6. Evolution: Early Systems. DX plain – CDSS – Diagnosis aid 1989 HELP – HIS integrated with CDSS 1980 Current Systems MYCIN – Infection management -Rule based, IF and THEN rules. PUFF – LIS for interpretation of Pulmonary function test. 1976 INTERNIST 1 – diagnosis 1974 AAPHELP –Leeds Abdominal Pain System 1972