratory began 
operations in July 2011 by combining 
Technologies Laboratory of CEA, the 
French Atomic Energy Commission) 
and INPG (Grenoble Institute of 
Technology) 
exhaust 
absorbing tarmac and carbon‐nanotube‐ 
coated clothes that can 
monitor health 
three of the country’s biggest nano 
research centers 
34 
“I can’t think of any industry that won’t eventually be impacted by nano” – Dick Siegel, Director of Rensselaer Nanotechnology 
Center
2.2 Nanotechnology: India Scenario 
35
Nanotechnology: India Scenario 
• Launch of NSTI 
• Establishments 
of COE's 
Launch of R&D 
projects under 
NSTI 
Establishment of 
characterization 
Facilities 
DIT Programmes 
on 
Nanoelectronics 
National 
knowledge 
commission 
2001 2002 2003 2004 2005 2006 
Nano INUP initiated by 
IISC & IITB 
(Funded by DIT 
& MSCIT) 
Introduction of 
PG programme 
in Nano Science 
and Technology 
Earmarking of 
USD 163.93 
million For Nano 
Mission 
mission to 
provide loans to 
industry to 
develop nano 
applications 
Nanotechnology 
intervention in 
mission mode 
programme 
2007 2008 2009 2010 2011 2012 
36
Nanotechnology: India Scenario 
Comparative investment scenario 
Country Funding Programme Funding Period 
Brazil Ministry for Science & Technology USD 6.605 million Annual Estimate 
China Medium & Long Term Development Plan USD 38.2 million 2006‐2008 
European Union Framework Programme 7 USD 4.718 billion 2007‐2013 
France Nano 2012 Programme USD 673.5 million 2008‐2012 
Germany Nano Initiative–Action Plan 2010 USD 498.39 million 2008‐2013 
India Nano Mission USD 195.05 million 2007‐2012 
Japan MEXT USD 633.09 million Annual 
Russia 
Development of nanotechnology infrastructure 
in Federation 
USD 4.66 billion 2008‐2015 
the Russian UK Research Councils UK/Technology Strategy Board USD 344.83 million Annual 
37 
USA National Nanotechnology Initiative USD 2.1 billion 2012
Nanotechnology: Nano Mission 
The Nano Mission is an umbrella programme for capacity building which envisages the overall 
development of this field of research in the country and to tap some of its applied potential for 
nation’s development 
C t f E ll Public Private Partnership 
Joint Institution ‐Industry linked Projects 
Nano Functional Materials 
Murugappa Chettiar & Orchid 
Centre of Excellence 
IIT Madras, Chennai 
IACS, Kolkata 
University of Pune 
Centre, IIT Madras 
Pharma 
Nano Technology Centre,Univ. 
of Hyderabad 
Dr. Reddy's Labs 
S.N. Bose National Centre for Basic Sciences, Kolkata 
NCL, Pune 
JNCASR, Bangalore 
BHU, Varanasi 
Centre for Interactive & Smart 
Textiles,IIT Delhi 
ARCI, Hyderabad & Textile 
Industry 
Centre for Pharmaceutical 
Nanotechnology, NIPER, 
Ch di h 
Pharma industry 
IIT Kanpur, Kanpur 
IISc, Bangalore 
IIT Delhi, New Delhi 
SINP, Kolkata 
Chandigarh 
Rubber Nanocomposites, MG 
University, Kottayam 
Apollo Tyres 
Nanophosphor Application Nanotech Corp., USA 
Amrita Institute of Medical Sciences, Kochi, Kerala 
S.N. Bose National Centre for Basic Sciences, Kolkata 
Tata Institute of Fundamental Research 
IIT‐Bombay, Mumbai 
38 
Centre, University of 
Allahabad 
y 
Centre for Computational Materials Science at Jawaharlal Nehru Centre for 
Advanced Scientific Research, Bangalore
2.3 Nanotechnology: Gujarat Scenario 
39
Nanotechnology: Gujarat Scenario 
Nanotechnology – identified as a fast developing and emerging field having vast opportunities for development 
of business and industries in Gujarat 
Productivity Productivity, conservation 
conservation, 
processing, packaging 
Agriculture 
Several chemicals and coatings 
Harvesting, conservation & 
distribution systems 
Technologies which add to 
quality & strength 
Wrinkle free & self‐cleaning 
textiles and others 
Nanotechnology 
Savings 
in Gujarat 
Generation (solar), storage & 
transmission 
Several pharmaceuticals, 
targeted drugs and 
equipments 
I i f i i Ai & t ifi ti d 
40 
Air water purification and 
other conservation measures 
In ceramics for engineering, 
auto and aerospace industry 
Source: Gujarat Council of Science and Technology (GUJCOST)
Nanotechnology: Gujarat Nano Mission (1/2) 
Gujarat Council on Science & Technology (GUJCOST) promotes the R&D activities in the state by encouraging 
scientists, researchers, faculties and students for taking up research activities in Nanotechnology 
j 
Gujarat Nano Mission 
• During 2011‐12, GUJCOST pushed the nanotechnology education and research in the state and established Gujarat Nano 
Mission on the lines of India Nano Mission 
• Gujarat Nano Mission will be responsible for designing and developing Nanoscience and nanotechnology education, research 
and development in the state and to keep pace with national and global streams of development 
dd l ti th t t d t k ith ti l d l b l t fd l t 
Gujarat Nano Mission for the Benefits of State Vision of Gujarat and the entire country 
To conduct and support Nanoscience and Nanotechnology awareness, education, 
research, development, design and engineering in nanotechnology, and transfer the 
technology to industrial sector in order to increase Gujarat’s competitiveness, and 
improve the quality of life and the environment 
Mission 
Source: Gujarat Council of Science and Technology (GUJCOST) 41
Nanotechnology: Gujarat Nano Mission (2/2) 
Goals 
To conduct R&D in order to acquire advanced knowledge in nanoscience and nanotechnology at 
international level, at the same time, built awareness to society and environment 
To drive national strategies and policies for nanoscience and nanotechnology that yield concrete and 
sustainable results 
To transfer the knowledge and know‐how in nanoscience and nanotechnology to the industrial sector 
while disseminating accurate information to the public 
To undertake capacity building of human resource development in nanoscience and nanotechnology 
To develop infrastructure that would facilitate nanoscience and nanotechnology development 
Gujarat Nano Mission will strive to be visible in global nanotechnology research arena 
To design and develop a Nanotechnology Park in the state for public awareness, understanding and 
appreciation 
42 
pp 
Source: Gujarat Council of Science and Technology (GUJCOST)
Nanotechnology: Centre of Excellences (CoEs) 
• These centers have become hub of resources, manpower training and guiding industries 
• Government of India has also sanctioned various projects for strengthening R&D activities 
Nanotechnology of 
Nanomagnetic particles, 
Bhavnagar Universtiy 
Development of Oxide 
Nanomaterial Thin Films & 
Mutlilayers of Device 
Applications, Saurashtra 
University Rajkot Supramolecules 
Material Science – Nano 
Polymeric Materials, MS 
University, Vadodara 
University, p 
Fullerene, Nanotubes, 
Rotaxanes, Calixarenes and 
their applicability in 
Environmental & Material 
Sciences, Gujarat University 
Nanoscience & Nanomaterials, 
Sardar Patel University, 
Vallabh Vidyanagar 
CoEs Nanocatalysts: Development 
& Applications, DDU, Nadiad 
Source: Gujarat Council of Science and Technology (GUJCOST) 43
Nanotechnology: Investment Opportunities 
Nano‐enabled Wireless Handsets Packaging Nano‐water 
Quantum Dots Thin film Lithium‐ion 
battery Nanofibers 
Nanomedicine market Nanocoating 
Source: Gujarat Council of Science and Technology (GUJCOST) 44
FOR ADDITIONAL INFORMATION CONNECT US @ 
Department of Science and Technology http://www.dst.gujarat.gov.in 
Gujarat Council on Science and Technology (Gujcost) http://www.gujcost.gujarat.gov.in 
Gujarat State Biotechnology Mission (GSBTM) http://www.btm.gujarat.gov.in 
45
ORGANISED BY KNOWLEDGE PARTNER EVENT PARTNER 
Visit us at www.vibrantgujarat.com 
46

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Vibrant Gujarat Summit Profile for Biotechnology and Nano Technology Sector

  • 2. Table of Contents 1. Biotechnology 1.1 Biotechnology: Indian Scenario 1.2 Biotechnology: Gujarat Scenario 2. Nanotechnology 2.1 Nanotechnology: Global Scenario 2.2 Nanotechnology: India Scenario 2.3 Nanotechnology: Gujarat Scenario
  • 5. Biotechnology: India Scenario “BT Jogindernagar Shimla Chandigarh Pantnagar + BT = BT” “Bharat Today + Bio Technology = Bharat Tomorrow” – Shri NarendraModi, Hon’ble Prime Minister India is already ranked among the top 12 biotech destinations worldwide and third largest in the Asia ‐ Pacific region  Increasing government expenditure is likely to augment growth Alwar Sohna Jodhpur Jaipur Gandhinagar Anand Baroda Jamnagar Midnapore g g p y g g  By FY17, India’s biotech industry is estimated to increase to USD 11.6 billion from USD 4.3 billion in FY12  Rising pharmaceuticals market is estimated to aid growth of the biotech industry Aurangabad Pune Karwar Bhubaneshwar Konark Hyderabad Visakhapatnam Bengaluru 20 10 Biotech market (USD billion) CAGR: 21.9% Kochi Madurai Chennai Puducherry 0 4.3 11.6 FY12 FY17 Biotech market (USD billion) Pharma Biotechnology Parks World’s largest producer of Vaccines 40 30 20 10 market in India (USD billion) 15.6 35.9 CAGR: 18.1% World’s largest cultivator of Bt Cotton 1st in terms of growth in transgenic crops 3rd with 5 0 2P0h1a1rma market in Indi2a0 (U16SDF billion) Source: Ministry of Health, Government of India, Planning Commission, GSBTM highest biotech companies in Asia Pacific
  • 6. Biotechnology: India Scenario Market Share & Future plan The Indian biotechnology sector is one of the fastest growing knowledge‐based sectors in India and is expected to play a key role in shaping India's rapidly developing economy • The 12th Five‐Year Plan aims to accelerate the pace of research, innovation and development to improve biotechnology in India • Industry growth is concentrated in a relatively small number of companies • The Indian Biopharmaceutical segment holds the largest market share in the Biotech Industry in India and continues to grab the highest share of the entire Biotechnology sector • The government plans to strengthen regulatory science and infrastructure, which involves setting up of Biotechnology Regulatory Authority of India (BRAI) and a central agency for regulatory testing and certification laboratories Market Share of Biotechnology S 12th Five‐Year Plan Fund allocation (USD billi ) 14% 3% 1% Segments Bio - pharmaceuticals Bio - Services billion) Medical Biotech 21% 26% Agri Biotech 18% Bio - Agriculture 64% Bio - Industrial 22% 14% Basic bio & emerging areas Biodiversity, bioresources & Environment 6 17% Capacity building Bio - Informatics Source: Planning Commission, FICCI
  • 7. Biotechnology: India Scenario Parks and M&A Biotechnology infrastructure is witnessing a shift from traditional clusters to specialized industrial infrastructure such as biotech or science parks • Set up of biotech parks, incubators as well as pilot Pl E dit billi ) projects by the Central and State governments to promote and encourage entrepreneurial ventures in biotech 4 3 Plan Expenditure (USD billion) 3.7 CAGR: 336.3% • The 12th Five Year Plan aims to set up 3‐5 bio‐clusters with technology incubators, technology parks, innovation centers and entrepreneurship development units 2 1 0 1.1 11th five year plan 12th five year plan Pl Plan E dit Expenditure (USD billi ) billion) Major Merger and Acquisitions • Sun Pharma acquired Ranbaxy Laboratories aboratories to create world s world’s 5 5th largest generic drug makers by sales • Matrix Lab acquired by US‐based Mylan Inc • Shantha Biotech took over by France‐based Sanofi Aventis • Piramal Healthcare acquired by US‐based Abbot Laboratories • Dabur Pharma acquired by Fresenius, Singapore 7 • Orchid Chemicals acquired by Hospira, US
  • 8. Biotechnology: India Scenario Major Milestones 1978‐90 1990‐99 Post 2000 • 1978: India’s first biotech firm, Biocon, was setup • 1981: Centre for Cellular and • 1991: National Centre for Biological Sciences pursues R&D in molecular biology • 2001: The drug authority implements Good Clinical Practice (GCP) guidelines for Molecular Biology was setup in Hyderabad • 1984: Institute for Microbial Technology, Chandigarh was setup • 1994: Syngene, India’s first Contract Research Organisation(CRO), starts its R&D services • 1997: Centre for Biological clinical trials • 2007: National Biotechnology Development Strategy launched • 2009: Launch of Biotechnology Industry Partnership • 1986: Department of Biotechnology (DBT) was formed • 1987: National Institute of I l t b DBT Technology (CBT) was established to focus on bioinformatics and genomics • 1998: Monsanto Research t bli h d R&D t f Programme • 2009: National Biotechnology Regulatory Authority Bill 2008 to be introduced in parliament • 2011: Government approved Immunology was setup by tti f Bi t h l • 1989: Bangalore Genei commenced operations established an centre for plant genomics • 1998: DBT approves Mahyco‐ Monsanto to grow Bt cotton setting up of Biotechnology Industry Research Assistance Council (BIRAC) Source: Exim Bank of India Research, IBEF 8
  • 9. Biotechnology: India Scenario Key segments & Major products of Indian industry Biotechnology Bio‐informatics Bio‐pharma Bio‐services Bio‐agri Bio‐industrial Database services Vaccines CRO Hybrid seeds Industrial enzymes Integrated Biotech Diagnostic Custom Manufacturing Bio‐fertilizers research app software software services Therapeutic Bio‐pesticides Source: FICCI, IBEF 9
  • 11. Biotechnology: Gujarat Scenario With its strategic initiatives over the last ten years, Gujarat has emerged as a preferable destination for investments across the globe • Gujarat was ranked as Best Bio‐State in b d h i i i i k b Gandhinagar Biotechnology in Gujarat – Location Analysis 2007‐08 based on the initiatives taken by State Government for the development of Biotechnology in the state Th l i Patan Mehsana Sabarkantha • The present annual turnover in biotechnology in Gujarat has been around USD 150 – 175 million S f h i d i bi h Rajkot Surendranagar • Some of the prominent domestic biotech companies include Zydus Cadila, Concord biotech, Cadila Pharmaceuticals, Maps India and Intas Junagadh Amreli Bharuch Surat Bhavnagar Anand • 5 international companies have set up in the state – Nanobiosym, Stemcyte Technology, Alexendria Real Estate Equities I A i P ifi Bi i f ti N t k Ahmedabad Biotech Cluster Valsad Academic institution Vadodara Biotech Cluster M f i i i Inc., Asia Pacific Bioinformatics Network and Progeniq Pvt. Ltd Manufacturing organisation R & D organisation Source: Gujarat State Biotechnology Mission (GSBTM) 11
  • 12. Biotechnology: The Next Big Frontier Others 8% Stakeholders Sector Break-up Environment 6% Academic institutions 20% Industrial 6% Agriculture 20% Healthcare Corporates 67% R & D institutions NGOs 2% 11% g 60% value Gujarat biotech proposition Rich bioresource Rich reservoir of medicinal and marine resources Strong base of pharma and healthcare sector Emerging Education and Research base 5% biodiversity of the country 926 species of medicinal plants 462 species of marine flora 783 species of marine fauna pharma sector meeting 45% of nation’s needs 4 agriculture universities and 29 biotech colleges Marine, Bioinformatics, Agriculture and other Source: Gujarat State Biotechnology Mission (GSBTM) 12
  • 13. Biotechnology: Gujarat Scenario Investment Snapshot 12 10 8 Biotech cities of Gujarat Commissione Major alliances with foreign partners Zydus Altana and Biogen Reliance 6 d Projects 4 2 0 Under Implementati on Projects Life sciences GenMedix Intas Biopharma Virionics Corporation Synchron Parexel and Innovance Alembic UCB Year 2009 saw the largest number of successful MoUs which New Projects 16 14 12 10 g brought USD 143.44 million for the state The central zone of Gujarat comprising of Ahmedabad, Gandhinagar, Mehsana, and Sabarkantha, is the highest investment region of Gujarat followed by South zone, comprising of Bharuch Surat Navsari and Valsad 8 6 4 2 0 State wide investments Bharuch, Surat, The different summits of Vibrant Gujarat has seen MoU of 88 large, medium and small biotech companies, with 52 home grown companies and 12 outside state companies, initiating their functions in Gujarat 13 2007 2009 2011 The biotech sector has seen the expansion of 18 companies and diversification of 6 companies Source: Gujarat State Biotechnology Mission (GSBTM)
  • 14. Gujarat: Industrial Strengths and Opportunities Agriculture Biotechnology  Gujarat has sizeable agrarian economy with major percentage of land under cultivation in central Gujarat  Stakeholders in Agri‐biotech segment represent industry, Major players  Bayer Cropscience Ltd.  Excel Cropcare Ltd.  Gujarat life sciences Opportunities  Tissue culture  Biofertiliser and Biopesticides  Biofuel NGOs, Government PSUs and laboratories and Centres of Excellence Pharmaceutical and  Gujarat State Fertiliser Corporation  Transgenic crops and GM crops  Organic food Major players healthcare biotechnology Opportunities  Gujarat’s pharmaceutical sector accounts for around 45% of the total pharmaceutical output in the country  Zydus Cadila  Torrent Pharmaceuticals  Sun Pharma  Concord  Biopharmaceuticals  Vaccines  Diagnostics  Monoclonal antibodies  The State has around 3267 registered units with total investments of US$1.6 billion  Cadila Pharma  Intas  Stem cell  Animal healthcare Industrial biotechnology Major players gy  Gujarat being home to the chemical industry, has developed strengths in the industrial enzymes segment and has been able to leverage its manufacturing  Maps (India) Ltd.  Anil Biochem Ltd.  Americos Industries Inc.  Zytex Biotech Opportunities  Industrial enzymes  Yeast‐based products  Specialty chemicals  Organic amino acid strength in industrial biotechnology Source: Gujarat State Biotechnology Mission, An Analytical Report on the Biotechnology Sector in Gujarat 14
  • 15. Gujarat: Industrial Strengths and Opportunities Environmental lb h l biotechnology  Gujarat has varied climate with diverse ecosystem  Various organisations playing key role in the areas of environment conser ation incl de centre for En ironment Ed cation The Opportunities  Biofuel  Bioremediation services  Effluent treatment / solid waste management conservation include Environment Education, Science Ashram, Gujarat Science Foundation, SRISTI, VIKSAT Bioinformatics  Biofertiliser  There are eight universities in Gujarat offering graduate and post graduate courses in Bioinformatics  Some of the government and industrial organisations involved in research include IIAR, GCRI, B.V.Patel PERD centre, Zydus Research Opportunities  Drug discovery and development  Bioinformatics software development  Proteomics and Molecular modeling esea c c ude , GC , ate ce t e, ydus esea c Centre, Dhirubhai Ambani‐IICT among others  Structural and functional genomics  Analysis of online biological databases Marine biotechnology  Gujarat has 1600 km long coastline, rich in marine resources Opportunities  Marine biotechnology has found its application in an array of industries like pharmaceuticals / healthcare, consumer products, industrial products and processes, agricultural, environmental  Bioprospecting  ISO or GMP certified Hatcheries  Cultivation of Seaweeds for Biomolecules and Biofuel  Diagnostics for Aquaculture 15 remediation and pollution control Source: Gujarat State Biotechnology Mission, Bioinformatics Compendium, An Analytical Report on the Biotechnology Sector in Gujarat
  • 16. Gujarat: Value Chain Analysis Basic research Drug discovery Integration and product development Manufacturing Transportation logistics Marketing and sales Services Business Areas R & D ufacturing rketing ervices  Agriculture biotechnology  Microbiology  Biochemistry  Clinical research  Industrial testing  water, Manu Ma Se Presence across value chain Research Education Areas  Genetic engineering  Plant tissue culture  Plant and animal sciences  Pharma technology Sea marine algae  Environmental  Agriculture  Medicinal and aromatic plants  Blood riculture dustrial Marine nformatics maceutical  Industrial biotechnology collection and testing  Healthcare Seeds Agr Ind M Bioin Pharm Sector areas Crop protection Growth Preventive medicines Diagnostics Nutraceuticals Biopharma therapeutics Vaccines 16 stimulator Phyto pharmaceuticals Source: A Compendium of Biotechnology Organizations in Gujarat, E&Y analysis
  • 17. Gujarat Biotechnology: Enabling Environment Biotechnology policy • Vadodara – Industrial Park • Jamnagar/Bhavnagar – Marine Biotechnology Park • Gandhinagar/Mehsana – A iBi h l P k Infrastructure  BT parks  BT zones  SEZs Business facilitation And networking Agri Biotechnology Park • Ahmedabad – Surendranagar: Biopharma Zone • Jamnagar – Dwarka – Porbandar: Gujarat Biotechnology Education Marine Biotechnology Zone • Vapi – Surat – Bharuch – Ankleshwar: Biochemical Engineering for Industrial Biotehnology  PG courses  Specialised courses  Value added courses Entrepreneurial support • Under Graduate Programs • Post Graduate Programs Biotechnology research • Post Master’s Programs 17
  • 18. Biotechnology: Gujarat Scenario Investment Opportunities R & D / Manufacturing Marine Agriculture Pharmaceuticals/ Industrial • Aquaculture • Enzymes from marine resources • Marine resources for • Ethanol manufacturing unit • Manufacturing of biofertilisers • Manufacturing of biopesticides f i f l di i Healthcare • Manufacturing of human diagnostic kits • Manufacturing unit for monoclonal antibodies • Biopolymer manufacturing • Manufacturing of industrial biocatalysts new molecules • Manufacturing of plant diagnostic kits • Biodiesel plant‐based on Jatropha • GM crops with seeds • Tissue culture • Veterinary vaccines manufacturing unit • Stem cell • Bionutraceuticals Infrastructure Bioservices • Marine biotechnology park • Agricultural biotechnology Park • Biotechnology training centres • Contract research (pre‐clinical and Clinical) • Bioremediation / 18 • Quality certification validation facilities
  • 19. Biotechnology: Gujarat Scenario Prominent Players and Start ups and Planned Infrastructure Ahmedabad Vadodara Location Biotech parks (Proposed) Vadodara Industrial Park Anand Food Biotechnology Park Rajkot gy Jamnagar/Bhavnagar Marine Biotechnology Park Gandhinagar/Mehsana Agri Biotechnology Park Ankleshwar Surat Location Biotech zones (Proposed) Ahmedabad-Surendranagar Biopharma Zone Jamnagar-Dwarka-Porbandar Marine Biotechnology Zone F d d f d i Vadodara-Anand-Nadiad Food and food processing for Animal Biotechnology Vapi-Surat-Bharuch- Ankleshwar Biochemical engineering for Industrial Biotechnology Junagadh-Bhavnagar Banaskantha-Mehsana Agri Biotechnology Source: Gujarat State Biotechnology Mission (GSBTM) 19
  • 20. Biotechnology: Gujarat Scenario Business Infrastructure Biotech Park, Savli, Vadodara • Developed by Gujarat State Biotechnology Mission (GSBTM) and GIDC • The park provides well developed infrastructure and basic amenities • Phase I of 100 acres consists of 38 acres of SEZ area, 62 acres of Non SEZ area Agro‐Biotech Park and Marine Biotech Park • Feasibility studies have been completed for examining the possibilities of developing these industrial 20 clusters in Gujarat Source: Gujarat State Biotechnology Mission (GSBTM)
  • 21. Biotechnology: Gujarat Scenario Education Infrastructure (1/2) • 30 different subjects heads in 25 different universities spread over about 30 towns all over the state of Gujarat • Subjects like Microbiology, Biochemistry, Biotechnology, Environmental Sciences, Genetics, Bioinformatics, Aquatic Biology, Marine Biology, Agriculture Biotechnology, Medical Laboratory Technology, Biomedical Engineering etc. are offered Education Clusters Ahmedabad – Nadiad Region Rajkot – Amreli Region Vadodara – Vallabh Vidyanagar – Surat Region Anand Region Source: Gujarat State Biotechnology Mission (GSBTM) 21
  • 22. Biotechnology: Gujarat Scenario Education Infrastructure (2/2) GSBTM initiatives in building world‐class Biotech Work‐force • Initiated various human resource development activities right from its inception with some general popular lectures, supporting seminars/workshops etc. and then taking rigorous capacity building programmes for students, teachers, clinicians/medico fraternity researchers, entrepreneurs, etc. • Formation of a Network of all Biotech teaching Colleges/Departments – Gujarat Integrated Bio Network [GIBioN] and a Network of Capacity Building Cells involving various Colleges/Departments of different Universities Source: Gujarat State Biotechnology Mission (GSBTM) 22
  • 23. Biotechnology: Gujarat Scenario Research ■ Gujarat has definite strengths in pharmaceuticals & healthcare, agriculture, animal husbandry, medicinal plants, biodiversity sectors while environment and marine are potential sectors needing biotechnology applications ■ Academic organizations largely involved in basic research ■ Industries mainly engaged in application based research, product development and contract research ■ Major research areas are conservation biology, genetic diagnostics, molecular biology, cancer biology genomics proteomics etc Research Areas USD 2.46 million of State support biology, genomics, proteomics, Research in Academics USD 4.92 million of National support 90 DSIR Centers in Industries • Nearly 11 universities, 70 colleges and 18 institutes are engaged in research in different areas of Biotechnology • As per the data of last three years, around 175 3000 Publications 300 Research Grants faculties are active in biotechnology research with outcome of around 3000 publications and 30 patents 23 30 Patents Source: Gujarat State Biotechnology Mission (GSBTM)
  • 24. Biotechnology: Gujarat Scenario Research Institutions Agro Biotech  Anand Agriculture University, Anand  CP college of Agriculture, Sardar Krushinagar  Junagadh Agricultural University, Junagadh  Navsari Agricultural University, Navsari  National Research Centre in Medicinal and Aromatic plants  Genome Research Centre, Baroda  National Research Centre Groundnut Banaskantha for Pharma Biotech  L.M. college of pharmacy  B.V. Patel PERD (Pharmaceutical Education and Research Development) Centre  Nirma Institute of Pharmacy Marine Biotech  Centre for Salt and Marine Chemical Research Institute (CSMCRI)  Department of Marine Sciences, Bhavnagar University Rajkot Gandhinagar Ahmedabad Anand Vadodara Environment Biotech  Department of Bioscience, S.P. University  The National Institute of Occupational Health  Department of Microbiology, MS University of Baroda  Department of Microbiology, Gujarat University  Department of Life science, Bhavnagar University  Gujarat Ecological Education and Research Foundation Junagadh Bhavnagar Navsari Medical Biotech  Cancer Research Institute, Ahmedabad  Genetics centre Ahmedabad Biotech Engineering  Department of Microbiology and Biotechnology, MS University of Baroda  Department of Biotechnology, Hemchandracharya, North Gujarat University  Department of Biochemistry, MS University of Baroda  Department of Food and Nutrition, MS University of Baroda Bioinformatics  MSc in Bioinformatics, Gujarat University  Sardar Patel University, Vallabh Vidhyanagar  MS University of Baroda  Bhavnagar University, Bhavnagar  Saurashtra University, Rajkot  Indian Institute of Advanced Research, Gandhinagar  Sikkim Manipal University, Ahmedabad Study centre  Bioinformatics Institute of India, Ahmedabad Study centre Source: Gujarat State Biotechnology Mission (GSBTM) 24
  • 25. Biotechnology: Gujarat Scenario Research Infrastructure (1/2) Gujarat Genomics Initiative (GGI) • A collaborative initiative between state agencies for undertaking Biodiversity Gene Bank (BioGene) • A collaborative initiative with state forest department for using Marine Bio‐Resource Center (MBRC) • Collaborative initiative with forest department and state Ayurveda g g genomic research in Gujarat • Activities include undertaking research in molecular biology, DNA based species identification, developing molecular markets for p g biotechnology application for biodiversity conservation and management • Activities include DNA banking, in– vitro banking cryo banking seed p y university • Focuses biotechnology application in conservation of Marine flora, fauna and microbial bio diversity • Activities include DNA based key floral and faunal species, problem solving, providing services to industries, academia, skill development in molecular biology banking, cryo‐banking, banking, bio‐prospecting research and application‐based research • Website: www.biogene.in species identification for important marine microbes, phyto‐plankton and other important flora group • Website: www.mbrc.res.in • Website: www.gujaratgenomics.in Source: Gujarat State Biotechnology Mission (GSBTM) 25
  • 26. Biotechnology: Gujarat Scenario Research Infrastructure (2/2) The Virtual Institute of Bioinformatics [BITVirtual] • A collaborative and multi‐institutional project for developing research and skills in field of bio‐ Shivrath Centre for Excellence in Clinical Research • Developed under Public‐Private Partnership for generating skilled human resources for contract p g informatics in Gujarat • Activities include providing state of art centralized bio‐informatics facilities, for research and imparting degree programs in Bioinformatics • Website: www bitvirtual org g g research organization • Activities include specific skill development and educational programs • Website: www.shivrath.com www.bitvirtual.Genetic Diagnostic Centre • A collaborative initiative with Gujarat University and its zoology department for extending molecular and genetic diagnostic services to society 26 • Activities include research, awareness and services in areas of genetic disorders Source: Gujarat State Biotechnology Mission (GSBTM)
  • 27. Biotechnology: Gujarat Scenario Promoting BT Entrepreneurship Technology Facilitation Cell [TFC] • Reports & Compilation: Bio‐Business Guides for Businesses of Bio‐fertilizer, Tissue Culture, Jatropha, Industrial Enzymes, status of Genetic Disorders in Gujarat, Drug Report etc. • Databases: Marine Patent Database, Genome Resource database of Gujarat, Company Database, Technology gy Database, technologies available for commercialization, transfers, partnerships, Bio‐Suppliers Database, etc Biotechnopreneur • Include short‐term awareness programmes for viz. creating awareness regarding Biotech Business Opportunities and Support Systems in Camps g g pp pp y different sectors of biotechnology • Website: www.biotechnopreneur.in Biotechnopreneur • Ten‐month long weekend based Structured Capacity Building Programme for Professionals to Programme help them spin‐off Biotech Enterprises Gujarat Biotech Venture Fund • Venture fund for biotechnology initiated and supported by State • Operational since 2004 and has supported many projects, technologies and companies while [GBVF] other projects are in pipeline Entrepreneur Support Cell [BT‐ESC] • GSBTM has formed a cell which provides holding to biotech units/companies in Gujarat and facilitation for availing various subsidies, incentives, benefits etc., from various government d / i ESC] departments/agencies Source: Gujarat State Biotechnology Mission (GSBTM) 27
  • 28. Biotechnology: Gujarat Scenario Building Public Consensus & Awareness Biotech Awareness Corners [Bio‐A‐Corn] • Aesthetically designed Bio‐A‐Corn developed in district Community Science Centres to impart general information about biotechnology to stakeholders, general public and students Bio‐safety Online Training Programme • Online Training Programme with a bid to develop awareness & technical understanding regarding the Laws, Technologies and Practices in different countries about ethical adoption of Genetic Modification of Biological Resources in Health, Agriculture and Food Sectors • Website: www.biosafety.org.in Information Dissemination • To update the stakeholders with biotechnology development in Gujarat, GSBTM publishes BT‐Chronicle: a quarterly Biotech magazine, in electronic and print format Seminars, Workshops & Conferences • With an objective to encourage interaction and bring national and global expertise at the doorsteps of the Biotech stakeholders GSBTM conducts and supports seminars conferences and workshops 28 stakeholders, seminars, Source: Gujarat State Biotechnology Mission (GSBTM)
  • 29. Biotechnology: Gujarat Scenario Gujarat State Biotechnology Mission [GSBTM] GSBTM: Established in April 2004 as an Autonomous Nodal Agency under the aegis of Department of Science and Technology, Gujarat Govt. Policy Planning To promote, support and facilitate the overall development of biotechnology in Gujarat To facilitate the development of biotechnology business, entrepreneurship and research infrastructure GSBTM Supporting Biotechnology Infrastructure Awareness Generation & Networking GSBTM Supporting Biotechnology Research & Technology Development Encouraging Biotechnology Entrepreneur‐ship Mandate To create scientific awareness and To facilitate networking among p Creation of Quality Human Resources stakeholders at regional, national and international level build public consensus regarding the potentials and socio‐economic impact of the ethical applications of biotechnology Source: Gujarat State Biotechnology Mission (GSBTM) 29
  • 30. Biotechnology: Gujarat Scenario Achievements Asset & infrastructure creation • Scientific assets created worth USD 2.29 million – around 50 major instruments and 200 minor i • Around 75 PG students, 38 faculty of different universities engaged in research • Around 20 international and 40 national research bl Advanced study & research instruments • Platform of establishing 3‐4 science based institutes/centres publication • Creating facilities, initiating research resulting in output in high end life science field like Genomics, Bioinformatics Biotech business & industries Entrepreneurship • Establishment of around 75‐80 new biotech industries • Around 700‐800 beneficiaries covered by entrepreneurship programs • Venture support to many start up companies and in Gujarat • Completed investment of around USD 262.29 million • Submitted first whole genome sequence work to an International organization • 40 M.Phils in bio‐informatics • Around 2000 genetic database submission to International pp y p p technologies • 15‐20 new biotech entrepreneurs g HR and skill building databases • DNA barcodes developed for around 100 plant species, DNA banking of around 700 species • First Whole Mitochondrial genome sequencing done for Asiatic lion in India by GSBTM G j t th fi t t t t t bli h GSBTM t t l l • Around 3000 UG/PG students from 100 organizations benefitted by various skill development programs/activities • Around 150 UG/PG faculty supported by skill development increased number 30 • Gujarat the first state to establish as state level nodal agency for biotechnology development, of students selection in national competitive examination Source: Gujarat State Biotechnology Mission (GSBTM)
  • 33. Nanotechnology: Global Scenario Nanotechnology — the science of objects 100 nanometers or smaller —has created enormous opportunities Potential uses • Novel approach to curing human illness • Enhanced computational power • New materials • Improved chemicals and catalysts • Bottom‐up manufacturing processes Potential support of other • New energy production • Next‐generation key technologies genomics • Power for artificial intelligence Promising demonstrations • 4nm robot constructed from pieces of DNA • Paperclip‐sized nanogenerator producing as much power as an AA battery • Solar cells printed onto paper, creating flexible PV at a fraction of current cost Nanotechnology market share 2015 6% 2% 4%3% New Materials 31% 9% 17% Electroics Pharmaceuticals Chemicals Aerospace Sustainability Healthcare 33 28% Tools
  • 34. Nanotechnology: Global Scenario Russia More than 60 countries have established national nanotechnology programs since 2000 Japan United States Rusnano, one of the world’s most ambitious nano‐technology projects, represents a determined effort by Russian leaders to make their country a l b l global l d leader in h the nano field In 2001, the U.S. government created the National Nano‐technology Initiative, helping to jump‐start U.S. nano‐technology work by d coordinating nano‐l d related h research across all federal agencies Support for nano‐technology research dates back to 2001, and nano is now regarded as one of the country’s four priority research fields France China Brazil Minatec was launched in 2006 as a collaboration between LETI (the Electronics and Information Nanotech manufacturing plants throughout China are developing nano products, including exhaust‐ The Brazilian Nano‐technology National Laboratory began operations in July 2011 by combining Technologies Laboratory of CEA, the French Atomic Energy Commission) and INPG (Grenoble Institute of Technology) exhaust absorbing tarmac and carbon‐nanotube‐ coated clothes that can monitor health three of the country’s biggest nano research centers 34 “I can’t think of any industry that won’t eventually be impacted by nano” – Dick Siegel, Director of Rensselaer Nanotechnology Center
  • 36. Nanotechnology: India Scenario • Launch of NSTI • Establishments of COE's Launch of R&D projects under NSTI Establishment of characterization Facilities DIT Programmes on Nanoelectronics National knowledge commission 2001 2002 2003 2004 2005 2006 Nano INUP initiated by IISC & IITB (Funded by DIT & MSCIT) Introduction of PG programme in Nano Science and Technology Earmarking of USD 163.93 million For Nano Mission mission to provide loans to industry to develop nano applications Nanotechnology intervention in mission mode programme 2007 2008 2009 2010 2011 2012 36
  • 37. Nanotechnology: India Scenario Comparative investment scenario Country Funding Programme Funding Period Brazil Ministry for Science & Technology USD 6.605 million Annual Estimate China Medium & Long Term Development Plan USD 38.2 million 2006‐2008 European Union Framework Programme 7 USD 4.718 billion 2007‐2013 France Nano 2012 Programme USD 673.5 million 2008‐2012 Germany Nano Initiative–Action Plan 2010 USD 498.39 million 2008‐2013 India Nano Mission USD 195.05 million 2007‐2012 Japan MEXT USD 633.09 million Annual Russia Development of nanotechnology infrastructure in Federation USD 4.66 billion 2008‐2015 the Russian UK Research Councils UK/Technology Strategy Board USD 344.83 million Annual 37 USA National Nanotechnology Initiative USD 2.1 billion 2012
  • 38. Nanotechnology: Nano Mission The Nano Mission is an umbrella programme for capacity building which envisages the overall development of this field of research in the country and to tap some of its applied potential for nation’s development C t f E ll Public Private Partnership Joint Institution ‐Industry linked Projects Nano Functional Materials Murugappa Chettiar & Orchid Centre of Excellence IIT Madras, Chennai IACS, Kolkata University of Pune Centre, IIT Madras Pharma Nano Technology Centre,Univ. of Hyderabad Dr. Reddy's Labs S.N. Bose National Centre for Basic Sciences, Kolkata NCL, Pune JNCASR, Bangalore BHU, Varanasi Centre for Interactive & Smart Textiles,IIT Delhi ARCI, Hyderabad & Textile Industry Centre for Pharmaceutical Nanotechnology, NIPER, Ch di h Pharma industry IIT Kanpur, Kanpur IISc, Bangalore IIT Delhi, New Delhi SINP, Kolkata Chandigarh Rubber Nanocomposites, MG University, Kottayam Apollo Tyres Nanophosphor Application Nanotech Corp., USA Amrita Institute of Medical Sciences, Kochi, Kerala S.N. Bose National Centre for Basic Sciences, Kolkata Tata Institute of Fundamental Research IIT‐Bombay, Mumbai 38 Centre, University of Allahabad y Centre for Computational Materials Science at Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore
  • 40. Nanotechnology: Gujarat Scenario Nanotechnology – identified as a fast developing and emerging field having vast opportunities for development of business and industries in Gujarat Productivity Productivity, conservation conservation, processing, packaging Agriculture Several chemicals and coatings Harvesting, conservation & distribution systems Technologies which add to quality & strength Wrinkle free & self‐cleaning textiles and others Nanotechnology Savings in Gujarat Generation (solar), storage & transmission Several pharmaceuticals, targeted drugs and equipments I i f i i Ai & t ifi ti d 40 Air water purification and other conservation measures In ceramics for engineering, auto and aerospace industry Source: Gujarat Council of Science and Technology (GUJCOST)
  • 41. Nanotechnology: Gujarat Nano Mission (1/2) Gujarat Council on Science & Technology (GUJCOST) promotes the R&D activities in the state by encouraging scientists, researchers, faculties and students for taking up research activities in Nanotechnology j Gujarat Nano Mission • During 2011‐12, GUJCOST pushed the nanotechnology education and research in the state and established Gujarat Nano Mission on the lines of India Nano Mission • Gujarat Nano Mission will be responsible for designing and developing Nanoscience and nanotechnology education, research and development in the state and to keep pace with national and global streams of development dd l ti th t t d t k ith ti l d l b l t fd l t Gujarat Nano Mission for the Benefits of State Vision of Gujarat and the entire country To conduct and support Nanoscience and Nanotechnology awareness, education, research, development, design and engineering in nanotechnology, and transfer the technology to industrial sector in order to increase Gujarat’s competitiveness, and improve the quality of life and the environment Mission Source: Gujarat Council of Science and Technology (GUJCOST) 41
  • 42. Nanotechnology: Gujarat Nano Mission (2/2) Goals To conduct R&D in order to acquire advanced knowledge in nanoscience and nanotechnology at international level, at the same time, built awareness to society and environment To drive national strategies and policies for nanoscience and nanotechnology that yield concrete and sustainable results To transfer the knowledge and know‐how in nanoscience and nanotechnology to the industrial sector while disseminating accurate information to the public To undertake capacity building of human resource development in nanoscience and nanotechnology To develop infrastructure that would facilitate nanoscience and nanotechnology development Gujarat Nano Mission will strive to be visible in global nanotechnology research arena To design and develop a Nanotechnology Park in the state for public awareness, understanding and appreciation 42 pp Source: Gujarat Council of Science and Technology (GUJCOST)
  • 43. Nanotechnology: Centre of Excellences (CoEs) • These centers have become hub of resources, manpower training and guiding industries • Government of India has also sanctioned various projects for strengthening R&D activities Nanotechnology of Nanomagnetic particles, Bhavnagar Universtiy Development of Oxide Nanomaterial Thin Films & Mutlilayers of Device Applications, Saurashtra University Rajkot Supramolecules Material Science – Nano Polymeric Materials, MS University, Vadodara University, p Fullerene, Nanotubes, Rotaxanes, Calixarenes and their applicability in Environmental & Material Sciences, Gujarat University Nanoscience & Nanomaterials, Sardar Patel University, Vallabh Vidyanagar CoEs Nanocatalysts: Development & Applications, DDU, Nadiad Source: Gujarat Council of Science and Technology (GUJCOST) 43
  • 44. Nanotechnology: Investment Opportunities Nano‐enabled Wireless Handsets Packaging Nano‐water Quantum Dots Thin film Lithium‐ion battery Nanofibers Nanomedicine market Nanocoating Source: Gujarat Council of Science and Technology (GUJCOST) 44
  • 45. FOR ADDITIONAL INFORMATION CONNECT US @ Department of Science and Technology http://www.dst.gujarat.gov.in Gujarat Council on Science and Technology (Gujcost) http://www.gujcost.gujarat.gov.in Gujarat State Biotechnology Mission (GSBTM) http://www.btm.gujarat.gov.in 45
  • 46. ORGANISED BY KNOWLEDGE PARTNER EVENT PARTNER Visit us at www.vibrantgujarat.com 46