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Intrathecal Delivery of PEG-FGF2

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CANADIAN RESEARCH FOCUS Interview with Dr. Molly Shoichet “ Poly(ethylene glycol) modification enhances penetration of fibroblast growth factor 2 to injured spinal cord tissue from an intrathecal delivery system ”, J. Control. Release (2010). doi:10.1016/j.j.conrel.2010.01.029 June 22 nd , 2010 conducted by Patricia Comeau
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Figure 1: Injectable Delivery Strategy to the Intrathecal Space of the Spinal Cord Image reproduced with permission, copyright Michael Corrin, 2005; Molly Shoichet, 2010
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Interview with Dr. Shoichet Terrence Donnelly Centre for Cellular & Biomolecular Research, Department of Chemical Engineering & Applied Chemistry, Institute of Biomaterials & Biomedical Engineering, Department of Chemistry University of Toronto
Why was maleimide used to functionalize PEG? Is there any significance in this choice? ,[object Object],… continued on next slide ->
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How selective is PEG conjugation to each conjugation site ? ,[object Object]
Is there a limit to the degree of PEGylation that can occur before bioactivity is lost ? ,[object Object]
What is the relevance of the target tissue to FGF2?  Is there a certain cell type that is expected to respond ? ,[object Object]
What is the loading capacity of HAMC?  How does this gel degrade? ,[object Object]
Will the spinal cord present a challenge for metabolism of degradation products ? ,[object Object]
Over what time period should FGF2 delivery be sustained?  ,[object Object]
Do you plan to combine FGF2 with any other molecules?  ,[object Object]
Could this delivery system be applied in the brain or to other tissue? ,[object Object]
What future work do you have planned ? ,[object Object],… continued on next slide ->
[object Object]
CC-CRS Question #8 Thank you for the interview!
Dr. Molly Shoichet Biography of
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[object Object],[object Object],… continued on next slide ->
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Intrathecal Delivery of PEG-FGF2

  • 1. CANADIAN RESEARCH FOCUS Interview with Dr. Molly Shoichet “ Poly(ethylene glycol) modification enhances penetration of fibroblast growth factor 2 to injured spinal cord tissue from an intrathecal delivery system ”, J. Control. Release (2010). doi:10.1016/j.j.conrel.2010.01.029 June 22 nd , 2010 conducted by Patricia Comeau
  • 2.
  • 3.
  • 4. Figure 1: Injectable Delivery Strategy to the Intrathecal Space of the Spinal Cord Image reproduced with permission, copyright Michael Corrin, 2005; Molly Shoichet, 2010
  • 5.
  • 6. Interview with Dr. Shoichet Terrence Donnelly Centre for Cellular & Biomolecular Research, Department of Chemical Engineering & Applied Chemistry, Institute of Biomaterials & Biomedical Engineering, Department of Chemistry University of Toronto
  • 7.
  • 8.
  • 9.
  • 10.
  • 11.
  • 12.
  • 13.
  • 14.
  • 15.
  • 16.
  • 17.
  • 18.
  • 19. CC-CRS Question #8 Thank you for the interview!
  • 20. Dr. Molly Shoichet Biography of
  • 21.
  • 22.
  • 23.
  • 24.