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Taste Genetics & Food Acceptance Trey Sanders, BSFCS [email_address] October 8, 2009
Outline ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Outline ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Is there a Relationship? ,[object Object],[object Object],Duffy & Bartoshuk, 2000 ; Mennella et al., 2005
Chemical Forms ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Zhao et al., 2007; The Interactive Library, 1999; Chemical Book, 2007
Taste & Genetics ,[object Object],[object Object],[object Object],[object Object],[object Object],Mennella et al., 2005
Taste & Genetics ,[object Object],[object Object],[object Object],[object Object],[object Object],Basson et al., 2005; Kids Do Science, 2002
Taste & Genetics ,[object Object],[object Object],[object Object],[object Object],Basson et al., 2005
Taste & Genetics ,[object Object],[object Object],[object Object],[object Object],Mennella et al., 2005; Garcia-Bailo et al., 2009; Krebs, 2009
Biomarkers ,[object Object],[object Object],Zhao et al., 2007
Types of Cellular & Animal Studies ,[object Object],[object Object],[object Object],Krebs, 2009; Garcia-Bailo et al., 2009
Types of Human Studies ,[object Object],[object Object],[object Object],[object Object],[object Object],Krebs, 2009
Gaps in Knowledge ,[object Object],[object Object],[object Object],Krebs, 2009;  Zhao et al., 2007
Taste Disorders Evergreen Science Center, 2008
What is a Taste Disorder? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],National Institute of Deafness and other Communication Disorders, 2002
Who do Taste Disorders Affect? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],National Institute of Deafness and other Communication Disorders, 2002; National Institute of Deafness and other Communication Disorders, 2008
Diagnosis of Taste Disorders ,[object Object],[object Object],[object Object],[object Object],National Institute of Deafness and other Communication Disorders, 2002
Causes of Taste Disorders ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],National Institute of Deafness and other Communication Disorders, 2002; National Institute of Deafness and other Communication Disorders, 2008;  Duffy & Bartoshuk, 2000
Underlying Mechanisms ,[object Object],[object Object],Duffy & Bartoshuk; National Institute of Deafness and other Communication Disorders, 2008
Treatments ,[object Object],[object Object],[object Object],[object Object],[object Object],National Institute of Deafness and other Communication Disorders, 2002
Prevention ,[object Object],[object Object],[object Object],National Institutes of Health Senior Health, 2008
Food Acceptance http://www.mychildhealth.net/wp-content/uploads/2009/04/kids-vegetable.jpg
Food Acceptance ,[object Object],[object Object],[object Object],[object Object],Duffy & Bartoshuk, 2000
Dietary Guidelines & Reference Intakes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],United States Department of Agriculture, 2005
Health Risks & Medication Interactions ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Mahan & Escott-Stump, 2008
Gaps in Knowledge ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Duffy & Bartoshuk, 2000;  Zhao et al., 2007
Food Acceptance & Genetic Variation on Taste
Introduction ,[object Object],[object Object],[object Object],Duffy & Bartoshuk, 2000
Background ,[object Object],[object Object],[object Object],[object Object],[object Object],Mennella et al., 2005;  Duffy & Bartoshuk, 2000
Background ,[object Object],[object Object],[object Object],Duffy & Bartoshuk, 2000 ; Basson et al., 2005
Research Question ,[object Object],Duffy & Bartoshuk, 2000
Hypothesis ,[object Object],[object Object],Duffy & Bartoshuk, 2000
Aims of Study ,[object Object],[object Object],[object Object],[object Object],Duffy & Bartoshuk, 2000
Methods ,[object Object],[object Object],[object Object],[object Object],[object Object],Duffy & Bartoshuk, 2000
Research Design ,[object Object],[object Object],[object Object],[object Object],[object Object],Duffy & Bartoshuk, 2000
Research Design ,[object Object],[object Object],[object Object],[object Object],Duffy & Bartoshuk, 2000
Research Design ,[object Object],[object Object],[object Object],[object Object],Duffy & Bartoshuk, 2000
Food Liking/Disliking Groups Duffy & Bartoshuk, 2000
Results ,[object Object],[object Object],[object Object],Duffy & Bartoshuk, 2000
Results ,[object Object],[object Object],[object Object],[object Object],[object Object],Duffy & Bartoshuk, 2000
Results ,[object Object],[object Object],[object Object],Duffy & Bartoshuk, 2000
Results, Table 3 Duffy & Bartoshuk, 2000
Results, continued ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Duffy & Bartoshuk, 2000
Results, continued ,[object Object],[object Object],[object Object],[object Object],Duffy & Bartoshuk, 2000
Discussion ,[object Object],[object Object],[object Object],[object Object],Duffy & Bartoshuk, 2000
Discussion ,[object Object],[object Object],[object Object],Duffy & Bartoshuk, 2000
Limitations ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Duffy & Bartoshuk, 2000
Future Recommendations ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Duffy & Bartoshuk, 2000 ;  Krebs, 2009
Implications for Consumers & Patients  ,[object Object],[object Object],[object Object],Duffy & Bartoshuk, 2000
Questions?
Q&A ,[object Object],[object Object],[object Object],[object Object]
References ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
References ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
References ,[object Object],[object Object],[object Object],[object Object],[object Object]

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Effects Of Taste Genetics On Food Acceptance

Hinweis der Redaktion

  1. Focus of taste genetics will be on bitterness because it has been the most extensively studied taste modality
  2. PTC & PROP are members of the thioureas; do not occur naturally in foods Often used interchangeably because of common association of being markers for bitterness perception; PROP is generally used for threshold detection in studies because PTC has a slight smell when used in solutions… TAS2R38 gene has been identified as the gene for PTC sensitivity; three functional single nucleotide polymorphisms within this gene have been found to explain up to 85% of the observed variance in PTC taste sensitivity; some research does show that TAS2r38 polymorphisms aren’t sufficient enough to explain PROP bitterness perception at suprathreshold concentrations suggesting that other genetic or environmental mechanisms might also play a role in PROP taste perception
  3. N-C=s group= Thiocyanate moiety Nontasters- Some people cannot taste this chemical at all Tasters- perceive this chemical to be bitter Being a taster has been shown to correlate with a greater general taste acuity, having heightened responses to sweet & salty stimuli and show increased sensitivity to olfactory cues & viscous substances such as fats and food thickeners
  4. T2Rs are a family of G protein-coupled taste receptors located at the surface of taste cells as well as palate and epiglottis; Polymorphisms of the genes that code for these receptors are what may explain the variability in taste perception These vegetables usually tend to be nutritionally significant (i.e. spinach, endives and many cruciferous vegetables like broccoli, cabbage, cauliflower, and kale just to name a few) Secondary compounds in these veggies include phytochemicals such as polyphenols, methylxanthines, isoflavones and sulfamides which might protect against certain illnesses
  5. do not occur naturally in foods but the variability in response to their taste correlates with taste sensitivity to other bitter substances present in foods
  6. Sweetness- different strains of mice used to detect differences in sweet taste perception of saccaharin, to the point where direct evidence for the role of Tas1r3 in saccharin preference came from studies with mice Umami- studies using rats and Chinese hamster ovary cells helped identify genes associated with umami Sour-coexpression of ion channels associated with this modality were first observed in rats Salty- identification of epithelial sodium channels in rodents may have a role in perception of NaCl Research in all these areas are still in their infancy, and though animal research has helped identify possible genes and ion channels, exact mechanisms for these modalities are still unclear. Could be due to fact that bitterness perception and its genetic basis were discovered over 75 years ago through a series of individual responses
  7. Relationship between food acceptance and bitterness perception are still being defined
  8. Examines the relationship between genetic variation and food acceptance by
  9. Subjects tasted room temperature solutions, expectorated and rinsed to ensure that the threshold is roughly halfway between chance and perfect performance Magnitude Estimation with two or more sense modalities create a common scale of sensory magnitude (if a person assigns the same number to two different sensory events, it would mean they have the same sensory magnitude
  10. 1. stimuli were randomized within each block and a tone series always followed a taste series
  11. using principal component analysis with varimax rotation… Factor analysis with principal component solution can be used to reduce a large set of variables into a few underlying dimensions which can be treated as independent variables. These new dimensions account for the most of the variance of the original set of variables. Forming the food categories was necessary because of the large number of food items. Principal component analysis was based on the use frequencies and same categories were applied to desired use and liking scores as the factor solutions for these ratings were almost identical with those from use frequencies. These factor solutions could explain % of the variation of sweet foods Cronbach's alpha measures how well a set of items (or variables) measures a single dimensional construct; a value of 0.70 or higher is generally considered exceptable
  12. The authors felt Ceiling factors are limits that are established not by the intensity of the phenomenon but the measuring instrument; this can inhibit expression of sensory intensity. For example labeled scales have ceilings that force supertasters to give erroneously low ratings