Its binding conformation and interaction mode were studied with molecular docking experiments. Compound 20f could become a lead compound for further development for potential anti-inflammatory drugs.
1. Nimesulide synthesis
Nimesulide, a COX-2 selective drug, possesses anti-inflammatory and analgesic
properties. Moreover, it has low gastro-intestinal and renal toxicity.
Its main purpose is to treat acute pain, the symptomatic treatment of osteoarthritis and
primary dysmenorrhoea .
As for other NSAIDs the use of Nimesulide is preffered for the shortest duration necessary
to control symptoms in patients with acute pain or primary dysmenorrhoea. The efficacy of
Nimesulide was consistently superior to placebo with its particularly rapid onset action.
Nimesulide is a non-steroidal anti-inflammatory agent that is generally utilized as a part of
the treatment of inflammatory torment which hinders the protein cyclooxygenase-2 (COX-
2) and has better gastro-intestinal mediocrity in addition to different NSAIDs in its class.
Its approved signs are the treatment of intense torment, the symptomatic treatment of
osteoarthritis and essential dysmenorrhoea, sports wounds and so on.
A variety of new Nimesulide derivatives were synthesized through incorporation of a 5-
LOX pharmacophore into nimesulide followed with some structural modifications, which
were then characterized for dual enzyme inhibitors for these two types of enzymes
(Cyclooxygenase-½ (COX-½) and 5-lipoxygenase (5-LOX) ).
