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Pediatric obstructive sleep apnea
syndrome : time to wake up
Veena Arali, Srinivas Namineni, Ch Sampath
IJCPD , JAN-APRIL 2012, 5 (1)
Introduction

“On Some Causes Backwardness
In Children”

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History
• OSAS – 1966

• PMC

• In 1976
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Guilleminault et al jop

3
 Obstructive Apnea: continued chest and abdominal
motion in the absence of airflow during sleep
 Obstructive Hypopnea: decreased airflow and alveolar
ventilation in the presence of paradoxical motion of chest
and abdomen
 Apnea-Hypopnea Index: # of events/hour
• Used to categorize severity of condition
• AHI > 1 abnormal, but clinically significant?
• Pathology in a snoring child not yet clearly defined
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Definition
• OSAS in childhood, as defined by the American Thoracic
Society, is a disorder of breathing during sleep
characterized by prolonged partial upper airway
obstruction and/or intermittent complete obstruction,
obstructive apnea, that disrupts normal ventilation during
sleep and normal sleep patterns.

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Epidemiology
• 8-12%
• 1-3%
• 5-6%

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Physiology of breathing and
sleep
• Upper air way resistance

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Types of sleep
• There are five stages of sleep; four stages are
considered non-REM sleep and one stage of
REM sleep

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What is REM sleep?
• Rapid eye movement..during a sleep period
(eyes dart from right to left) stimulates occular
muscles;
• Called “active sleep” or “paradoxical sleep”;
• Respiration is irregular, heart rate is generally
faster, blood pressure is higher…brain waves
fast and shorter;
• Dreaming occurs;
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EPIDEMIOLOGY
•

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Pathophysiology

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Pathophysiology
• Role of the Tonsils & Adenoids

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Role of upper airway
neuromotor tone
• Children with OSAS – ventilatory drive
• Neuromotor function- abnormal
• Accessory muscles- hypoxemia , hypercapnia

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• Role of Arousal

• Role of structural factors

• Role of genetic factors
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Clinical Symptoms
• Vary with the age

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Clinical evaluation & diagnosis of
SDB
1. The nose, one should look for asymmetry of the nares, a large
septal base, collapse of the nasal valves during inspiration, a
deviated septum or enlargement of the inferior nasal turbinates.
2. The oropharynx should be examined for the position of
the uvula in relation to the tongue.

3. The size of the tonsils should be compared with the size
of the airway.
4. The presence of a high and narrow hard palate, overlapping incisors,
a crossbite and an important overjet are indicative of a small jaw
and or abnormal maxilla-mandibular development

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Objective confirmation of SDB
•
•
•
•
•

Testing during sleeping –SDB
Questionnaires
Home monitoring
Ambulatory monitoring
Polysomnography

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• Questionnaires
 Brouillette’s OSA questionnaire initially appeared
accurate in small sample, but on subsequent
studies was indeterminate in 47%
» Brouillette, J Pediatr, 1984

 Parents cannot predict severity of OSA based on
their observations
» Preutthipan, Acta Paediatr, 2000

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Home monitering
Audiotapes
– lack specificity to distinguish OSAS from primary snoring.
» Lamm, Ped Pulm 1999

Videotapes
– sensitivity 94%, specificity 68%
» Sivan, Eur Respir J, 1996

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Diagnosis
PSG

• Polysomnography = sleep study
• “Gold standard”
• Only technique that allows comprehensive
monitoring of both cardiorespiratory function
and sleep noninvasively

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Polysomnography
• Polysomnography is the only test that may exclude the
diagnosis of SDB. It must always include monitoring of
sleep/wake states through electroencephalography (EEG),
electrooculography, chin and leg electromyography,
electrocardiography, body position and appropriate
monitoring of breathing.

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• The American Thoracic Society has defined
their criteria for an abnormal PSG in children
as follows:
• Apnea index (AI) 1/hour
• Apnea-hypopnea index 5/hour
• Peak end-tidal carbon dioxide 53 mm Hg or
• An end-tidal carbon dioxide tension 50 mm Hg for
10% of the sleep period and
• A minimum hemoglobin oxygen saturation 92%.
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Orofacial implications

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• The most common orofacial characteristics encountered include

 a retrognathic mandible,
 narrow palate,
 large neck circumference,
 long soft palate (which leads to dentists’being unable to visualize the
entire length of the uvula when the patient’s mouth is open wide),
tonsillar hypertrophy,
 nasal septal deviation
 and relative macroglossia.
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• The following features are found in OSA patients on a cephalogram:

 An increased incidence of maxillary retrusion (ANB < 0)
 An increased incidence of mandibular retrusion(ANB > 0)
 An increased incidence of maxillary and mandibular
retrusion (SNA and SNB)
 The hyoid was more inferiorly and anteriorly placed
 A thicker soft palate
 A larger tongue; a longer pharyngeal length.
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Treatment
• Adenotonsillectomy
• Medical therapies
 Nasopharyngeal airway
Insufflations of pharynx during sleep
Continuous positive airway pressure via nasal
mask
• Tracheostomy
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• Pharmacological
– Topical nasal steroids
– Antibiotics
– Nasal decongestant
– Weight loss
• Other surgical therapies
– Craniofacial surgical procedures
– Mandibular/maxillary plastic surgical procedures
– Stenting procedures for nasal stenosis
– Cleft palate revision procedures
– Uvulopalatopharyngoplasty
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Adenotonsillectomy
• Adenotonsillectomy is the most common treatment
for childhood OSA
• Cure rate = 75-100%
» Suen, Arch Otolaryngol Head and Neck Surg, 1995

• Complications
– anesthetic

– post-op pain, poor oral intake and bleeding
– airway edema
– pulmonary edema
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• 24 months of age
• OSA – 3wks of age

• Severe snoring & clinical symptoms- 6-24
months
• 6months of age.
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Orthodontic treatment
• RMD
• SMD
• Rapid and slow maxillary distractions are performed
between 5 and 11 years of age.
• Distraction results in widening of the palate and the
nose; thus, these procedure remedies nasal occlusion
related to a deviated septum, for which little can be
done before 14 to 16 years of age.
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Oral appliances

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Surgical treatment
• Surgeries, such as nasal septoplasty and other
maxillofacial surgeries, are indicated in some rare cases
but not usually seen in the pediatric population.
• Orthognathic surgery is normally postponed until 10 to
13 years of age.
• Two surgical techniques used in patients with SDB are
 mandibular distraction osteogenesis
 and maxillomandibular advancement
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CPAP

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positive airway pressure

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Sequelae of OSAS in Children
• Cardiopulmonary:
– Right ventricular hypertrophy
– Left ventricular hypertrophy
– Pulmonary hypertension
– Systemic hypertension
– Cor pumonale
– Polycythemia
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• Neurodevelopmental:
– Developmental delay
– Hypersomnolence
– Poor school performance
– Leaning problems
– Hyperactivity
– Mood and behavior problems.
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J. M. Battagel & P R. L'Estrange
• lateral cephalometric radiographs of 59
dentate, white, Caucasian males.
• 35patients with proven obstructive sleep
apnoea (OSA) &
• 24 –conrol
• Radiograph traced
• conventional cephalometric measurements
did not differ
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European Journal of Orthodontics 18 (J996) 557-569
• significant reductions were found in the lengths
of the mandibular body and cranial base and in
cranial base angulation in OSA subjects.
• The combination of a short mandible and
intermaxillary space, with an enlarged soft palate
but decreased pharyngeal airway has relevance
to the effective management of OSA.
• Inselected patients, advancement of the lower
jaw by a nocturnal mandibular repositioning
splint may be indicated.
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European Journal of Orthodontics 18 (J996) 557-569
journal club

39
Wilhelmsson B et al
• To compare – dental appliance &
uvulopalatopharyngoplasty for Rx of OSA
• RCT –UPPP or a dental appliance to achieve
mandibular advancement of 50% of max
protrusive capacity.
• Apnea Index (AI) Apnea & Hypoxia Index(AHI)
Oxygen Distraction Index(ODI) & Snoring Index(SI).
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journal Acta
club

oto laryngeal 1999; 119 : 503 -509

40
• Both groups show significant
AHI, ODI, & SI .

values of AI,

• dental appliance - adjunctive

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Acta oto laryngeal 1999; 119 : 503 -509
41
Conclusion

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References
• A diagnostic approach to suspected obstructive sleep
apnea in children journal of pediatrics Volume 105,
Issue 1, July 1984, Pages 10–14.
• Can parents predict the severity of childhood
obstructive sleep apnoea? Journal of acta pediatrecia
vol 89 ,issue 6 june 2000 ,708-712
• The cephalometric morphology of patients with
obstructive sleep apnoea European Journal of
Orthodontics 18 (J996) 557-569
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Pediatric obstructive sleep apnea

  • 1. Pediatric obstructive sleep apnea syndrome : time to wake up Veena Arali, Srinivas Namineni, Ch Sampath IJCPD , JAN-APRIL 2012, 5 (1)
  • 2. Introduction “On Some Causes Backwardness In Children” 11/22/2013 journal club 2
  • 3. History • OSAS – 1966 • PMC • In 1976 11/22/2013 journal club Guilleminault et al jop 3
  • 4.  Obstructive Apnea: continued chest and abdominal motion in the absence of airflow during sleep  Obstructive Hypopnea: decreased airflow and alveolar ventilation in the presence of paradoxical motion of chest and abdomen  Apnea-Hypopnea Index: # of events/hour • Used to categorize severity of condition • AHI > 1 abnormal, but clinically significant? • Pathology in a snoring child not yet clearly defined 11/22/2013 journal club 4
  • 5. Definition • OSAS in childhood, as defined by the American Thoracic Society, is a disorder of breathing during sleep characterized by prolonged partial upper airway obstruction and/or intermittent complete obstruction, obstructive apnea, that disrupts normal ventilation during sleep and normal sleep patterns. 11/22/2013 journal club 5
  • 6. Epidemiology • 8-12% • 1-3% • 5-6% 11/22/2013 journal club 6
  • 7. Physiology of breathing and sleep • Upper air way resistance 11/22/2013 journal club 7
  • 8. Types of sleep • There are five stages of sleep; four stages are considered non-REM sleep and one stage of REM sleep 11/22/2013 journal club 8
  • 9. What is REM sleep? • Rapid eye movement..during a sleep period (eyes dart from right to left) stimulates occular muscles; • Called “active sleep” or “paradoxical sleep”; • Respiration is irregular, heart rate is generally faster, blood pressure is higher…brain waves fast and shorter; • Dreaming occurs; 11/22/2013 journal club 9
  • 12. Pathophysiology • Role of the Tonsils & Adenoids 11/22/2013 journal club 12
  • 13. Role of upper airway neuromotor tone • Children with OSAS – ventilatory drive • Neuromotor function- abnormal • Accessory muscles- hypoxemia , hypercapnia 11/22/2013 journal club 13
  • 14. • Role of Arousal • Role of structural factors • Role of genetic factors 11/22/2013 journal club 14
  • 15. Clinical Symptoms • Vary with the age 11/22/2013 journal club 15
  • 17. Clinical evaluation & diagnosis of SDB 1. The nose, one should look for asymmetry of the nares, a large septal base, collapse of the nasal valves during inspiration, a deviated septum or enlargement of the inferior nasal turbinates. 2. The oropharynx should be examined for the position of the uvula in relation to the tongue. 3. The size of the tonsils should be compared with the size of the airway. 4. The presence of a high and narrow hard palate, overlapping incisors, a crossbite and an important overjet are indicative of a small jaw and or abnormal maxilla-mandibular development 11/22/2013 journal club 17
  • 18. Objective confirmation of SDB • • • • • Testing during sleeping –SDB Questionnaires Home monitoring Ambulatory monitoring Polysomnography 11/22/2013 journal club 18
  • 19. • Questionnaires  Brouillette’s OSA questionnaire initially appeared accurate in small sample, but on subsequent studies was indeterminate in 47% » Brouillette, J Pediatr, 1984  Parents cannot predict severity of OSA based on their observations » Preutthipan, Acta Paediatr, 2000 11/22/2013 journal club 19
  • 20. Home monitering Audiotapes – lack specificity to distinguish OSAS from primary snoring. » Lamm, Ped Pulm 1999 Videotapes – sensitivity 94%, specificity 68% » Sivan, Eur Respir J, 1996 11/22/2013 journal club 20
  • 21. Diagnosis PSG • Polysomnography = sleep study • “Gold standard” • Only technique that allows comprehensive monitoring of both cardiorespiratory function and sleep noninvasively 11/22/2013 journal club 21
  • 22. Polysomnography • Polysomnography is the only test that may exclude the diagnosis of SDB. It must always include monitoring of sleep/wake states through electroencephalography (EEG), electrooculography, chin and leg electromyography, electrocardiography, body position and appropriate monitoring of breathing. 11/22/2013 journal club 22
  • 23. • The American Thoracic Society has defined their criteria for an abnormal PSG in children as follows: • Apnea index (AI) 1/hour • Apnea-hypopnea index 5/hour • Peak end-tidal carbon dioxide 53 mm Hg or • An end-tidal carbon dioxide tension 50 mm Hg for 10% of the sleep period and • A minimum hemoglobin oxygen saturation 92%. 11/22/2013 journal club 23
  • 26. • The most common orofacial characteristics encountered include  a retrognathic mandible,  narrow palate,  large neck circumference,  long soft palate (which leads to dentists’being unable to visualize the entire length of the uvula when the patient’s mouth is open wide), tonsillar hypertrophy,  nasal septal deviation  and relative macroglossia. 11/22/2013 journal club 26
  • 27. • The following features are found in OSA patients on a cephalogram:  An increased incidence of maxillary retrusion (ANB < 0)  An increased incidence of mandibular retrusion(ANB > 0)  An increased incidence of maxillary and mandibular retrusion (SNA and SNB)  The hyoid was more inferiorly and anteriorly placed  A thicker soft palate  A larger tongue; a longer pharyngeal length. 11/22/2013 journal club 27
  • 28. Treatment • Adenotonsillectomy • Medical therapies  Nasopharyngeal airway Insufflations of pharynx during sleep Continuous positive airway pressure via nasal mask • Tracheostomy 11/22/2013 journal club 28
  • 29. • Pharmacological – Topical nasal steroids – Antibiotics – Nasal decongestant – Weight loss • Other surgical therapies – Craniofacial surgical procedures – Mandibular/maxillary plastic surgical procedures – Stenting procedures for nasal stenosis – Cleft palate revision procedures – Uvulopalatopharyngoplasty 11/22/2013 journal club 29
  • 30. Adenotonsillectomy • Adenotonsillectomy is the most common treatment for childhood OSA • Cure rate = 75-100% » Suen, Arch Otolaryngol Head and Neck Surg, 1995 • Complications – anesthetic – post-op pain, poor oral intake and bleeding – airway edema – pulmonary edema 11/22/2013 journal club 30
  • 31. • 24 months of age • OSA – 3wks of age • Severe snoring & clinical symptoms- 6-24 months • 6months of age. 11/22/2013 journal club 31
  • 32. Orthodontic treatment • RMD • SMD • Rapid and slow maxillary distractions are performed between 5 and 11 years of age. • Distraction results in widening of the palate and the nose; thus, these procedure remedies nasal occlusion related to a deviated septum, for which little can be done before 14 to 16 years of age. 11/22/2013 journal club 32
  • 34. Surgical treatment • Surgeries, such as nasal septoplasty and other maxillofacial surgeries, are indicated in some rare cases but not usually seen in the pediatric population. • Orthognathic surgery is normally postponed until 10 to 13 years of age. • Two surgical techniques used in patients with SDB are  mandibular distraction osteogenesis  and maxillomandibular advancement 11/22/2013 journal club 34
  • 36. Sequelae of OSAS in Children • Cardiopulmonary: – Right ventricular hypertrophy – Left ventricular hypertrophy – Pulmonary hypertension – Systemic hypertension – Cor pumonale – Polycythemia 11/22/2013 journal club 36
  • 37. • Neurodevelopmental: – Developmental delay – Hypersomnolence – Poor school performance – Leaning problems – Hyperactivity – Mood and behavior problems. 11/22/2013 journal club 37
  • 38. J. M. Battagel & P R. L'Estrange • lateral cephalometric radiographs of 59 dentate, white, Caucasian males. • 35patients with proven obstructive sleep apnoea (OSA) & • 24 –conrol • Radiograph traced • conventional cephalometric measurements did not differ 11/22/2013 journal club 38 European Journal of Orthodontics 18 (J996) 557-569
  • 39. • significant reductions were found in the lengths of the mandibular body and cranial base and in cranial base angulation in OSA subjects. • The combination of a short mandible and intermaxillary space, with an enlarged soft palate but decreased pharyngeal airway has relevance to the effective management of OSA. • Inselected patients, advancement of the lower jaw by a nocturnal mandibular repositioning splint may be indicated. 11/22/2013 European Journal of Orthodontics 18 (J996) 557-569 journal club 39
  • 40. Wilhelmsson B et al • To compare – dental appliance & uvulopalatopharyngoplasty for Rx of OSA • RCT –UPPP or a dental appliance to achieve mandibular advancement of 50% of max protrusive capacity. • Apnea Index (AI) Apnea & Hypoxia Index(AHI) Oxygen Distraction Index(ODI) & Snoring Index(SI). 11/22/2013 journal Acta club oto laryngeal 1999; 119 : 503 -509 40
  • 41. • Both groups show significant AHI, ODI, & SI . values of AI, • dental appliance - adjunctive 11/22/2013 journal club Acta oto laryngeal 1999; 119 : 503 -509 41
  • 43. References • A diagnostic approach to suspected obstructive sleep apnea in children journal of pediatrics Volume 105, Issue 1, July 1984, Pages 10–14. • Can parents predict the severity of childhood obstructive sleep apnoea? Journal of acta pediatrecia vol 89 ,issue 6 june 2000 ,708-712 • The cephalometric morphology of patients with obstructive sleep apnoea European Journal of Orthodontics 18 (J996) 557-569 11/22/2013 journal club 43