3. Focused Research on Metabolism For close to a decade, NuLiv has centered its research around metabolism, the biological functions that sustain life, at cellular and systemic levels 1. Research initiatives (slides 4 – 6) 1.1 Central belief 1.2 Hypothesis 1.3 Strategy 2. Life Science and Clinical Research platforms (slides 7 –14) 2.1 Facility 2.2 Staff & advisors 2.3 Validation platform 2.4 Supporting framework 3. Patents (slide 15) 4. Papers (slide 16)
4.
5.
6.
7. NuLiv’s Advanced and Integrated Life Science and Clinical Research Platform Component Description Facility NuLiv Taipei Laboratory NuLiv Shanghai Laboratory Management, Staff and Advisors Highly educated and trained in business, multi scientific & clinical disciplines, and work closely in a truly interdisciplinary manner Discovery and Validation In-house and 3 rd party in vitro, in vivo, and human use study platforms Supporting Framework/Network Supported by NuLiv’s own subsidiaries and affiliates, and long term strategic partners and alliances in many distinguished academic and research institutions
8.
9. NuLiv Taipei Laboratory Has Access to Equipments to Perform a Wide Range of In Vitro and In Vivo Studies Laminar Flow, Cell Culture Water Purification System CO2 Incubator Lab Bench Spectrophotometer Photomicrographic Equipment High Speed Centrifuge PCR machine Gel Dryer Deep Fryer Gel Photosystem Animal Room National Defense Medical Center
10.
11. NuLiv Management /Business & Research Executives Founder & CEO Austin Wang, M.S. NuLiv Holdings, Inc. (World Headquarters) Taipei City, Taiwan Executive Director Y.H. Lee, M.D. Vice Chancellor, China Medical Univ. (Taiwan), Previously Dean, Chang Kung Medical School, Dep. Director, Chang Kung Hospital System (10,000+ beds) Principle Scientific Advisor H.C. Lin, Ph.D. Univ. of North Carolina. Taught TCM at NDMC for over 20 years. Pioneered the hypothesis that “Qi” herbs regulate absorption and other metabolic functions President Americas, Europe, Asia, Africa Business Development Sales & Marketing Representative Americas, Europe, Asia, Africa Michael Wang, M.S. NuLiv Science USA, Walnut, CA David Allen, Ph.D. World Wellness, LLC., San Diego, CA President Greater China David Wu, Ph.D. Business Administration, Univ. of South Australia, Director Research & Development NuLiv Taipei Laboratory Thomas Yang, Ph.D., Molecular Microbiology, Univ. of Texas, Southwestern Medical Center Director NuLiv Shanghai Laboratory Sunnie Sun, Ph.D., Pharm. Analysis, Sheng Yang Pharm. Univ. Director Clinical Research Rose Chen, M.D., Ph.D., Shanghai TCM University
12. NuLiv’s Scientific Advisors Chang, T.C., Ph.D. Biochemistry, Univ. of Illinois, Professor, Dept. of Biochemistry, National Defense Medical Center,Taiwan Chang, W.L., Ph.D. Pharmacy, National Taiwan Univ., Professor, School. of Pharmacy, National Defense Medical Center, Taiwan Kuo, C.H., Ph.D. Physiokinetics, Univ. of Texas, Professor and Chair, Department of Exercise Science, National Taipei Physical Education College, Taiwan Chen, C.X., Professor Director, Department of Pharmacology, TCM Univ., Shanghai, China. Serves as our toxicity and safety advisor on TCM and other herbs Komatsu, Yasuhiro, Ph.D. Medical science, Juntendo University, Prior Dean of R&D department, Tsumura & Co. Chu, C. H, Ph.D. Food engineering, University of Tokyo, expert in pre-clinical pharmacology tests Fan, David, Ph.D. Senior Lecturer, Trinity College, Cambridge Univ., Editor-in-chief, Angiogenesis Hsieh, Steve, Ph.D. Nutritional Biochemistry, Univ. of Wisconsin, Ex Vice Chairman, National Science Council, R.O.C. Government Looi Hwang, Ph.D. Industrial & Environmental Pharmacy Ph.D. from Purdue, previously G.M. of MSD, Hanzhou, China & and Merck of Singapore J.K. Luo, Ph.D. Editor (acting), Journal of Heterocyclic Chemistry, Professor at University of S. Florida Funfack, Wolf, M.D. Metabolic Balance founder. Peng, C.K., Ph.D. Statistical Physics, Boston Univ., Assoc. Professor/Co-director, Rey Institute for Nonlinear Dynamics in Physiology and Medicine, Harvard Medical School.
13.
14. Our Supporting Framework & Network Facility, equipment, interdisciplinary consultation National Defense Medical Center Industrial Technology Research institute, Taiwan Yang Ming University, Taiwan Taipei Medical University, Taiwan In vivo and human study China Pharmaceutical University, Nanjing, China Taipei Physical Education College I-Shou University Hospital NuLiv Wellness Clinic Consultation, Cellular science Metabolic health TCM pharmacology & toxicology angiogenesis Yang Ming Univ. Stem Cell Research Center Taipei Medical Univ. Stem Cell Research Center Dr. Wolfgang Funfack, Metabolic Balance, De. Shanghai TCM university China Medical University, Taiwan Trinity college, Cambridge University, UK
15. Patents from NuLiv’s Research Title Country/Region Patent NO. Application NO. Method for Regulating Nutrient Absorption with Astragalosides USA US11/426,029 China CN200610090113.0 Taiwan I271195 Method for Regulating Nutrient Absorption with Ginsenosides USA US11/426,06 China CN200610090114.5 CN200910178493.7 CN200910178492.2 Taiwan I317280 Method for Skin Care PCT PCT/US07/77326 USA US11/469,659 China CN200710089586.3 Taiwan TW095132614 Use of Cycloartane compounds for treating arthritis USA US12/353,779 China N/A yet Taiwan TW098135306
16.
17.
18. 6 Fractions / Compounds from our Research and Their Biological Functions Fractions/Compounds Discovered Functions NL-F001 Anti-angiogeneis NL-F002 Enhance amino acids, vitamins, and glucose absorption at the cellular level; anti-angiogenesis NL-F003 Increase Adiponectin secretion Ergogenic/recovery NL-F004 Enhance amino acids, vitamins, and glucose absorption at the cellular level NL-F006 Enhance amino acids, vitamins, and glucose absorption at the cellular level ; Increase Adiponectin secretion NL-F007 Increase collagen and hyaluronic acid secretion; decrease MMP-1 secretion
19.
20. How ActiGin TM Works Creatine kinase MDA IL-6 Inflammatory biomarkers inhibition Exercise Performance Fast Recovery Exercise Oxidative stress elevation Glucose uptake Oxidative stress reduction ATP
28. The Purity and Concentration Level of our Bioactive Fractions and Compounds are Identified and Measured by Specific Bioassays Active constituents Medicinal plants Crude extracts Fraction 1 Fraction 2 Fraction 3 Fraction 4 Fraction 5 Fraction 6 … fractionation extraction Formulation Depend on function Products & Marketing Structure elucidation UV MS NMR IR CD 1 H NMR 13 C NMR 2D NMR separation Absorption Anti-cancer Skin care, etc Active constituents QC systems -LC/UV -GC/MS Bioassay QC
29. Our Supplements are Highly Effective and Safe in Supporting Critical Human Health Functions
30. Our Sourcing Operations Guarantees Premier Quality Products with Competitive Prices and Timely Delivery to our Customers NuLiv/ Customer specifications/requirements Vendor Vendor Survey for Certificates, Qualifications, MOA, COA, sample Onsite Vendor Survey Disqualified Qualified Contract / Agreement Primary suppliers Secondary Supplier
31.
32. Futuristic Wellness Product and Service Platform (A NuLiv Experimental Model) Wellness Advisors Interactive and personal wellness information exchange and virtual community management NuLiv Wellness Management Inc. Device HRM Meridian Blood analysis CD/Biochips Nutritional Sciences NuLiv Laboratories (Slides 1 – 42) System complexity analysis DynaDx – Harvard Reylab Evidence based wellness know-how NuLiv Wellness Clinic Wellness/Sub-clinical Primary Care Clinic Cellular sciences Steminent Therapeutic Inc .