Generic Ovestin Cream (Evalon Vaginal Cream) is used in Hormone Replacement Therapy (HRT) in women. It substitutes for the loss of Oestrogen production in menopausal women and alleviates menopausal symptoms.
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Generic Ovestin Cream for Treatment of Menopausal Symptoms
1. Generic Ovestin Cream
Generic Ovestin Cream (Evalon
Vaginal Cream) is used in Hormone
Replacement Therapy (HRT) in
women. It substitutes for the loss of
oestrogen production in menopausal
women and alleviates menopausal
symptoms.
Š The Swiss Pharmacy, Geneva Switzerland
2. Generic Ovestin Cream
Chemical Structure (Estriol)
Š The Swiss Pharmacy, Geneva Switzerland
3. Generic Ovestin Cream
Active Ingredient
The active pharmaceutical ingredients contained
in Generic Ovestin Cream (Evalon Vaginal
Cream) is Oestriol (Estriol).
Generic Ovestin Cream contains 1 mg of
Oestriol (Estriol) in 1gm of the cream.
Š The Swiss Pharmacy, Geneva Switzerland
4. Generic Ovestin Cream
Uses
Generic Ovestin Cream is used for the
treatment of Atrophy of the lower urogenital
tract related to oestrogen deficiency, notably:
(a)For the treatment of vaginal complaints such
as dyspareunia, dryness and itching.
(b) for the prevention of recurrent infections of
the vagina and lower urinary tract.
It is also used in the management of micturition
complaints (such as frequency and dysuria)
and mild urinary incontinence and in Pre- and
post-operative therapy in postmenopausal
women undergoing vaginal surgery.
Š The Swiss Pharmacy, Geneva Switzerland
5. Generic Ovestin Cream
Recommended Dosage
The usual dose is 0.5g Generic Ovestin
Cream (Evalon Vaginal Cream)
containing 0.5mg Estriol per day for 2 to
3 weeks. As maintenance dosage, 0.5g
of Generic Ovestin Cream twice a week.
Pre-surgery Therapy :
One 0.5g Generic Ovestin Cream per day
should begin 2 weeks before the operation.
Š The Swiss Pharmacy, Geneva Switzerland
6. Generic Ovestin Cream
Recommended Dosage
Following Surgery:
A period of at least 2 weeks should be allowed
before resuming therapy using 0.5g Generic
Ovestin Cream twice a week.
Generic Ovestin Cream (Evalon Vaginal Cream)
may be started on any day in women not taking
HRT or switching from another continuous
combined HRT product. In women switching from a
cyclic HRT product, Ovestin Cream should be
started one week after completion of the cycle
Š The Swiss Pharmacy, Geneva Switzerland
7. Generic Ovestin Cream
Contraindications
Generic Ovestin Cream (Evalon Vaginal
Cream) is contraindicated in patients
with the following conditions:
âHypersensitivity to Oestriol (Estriol) or to any
inactive ingredient present in the medication.
âPregnancy
âKnown, past or suspected breast cancer
âKnown or suspected oestrogen-dependent
malignant tumours (e.g. endometrial cancer)
âUndiagnosed genital bleeding
âUntreated endometrial hyperplasia
âPrevious or current venous thromboembolism
(deep venous thrombosis, pulmonary embolism)
Š The Swiss Pharmacy, Geneva Switzerland
8. Generic Ovestin Cream
Contraindications
Generic Ovestin Cream (Evalon Vaginal Cream) is
contraindicated in patients with the following
conditions:
âKnown thrombophilic disorders (e.g. protein C,
protein S, or antithrombin deficiency)
âActive or recent arterial thromboembolic disease
(e.g. angina, myocardial infarction)
âAcute liver disease, or a history of liver disease
as long as liver function tests failed to return to
normal
âPorphyria
Š The Swiss Pharmacy, Geneva Switzerland
9. Generic Ovestin Cream
Side Effects of Generic Ovestin Cream
The most commonly observed side
effects associated with the use of
Generic Ovestin Cream (Evalon Vaginal
Cream) were nausea and vomiting,
breast tenderness or pain in the
breasts, vaginal bleeding or spotting
during or on withdrawal of therapy,
excessive production of cervical
mucous, headache, application site
irritation and pruritus.
Š The Swiss Pharmacy, Geneva Switzerland
10. Generic Ovestin Cream
Warnings And Precautions
âFor the treatment of postmenopausal symptoms, HRT
should only be initiated for symptoms that adversely affect
quality of life. In all cases, a careful appraisal of the risks
and benefits should be undertaken at least annually and
HRT should only be continued as long as the benefit
outweighs the risk.
âIf prescribing HRT, the potential for increased
cardiovascular, thrombotic and neoplastic adverse events
must be considered.
âDiscontinue treatment if contraindicated, jaundice or a
deterioration in liver function occurs, there is a significant
increase in blood pressure, a new onset of migraine or
pregnancy occurs. If breakthrough bleeding or spotting
occurs, the reason should be investigated.
Š The Swiss Pharmacy, Geneva Switzerland
11. Generic Ovestin Cream
Warnings And Precautions
âPatients with some medical conditions including, leiomyoma
or endometriosis, a history of or risk factors for
thromboembolic disorders, hypertension, liver disorders,
diabetes mellitus with or without vascular involvement,
cholelithiasis, migraine or (severe) headache, systemic lupus
erythematosus, a history of endometrial hyperplasia, epilepsy,
asthma and otosclerosis, will need close supervision
particularly when the condition is active, or has occurred
previously and/or was aggravated during pregnancy or
previous hormone treatment.These conditions may recur or be
aggravated during treatment with Generic Ovestin cream.
âPatients with cardiac or renal dysfunction or hypertri-glyceridemia
should be carefully observed.
Š The Swiss Pharmacy, Geneva Switzerland
12. Generic Ovestin Cream
Overdose Symptoms and Treatment
Overdosage with Generic Ovestin Cream
(Estriol) after vaginal administration is
unlikely.
However, in cases where large quantities
are ingested, nausea, vomiting and
withdrawal bleeding in females may
occur.
No specific antidote is known.
Symptomatic treatment can be given if
necessary.
Š The Swiss Pharmacy, Geneva Switzerland
13. Generic Ovestin Cream
Evalon Vaginal Cream
manufactured by Organon
Pharmaceuticals
For more information click here
Š The Swiss Pharmacy, Geneva Switzerland