Lecture 6. cholera

Cholera Sorokhan MD, PhD Bukovinian State Medical University Department of the infection diseases and epidemiology

Etiology ,[object Object],Scanning electron microscope image of Vibrio cholerae bacteria, which infect the digestive system.

Etiology ,[object Object],[object Object],[object Object],[object Object],This scanning electron micrograph (SEM) depicts a number of Vibrio cholerae bacteria of the serogroup 01; magnified 22371x. Image courtesy of CDC/Janice Haney Carr.

Epidemiology ,[object Object],Vibrio cholerae is the causal agent of the diarrheal disease cholera. Cholera is a major epidemic disease that has killed millions of people, and continues to be a major health problem worldwide. Provider CDC .

Epidemiology ,[object Object],Ingestion of V. cholera contaminated water is a typical mode of pathogen transmission. Provider CDC

Pathophysiology ,[object Object],Vibrio cholerae is transmitted to humans through the ingestion of contaminated food or water, and produces a cholera toxin, which acts on the intestinal mucosa, and causes severe diarrhea. Provider CDC

Pathophysiology ,[object Object]

Pathophysiology ,[object Object],[object Object]

Mortality/Morbidity ,[object Object]

Physical ,[object Object],[object Object],[object Object]

Physical ,[object Object],Due to severe dehydration, cholera manifests itself in decreased skin turgor, which produces the so-called "Washer Woman's Hand" sign. Provider CDC

Differential diagnoses ,[object Object]

Workup Laboratory Studies ,[object Object],[object Object]

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Treatment ,[object Object],[object Object],[object Object],[object Object]

Treatment This patient with cholera is drinking oral rehydration solution (ORS) in order to counteract the cholera-induced dehydration. Image courtesy of the CDC.

Treatment ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Antibiotics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Prevention ,[object Object],[object Object]

Complications ,[object Object],[object Object]

Lecture 6. cholera

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