1. AN ADVANCED TECHNOLOGY IN TREATMENT OF CANCERS

2. Introduction
 Proton therapy is a form of particle therapy
which uses a beam of protons to irradiate
diseased tissue, most often in the treatment of
cancer.
 The chief advantage of proton therapy is the
ability to more precisely localize the radiation
dosage when compared with other types of
external beam radiotherapy.

3. Description
 The accelerators used for proton therapy typically produce
protons with energies in the range of 70 to 250 MeV .
 Such protons cause DNA damage specifically to the cells of
the selected area without affecting the nearby tissue.
 The dose delivered to tissue is maximum just over the last
few millimeters of the particle’s range; this maximum is
called the Bragg peak.
 All protons of a given energy have a certain range, very few
protons penetrate beyond that distance.

4. Depth-dose plot of proton and x-ray beam

5. COMPOSITION OF PROTON
ACCELERATOR

6. Advantages
1. Most precise form of radiation treatment available
today.
2. Is non-invasive and painless.
3. Avoids the usual side effects of standard x-ray
radiation.
4. Highly preferred radiation treatment modality option for
pediatric cases because children are susceptible to
injury from standard x-ray radiation .

7. Side effects and risks
 Preliminary results from a 2009
study, including high dose treatments, show
very few or no side effects.

8. Applications
 Conditions Treated
 Prostate,
 Base of Skull,
 Brain and Spinal Cord,
 Eye,
 Head and Neck,
 Chest and Abdomen,
 Tumors in Children.

9. Comparison with other treatment
options
 X-ray radiotherapy
 X-ray radiation dose falls off gradually, while tissues
deeper in the body than the tumor receive essentially no
radiation during proton therapy.
 X-ray therapy causes damage to the tumor as well as the
surrounding healthy tissues. .

10.  Surgery
 The benefit of external beam proton radiation lies in the
dosimetric difference from external beam x-ray radiation
and brachytherapy in cases, where the use of radiation
therapy is already indicated, rather than as a direct
competition with surgery.

11. THANKS
FOR
ATTENTION
M. Deyab
CELL BIOLOGY