1. Fostamatinib (Rheumatoid Arthritis) Forecast and Market
Analysis
Report Details:
Published:November 2012
No. of Pages: 47
Price: Single User License – US$6995
Fostamatinib (Rheumatoid Arthritis) Forecast and Market Analysis
Summary
GlobalData has released its new PharmaPoint Drug Evaluation report, Fostamatinib (Rheumatoid
Arthritis) Forecast and Market Analysis. The RA market is currently very dynamic, with the
November 6, 2012 FDA approval of Pfizer’s Xeljanz (tofacitinib) and novel oral therapies awaiting
approval such as: Eli Lilly’s anti-BAFF, tabalumab and JAK1,2 inhibitor, baricitinib, and Rigel/AZ’s
SYK inhibitor, fostamatinib. These compounds will challenge the current biologics in the attempt to
dislodge the stronghold of the TNF inhibitors, if their safety and efficacy profiles are proven once
they enter the market. Fostamatinib is an oral, small molecule that disrupts B-cell receptor-
mediated signaling by inhibiting SYK. Its action affects the inflammatory mechanisms of TNF-a, IL-
1, and IL-6. An in-license deal in 2010 has allowed the joint venture between Rigel
Pharmaceuticals and AstraZeneca to bring this drug to Phase III development for oncology and
RA. Regulatory filings are anticipated for 2013
Scope
- Overview of RA, including epidemiology, etiology, symptoms, diagnosis, pathology and treatment
guidelines as well as an overview on the competitive landscape.
- Detailed information on Fostamatinib including product description, safety and efficacy profiles as
well as a SWOT analysis.
- Sales forecast for Fostamatinib for the top eight countries from 2011 to 2022.
- Sales information covered for the US, France, Germany, the UK, Italy, Spain, Japan and
Australia
Reasons to buy
- Understand and capitalize by identifying products that are most likely to ensure a robust return

2. - Stay ahead of the competition by understanding the changing competitive landscape for
rheumatoid arthritis.
- Effectively plan your M&A and partnership strategies by identifying drugs with the most promising
sales potential
- Make more informed business decisions from insightful and in-depth analysis of Fostamatinib
performance
- Obtain sales forecast for Fostamatinib from 2011 to 2022 in (the US, France, Germany, the UK,
Italy, Spain, Japan and Australia)
Get your copy of this report @
http://www.reportsnreports.com/reports/213178-fostamatinib-rheumatoid-arthritis-forecast-and-market-
analysis.html
Major points covered in Table of Contents of this report include
1 Table of Contents
1 Table of Contents 4
1.1 List of Tables 6
1.2 List of Figures 6
2 Introduction 7
2.1 Catalyst 7
2.2 Related Reports 8
3 Disease Overview 10
3.1 Etiology and Pathophysiology 10
3.1.1 Etiology 10
3.1.2 Pathophysiology 10
3.1.3 Prognosis 13
3.1.4 Quality of Life 13
3.2 Symptoms 14
4 Disease Management 15
4.1 Overview 15
4.2 Diagnosis 15
4.3 Treatment 17
5 Competitive Assessment 21
5.1 Overview 21
5.2 Strategic Competitor Assessment 21
6 Opportunity and Unmet Need 23
6.1 Overview 23
6.2 Unmet Needs 24
6.2.1 More rheumatologists in the field and physician knowledge of the disease 24
6.2.2 More cost-effective therapies through oral formulation and biosimilars 24
6.2.3 The development of predictive tests and discovery of biomarkers 25
6.2.4 The discovery of curative therapies 25
6.2.5 Improved drug safety and efficacy profiles 25

3. 6.3 Gap Analysis 26
6.4 Opportunities 27
6.4.1 Predictive tools for diagnosis and treatment 27
6.4.2 Target specificity 27
7 Pipeline Assessment 28
7.1 Overview 28
7.2 Promising Drugs in Clinical Development 29
8 Fostamatinib (previously R788) 31
8.1 Overview 31
8.2 Efficacy 32
8.3 Safety 33
8.4 Dosing and Formulation 33
8.5 Potential Clinical Positioning 33
8.6 Potential Commercial Positioning 33
8.7 Pricing and Reimbursement 34
8.8 SWOT Analysis 34
8.9 Forecast 35
9 Appendix 36
9.1 Abbreviations 36
9.2 Bibliography 38
9.3 Methodology 42
9.4 Forecasting Methodology 42
9.4.1 Diagnosed Rheumatoid Arthritis Patients 42
9.4.2 Percent Drug-treated Patients 43
9.4.3 General Pricing Assumptions 43
9.4.4 Pricing of Pipeline agents 44
9.5 Physicians and Specialists Included in this Study 44
9.6 Primary Research - Prescriber Survey 45
9.7 About the Authors 45
9.7.1 Analysts 45
9.7.2 Global Head of Healthcare 46
9.8 About GlobalData 47
9.9 Contact Us 47
9.10 Disclaimer 47
1.1 List of Tables
Table 1: Symptoms of Rheumatoid Arthritis 14
Table 2: Treatment Guidelines for Rheumatoid Arthritis 18
Table 3: Top Three Biologics Prescribed for Moderate-Severe Rheumatoid Arthritis by Market 20
Table 4: Treatment Guidelines for Rheumatoid Arthritis 22
Table 5: Overall Unmet Needs - Current Level of Attainment 23
Table 6: Clinical Unmet Needs - Gap Analysis, 2012 27

4. Table 7: Rheumatoid Arthritis - Phase Pipeline, 2012 29
Table 8: Comparison of Therapeutic Classes in Development for RA, 2012 30
Table 9: Product Profile - Fostamatinib 31
Table 10: ACR Responses and DAS28 Scores for Fostamatinib vs. Placebo at Month Three 32
Table 11: Fostamatinib SWOT Analysis, 2012 34
Table 12: Global Sales Forecasts ($m) for Fostamatinib 35
Table 13: Physicians Surveyed, By Country 45
1.2 List of Figures
Figure 1: Healthy and Arthritic Joint with Rheumatoid Arthritis 10
Figure 2: Rheumatoid Arthritis Biologic Drug Targets 12
Figure 3: Diagnosis Criteria for Rheumatoid Arthritis Based on 2010 ACR/EULAR Criteria Point
System 16
Figure 4: Severity of Rheumatoid Arthritis 17
Figure 5: Biologic Treatment Flow Based on Updated 2012 ACR Treatment Recommendations*
19
Figure 6: Competitive Assessment of Late-Stage Pipeline Agents in RA, 2012-2022 29
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