1. The document discusses several skeletal developmental and genetic disorders including osteogenesis imperfecta, as well as metabolic bone diseases such as osteoporosis, renal osteodystrophy, osteomalacia, rickets, and hyperparathyroidism. 2. Inflammatory bone disorders including osteomyelitis, sarcoidosis, Paget's disease of bone, and osteonecrosis are described. Trauma and fracture repair processes are also summarized. 3. Several primary bone tumors are discussed including osteoid osteoma, osteosarcoma, chondroma, osteochondroma, and chondroblastoma.

1. BONES AND MUSCLES ROBERTO D. PADUA JR., MD, FPSP DEPARTMENT OF PATHOLOGY FATIMA COLLEGE OF MEDICINE

22. OSTEOMYELITIS X-RAY GROSS : UPPER FEMUR

23. Osteomyelitis

29. PAGET’S DISEASE OF BONE X-RAY OF TIBIA SHOWING BONE DESTRUCTION AND BONE FORMATION

30. PAGET’S DISEASE OF BONE EARLY CHANGES SHOWING PROMINENT OSTEOCLASTIC ACTIVITY

37. OSTEOID OSTEOMA X-RAY GROSS MICROSCOPIC

45. OSTEOSARCOMA GROSS SHOWING SKIP METASTASIS MICROSCOPIC APPEARANCE

46. OSTEOSARCOMA TELANGIECTATIC VARIANT OF OSTEOSARCOMA

47. OSTEOSARCOMA JUXTACORTICAL OSTEOSARCOMA

50. Distribution according to the age and sex and the site of the lesion.

51. CHONDROMA X-RAY GROSS MICROSCOPIC

52. Distribution of multiple chondromas according to the age and sex of the patient.

53. MULTIPLE CHONDROMAS IN OLLIER’S DISEASE. The left hand of this 27-year-old man contains multiple deforming chondromas.

54. MULTIPLE CHONDROMAS. The tumors involve the bones of the second and third rays with sparing of the joint spaces.

55. MAFFUCCI’S SYNDROME. Left – multiple benign cartilage tumors involve the metacarpals and phalanges of the first to third digits. Soft tissue swelling and masses with calcified phleboliths are compatible with soft tissue hemangiomas. Right – Coronal short tau inversion recovery image shows multiple high signal intensity lesions in phalanges of the 2 nd and 3 rd digits and 2 nd metacarpal consitent with enchondromas. The small soft tissue mass in the 2 nd digit and serpigenous vessels in the 2 nd and 3 rd digits are compatible with hemangiomas.

57. Distribution according to the age and sex and the site of the lesion.

58. OSTEOCHONDROMA GROSS, CUT SECTION MICROSCOPIC

59. The cartilage cap is somewhat thick but smooth. The chalky white area are calcification.

60. OSTEOCHONDROMA. A cartilage cap overlies cancellous bone of the stalk

63. Distribution according to the age and sex and the site of the lesion

64. CHONDROBLASTOMA X-RAY GROSS

65. This chondroblastoma arising from the temporal bone contains areas of spindled mononuclear cells, hemosiderin deposition , and multinucleated giant cells.

66. CHONDROBLASTOMA MICROSCOPIC

68. Distribution according to age and sex and the site of the lesion.

69. CHONDROMYXOID FIBROMA X-RAY GROSS MICROSCOPIC

70. Curetted fragments of a glistening blue-gray tumor. There is no obvious evidence of cartilaginous tissue.

71. Macroglobular growth pattern Micronodular growth pattern

74. Distribution according to the age and sex and the site of the lesion.

75. CHONDROSARCOMA GROSS APPEARANCES OF CHONDROSARCOMA

76. The tumor arose in the sternum. It has a characteristic gray-blue appearance, is lobulated and has a chalky-white calcific deposits. Cartilage tumors at this site are almost always malignant.

77. CHONDROSARCOMA X-RAY, FEMUR

78. CHONDROSARCOMA WELL-DIFFERENTIATED CLEAR CELL VARIANT

80. Distribution by age and sex and the site of the lesion

84. GIANT CELL TUMOR X-RAY GROSS APPEARANCE

85. The tumor arises in the distal radius and forms a large destructive mass. The treatment was amputation.

86. GIANT CELL TUMOR MICROSCOPIC APPEARANCE

91. Distribution by age and sex and the site of the lesion

92. EWING’S SARCOMA/PNET X-RAY GROSS APPEARANCE

93. EWING’S SARCOMA/PNET MICROSCOPIC APPEARANCE

94. Prominent rosette formation occurs throughout the tumor

95. The tumor cells show diffuse immunoreactivity for CD99

99. Fluorescence in situ hybridization (FISH) in Ewing’s sarcoma

103. MALIGNANT LYMPHOMA X-RAY MICROSCOPIC APPEARANCE

108. VASCULAR TUMORS CAVRNOUS HEMANGIOMA OF BONE

112. VASCULAR TUMORS EPITHELIOID HEMANGIOENDOTHELIOMA

118. SOLITARY BONE CYST X-RAY GROSS APPEARANCE

122. Distribution by age and sex and the site of the lesion

123. ANEURYSMAL BONE CYST X-RAY GROSS APPEARANCE

124. ANEURYSMAL BONE CYST MICROSCOPIC APPEARANCE

138. Thank You