How did it all start

1. HOW DID IT ALL START ?
DR. MOHAMMAD ABBAS
Assistant Professor
& Orthopedic Consultant
Faculty of Medicine
King Abdulaziz University

2. NOVEMBER 2009
 KNEE COURSE BY SMITH & NEPHEW IN TOURS,
FRANCE.
 THE TRUFIT PLUG FOR FOCAL CHONDRAL
DEFECT WAS INTRODUCED BY DANIEL SARIS

3. FOR FOCAL CHONDRAL DEFECT
TRUFIT PLUG

4. MSCs
? FOR LARGER AREA OF CARTILAGE DEGENERATION
? TOTAL OSTEOARTHRITIS
TRUFIT PLUG

5. JANUARY 2010
THE IDEA AND PROCESS OF
STARTING A SCIENTIFIC CHAIR
THROUGH RACI @ KAU

6. A long tedious process to fulfill
the RACI requirements
 Sponsor.
 Distinguished stem cell professor.
 3 years detailed plan.
 Organizational chart.
 Web page.

7. “ There is a huge gap between
clinicians and scientists ”
Building up the team

8. Stem cells ProfessorMolecular hematologist
Building up the team

9.  Biochemistry professor.
 Consultant Hematologist
 Consultant Radiologist.
 PhD scientist in stem cell biology
 Orthopedic surgeons.
 Lab. specialist with
master in tissue culture.
Building up the team

10. ‫الكرسي‬ ‫مشـــرف‬
‫د‬.‫عباس‬ ‫محمد‬
‫الكرسي‬ ‫أستـاذ‬‫الكرسي‬ ‫أعضاء‬‫البحثية‬ ‫المجموعات‬
‫الخاليا‬ ‫مختبر‬
‫الجذعية‬
‫المالية‬ ‫اإلدارة‬
‫ا‬.‫د‬.‫كافينا‬ ‫وائل‬‫د‬.‫السايس‬ ‫فاتن‬
‫أ‬.‫د‬.‫قاري‬ ‫ممدوح‬
‫أ‬.‫د‬.‫عطا‬ ‫حازم‬
‫د‬.‫الكاف‬ ‫محمد‬
‫أبحاث‬ ‫مجموعة‬
‫العظام‬
‫د‬.‫عباس‬ ‫محمد‬
‫د‬.‫شودري‬ ‫علي‬
‫د‬.‫درويش‬ ‫حسام‬
‫د‬.‫حمدي‬ ‫عمرو‬
‫د‬.‫الكاف‬ ‫محمد‬
‫أبحاث‬ ‫مجموعة‬
‫الدم‬ ‫أمراض‬
‫د‬.‫السايس‬ ‫فاتن‬
‫أ‬.‫د‬.‫قاري‬ ‫ممدوح‬
‫د‬.‫جوثمان‬ ‫كالميجام‬
‫أ‬.‫السهلي‬ ‫حنين‬
‫األشعة‬ ‫أبحاث‬ ‫مجموعة‬
‫د‬.‫قطب‬ ‫ممدوح‬
‫الكيمياء‬ ‫أبحاث‬ ‫مجموعة‬
‫الحيوية‬
‫أ‬.‫د‬.‫عطا‬ ‫حازم‬
‫أ‬.‫د‬.‫قاري‬ ‫ممدوح‬
‫د‬.‫جوثمان‬ ‫كالميجام‬
‫أ‬.‫النونو‬ ‫رهام‬
‫أ‬.‫السهلي‬ ‫حنين‬
‫مع‬ ‫بالتعاون‬
‫البحوث‬ ‫مركز‬
‫واالستشارات‬
Organizational chart

12. 3 years detailed plan

13. Inauguration was on 22 Feb. 2012.

15. ESTABLISHING THE
STEM CELL LAB. IN THE
OPRATING THEATRE

16. Establishing a stem cells
unit in CEGMR in KFRMC

17. Isolation & characterization of MSCs

18. Team members
are regularly
attending ICRS
world congress
2015
2013
2012
Team Development

19. Participation in ICRS courses
 Radiologist  MRI T2
mapping of cartilage
course in Vienna 2012.
 Orthopedic surgeons
 learning surgical
procedures for cartilage
regeneration.
Team Development

20. 1- Isolation and Characterization of
Mesenchymal Stem Cells from Bone Marrow
of Osteoarthritis patients
2- Epigenetic analysis of osteoarthritis
patients
3- Exome sequence analysis for osteoarthritis
patients
4- Evaluation of ex-vivo cartilage regeneration
with mesenchymal stem cells derived from
the human bone marrow (hBM-MSCs) and
synovial fluid (hSF MSCs) from osteoarthritis
patients
Molecular Hematology Research

21. 1- EFFECT OF ADRENALINE & VOLTAREN
ON VIABILITY and PROLIFERATION of
HUMAN MESENCHYMAL STEM CELLS
2- EFFECT OF MARCAINE &
DEXAMETHASONE ON VIABILITY and
PROLIFERATION of HUMAN
MESENCHYMAL STEM CELLS
0
0.2
0.4
Control Adrenaline
100ug/ml
Adrenaline
300ug/ml
OD
Effect of Adrenaline on the
Viability and Proliferation
of Human MSCs
Mean
0
0.1
0.2
0.3
OD
Effect of Marcaine on the
viability and proliferation
of human MSCs
Mean
Biochemistry Research

22. The focus was on building
up Articular Cartilage
Orthopedic Animal Research

23. Two projects done on
rabbits for focal defects
Orthopedic Animal Research

24. Most recent research
focuses on Induced Total
Surgical Arthritis in Rabbits
using
 MSCs + Scaffolds
Orthopedic Animal Research

25.  6 monthly report
 A yearly presentation to RACI
committee
 A yearly financial report
Fulfilling RACI follow up

26. A yearly meeting with the sponsor

27. PLEASE VISIT OUR WEB PAGE