Magnetic Resonance Navigation with Therapeutic Microcarriers

CANADIAN RESEARCH FOCUS Interview with Dr. Sylvain Martel “ Co-encapsulation of magnetic nanoparticles and doxorubicin into biodegradable microcarriers for deep tissue targeting by vascular MRI navigation”, Biomaterials (2011). 32: 3481-3486. November 2 nd , 2011 conducted by Patricia Comeau

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Figure 1: Targeting of TMMC in the left lobe of a liver of a rabbit using an upgraded clinical MRI scanner . Image courtesy of the NanoRobotics Laboratory, École Polytechnique de Montréal, 2011

Interview with Dr. Martel Department of Electrical & Computer Engineering, Ecole Polytechnique de Montreal (EPM) Institute of Biomedical Engineering, EPM NanoRobotics Laboratory, EPM

Please explain the design requirements for the TMMC and how these will be monitored prior to use in a clinical setting? ,[object Object],… continued on next slide ->

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What is the relationship between catheter proximity to the bifurcation and flow velocity? ,[object Object],… continued on next slide ->

What is the desired timeline for polymer degradation? ,[object Object]

Does the polymer limit the targeting and should care be taken in which type of polymer is used? ,[object Object]

What happens to the magnetic nanoparticles once they have been released from the polymeric carrier? ,[object Object],… continued on next slide ->

How do you explain the higher steering efficiency for left steering compared to the right steering? ,[object Object]

Do you have any plans to further optimize the design to achieve greater effect (e.g. steering efficiency)? ,[object Object],… continued on next slide ->

Do you expect the design of the TMMCs to be altered in any form for clinical application in humans? ,[object Object]

What major hurdles remain to be overcome in this technology before clinical application? ,[object Object],… continued on next slide ->

CC-CRS Question #8 Thank you for the interview!

Dr. Sylvain Martel Biography of

Magnetic Resonance Navigation with Therapeutic Microcarriers

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Magnetic Resonance Navigation with Therapeutic Microcarriers