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Global health, neglected diseases, and drug development -- a newcomer's perspective

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Greg Crowther
Greg Crowther

Greg Crowther's talk to Glacier Peak High School's "Biotechnology and Global Health" class.

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Global health, neglected diseases, and drug development – a newcomer’s perspective Gregory J. Crowther, Ph.D. Department of Medicine University of Washington http://faculty.washington.edu/crowther/ early-stage research preclinical studies clinical trials (I) clinical trials (II) clinical trials (III) FDA review & approval market
What does that title mean? ,[object Object],[object Object],[object Object],about health disparities between rich & poor malaria, tuberculosis, dengue, filariasis, etc. early-stage research preclinical studies clinical trials (I) clinical trials (II) clinical trials (III) FDA review & approval market
“A shot at adulthood” video http://zooppa.com/ads/uw-pocket-media-film-festival/videos/a-shot-at-adulthood
Drug development for neglected diseases: Why is it so hard? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Image: tulane.edu/~wiser/
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Drug development for neglected diseases: Are there reasons for optimism?
What would a perfect drug be like? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
What would a perfect drug be like? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
What would a perfect drug be like? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Image: alphahelix.co.uk
What would a perfect drug be like? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Structure-based drug design Nelfinavir in the active site of HIV-1 protease. Image from C.M. Henry, C&EN 79 : 69, 2001.
Recent advances in malaria research: cool example #1 ,[object Object],[object Object],[object Object],[object Object],[object Object],Reference: F.J. Gamo et al., Nature 465 : 305, 2010
Recent advances in malaria drug research: cool example #2 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Reference: M. Rottmann et al., Science 329 : 1175, 2010
Conclusion ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
T I M E S ’ U P
The malaria song ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],to the tune of “Maria” ( West Side Story ) music by Leonard Bernstein lyrics by Wes Van Voorhis, MD, PhD
Recent advances in malaria research: bonus example ,[object Object],[object Object],[object Object],[object Object],Reference: R. Gujjar et al., Journal of Medicinal Chemistry 52 : 1864, 2009.
Research frontier: the challenge of drug resistance and “polypharmacology” ,[object Object],[object Object],[object Object],[object Object],[object Object],Image from Chemical & Engineering News after M.J. Keiser et al., Nature 2009

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