2. INTRODUCTION
• Von Pirquet (1906) - Gk: ‘Allos’ = Other ; ‘Ergon’ – Work
• 1840 - Dakin Dermatitis Venenata / Rhus dermatitis
• Bloch / Steiner-Worlich Allergic Sensitization of skin
(Primula sp)
• Haxthausen (1942) ‘Allergy stems from within’
• Landsteiner / Chase (1949)
hypersensitivity reaction to HAPTENS
Cell-mediated
• Staedler (1847) – Blotting paper patch test ; modified by
Jadassohn – Dermatitis Medicamentosa
3. DEFINITION
• type of contact dermatitis
• Delayed cell-mediated HSN
• manifestation of an allergic response
• contact with an exogenous substance
• previous sensitization
4. EPIDEMIOLOGY
• 3700 documented allergens
• Children > Adults
• Females > Males ? Ni ? Fragnance Mix
• Males : 10-19 % Occupational (44% - Hand
Dermatitis)
5. ETIOPATHOGENESIS
• Type IV HSN
• T-cell mediated Inflammation to Haptens
• Genetic Susceptibility HLA alleles to Co / Ni /
Cr
• Sensitization (Induction) – Elicitation –
Resolution
• Hapten + Epidermal Carrier Protein (LC) = Contact
Allergen
• Contact Allergen conjugate recognized by LC
Presented to T-cells
• Internalized to LNs LCs differentiate into DCs