This document discusses how lifestyle and dietary factors can impact cancer risk and outcomes. It notes that cancer rates have increased significantly since the early 1900s, which correlates with changes in the Western diet including increased consumption of refined sugar and omega-6 fatty acids compared to omega-3s. Several studies are cited showing links between certain foods/nutrients and various cancer types, including breast cancer risks associated with higher omega-6 intake and colon cancer risks associated with a non-organic diet. The document also discusses stress/hopelessness, physical activity, and social support as behavioral factors that can influence cancer progression and survival.

1. David Servan-Schreiber, MD, PHD Clinical Professor of Psychiatry, University of Pittsburgh Lecturer, Faculté de Médecine Lyon I Anticancer A New Way of Life

2. Epidemic 1 - Evolution SEER, 2003 NCI

3. Epidemic 2 - Distribution

4. Key difference = Life style For 100,000 Sasco, 1989 Rev Med Int

5. Refined Sugar WW I WW II

7. Soy Oil (omega-6)

8. Duckett et al., 1993 J Animal Sci

9. Transformation of food chain Simopoulos & Salem. NEJM, 1989 - Ailhaud et al., Prog. Lip. Res., 2006 – Omg-6 /Omg-3 x6 x10 x15 x30

10. Evolution of Diet Saturated Fat Omega-6 Fatty Acids Omega-3 Fatty Acids % Calories 10 20 - 4M - 10,000 1800 1900 2000 WW II Leaf, A. and P. Weber Am. Jal. Clin. Nut. 1987

11. Omega-6 fatty acids and mammary tumors Carroll et al, 1975 Cancer Res. Days post graft Nb of tumors

12. Advanced Breast Cancer Gago-Dominguez et al., 2003 Brit J Ca – Singapore Prospective 35 298 women

13. Breast Cancer Goodstine et al, J Nut 2003

14. Colon Cancer EPIC Norat et al, 2005 JNCI IARC - Prospective - 478 040 Europeans

15. Chemical Contamination

17. Heatlh Behaviors Years Survival Khaw et al., 2008 PLoS Med. Relative Risk = 4,04

18. Cui et al., 2003 Proc Nat Acad Sci - Koebel et al. 2007, Nature

19. Anticancer Phytochemicals Surh, 2003 Nature

20. Specific Activity Boivin et al., 2008 Food Chem.

21. After Breast Cancer Holmes et al., 2005 JAMA Physical Activity

23. What kind of stress? Visintainer & Seligman, 1982 Science % Tumor rejection 54% 23% 63% No Shock Shock – no Control Shock + Control