3. T Cells
Introduction
Tymus derived T lymphocytes
Effectors and regulatory response
Function of T cells
Cytotoxic, suppression and killer property
4. T Cells
T Cell origin
Start from multipotent stem cell
From bone marrow to thymus
Epithelium stroma and sponge contains
lymphocytes
Migrates to blood stream
5. Immunological function of
Thymus
Production of T cells
T cells are involved in cell mediated
immunity
T cell cannot produces antibodies
Thymic hormones
6. Immunological function of
Thymus
Production of T cells
T cells are involved in cell mediated
immunity
T cell cannot produces antibodies
7. Immunological function of
Thymus
Thymic extract – thymosin – induce
differentiation
Self reactive – Purine deoxynucleotides
Non self reactive - MHC antigen
Multipotent
cell
Pre T
Cell
Thymus
T helper Cell
Cytotoxic T Cell
Supressor T Cell
Delayed Hypersensitivity T Cell
8. Immunological function of
Thymus
Emergence of T cell Subset
Thymus - Spleen – Blood –Lymphoid system
T helper Cells THF
Cytotoxic T cells TcF
Suppressor - inducer T cells Ts
Delayed hypersensitivity T cells TDH
9. Immunological function of
Thymus
Thymic extract – thymosin – induce
differentiation
Self reactive – Purine deoxynucleotides
Non self reactive - MHC antigen
Multipotent
cell
Pre T
Cell
Thymus
T helper Cell
Cytotoxic T Cell
Supressor T Cell
Delayed Hypersensitivity T Cell
12. Surface marker of T
lymphocytes
Surface marker of T lymphocytes
Displaying of surface markers
Markers are glycoprotein coded by MHC
genes
Identify T cell subset and their function
13. Surface marker of T
lymphocytes
Thy 1 in mouse
Marker on T cell bind with sheep erythrocytes
First CD2 CD4, CD5 and CD8 are
expressed
CD4 and CD8 appears
14. T cell receptors
Antigen specific receptors
α – β disulphide bonds
CD2 – sheep red cells
CD3 – stabilize cell
CD4 –MHC class II
CD8 – MHC class I
15. T cell receptors
Antigen specific receptors
α – β disulphide bonds
CD2 – sheep red cells
CD3 – stabilize cell
CD4 –MHC class II
CD8 – MHC class I
17. T cell receptors
Receptor is heterodimer
α and β chain linked with disulphide bond
Sheep erythrocyte and CD2
CD3 molecules – stabilize T cell
CD4 and CD8 with MHC class I and II
18. Function of T subset
Tc cell – Lymphotoxins
Activating signals IL1 and IL2
TH cells
MHC class I and II
Ts cell
TDH
Inducer of help
Inducer of suppression