Brufen tablets contain the active ingredient ibuprofen, which is used to relieve signs and symptoms of various conditions like rheumatoid arthritis, osteoarthritis, juvenile rheumatoid arthritis, and pain. The document provides information on Brufen's dosage, contraindications, side effects, warnings, and overdose treatment. It is manufactured by Abbott, India.

1. Brufen Tablets
Brufen Tablets (Ibuprofen) is used for relief of the
signs and symptoms of Rheumatoid arthritis,
Osteoarthritis, Juvenile rheumatoid arthritis,
Primary dysmenorrhoea, and Pyrexia. Brufen is
also used for the relief of acute and/or chronic
pain states in which there is an inflammatory
component.
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2. Brufen Tablets
Chemical Structure
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3. Brufen Tablets
Active Ingredient
The active pharmaceutical ingredient
present in Brufen Tablets is
Ibuprofen. Each 400 mg Brufen Tablet
contains 400 mg of Ibuprofen.
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4. Brufen Tablets
Recommended Dosage
Recommended Adult Dosage:
The recommended initial dosage of Brufen tablets
is 1200 mg to 1800 mg daily in divided doses.
Some patients can be maintained on 600 to 1200
mg daily.
In severe or acute conditions it can be
advantageous to increase the dosage until the
acute phase is brought under control, providing
that the total daily dosage does not exceed 2400
mg in divided doses.
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5. Brufen Tablets
Recommended Dosage
Primary Dysmenorrhoea:
For the treatment of dysmenorrhea,
beginning with the earliest onset of such
pain or menstrual bleeding, Ibuprofen
tablets should be given in a dose of 400
mg every 4 to 6 hours as necessary with
a maximum total daily dose of 1,600 mg.
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6. Brufen Tablets
Recommended Dosage
Children:
The daily dosage of Brufen tablets
(Ibuprofen) is 20 mg per kg of body weight in
divided doses. In juvenile rheumatoid arthritis
up to 40 mg per kg of body weight in divided
doses may be given.
In children weighing less than 30 kg the total
dose should not exceed 500 mg in a 24 hour
period.
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7. Brufen Tablets
Recommended Dosage
Maintenance Dose:
In all indications the doses should be adjusted for
each patient and the smallest dose that results in
acceptable control of the symptoms employed.
In general, patients with rheumatoid arthritis and
osteoarthritis tend to require higher doses than
patients with other conditions.
Mild to Moderate Pain:
The recommended adult dosage is 400 mg every 4
to 6 hours as necessary for relief of pain.
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8. Brufen Tablets
Contraindications
Brufen Tablets is contraindicated in
patients with the following conditions:
➔Hypersensitivity to Ibuprofen, or any inactive
component of this medication.
➔Ibuprofen should not be given to patients who
have experienced asthma, urticaria, or allergic-type
reactions after taking aspirin or other NSAIDs.
➔Ibuprofen is contraindicated for the treatment of
peri-operative pain in the setting of coronary artery
bypass graft (CABG) surgery
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9. Brufen Tablets
Side Effects of Brufen Tablets
The common side effects of Brufen Tablets
(Ibuprofen) are nausea, epigastric pain,
heartburn, diarrhea, abdominal distress, nausea
and vomiting, indigestion, constipation,
abdominal cramps or pain, fullness of GI tract
(bloating and flatulence), dizziness, headache,
nervousness, rash (including maculopapular
type), pruritus, tinnitus, decreased appetite,
edema, and fluid retention.
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10. Brufen Tablets
Side Effects of Brufen Tablets
The rare side effects of Brufen Tablets (Ibuprofen)
include Gastic or duodenal ulcer with bleeding and/or
perforation, gastrointestinal hemorrhage, melena,
gastritis, hepatitis, jaundice, abnormal liver function
tests; pancreatitis, Depression, insomina, confusion,
emotional lability, somnolence, aseptic meningitis with
fever and coma, vesiculobullous eruptions, urticaria,
erythema multiforme, Stevens-Johnson syndrome,
alopecia, hearing loss, amblyopia (blurred and/or
diminished vision, scotomata and/or changes in color
vision).
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11. Brufen Tablets
Side Effects of Brufen Tablets
The rare side effects of Brufen Tablets (Ibuprofen)
include neutropenia, agranulocytosis, aplastic
anemia, hemolytic anemia (sometimes Coombs
Positive), thrombocytopenia with or without purpura,
eosinophilia, decreases in hemoglobin and
hematocrit, congestive heart failure in patients with
marginal cardiac function, elevated blood pressure,
palpitations, Syndrome of abdominal pain, fever,
chills, nausea and vomiting; anaphylaxis;
bronchospasm, acute renal failure, decreased
creatinine clearance, polyuria, azotemia, cystitis,
hematuria, dry eyes and mouth, gingival ulcer and
rhinitis.
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12. Brufen Tablets
Warnings And Precautions
➔Cardiovascular Thrombotic Events: Increased risk of
serious cardiovascular (CV) thrombotic events, myocardial
infarction, and stroke, which can be fatal. All NSAIDs, both
COX-2 selective and nonselective, may have a similar
risk.
➔Hypertension: NSAIDs, including Ibuprofen, can lead to
onset of new hypertension or worsening of preexisting
hypertension, either of which may contribute to the
increased incidence of cardiovascular events.
➔Congestive Heart Failure and Edema: Fluid retention
and edema have been observed in some patients taking
NSAIDs. Ibuprofen should be used with caution in
patients with fluid retention or heart failure.
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13. Brufen Tablets
Warnings And Precautions
➔Gastrointestinal Effects: NSAIDs, including Ibuprofen
tablets, can cause serious gastrointestinal (GI) adverse
events including inflammation, bleeding, ulceration, and
perforation of the stomach, small intestine, or large
intestine, which can be fatal.
➔Renal Effects: Long-term administration of NSAIDs has
resulted in renal papillary necrosis and other renal injury.
➔Advanced Renal Disease: Treatment with Ibuprofen
tablets is not recommended in these patients with
advanced renal disease.
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14. Brufen Tablets
Warnings And Precautions
➔Anaphylactic/Anaphylactoid Reactions: As with other
NSAIDs, anaphylactic/anaphylactoid reactions may occur in
patients without known prior exposure to Ibuprofen. Ibuprofen
should not be given to patients with the aspirin triad. This
symptom complex typically occurs in asthmatic patients who
experience rhinitis with or without nasal polyps, or who exhibit
severe, potentially fatal bronchospasm after taking aspirin or
other NSAIDs.
➔Skin Reactions: NSAIDs, including Ibuprofen, can cause
serious skin adverse events such as exfoliative dermatitis,
Stevens-Johnson Syndrome (SJS), and toxic epidermal
necrolysis (TEN), which can be fatal. These serious events may
occur without warning. Patients should be informed about the
signs and symptoms of serious skin manifestations and use of
the drug should be discontinued at the first appearance of skin
rash or any other sign of hypersensitivity.
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15. Brufen Tablets
Warnings And Precautions
➔Pregnancy: In late pregnancy, as with other NSAIDs, Brufen
tablets should be avoided because it may cause premature
closure of the ductus arteriosus.
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16. Brufen Tablets
Overdose Symptoms
The following symptoms may be
observed following Brufen Tablets
(Ibuprofen) overdosage: Depression
of the central nervous
system and the respiratory system..
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17. Brufen Tablets
Overdose Treatment
In cases of acute overdose of Brufen Tablets
(Ibuprofen), the stomach should be emptied by
vomiting or lavage, although little of the drug will
be likely to be recovered if it is more than an
hour since ingestion.
Because the drug is acidic and excreted in the
urine, it is theoretically beneficial to administer
alkali and induce diuresis. In addition to
supportive measures, the use of oral activated
charcoal may help reduce the absorption of
Ibuprofen.
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18. Brufen Tablets
Brufen Tablets Manufactured
by Abbott, India
For more information click here
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