1. Ideagen Workshop
Dr Peter Donnelly
Chief Executive Officer
BioBusiness Ltd.
Chief Technology Officer
Bluescope Medical Technologies Ltd.
Life and Health Technologies Sector in Ireland
Copyright © 2010 BioBusiness Ltd.

2. Ideagen Workshop
Background
Development of Medical Device and Technology Platform
Bluescope Bluescope
IQ Medical
Medical Medical Axellis
Systems
Technologies Technologies
Support to the Life and Health Technology Sector
IQ Solutions BioBusiness
Life and Health Technologies Sector in Ireland
Copyright © 2010 BioBusiness Ltd.

3. Ideagen Workshop
Bluescope Medical Technologies
First patent filed in 2002
Bluescope established as QUB spin-out in 2004.
Partner (CEO) and I bought out other parties in
2006.
Opened office in Lisburn May 2006
Funded by Invest NI April 2007
Acquired by Axellis in November 2007
HQ London, 3 offices in the US, 1 office SW
England, 1 office in NI.
Axellis Product Platforms:
• Compensators and Immobilisers for Radiotherapy
Treatment.
• Cardio-respiratory Platform for Vital Sign Monitoring
Life and Health Technologies Sector in Ireland
Copyright © 2010 BioBusiness Ltd.

4. Ideagen Workshop
Clinical Need – Critical Care
Acute Trauma Patient
Non-invasive and unobtrusive
Continuously monitor lung sounds
to assess respiratory condition.
Identify trends in disease, and
treatment states.
Provide an ‘easy-view’ user
interface to provide real time
feedback on lung condition.
Provide access to key respiratory
sites.
Diagnostically consistent.
Life and Health Technologies Sector in Ireland
Copyright © 2010 BioBusiness Ltd.

5. Ideagen Workshop
Nightingale® Monitor
Provides continuous visual
anatomical representation of
lung condition, respiratory rate
and trended information
Life and Health Technologies Sector in Ireland
Copyright © 2010 BioBusiness Ltd.

6. Ideagen Workshop
Clinical Need – General Ward
Deteriorating Patient
Respiratory condition and rate is
an important vital sign & an
indicator of deterioration.
Increasing prevalence of
respiratory conditions in aging
patients.
Provide a glanceable user interface
for real-time feedback of lung
condition for nursing support.
Hospital Scoring Systems to
identify at-risk patients.
Wireless capability
Life and Health Technologies Sector in Ireland
Copyright © 2010 BioBusiness Ltd.

7. Ideagen Workshop
Clinical Need – Home-Based
Chronically Ill Aging Patient
Reduction in hospital admissions,
hospital bed days and A&E visits.
Healthcare cost savings.
Improved quality of life for aging
and chronically ill patients.
Improved disease management
and life trending analysis.
Carer alert facility.
Integration into telemedicine and
telecare systems.
Wireless capability
Life and Health Technologies Sector in Ireland
Copyright © 2010 BioBusiness Ltd.

8. Ideagen Workshop
Problems with current solutions
Entirely subjective.
Quantification difficult.
Cross infection.
Lack of access.
Poorly recorded.
No continuous trend assessment.
Difficulty operating in noisy environments.
No continuous, unobtrusive, robust method
of assessing respiratory condition currently
exists.
Life and Health Technologies Sector in Ireland
Copyright © 2010 BioBusiness Ltd.

9. Ideagen Workshop
Key Lessons Learned
Academic prototypes are not ready for market.
Clinicians do not make good business people.
Business conditions and models are constantly
changing.
Investment timelines are much much longer than
you anticipate.
1 Golden Rule –
He who has the gold makes the rule.
Life and Health Technologies Sector in Ireland
Copyright © 2010 BioBusiness Ltd.

10. Ideagen Workshop
BioBusiness
Established May 2004 as Northern Ireland organisation
All-Island organisation in 2010 with All-Island membership
Sector representation covers:
• Medical Devices, Diagnostics, Pharmaceuticals, Biotechnology, Agri-Foods and
Support Companies
Funding Support
• Invest NI, InterTradeIreland & Enterprise Ireland
• Dept Employment & Learning (NI)
• European (FP7, NPP, Interreg, Eurostars)
Capability
• Trained facilitators
• Experienced project managers
• Clinical advisor on staff
Life and Health Technologies Sector in Ireland
Copyright © 2010 BioBusiness Ltd.

11. Ideagen Workshop
Strategic Goals
Provide a strong advocacy role for the industry.
Contribute to the competitiveness and size of Life
and Health Technology Sector in Ireland.
Facilitate and broker opportunities in innovation
and collaboration.
Play an industrial role in the skills development of
the Sector.
Champion Ireland and UK Connected Health and
Personalised Medicine activities.
Life and Health Technologies Sector in Ireland
Copyright © 2010 BioBusiness Ltd.

12. Ideagen Workshop
Programmes & Initiatives
Current Programmes
• ABC Collaborations
• Medical Devices in Connected Health
• ABC Ireland ABC
Ireland
• Healthy Living
• Medilink UK
• Health Tech & Medicines KTN
• Skills Academy
Connected Health Initiatives
• All-Island Connected Health Review
• Connected Health Clinical Trials
• UK Connected Health @ IBIZ
• All-Island Connected Health Mission to Boston
Life and Health Technologies Sector in Ireland
Copyright © 2010 BioBusiness Ltd.

13. Ideagen Workshop
ABC Innovation Model
Academia Clinical
HSC Innovations
Universities / HSC R&D Office
Colleges and RCS in Ireland
Institutes of RCP in Ireland
Technology GP Consortia
Priority Areas
Priority areas have strong Connected Health and
All-Island capability Personalised Medicine
Healthy Living
Business
BioBusiness &
Members
ABC Interface
Life and Health Technologies Sector in Ireland
Copyright © 2010 BioBusiness Ltd.

14. Ideagen Workshop
ABC Innovation Model
Academia Clinical
Identify Clinical
Applied research
Need
for medium term
Provide Clinical
innovation.
Efficacy
Blue skies
Early Adopters
research for long
term innovation
Priority Areas
Priority areas have strong Connected Health and
All-Island capability Personalised Medicine
Healthy Living
Business
Commercial
Regulatory
Approved ABC Interface
Products
Life and Health Technologies Sector in Ireland
Copyright © 2010 BioBusiness Ltd.

15. Ideagen Workshop
Innovation
Key to any Innovation Strategy is the correct insights and
knowledge of the:
• Market,
• Customer base,
• Technologies,
• Regulatory environment and
• Internal capability.
Collaboration is often the easiest way to gain knowledge,
find solutions and source capability.
Successful ABC collaborations are very important to
successful commercial opportunities and initiatives.
Life and Health Technologies Sector in Ireland
Copyright © 2010 BioBusiness Ltd.

16. Ideagen Workshop
Capability Building
Sales and
Marketing
Clinical Trials
• Statistical
Requirements
Regulatory • Trial Protocols
Environment • Ethics Approval
• FDA, MDD, GxP,
Investment
Innovation
• Insights
• Collaboration
• Intellectual
Property
Life and Health Technologies Sector in Ireland
Copyright © 2010 BioBusiness Ltd.

17. Ideagen Workshop
Academic & Clinical Engagement
Altnagalvin Hospital
Beacon Hospital
Beaumont Hospital
Belfast Hospital Trust
Cork University Hospital
Craigavon Area Hospital
HSC Innovation and R&D Division
Nenagh Hospital
RCSI & RCPI
St James’ Hospital
St Vincent’s Hospital
Tallaght Hospital
Ulster Hospital
General Practitioners (GPs)
Life and Health Technologies Sector in Ireland
Copyright © 2010 BioBusiness Ltd.

18. Ideagen Workshop
BioBusiness Projects
Doctor Office Laboratory
Cardiac Care in the Community
Connected Health Monitoring Centre
Addressing Rural Isolation using Telecare
Clinical Trial Network
Remote Vital Sign Monitoring
mHealth Applications for Mental Illness
Stroke Screening
Thrombolysis Automated Work Practice
Respiratory Database Development
Tissue Sample Database
Life and Health Technologies Sector in Ireland
Copyright © 2010 BioBusiness Ltd.

19. Ideagen Workshop
McElwaine Smart Case Study
McElwaine Smart offers tele-health and
tele-care solutions.
International partnership established
with Bosch GmbH.
Academic research collaborations
established with UU, QUB, DkIT and
Limerick University.
Commercial links established with
McElwaine SMART, Friendly Call Service.
Invested £3.5 million in new staff,
products, infrastructure and marketing.
Leverage of funding ratio 1:35
Life and Health Technologies Sector in Ireland
Copyright © 2010 BioBusiness Ltd.

20. Ideagen Workshop
Intelesens Case Study
Intelesens company providing remote vital
sign monitoring devices.
First home-based clinical trial.
Clinical trial protocols developed and ethics
approval achieved.
Commercial links established between
device company and communication
platform company –Valentia Technologies.
Invested £800,000 with public grant
support.
Leverage of funding ratio 1:30
Life and Health Technologies Sector in Ireland
Copyright © 2010 BioBusiness Ltd.