This document discusses the changing dynamics affecting distribution centers and implications for location strategies. Key factors driving changes include shifting global sourcing costs, rising fuel costs, and environmental concerns, which are resulting in needs for more and smaller distribution centers located closer to consumer markets. An effective location selection process involves defining strategy and criteria, evaluating a universe of locations, screening to a shortlist, and finally selecting locations based on factors like market access, transportation networks, costs and incentives. Coordinating supply chain, real estate, transportation and economic development is important for future network optimization.