This document discusses laryngeal cancer including its: - Anatomy, epidemiology, etiology, pathology, symptoms, clinical features, staging, treatment including surgery and radiation therapy options, and prognosis. It covers cancer types like squamous cell carcinoma and details staging and treatment for supraglottic, glottic, and subglottic cancers. Survival rates are provided for different stages.

1. Laryngeal cancer LIU Wei Wei, MD Department of Head and Neck Surgery Email: drliuww@gmail.com

2. Anatomy

3. Anatomy

4. Anatomy

5. Anatomy

6. Anatomy

7. Anatomy

8. Anatomy

9. Anatomy

10. Histology

11. Laryngeal Epithelium

12. Goblet Cells and Columnar Mucinous Cells Squamous Epithelium

14. Etiology

24. supraglottic

25. glottic

26. subglottic

29. Video

30. Laryngeal TB 病灶多位于杓状软骨间隙 表现为脓性分泌物覆盖的浅表溃疡 肺部大多有结核病灶存在 可有咳嗽、胸痛、午后潮热的症状

40. Keratosis 临床表现为声嘶、喉内不适 声带增厚，呈粉红色或白色斑块 病理上为不同程度的上皮增生和角质层 可伴有角化不全和乳头瘤样增生

41. Laryngeal Leukoplakia

44. Staging(supraglottic) Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures T4b Tumor invades through the thyroid cartilage and/or invades tissue beyond the larynx (e.g. trachea, soft tissues of neck including deep extrinsic muscles of the tongue, strap muscles, thyroid, or esophagus) T4a Tumor limited to larynx with vocal cord fixation and or invades any of the following: postcricoid area, preepiglottic tissue, paraglottic space, and/or minor thyroid cartilage erosion (e.g. inner cortex) T3 Tumor involves mucosa of more than one adjacent subsite of supraglottis or glottis, or region outside the supraglottis (e.g. mucosa of base of the tongue, vallecula, medial wall of piriform sinus) without fixation T2 Tumor limited to one subsite of supraglottis with normal vocal cord mobility T1

45. Staging(Glottic) Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures T4b Tumor invades through the thyroid cartilage, and/or invades tissues beyond the larynx (e.g. trachea, soft tissues of the neck including deep extrinsic muscles of the tongue, strap muscles, thyroid, or esophagus T4a Tumor limited to the larynx with vocal cord fixation and/or invades paraglottic space, and/or minor thyroid cartilage erosion (e.g. inner cortex) T3 Tumor extends to supraglottis and/or subglottis, and/or with impaired vocal cord mobility T2 Tumor involves both vocal cords T1b Tumor limited to one vocal cord T1a Tumor limited to the vocal cord (s) (may involve anterior or posterior commissure) with normal mobilty T1

46. Neck staging Single or multiple lymph nodes > 6cm N3 Bilateral or contralateral lymph nodes, each ≤6cm N2c Multiple ipsilateral lymph nodes, each ≤ 6cm N2b Single ipsilateral node > 3cm and ≤6cm N2a Single ipsilateral lymph node ≤ 3cm N1 No cervical lymph nodes positive N0

47. 临床分期 M1 Any N Any T IVC M0 N3 Any T M0 Any N T4b IVB M0 N2 T1-4a M0 N0-2 T4a IVA M0 N1 T1-3 M0 N0 T3 III M0 N0 T2 II M0 N0 T1 I M0 N0 Tis 0

50. Laser surgery

51. Laser surgery

53. Vertical partial laryngectomy

55. Supraglottic partial laryngectomy

56. Total laryngectomy

57. Total laryngectomy

62. Prognosis 50-60% Stage IV 70-80% Stage III 85-90% Stage II >95% Stage I 5 year survival

63. Thanks! Contact me: LIU Wei Wei [email_address]