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www.venturevaluation.com




   Comparison on European biotech
   locations – where does
   Switzerland stand?
   Dr. Patrik Frei
   January 2013 | San Francisco
www.venturevaluation.com




Country comparison

                                                                                                        Bay
                           Germany France         Ireland Netherlands               UK    Switzerland
                                                                                                        Area


Biotechnology
                            897     451               61                288         624      327        318
Companies

   Biotech -
                            149     116               15                  66        172       93        198
   Therapeutics

   Biotech – R&D
                            607     260               22                156         399      171        99
   Services

   Biotech - Other          141      75               24                  66        53        63        21




                                     Source: Biotechgate.com by Venture Valuation
www.venturevaluation.com




Companies Founded
   35

   30

   25

   20

   15

   10

     5

     0
             2004          2005    2006   2007     2008     2009   2010     2011    2012
                 Ireland      UK     Netherlands   France    Germany      Switzerland
www.venturevaluation.com




Source of new companies
  100%                                                100%

    80%                                               90%
                                                      80%
    60%
                                                      70%
    40%                                               60%
                                                      50%
    20%
                                                      40%
      0%                                              30%
                                                      20%
                                                      10%
                                                       0%
        Independent foundation
        Spin-off from company
        Spin-off from University/Public Institution
        Subsidiary
        Other                                                Public   Private
www.venturevaluation.com




Product pipeline
   Switzerland               48%            22%       21%   9%


       Germany                     49%                      22%            23%        6%


          France             48%            18%       27%     7%


  Netherlands              54%    14% 25%7%


                 UK                51%                  16%              25%         8%


           Ireland


                       0     50       100      150      200        250         300    350   400
                                                  No. of Products

                             Preclinical    Phase I    Phase II     Phase III
www.venturevaluation.com




Financing
                                                                                                      France
                         500                                                                          Germany
                                                                455                                   Ireland
                         450
                                                                                                      Netherlands
                         400                                                                          Switzerland
                                                                                                      United Kingdom
 Total Financing USD M




                         350
                                                                            305
                         300    286                                                                              292

                         250
                                                       214                                     219
                         200                                                               180
                                                164                                167                160
                                                           148 143      146              144
                         150           125
                                         107
                         100
                                                                                                            6959
                                      47                              43                             47
                          50   29              21   2934
                                                                                  15   8                  11
                           0
                                    2008            2009             2010              2011               2012
www.venturevaluation.com




Biotechgate
  • Subscription based Database with
           26‘000 company profiles in over 70 countries
           26‘000 products
           6‘300 licensing opportunities
           1’400 licensing deals


  • Global Life Sciences Database to map clusters / countries
  • 28 country databases
  • Life Sciences statistics
  • Membership / Regional Directory


                                                                7
www.venturevaluation.com




 Global Partners




                           8
www.venturevaluation.com




Venture Valuation
   Mission                  Independent assessment and valuation of
                            technology driven companies / products in
                            growth industries

                           Life Sciences Database Biotechgate:
                           www.biotechgate.com


   Offices                 HQ: Zurich with representative offices in North
                           America, Europe and Asia (Seoul)

   Employees               6 people in Switzerland, 8 representatives, JV in India

   Clients                 Pharma, Biotech and Investors such as Novartis Venture
                           Fund, GSK, European Investment
                           Bank, 4SC, Arpida/Evolva, Celtic Pharma
www.venturevaluation.com




   Thank you for listening!
   Slides available on www.venturevaluation.com

   Tel.:   +41 (43) 321 86 60                     Venture Valuation AG
   Fax:    +41 (43) 321 86 61                     Kasernenstrasse 11
   www.venturevaluation.com                       8004 Zürich
   p.frei@venturevaluation.com                    Switzerland
www.venturevaluation.com




Panel Discussion
  To be a successful entrepreneur in Switzerland / the Bay
  Area – or how to raise more money than you burn?


  Participants:
       • Simon Meier, Investment Director, Roche Venture Fund
       • Simon Nebel, Managing Partner, Aravis
       • Christian Zahnd, CEO, Molecular Partners AG
       • Panel moderated by Patrik Frei, CEO Venture Valuation




                                                                 11

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Biotech Success in Switzerland and the Bay Area - Patrik Frei

  • 1. www.venturevaluation.com Comparison on European biotech locations – where does Switzerland stand? Dr. Patrik Frei January 2013 | San Francisco
  • 2. www.venturevaluation.com Country comparison Bay Germany France Ireland Netherlands UK Switzerland Area Biotechnology 897 451 61 288 624 327 318 Companies Biotech - 149 116 15 66 172 93 198 Therapeutics Biotech – R&D 607 260 22 156 399 171 99 Services Biotech - Other 141 75 24 66 53 63 21 Source: Biotechgate.com by Venture Valuation
  • 3. www.venturevaluation.com Companies Founded 35 30 25 20 15 10 5 0 2004 2005 2006 2007 2008 2009 2010 2011 2012 Ireland UK Netherlands France Germany Switzerland
  • 4. www.venturevaluation.com Source of new companies 100% 100% 80% 90% 80% 60% 70% 40% 60% 50% 20% 40% 0% 30% 20% 10% 0% Independent foundation Spin-off from company Spin-off from University/Public Institution Subsidiary Other Public Private
  • 5. www.venturevaluation.com Product pipeline Switzerland 48% 22% 21% 9% Germany 49% 22% 23% 6% France 48% 18% 27% 7% Netherlands 54% 14% 25%7% UK 51% 16% 25% 8% Ireland 0 50 100 150 200 250 300 350 400 No. of Products Preclinical Phase I Phase II Phase III
  • 6. www.venturevaluation.com Financing France 500 Germany 455 Ireland 450 Netherlands 400 Switzerland United Kingdom Total Financing USD M 350 305 300 286 292 250 214 219 200 180 164 167 160 148 143 146 144 150 125 107 100 6959 47 43 47 50 29 21 2934 15 8 11 0 2008 2009 2010 2011 2012
  • 7. www.venturevaluation.com Biotechgate • Subscription based Database with  26‘000 company profiles in over 70 countries  26‘000 products  6‘300 licensing opportunities  1’400 licensing deals • Global Life Sciences Database to map clusters / countries • 28 country databases • Life Sciences statistics • Membership / Regional Directory 7
  • 9. www.venturevaluation.com Venture Valuation Mission Independent assessment and valuation of technology driven companies / products in growth industries Life Sciences Database Biotechgate: www.biotechgate.com Offices HQ: Zurich with representative offices in North America, Europe and Asia (Seoul) Employees 6 people in Switzerland, 8 representatives, JV in India Clients Pharma, Biotech and Investors such as Novartis Venture Fund, GSK, European Investment Bank, 4SC, Arpida/Evolva, Celtic Pharma
  • 10. www.venturevaluation.com Thank you for listening! Slides available on www.venturevaluation.com Tel.: +41 (43) 321 86 60 Venture Valuation AG Fax: +41 (43) 321 86 61 Kasernenstrasse 11 www.venturevaluation.com 8004 Zürich p.frei@venturevaluation.com Switzerland
  • 11. www.venturevaluation.com Panel Discussion To be a successful entrepreneur in Switzerland / the Bay Area – or how to raise more money than you burn? Participants: • Simon Meier, Investment Director, Roche Venture Fund • Simon Nebel, Managing Partner, Aravis • Christian Zahnd, CEO, Molecular Partners AG • Panel moderated by Patrik Frei, CEO Venture Valuation 11