2. History of Vaccines Thesis/Focus Definitions (Activity) Persona #1 (GEEK): Brenda Persona #2 (HEART): Razina Persona #3 (BEAN COUNTER): Sajeeda Conclusion Overview
8. Types of Vaccines 1. Live, Attenuated (weakened) Vaccines -Closest to real infection -Strong antibody response (T-cells & B-cells) -Memory cells created -Risk: attenuated microbes may mutate back into virulent form
9. Types of Vaccines 2. Inactivated (killed) Vaccines -Microbes killed with heat or chemicals - Alert only B-cells -Hormonal Immunity (1 st dose) & Protective reaction (later doses) -Risk: Not as effective; use adjuvants
10. Types of Vaccines 3. Conjugate Vaccines -Microbes with protective capsule (polysaccharides) HIDE ANTIGENS -Link polysaccharides to antigens/toxoids that an immature immune system can recognize -Usually used in babies
11. Types of Vaccines 4. Subunit Vaccines -Antigens of microbes to stimulate response -Created in 2 ways 1)Chemically break microbe apart 2) RECOMBINANT TECH.
12. Types of Vaccines 5. Recombinant Vaccines -Genes from disease-causing microbe inserted into a harmless vector -Inject vector OR purified antigens (as subunit) -E.g. Hepatitis B (Recombivax HB Hepatitis B Vaccine)