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Welcome to our Embase webinar!


Embase – Answers to your
  biomedical questions


         Your presenter: Ann-Marie Roche
About us
Need to know
• Webinar control panel:
  o‘chat’ or ‘ask a question’ for questions
    and comments
  o Option for full screen view

• Q&A at the end
Our value story
  With over 24 million indexed records and more than 7,600 currently indexed peer-
reviewed journals, Embase is a highly versatile, multipurpose and up-to-date database
covering the most important international biomedical literature from 1947 to the present
                                          day.

Core strengths of Embase include coverage and in-depth indexing of the drug-related
  and clinical literature, with a particular focus on comprehensive indexing of adverse
   drug reactions; emphasis on Evidence Based Medicine (EBM) indexing including
 systematic reviews, and coverage and indexing of journals and articles relevant to the
                         development and use of medical devices.

   If you are searching for answers to your questions or simply need reliable, peer-
  reviewed information on topics such as drug development or use, toxicology, drug
   safety / adverse drug reactions, clinical trials, evidence based medicine, medical
     devices, pharmacoeconomics, preclinical reports, basic biomedical science or
           regulatory affairs, then Embase is the solution you are looking for.
How Embase delivers value…
...by including literature and information   Conference                 Scientific              In Press     We make sure you don’t
       resources in a timely manner          proceedings                Journals             (unpublished)         miss any
                                                                                                              biomedical literature

   ...by reading full-text to identify
       drugs, diseases, adverse
                                                Deep indexing using own                                          They only close
                                                                                                              alternative is reading
   affects, clinical trials, drug trade
               names etc.                              taxonomy                                                   all the articles



...by enabling advanced search filters to
 drill down a comprehensive search to a
  relevant and manageable record set
                                                            Very powerful                                     Good precision and
                                                                                                                recall balance
                                                               Search
                                                            Environment
...by allowing users to automate searching                                                                      Automation and
           and result management                                                                                documentation
                                                           E-mail Alerting      API   Interoperability




                                                                        5
How Embase delivers value…
Information overload                            Currency & Completeness                            Dispersed Information
With a growing universe of scientific           Information that can have impact on the future     Information resources are dispersed across
information, consumers have a hard time         of a research project, development pipeline or     different platforms, thus requiring multiple
keeping up with the latest information and      existing business is of high value. Getting that   searches to be executed and build in multiple
determining the value and reliability of that   information complete and in time is critical.      query languages. The more platforms, the
information. Evidence Based Medicine is         Pharma/ Device (co)vigilance is driven by          more cumbersome to maintain and support.
driven by the need to cope with information     the need to have timely insight into potential     Tools that help consolidate and search
overload.                                       adverse effects or new applications of a drug      comprehensive files are in demand.
                                                or device

 How do we find the most valuable               How do you make sure we capture                         How do you capture all the
         information?                            the most current information?                           information effectively?




          Research community                       Business community & regulators                          Information professionals

   By doing systematic                            By setting up structural                                By trying to
         reviews to                               searches and alerts to                                  consolidate
 identify, appraise, select                         monitor for drug or                                  searching and
and synthesize all scientific                        device mentions                                   storing on as few
        information                                                                                   systems as possible
Our strengths…
Our strengths…
CONFIDENCE




9
Content Overview


                        Emtree: Biomedical thesaurus, over 60k terms

 1947         1950                 1974                     2009
                                                                                  Including
                     Embase: Fully indexed: Over 7,700 journals (including MEDLINE), 1950-
                                                                                  5.5M not
                                                                                   found in
                       MEDLINE: 2,500 journals unique to Embase, mapped to Embase  MEDLINE
                                 indexing, 1950- (including MEDLINE Classic)


           Embase Classic:                                         AIP and In Process:
         Digitally scanned and                                  Indexing added, from 2009
        re-indexed, 1947-1973


                                                                  Conference Abstracts:
                                                                Indexing added, from 2009
DEEP INDEXING




11
Deep indexing - Emtree

                  60K terms (>260,000 synonyms) and all MeSH
                  terms
                                     29K drug and chemical terms
                  Updated 3 times a year (back-posting each time)

                           All drug generic names described by FDA
                           and EMA, all International Non-
                           Proprietary Names (INNs) described by
                           WHO from 2000.




What is mapping? Mapping means you retrieve the same results regardless of
which term you use e.g. Type II diabetes or non insulin dependant diabetes
mellitus.
Deep indexing - Emtree



          14 study types, including NEW Diagnostic Test
                         Accuracy Study




           78 drug and disease subheadings
PRECISE
RETRIEVAL
Start searching…




Find the best terms for your search and
 include synonyms automatically with
     autocomplete in Quick Search
Click on Disease Filter for example, to see
     which diseases are referenced with
Januvia, either as a therapeutic area or side
                    effect.
Conference Abstracts




                       • Coverage began in 2009.
                       • http://embase.com/info/wh
                         at-is-embase/coverage for
                         the up to date list of
                         conferences and number
                         of abstracts covered.




                                                     17
Registering in Embase




                             •Setting up email alerts
                             •Saving your searches
                        18   •Staying up to date
EMBASE: A CASE STUDY
Case study
•A clinician is working on a systematic review for publication.
She needs to adhere to certain guidelines to ensure she has
conducted a through search of the literature.


http://www.youtube.com/watch?v=QzZbYMS1tQ4

Question
•Are there any risks associated with the administration of
antibiotics together with digoxin in a patient with congestive
heart failure who has contracted pneumonia?
• Articles like this contain vital information...
For example…
Comprehensive searching in
Embase




  23
2 sets of results…Why are
the results so different and
     does it matter…?
23 synonyms as well as ‘antibacterial agent’ are
searched simultaneously as well as over 38 narrower
           terms (including moxifloxacin).




    No simultaneous searching of synonyms
     or narrower terms= Only ‘antibacterial
    agent’ is searched and this does not find
             all the vital information
Found in your Embase results, not in your
non-indexed supported search...
2 thesaurus assisted searches
but different results? Embase
 has unique content ,such as
    conference abstracts.
Found in your Embase search,
not in your MEDLINE search...




        We are looking for digoxin AND ‘antibacterial agent’
        but Medline does NOT index digoxin in this article.
Poll

The poll should appear on your screen shortly...
Let’s take a look at Embase...

…by going to www.embase.com
Building and combining searches

• Use single quotes to capture a phrase ‘diabetes mellitus’
  for example (not with Autocomplete in Quick Search)
• Break up your search into individual searches, such as a
  drug search (in Drug Search form) and a disease search
  (in Disease Search form) and combine your results in
  Session Results
• Run your cursor over your search to Edit or copy to a
  Search Form for guided editing.
• Truncation and operators, AND, OR, NOT, NEXT, NEAR

 Refer to http://info.embase.com/helpfiles for more guidance
     and links to materials such as the Quick User Guide.
Refining your search
• Quick and Advanced Limits on Advanced, Drug and
  Disease Search forms
• Major Focus on all advanced forms – major drugs and
  diseases retrieved
• Field limits under Advanced Search box to search in
  specific fields such as article title, abstract, conference
  name, drug name etc
• Drug and Disease Subheadings to limit to specific
  concepts such as Adverse Drug Reaction, Drug
  Comparison and Side Effect.
• Filters on Session Results page for specific diseases or
  study types for example
                Check out our training videos at
    www.trainingdesk.elsevier.com/embase for more guidance.
An introduction to Embase
Thank you and see you next time

• Q&A will be sent to you by email and for more
  information and questions please contact
  bdtraining@elsevier.com
• Embase webinars occur on the 04th Wednesday
  of every month and our next webinar Train the
  trainer is aimed at trainers.
• Go to www.trainingdesk.elsevier.com/embase for
  all training related materials

             Please fill out the survey that
             appears on your screen after
                 leaving the webinar.

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An introduction to Embase

  • 1. Welcome to our Embase webinar! Embase – Answers to your biomedical questions Your presenter: Ann-Marie Roche
  • 3. Need to know • Webinar control panel: o‘chat’ or ‘ask a question’ for questions and comments o Option for full screen view • Q&A at the end
  • 4. Our value story With over 24 million indexed records and more than 7,600 currently indexed peer- reviewed journals, Embase is a highly versatile, multipurpose and up-to-date database covering the most important international biomedical literature from 1947 to the present day. Core strengths of Embase include coverage and in-depth indexing of the drug-related and clinical literature, with a particular focus on comprehensive indexing of adverse drug reactions; emphasis on Evidence Based Medicine (EBM) indexing including systematic reviews, and coverage and indexing of journals and articles relevant to the development and use of medical devices. If you are searching for answers to your questions or simply need reliable, peer- reviewed information on topics such as drug development or use, toxicology, drug safety / adverse drug reactions, clinical trials, evidence based medicine, medical devices, pharmacoeconomics, preclinical reports, basic biomedical science or regulatory affairs, then Embase is the solution you are looking for.
  • 5. How Embase delivers value… ...by including literature and information Conference Scientific In Press We make sure you don’t resources in a timely manner proceedings Journals (unpublished) miss any biomedical literature ...by reading full-text to identify drugs, diseases, adverse Deep indexing using own They only close alternative is reading affects, clinical trials, drug trade names etc. taxonomy all the articles ...by enabling advanced search filters to drill down a comprehensive search to a relevant and manageable record set Very powerful Good precision and recall balance Search Environment ...by allowing users to automate searching Automation and and result management documentation E-mail Alerting API Interoperability 5
  • 6. How Embase delivers value… Information overload Currency & Completeness Dispersed Information With a growing universe of scientific Information that can have impact on the future Information resources are dispersed across information, consumers have a hard time of a research project, development pipeline or different platforms, thus requiring multiple keeping up with the latest information and existing business is of high value. Getting that searches to be executed and build in multiple determining the value and reliability of that information complete and in time is critical. query languages. The more platforms, the information. Evidence Based Medicine is Pharma/ Device (co)vigilance is driven by more cumbersome to maintain and support. driven by the need to cope with information the need to have timely insight into potential Tools that help consolidate and search overload. adverse effects or new applications of a drug comprehensive files are in demand. or device How do we find the most valuable How do you make sure we capture How do you capture all the information? the most current information? information effectively? Research community Business community & regulators Information professionals By doing systematic By setting up structural By trying to reviews to searches and alerts to consolidate identify, appraise, select monitor for drug or searching and and synthesize all scientific device mentions storing on as few information systems as possible
  • 10. Content Overview Emtree: Biomedical thesaurus, over 60k terms 1947 1950 1974 2009 Including Embase: Fully indexed: Over 7,700 journals (including MEDLINE), 1950- 5.5M not found in MEDLINE: 2,500 journals unique to Embase, mapped to Embase MEDLINE indexing, 1950- (including MEDLINE Classic) Embase Classic: AIP and In Process: Digitally scanned and Indexing added, from 2009 re-indexed, 1947-1973 Conference Abstracts: Indexing added, from 2009
  • 12. Deep indexing - Emtree 60K terms (>260,000 synonyms) and all MeSH terms 29K drug and chemical terms Updated 3 times a year (back-posting each time) All drug generic names described by FDA and EMA, all International Non- Proprietary Names (INNs) described by WHO from 2000. What is mapping? Mapping means you retrieve the same results regardless of which term you use e.g. Type II diabetes or non insulin dependant diabetes mellitus.
  • 13. Deep indexing - Emtree 14 study types, including NEW Diagnostic Test Accuracy Study 78 drug and disease subheadings
  • 15. Start searching… Find the best terms for your search and include synonyms automatically with autocomplete in Quick Search
  • 16. Click on Disease Filter for example, to see which diseases are referenced with Januvia, either as a therapeutic area or side effect.
  • 17. Conference Abstracts • Coverage began in 2009. • http://embase.com/info/wh at-is-embase/coverage for the up to date list of conferences and number of abstracts covered. 17
  • 18. Registering in Embase •Setting up email alerts •Saving your searches 18 •Staying up to date
  • 19. EMBASE: A CASE STUDY
  • 20. Case study •A clinician is working on a systematic review for publication. She needs to adhere to certain guidelines to ensure she has conducted a through search of the literature. http://www.youtube.com/watch?v=QzZbYMS1tQ4 Question •Are there any risks associated with the administration of antibiotics together with digoxin in a patient with congestive heart failure who has contracted pneumonia?
  • 21. • Articles like this contain vital information...
  • 24. 2 sets of results…Why are the results so different and does it matter…?
  • 25. 23 synonyms as well as ‘antibacterial agent’ are searched simultaneously as well as over 38 narrower terms (including moxifloxacin). No simultaneous searching of synonyms or narrower terms= Only ‘antibacterial agent’ is searched and this does not find all the vital information
  • 26. Found in your Embase results, not in your non-indexed supported search...
  • 27. 2 thesaurus assisted searches but different results? Embase has unique content ,such as conference abstracts.
  • 28. Found in your Embase search, not in your MEDLINE search... We are looking for digoxin AND ‘antibacterial agent’ but Medline does NOT index digoxin in this article.
  • 29. Poll The poll should appear on your screen shortly...
  • 30. Let’s take a look at Embase... …by going to www.embase.com
  • 31. Building and combining searches • Use single quotes to capture a phrase ‘diabetes mellitus’ for example (not with Autocomplete in Quick Search) • Break up your search into individual searches, such as a drug search (in Drug Search form) and a disease search (in Disease Search form) and combine your results in Session Results • Run your cursor over your search to Edit or copy to a Search Form for guided editing. • Truncation and operators, AND, OR, NOT, NEXT, NEAR Refer to http://info.embase.com/helpfiles for more guidance and links to materials such as the Quick User Guide.
  • 32. Refining your search • Quick and Advanced Limits on Advanced, Drug and Disease Search forms • Major Focus on all advanced forms – major drugs and diseases retrieved • Field limits under Advanced Search box to search in specific fields such as article title, abstract, conference name, drug name etc • Drug and Disease Subheadings to limit to specific concepts such as Adverse Drug Reaction, Drug Comparison and Side Effect. • Filters on Session Results page for specific diseases or study types for example Check out our training videos at www.trainingdesk.elsevier.com/embase for more guidance.
  • 34. Thank you and see you next time • Q&A will be sent to you by email and for more information and questions please contact bdtraining@elsevier.com • Embase webinars occur on the 04th Wednesday of every month and our next webinar Train the trainer is aimed at trainers. • Go to www.trainingdesk.elsevier.com/embase for all training related materials Please fill out the survey that appears on your screen after leaving the webinar.

Hinweis der Redaktion

  1. MEDLINE you probably know and MEDLINE data is included in Embase, as well as unique Embase content, not found in MEDLINE. Will this additional content make a difference and most importantly lead you with more confidence to an answer? We will come back to this when in Embase later in the webinar.What about having the most up to date content when you carry out your search or including in regular email alerts? AiP/In Process and conference abstracts give you access to the most up to date research and we will show you how to integrate in your searches and email alerts later in the webinar. We now cover over 2.5K conferences with over 800K conference abstracts.
  2. If your research is around Diabetes type II or non-insulin dependant Diabetes Mellitus as it is also known for example, then you need to include all published research but what if an author uses a different term to the one you used in your search? Emtree, our biomedical thesaurus automatically supports your search and will map your search terms so all synonyms are included in your search. Here you can see the enormous selection of terms available, over 60K with 29K being drug and chemical terms.Maybe not all synonyms are there yet? Emtree is updated 3 times a year so the chance of missing a term is considerably lower compared to databases which are updated once a year with new terms. Content is updated daily by the way, here we are talking about updating the thesaurus with new terms.
  3. Here we see that studies directly related to levels of evidence used in evidence based medicine practice are included in Emtree, which means you can search for all RCTs indexed by our indexers, not just where they are mentioned or have to think of a sufficient search string to retrieve them. It is also possible to search for drugs and diseases within a specific context, such as drug combination, pharmacoeconomics, pharmaceutics, endogenous compound, disease management and epidemiology. Routes of drug administration may also be specifically searched for.
  4. And now you have access to the biomedical literature and a huge selection of relevant index terms, how DO you find your answers?Quick Search allows easy and quick access to the best terms for your search...
  5. And from the session results page, you can use the filters on the left of your results to further refine. Here you see the disease filter and we can see which diseases are referenced in our result set for Januvia, either as a therapeutic area or side effect.
  6. Searching for specific types of content is also possible but using the field limits as seen here to search for conference name, conference date and conference location.You may also select conferences from the Publication Type limit or AiP. You will also notice AiP/In Process in Quick limits for even easier accessibility.
  7. Don’t loose those important searches, register in Embase so you may save your searches or set up email alerts. Registering also means you receive all up to date information such as upcoming webinars.
  8. ME: May I introduce Pierre. Pierre is a clinical liaison librarian, in the Information Services Biomedical Library, Center for Evidence-Based Research. They work with 3 main hospitals.Pierre, can you tell us more about your role and your main points of concern?PIERRE: It is many, for example, I instruct users in the use of library resources and management of information and I assist with literature searches on evidence-based practice issues, consulting with staff conducting systematic reviews with regards to search strategies. I serve as the primary library contact for many of the resources used by clinicians.My users are mainly involved in finding information from relevant and reliable sources regarding the effects of different forms of healthcare and they must be through when conducting this research and when publishing.ME: Are your users preparing articles for publication, particularly Systematic Review Articles. PIERRE: Yes and we hear more and more that journal editors and referees now stipulate that Embase searches are needed and authors publishing in the field of EBM, who need to follow Cochrane guidelines MUST conduct Embase searches. How can we best incorporate this into their workflow? Some users are still convinced that Medline is enough and some have even asked about Scopus. ME: Let’s have a look at the unique value Embase offers and also how easy it is to search with confidence!
  9. We can now refer to the full text for more details, having already checked the relevance of the article to our clinical query , in Embase.
  10. One of the major steps in conducting a systematic review is a comprehensive literature search. With Embase, all users, regardless of experience may enter the best term or terms to search, even on the Quick Search page. Entering the drug in a non-indexed database is possible but if you do not enter the generic name, there are no prompts in Scopus, used here as an example. A clinician trying to carry out a literature search alone, may know to use some of the commonly known terms for his search but maybe not all. Embase will help him/her select the term which automatically includes all the synonyms for that term.In Scopus, they are carrying out a free text search for januvia. I would like to point out that Scopus is an excellent all-science database with strengths in citation and author analysis for example but here we are looking at finding the best biomedical results and how indexing impacts your results.
  11. Pubmed (MEDLINE) does allow thesaurus assistedsearching but here also we notice a difference in the number of results retrieved. Pubmed finds 132 results compared to 8,000 in Embase. We know there is unique content in Embase, the conference abstracts shown here for example,but there is also a difference in indexing focus and so Embase indexes more drugs, more deeply.
  12. In Medline, this article although present in Medline is not indexed with digoxin and therefore our search for digoxin and antibacterial agents did not find this article. As we know already, it is found in Embase.
  13. Antibiotic and digoxin with drug combinationANDCongestive heart failure with drug therapyAND PneumoniaSave this search – remove drug therapy from disease and rerun main searchNow in session results, remove drug comparison from drug sub-searches and note asterix (indicates which searches have been effected by a change to a related search)– now click on result number to update your search strategy.Compare the effectiveness of sitagliptin and saxagliptin in the treatment of type II diabetes mellitus (show this in Emtree)Go to Drug Search and type in sitagliptin and saxagliptin with drug comparison. Go to Emtree and show diabetes mellitus and then go to ‘type 2 diabetes mellitus’. Take this to Disease Search and combine with disease subheading ‘drug therapy’. Combine both searches.Show editing options. NOT [review]/limAdvanced combine on the Session Results: Last search above NOT saxagliptin search, for example #2 NOT #1.Quickly show Emtree to find suitable terms/subject headings and then using Drug Search to add subheadings.
  14. Find disease management studies for Type II diabetesGo to Emtree and type in diabetes. Once you see the tree, select non-insulin dependant diabetes mellitus. Click on ‘take this to Disease search’. Point out ‘major focus’ option if users would like to limit their search to only records where the disease is of major importance and show on Disease Search form. Show quick and advanced limits.You can then add the subheading ‘disease management’. Check filters for drugs and study types.